JP2018515495A5 - - Google Patents
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- Publication number
- JP2018515495A5 JP2018515495A5 JP2017557923A JP2017557923A JP2018515495A5 JP 2018515495 A5 JP2018515495 A5 JP 2018515495A5 JP 2017557923 A JP2017557923 A JP 2017557923A JP 2017557923 A JP2017557923 A JP 2017557923A JP 2018515495 A5 JP2018515495 A5 JP 2018515495A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- solvate
- acceptable salt
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000012453 solvate Substances 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- -1 di-substituted indole group Chemical group 0.000 claims description 5
- 208000001490 Dengue Diseases 0.000 claims description 4
- 206010012310 Dengue fever Diseases 0.000 claims description 4
- 208000025729 dengue disease Diseases 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 241000725619 Dengue virus Species 0.000 claims description 3
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000010076 replication Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 12
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020071412A JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166900.9 | 2015-05-08 | ||
| EP15166900 | 2015-05-08 | ||
| EP16163342 | 2016-03-31 | ||
| EP16163342.5 | 2016-03-31 | ||
| PCT/EP2016/059975 WO2016180696A1 (en) | 2015-05-08 | 2016-05-04 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020071412A Division JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515495A JP2018515495A (ja) | 2018-06-14 |
| JP2018515495A5 true JP2018515495A5 (enExample) | 2019-04-18 |
| JP6752821B2 JP6752821B2 (ja) | 2020-09-09 |
Family
ID=56026812
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557923A Active JP6752821B2 (ja) | 2015-05-08 | 2016-05-04 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2020071412A Active JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2021096927A Active JP7132399B2 (ja) | 2015-05-08 | 2021-06-09 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2022133239A Active JP7451626B2 (ja) | 2015-05-08 | 2022-08-24 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020071412A Active JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2021096927A Active JP7132399B2 (ja) | 2015-05-08 | 2021-06-09 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2022133239A Active JP7451626B2 (ja) | 2015-05-08 | 2022-08-24 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Country Status (39)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| US9944598B2 (en) * | 2014-10-01 | 2018-04-17 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| BR112017006708A2 (pt) * | 2014-10-01 | 2017-12-26 | Janssen Pharmaceuticals Inc | indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| CR20190531A (es) * | 2017-05-22 | 2020-03-05 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| PH12022551160A1 (en) * | 2019-11-15 | 2023-09-25 | Janssen Pharmaceuticals Inc | Treatment and prevention of dengue disease |
| WO2022094817A1 (en) * | 2020-11-04 | 2022-05-12 | Janssen Pharmaceuticals, Inc. | Pharmaceutical formulation |
| WO2022094816A1 (en) * | 2020-11-04 | 2022-05-12 | Janssen Pharmaceuticals, Inc. | Solid formulation |
| CN113024440B (zh) * | 2021-03-17 | 2023-05-16 | 凯莱英医药集团（天津）股份有限公司 | 连续化合成取代吲哚-2-羧酸的方法 |
| MX2023014787A (es) | 2021-06-29 | 2024-03-25 | Janssen Pharmaceuticals Inc | Procesos para la preparación de derivados de (s)-2-(4-cloro-2-meto xifenil)-2-(3-metoxi-5 (metilsulfonil)fenil)amino)- 1-(1h-indol-3-il)etenona. |
| CN119173261A (zh) | 2022-05-12 | 2024-12-20 | 杨森制药公司 | 登革热病毒感染的治疗和/或预防 |
| CN115521307B (zh) * | 2022-09-30 | 2023-09-22 | 甘肃皓天医药科技有限责任公司 | 一种5-卤代-7-氮杂吲哚的制备方法 |
| WO2025253267A1 (en) | 2024-06-06 | 2025-12-11 | Janssen Pharmaceuticals, Inc. | Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease |
| WO2026018176A1 (en) | 2024-07-17 | 2026-01-22 | Janssen Pharmaceuticals, Inc. | 2-(4-chloro-2 methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(5-(trifluoro¬methoxy)-1h-indol-3-yl)ethanone and pharmaceutical compositions comprising the same |
| WO2026057013A1 (zh) * | 2024-09-14 | 2026-03-19 | 华武生物医药技术(湖北)有限责任公司 | 一类登革热病毒复制抑制剂、其制备方法和用途 |
| CN119306651B (zh) * | 2024-10-11 | 2025-12-05 | 山东大学 | 一种吲哚3-酰胺类衍生物及其制备方法与应用 |
| CN121378100B (zh) * | 2025-12-24 | 2026-04-21 | 浙江大学医学院附属第二医院 | 一种苯并[g]吲哚衍生物及其在制备抗登革热药物中的应用 |
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|---|---|---|---|---|
| AU1200899A (en) | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| EP1519735A4 (en) | 2001-12-12 | 2006-01-11 | Conforma Therapeutic Corp | ASSAYS AND DEVICES FOR DETERMINING AND MODULATING HSP90 BINDING ACTIVITY |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| CN101103026A (zh) | 2005-01-14 | 2008-01-09 | 健亚生物科技公司 | 用于治疗病毒感染的吲哚衍生物 |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| MX2011001872A (es) * | 2008-08-18 | 2011-05-23 | Univ Yale | Moduladores de mif. |
| EP2331499B1 (en) | 2008-08-19 | 2016-09-21 | Janssen Pharmaceutica NV | Cold menthol receptor antagonists |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
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| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
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| WO2011120025A1 (en) | 2010-03-26 | 2011-09-29 | Glaxo Group Limited | Indazolyl-pyrimidines as kinase inhibitors |
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| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
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| JP6505727B2 (ja) | 2014-01-31 | 2019-04-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロ環式ｐ２’基を有する第ｘｉａ因子阻害剤としてのマクロ環 |
| KR102382905B1 (ko) | 2014-06-04 | 2022-04-04 | 프레드 헛친슨 켄서 리서치 센터 | 노치 1 및/또는 노치 2 작용제를 사용한 줄기 세포의 확장 및 생착 |
| KR102391259B1 (ko) | 2014-06-04 | 2022-04-26 | 암젠 인크 | 포유류 세포 배양물을 회수하는 방법 |
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| BR112017006708A2 (pt) | 2014-10-01 | 2017-12-26 | Janssen Pharmaceuticals Inc | indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue |
| NO2721243T3 (enExample) | 2014-10-01 | 2018-10-20 | ||
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| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP6636133B2 (ja) | 2015-07-22 | 2020-01-29 | オメイコス セラピューティクス ゲーエムベーハー | 心疾患の治療に対するｃｙｐ−エイコサノイドの代謝的にロバストな類縁体 |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3002214C (en) | 2015-11-03 | 2022-01-04 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
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| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
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| US10576085B2 (en) | 2016-04-01 | 2020-03-03 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| KR102427334B1 (ko) | 2016-04-01 | 2022-08-03 | 카이트 파마 인코포레이티드 | 키메라 항원 및 t 세포 수용체 및 사용 방법 |
| SG10201912519VA (en) | 2016-04-01 | 2020-02-27 | Kite Pharma Inc | Chimeric receptors and methods of use thereof |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX2018012016A (es) | 2016-04-01 | 2019-01-24 | Basf Se | Compuestos biciclicos. |
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| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CR20190531A (es) | 2017-05-22 | 2020-03-05 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
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2016
- 2016-05-03 JO JOP/2016/0086A patent/JOP20160086B1/ar active
- 2016-05-04 RS RS20210800A patent/RS62029B1/sr unknown
- 2016-05-04 ES ES21159479T patent/ES2941674T3/es active Active
- 2016-05-04 ES ES16723965T patent/ES2877404T3/es active Active
- 2016-05-04 HU HUE16723965A patent/HUE054724T2/hu unknown
- 2016-05-04 UA UAA201909970A patent/UA128183C2/uk unknown
- 2016-05-04 SM SM20210367T patent/SMT202100367T1/it unknown
- 2016-05-04 CN CN202010168278.5A patent/CN111303000B/zh active Active
- 2016-05-04 EP EP16723965.6A patent/EP3294738B1/en active Active
- 2016-05-04 PE PE2017002377A patent/PE20180232A1/es unknown
- 2016-05-04 CN CN201680026606.XA patent/CN107873022B/zh active Active
- 2016-05-04 MX MX2020011156A patent/MX391754B/es unknown
- 2016-05-04 CN CN202110222667.6A patent/CN113045476B/zh active Active
- 2016-05-04 PL PL16723965T patent/PL3294738T3/pl unknown
- 2016-05-04 CA CA2981845A patent/CA2981845C/en active Active
- 2016-05-04 PE PE2021001440A patent/PE20221579A1/es unknown
- 2016-05-04 MX MX2017014293A patent/MX383932B/es unknown
- 2016-05-04 LT LTEP16723965.6T patent/LT3294738T/lt unknown
- 2016-05-04 HR HRP20210675TT patent/HRP20210675T1/hr unknown
- 2016-05-04 SI SI201631214T patent/SI3294738T1/sl unknown
- 2016-05-04 AU AU2016259677A patent/AU2016259677B2/en active Active
- 2016-05-04 UA UAA201711845A patent/UA121332C2/uk unknown
- 2016-05-04 BR BR112017023904-3A patent/BR112017023904A2/pt not_active Application Discontinuation
- 2016-05-04 EP EP21159479.1A patent/EP3896072B1/en active Active
- 2016-05-04 WO PCT/EP2016/059975 patent/WO2016180696A1/en not_active Ceased
- 2016-05-04 MD MDE20180272T patent/MD3294738T2/ro active IP Right Revival
- 2016-05-04 SG SG10201900315SA patent/SG10201900315SA/en unknown
- 2016-05-04 CR CR20200152A patent/CR20200152A/es unknown
- 2016-05-04 KR KR1020217011966A patent/KR102610493B1/ko active Active
- 2016-05-04 JP JP2017557923A patent/JP6752821B2/ja active Active
- 2016-05-04 CR CR20170490A patent/CR20170490A/es unknown
- 2016-05-04 KR KR1020177031660A patent/KR102610491B1/ko active Active
- 2016-05-04 EA EA201792429A patent/EA034978B1/ru unknown
- 2016-05-04 DK DK16723965.6T patent/DK3294738T3/da active
- 2016-05-04 US US15/571,930 patent/US10696632B2/en active Active
- 2016-05-04 MY MYPI2020005593A patent/MY198339A/en unknown
- 2016-05-05 TW TW109121289A patent/TWI744963B/zh active
- 2016-05-05 TW TW105113912A patent/TWI725969B/zh active
- 2016-05-06 UY UY0001039706A patent/UY39706A/es not_active Application Discontinuation
- 2016-05-06 UY UY0001036674A patent/UY36674A/es active IP Right Grant
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2017
- 2017-11-01 SV SV2017005557A patent/SV2017005557A/es unknown
- 2017-11-02 GT GT201700234A patent/GT201700234A/es unknown
- 2017-11-02 PH PH12017502000A patent/PH12017502000B1/en unknown
- 2017-11-05 IL IL255430A patent/IL255430B/en active IP Right Grant
- 2017-11-07 CL CL2017002817A patent/CL2017002817A1/es unknown
- 2017-11-07 NI NI201700137A patent/NI201700137A/es unknown
- 2017-11-07 ZA ZA2017/07524A patent/ZA201707524B/en unknown
- 2017-11-07 EC ECIEPI201773878A patent/ECSP17073878A/es unknown
- 2017-11-30 CO CONC2017/0012381A patent/CO2017012381A2/es unknown
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2020
- 2020-02-20 IL IL272814A patent/IL272814B/en active IP Right Grant
- 2020-04-13 JP JP2020071412A patent/JP6898493B2/ja active Active
- 2020-05-05 ZA ZA2020/02435A patent/ZA202002435B/en unknown
- 2020-05-13 US US15/930,738 patent/US10919854B2/en active Active
- 2020-11-19 AU AU2020273314A patent/AU2020273314B2/en active Active
- 2020-12-31 US US17/139,703 patent/US11827602B2/en active Active
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2021
- 2021-05-10 JO JOJO/P/2021/0109A patent/JOP20210109B1/ar active
- 2021-06-09 JP JP2021096927A patent/JP7132399B2/ja active Active
- 2021-07-06 CY CY20211100607T patent/CY1124548T1/el unknown
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2022
- 2022-03-25 EC ECSENADI202223220A patent/ECSP22023220A/es unknown
- 2022-08-24 JP JP2022133239A patent/JP7451626B2/ja active Active
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2023
- 2023-10-19 US US18/490,072 patent/US12172959B2/en active Active
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2024
- 2024-12-19 US US18/987,392 patent/US20250230127A1/en active Pending
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