JP2017511360A5 - - Google Patents
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- JP2017511360A5 JP2017511360A5 JP2016562752A JP2016562752A JP2017511360A5 JP 2017511360 A5 JP2017511360 A5 JP 2017511360A5 JP 2016562752 A JP2016562752 A JP 2016562752A JP 2016562752 A JP2016562752 A JP 2016562752A JP 2017511360 A5 JP2017511360 A5 JP 2017511360A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- therapeutic agent
- compound
- disease
- condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 4
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 230000003463 hyperproliferative effect Effects 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 229940083338 MDM2 inhibitor Drugs 0.000 claims 2
- 239000012819 MDM2-Inhibitor Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- -1 R d is Inorganic materials 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020033622A JP6909323B2 (ja) | 2014-04-17 | 2020-02-28 | Ｍｄｍ２阻害剤及びそれを使用する治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980747P | 2014-04-17 | 2014-04-17 | |
| US61/980,747 | 2014-04-17 | ||
| PCT/US2015/026098 WO2015161032A1 (en) | 2014-04-17 | 2015-04-16 | Mdm2 inhibitors and therapeutic methods using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020033622A Division JP6909323B2 (ja) | 2014-04-17 | 2020-02-28 | Ｍｄｍ２阻害剤及びそれを使用する治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511360A JP2017511360A (ja) | 2017-04-20 |
| JP2017511360A5 true JP2017511360A5 (enExample) | 2018-05-17 |
| JP6694827B2 JP6694827B2 (ja) | 2020-05-20 |
Family
ID=54321424
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562752A Active JP6694827B2 (ja) | 2014-04-17 | 2015-04-16 | Ｍｄｍ２阻害剤及びそれを使用する治療方法 |
| JP2020033622A Active JP6909323B2 (ja) | 2014-04-17 | 2020-02-28 | Ｍｄｍ２阻害剤及びそれを使用する治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020033622A Active JP6909323B2 (ja) | 2014-04-17 | 2020-02-28 | Ｍｄｍ２阻害剤及びそれを使用する治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9745314B2 (enExample) |
| EP (1) | EP3131544B1 (enExample) |
| JP (2) | JP6694827B2 (enExample) |
| KR (2) | KR102599945B1 (enExample) |
| CN (2) | CN111718354A (enExample) |
| AU (1) | AU2015247646B2 (enExample) |
| CA (1) | CA2945527C (enExample) |
| ES (1) | ES2712973T3 (enExample) |
| IL (2) | IL248211B (enExample) |
| MX (2) | MX373045B (enExample) |
| SG (2) | SG11201608667SA (enExample) |
| WO (1) | WO2015161032A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| WO2015161032A1 (en) * | 2014-04-17 | 2015-10-22 | The Regents Of The University Of Michigan | Mdm2 inhibitors and therapeutic methods using the same |
| EA038071B1 (ru) | 2014-08-21 | 2021-07-01 | Бёрингер Ингельхайм Интернациональ Гмбх | СОЕДИНЕНИЕ СПИРО[3H-ИНДОЛ-3,2'-ПИРРОЛИДИН]-2(1H)-ОНА И ЕГО ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ MDM2-p53 |
| US9962380B2 (en) * | 2015-09-23 | 2018-05-08 | Wisconsin Alumni Research Foundation | Methods for treating cognitive deficits associated with fragile X syndrome |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| PT3359542T (pt) | 2015-10-09 | 2021-05-25 | Boehringer Ingelheim Int | Compostos de espiro[3h-indole-3,2¿-pirrolidin]-2(1h)-ona e derivados como inibidores de mdm2-p53 |
| CN113788818A (zh) * | 2016-04-06 | 2021-12-14 | 密执安大学评议会 | Mdm2蛋白质降解剂 |
| ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| US11339171B2 (en) * | 2017-12-29 | 2022-05-24 | Gan & Lee Pharmaceuticals | MDM2 inhibitors |
| EP3511334A1 (en) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53 |
| KR102039696B1 (ko) | 2018-04-23 | 2019-11-04 | 충남대학교산학협력단 | 세포내 결핵균 제어를 위한 p53 발현 조절 가능한 조성물 (K279-1558) 또는 방법 |
| AU2019315466B2 (en) | 2018-07-31 | 2022-05-19 | Ascentage Pharma (Suzhou) Co., Ltd. | Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP |
| CN114522167A (zh) | 2018-07-31 | 2022-05-24 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| CA3095699A1 (en) | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CN110772639B (zh) * | 2018-07-31 | 2021-04-13 | 苏州亚盛药业有限公司 | Bcl-2抑制剂与MDM2抑制剂的组合产品及其在预防和/或治疗疾病中的用途 |
| JP2021534088A (ja) * | 2018-08-08 | 2021-12-09 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | 免疫療法とｍｄｍ２阻害剤の併用 |
| TWI750539B (zh) * | 2018-11-23 | 2021-12-21 | 大陸商蘇州亞盛藥業有限公司 | 新穎藥物組成物及其用途 |
| CA3095702A1 (en) * | 2018-12-14 | 2020-06-18 | Ascentage Pharma (Suzhou) Co., Ltd. | A compound for treating osteoarthritis |
| CN111607647A (zh) * | 2019-02-24 | 2020-09-01 | 苏州亚盛药业有限公司 | Mdm2抑制剂的治疗方法和生物标志物 |
| CN112209938B (zh) * | 2019-07-11 | 2021-06-11 | 苏州亚盛药业有限公司 | 2-吲哚啉螺环酮类化合物的制备方法及其中间体 |
| CN112237579B (zh) * | 2019-07-19 | 2022-03-29 | 苏州亚盛药业有限公司 | 药物组合及其用途 |
| AU2020323033A1 (en) * | 2019-07-26 | 2021-04-22 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition of MDM2 inhibitor and use thereof for preventing and/or treating disease |
| CN112852959A (zh) | 2019-11-27 | 2021-05-28 | 苏州亚盛药业有限公司 | 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物 |
| US11850239B2 (en) | 2019-12-19 | 2023-12-26 | Ascentage Pharma (Suzhou) Co., Ltd. | MDM2 inhibitor and a platinum compound for cancer treatment |
| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| EP4041736A4 (en) * | 2020-01-23 | 2023-06-07 | Ascentage Pharma (Suzhou) Co., Ltd. | AMORPHOUS FORM OR CRYSTALLINE FORM OF 2-INDOLINOLINOLOLYLSPIRONONE COMPOUNDS OR THEIR SALTS, SOLVENT COMPLEXES |
| CN113337602A (zh) * | 2020-03-02 | 2021-09-03 | 苏州亚盛药业有限公司 | Mdm2抑制剂的治疗方法和生物标志物 |
| IL296451A (en) * | 2020-03-19 | 2022-11-01 | Kymera Therapeutics Inc | Mdm2 degraders and uses thereof |
| WO2021208911A1 (en) * | 2020-04-14 | 2021-10-21 | Ascentage Pharma (Suzhou) Co., Ltd. | Novel medical use of mdm2 inhibitors |
| US20230218575A1 (en) * | 2020-06-15 | 2023-07-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Microsuspension of an mdm2 inhibitor and therapeautic applications thereof |
| AU2021333983A1 (en) | 2020-08-27 | 2023-01-05 | Otsuka Pharmaceutical Co., Ltd. | Biomarkers for cancer therapy using MDM2 antagonists |
| CN112022812B (zh) * | 2020-11-03 | 2021-01-29 | 上海亚盛医药科技有限公司 | 一种包含杂环类化合物的组合物、其制备方法和应用 |
| WO2022170108A1 (en) * | 2021-02-04 | 2022-08-11 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof in prevention of radiation injury |
| US12245355B2 (en) | 2021-02-19 | 2025-03-04 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| JP2024528174A (ja) | 2021-08-02 | 2024-07-26 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | 医薬組合せおよびその使用 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| CN116421598B (zh) * | 2022-01-11 | 2024-08-30 | 苏州亚盛药业有限公司 | 用于治疗aml-mrc和mds的方法 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
| US6605712B1 (en) | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
| NZ561215A (en) | 2005-02-22 | 2010-12-24 | Univ Michigan | Small molecule inhibitors of MDM2 and uses thereof |
| WO2007063013A1 (en) | 2005-12-01 | 2007-06-07 | F. Hoffmann-La Roche Ag | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents |
| CN101400680B (zh) * | 2006-03-13 | 2012-04-25 | 霍夫曼-拉罗奇有限公司 | 螺吲哚满酮衍生物 |
| EP1996591B1 (en) * | 2006-03-13 | 2011-01-12 | F. Hoffmann-La Roche AG | Spiroindolinone derivatives |
| EP2063887B1 (en) * | 2006-08-30 | 2013-05-29 | The Regents of the University of Michigan | New small molecule inhibitors of mdm2 and the uses thereof |
| US7737174B2 (en) | 2006-08-30 | 2010-06-15 | The Regents Of The University Of Michigan | Indole inhibitors of MDM2 and the uses thereof |
| US8222288B2 (en) | 2006-08-30 | 2012-07-17 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| US20080206794A1 (en) | 2006-09-15 | 2008-08-28 | Renovar Incorporated | Systems And Methods For Characterizing Contrast Induced-Nephropathy |
| US20080188506A1 (en) * | 2007-02-07 | 2008-08-07 | Qingjie Ding | Spiroindolinone derivatives |
| BRPI0919325A2 (pt) | 2008-09-18 | 2021-03-30 | F.Hoffmann-La Roche Ag | Pirrolidina-2-carboxamidas substituídas |
| US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
| US8076482B2 (en) * | 2009-04-23 | 2011-12-13 | Hoffmann-La Roche Inc. | 3,3′-spiroindolinone derivatives |
| KR20120099462A (ko) * | 2009-11-12 | 2012-09-10 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | 스피로-옥신돌 ｍｄｍ2 길항제 |
| US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| CA2800519A1 (en) * | 2010-04-09 | 2011-10-13 | The Regents Of The University Of Michigan | Biomarkers for mdm2 inhibitors for use in treating disease |
| US8217044B2 (en) * | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| US20120046306A1 (en) | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
| US8680132B2 (en) | 2010-11-12 | 2014-03-25 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| PT2684880T (pt) * | 2011-03-10 | 2018-04-27 | Daiichi Sankyo Co Ltd | Derivado de dispiropirrolidina |
| US8629141B2 (en) * | 2011-05-11 | 2014-01-14 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| EP3042906B1 (en) * | 2013-09-04 | 2019-10-23 | Daiichi Sankyo Company, Limited | Method for producing a spirooxindole derivative |
| WO2015161032A1 (en) * | 2014-04-17 | 2015-10-22 | The Regents Of The University Of Michigan | Mdm2 inhibitors and therapeutic methods using the same |
-
2015
- 2015-04-16 WO PCT/US2015/026098 patent/WO2015161032A1/en not_active Ceased
- 2015-04-16 ES ES15779988T patent/ES2712973T3/es active Active
- 2015-04-16 CN CN202010081463.0A patent/CN111718354A/zh active Pending
- 2015-04-16 MX MX2016013457A patent/MX373045B/es active IP Right Grant
- 2015-04-16 AU AU2015247646A patent/AU2015247646B2/en active Active
- 2015-04-16 KR KR1020227012871A patent/KR102599945B1/ko active Active
- 2015-04-16 JP JP2016562752A patent/JP6694827B2/ja active Active
- 2015-04-16 CA CA2945527A patent/CA2945527C/en active Active
- 2015-04-16 KR KR1020167031180A patent/KR102389552B1/ko active Active
- 2015-04-16 US US14/688,553 patent/US9745314B2/en active Active
- 2015-04-16 CN CN201580032547.2A patent/CN106794171B/zh active Active
- 2015-04-16 SG SG11201608667SA patent/SG11201608667SA/en unknown
- 2015-04-16 EP EP15779988.3A patent/EP3131544B1/en active Active
- 2015-04-16 SG SG10201913742TA patent/SG10201913742TA/en unknown
-
2016
- 2016-10-06 IL IL24821116A patent/IL248211B/en active IP Right Grant
- 2016-10-13 MX MX2020003939A patent/MX2020003939A/es unknown
-
2019
- 2019-09-19 IL IL269462A patent/IL269462B/en active IP Right Grant
-
2020
- 2020-02-28 JP JP2020033622A patent/JP6909323B2/ja active Active
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