JP2018515495A5 - - Google Patents
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- Publication number
- JP2018515495A5 JP2018515495A5 JP2017557923A JP2017557923A JP2018515495A5 JP 2018515495 A5 JP2018515495 A5 JP 2018515495A5 JP 2017557923 A JP2017557923 A JP 2017557923A JP 2017557923 A JP2017557923 A JP 2017557923A JP 2018515495 A5 JP2018515495 A5 JP 2018515495A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- solvate
- acceptable salt
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000012453 solvate Substances 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- -1 di-substituted indole group Chemical group 0.000 claims description 5
- 208000001490 Dengue Diseases 0.000 claims description 4
- 206010012310 Dengue fever Diseases 0.000 claims description 4
- 208000025729 dengue disease Diseases 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 241000725619 Dengue virus Species 0.000 claims description 3
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000010076 replication Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 12
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020071412A JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166900.9 | 2015-05-08 | ||
| EP15166900 | 2015-05-08 | ||
| EP16163342.5 | 2016-03-31 | ||
| EP16163342 | 2016-03-31 | ||
| PCT/EP2016/059975 WO2016180696A1 (en) | 2015-05-08 | 2016-05-04 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020071412A Division JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515495A JP2018515495A (ja) | 2018-06-14 |
| JP2018515495A5 true JP2018515495A5 (enExample) | 2019-04-18 |
| JP6752821B2 JP6752821B2 (ja) | 2020-09-09 |
Family
ID=56026812
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557923A Active JP6752821B2 (ja) | 2015-05-08 | 2016-05-04 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2020071412A Active JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2021096927A Active JP7132399B2 (ja) | 2015-05-08 | 2021-06-09 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2022133239A Active JP7451626B2 (ja) | 2015-05-08 | 2022-08-24 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020071412A Active JP6898493B2 (ja) | 2015-05-08 | 2020-04-13 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2021096927A Active JP7132399B2 (ja) | 2015-05-08 | 2021-06-09 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
| JP2022133239A Active JP7451626B2 (ja) | 2015-05-08 | 2022-08-24 | デングウイルス複製阻害剤としての一または二置換インドール誘導体 |
Country Status (39)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| BR112017006299A2 (pt) * | 2014-10-01 | 2018-01-16 | Janssen Pharmaceuticals, Inc. | derivados indol mono- ou dissubstituídos como inibidores da replicação viral da dengue |
| ME03344B (me) * | 2014-10-01 | 2019-10-20 | Janssen Pharmaceuticals Inc | Mono- ili di-supstituisani indoli kao inнibitori replikacije denga virusa |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| EP3436004B1 (en) * | 2016-04-01 | 2024-12-11 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA039702B1 (ru) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| EA201992782A1 (ru) | 2017-05-22 | 2020-03-24 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| IL292970A (en) | 2019-11-15 | 2022-07-01 | Janssen Pharmaceuticals Inc | Treatment and prevention of dengue disease |
| WO2022094816A1 (en) | 2020-11-04 | 2022-05-12 | Janssen Pharmaceuticals, Inc. | Solid formulation |
| WO2022094817A1 (en) * | 2020-11-04 | 2022-05-12 | Janssen Pharmaceuticals, Inc. | Pharmaceutical formulation |
| CN113024440B (zh) * | 2021-03-17 | 2023-05-16 | 凯莱英医药集团（天津）股份有限公司 | 连续化合成取代吲哚-2-羧酸的方法 |
| EP4363403A1 (en) | 2021-06-29 | 2024-05-08 | Janssen Pharmaceuticals, Inc. | Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives |
| AU2023269343A1 (en) | 2022-05-12 | 2025-01-02 | Janssen Pharmaceuticals, Inc. | Treatment or prevention of dengue viral infection |
| CN115521307B (zh) * | 2022-09-30 | 2023-09-22 | 甘肃皓天医药科技有限责任公司 | 一种5-卤代-7-氮杂吲哚的制备方法 |
| CN119306651B (zh) * | 2024-10-11 | 2025-12-05 | 山东大学 | 一种吲哚3-酰胺类衍生物及其制备方法与应用 |
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| AU1200899A (en) | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| AU2002364566B2 (en) | 2001-12-12 | 2009-03-26 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating HSP90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| CA2593450A1 (en) | 2005-01-14 | 2006-07-20 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| US20060194835A1 (en) | 2005-02-09 | 2006-08-31 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| US9029376B2 (en) | 2008-06-03 | 2015-05-12 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| EA201170349A1 (ru) * | 2008-08-18 | 2011-08-30 | Йейл Юниверсити | Модуляторы mif |
| JP5559174B2 (ja) | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| EP2393359A4 (en) | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| WO2011088303A1 (en) | 2010-01-15 | 2011-07-21 | Gilead Sciences , Inc. | Inhibitors of flaviviridae viruses |
| EP2552211A4 (en) | 2010-03-26 | 2013-10-23 | Glaxo Group Ltd | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| DK3060547T3 (en) | 2013-10-23 | 2018-01-15 | Janssen Sciences Ireland Uc | CARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATMENT OF HEPATITS B |
| UY35971A (es) | 2014-01-31 | 2015-07-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Macrociclos con grupos p2? aromáticos como inhibidores del factor xia |
| US10208286B2 (en) | 2014-06-04 | 2019-02-19 | Fred Hutchinson Cancer Research Center | Expansion and engraftment of stem cells using Notch 1 and/or Notch 2 agonists |
| IL294430B2 (en) | 2014-06-04 | 2025-08-01 | Amgen Inc | Methods for harvesting mammalian cell cultures |
| ME03344B (me) | 2014-10-01 | 2019-10-20 | Janssen Pharmaceuticals Inc | Mono- ili di-supstituisani indoli kao inнibitori replikacije denga virusa |
| BR112017006299A2 (pt) | 2014-10-01 | 2018-01-16 | Janssen Pharmaceuticals, Inc. | derivados indol mono- ou dissubstituídos como inibidores da replicação viral da dengue |
| NO2721243T3 (enExample) | 2014-10-01 | 2018-10-20 | ||
| JP6835712B2 (ja) | 2014-10-10 | 2021-02-24 | ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー | 結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｔｕｂｅｒｃｕｌｏｓｉｓ）のためのポリメラーゼ連鎖反応プライマーおよびプローブ |
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2016296923B2 (en) | 2015-07-22 | 2019-02-21 | Board Of Regents, The University Of Texas System | Metabolically robust analogs of CYP-eicosanoids for the treatment of cardiac disease |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN108601723B (zh) | 2015-11-03 | 2022-05-17 | 硕腾服务有限责任公司 | 溶胶-凝胶聚合物复合材料及其用途 |
| SG11201807539UA (en) | 2016-03-31 | 2018-09-27 | Takeda Pharmaceuticals Co | Heterocyclic compound |
| CA3013407A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| CN109069512B (zh) | 2016-04-01 | 2022-06-14 | 西格诺药品有限公司 | 取代的氨基嘌呤化合物、其组合物以及相关治疗方法 |
| UA128326C2 (uk) | 2016-04-01 | 2024-06-12 | Амджен Інк. | Химерний рецептор до flt3 та спосіб його застосування |
| SG11201808411RA (en) | 2016-04-01 | 2018-10-30 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102411744B1 (ko) | 2016-04-01 | 2022-06-21 | 바스프 에스이 | 바이시클릭 화합물 |
| EP3436004B1 (en) | 2016-04-01 | 2024-12-11 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| KR20210089262A (ko) | 2016-04-01 | 2021-07-15 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| WO2018167952A1 (ja) | 2017-03-17 | 2018-09-20 | 三菱電機株式会社 | アダプティブアレーアンテナ装置 |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA039702B1 (ru) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| EA201992782A1 (ru) | 2017-05-22 | 2020-03-24 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
-
2016
- 2016-05-03 JO JOP/2016/0086A patent/JOP20160086B1/ar active
- 2016-05-04 JP JP2017557923A patent/JP6752821B2/ja active Active
- 2016-05-04 EP EP16723965.6A patent/EP3294738B1/en active Active
- 2016-05-04 US US15/571,930 patent/US10696632B2/en active Active
- 2016-05-04 CN CN202010168278.5A patent/CN111303000B/zh active Active
- 2016-05-04 SI SI201631214T patent/SI3294738T1/sl unknown
- 2016-05-04 KR KR1020217011966A patent/KR102610493B1/ko active Active
- 2016-05-04 PE PE2017002377A patent/PE20180232A1/es unknown
- 2016-05-04 ES ES21159479T patent/ES2941674T3/es active Active
- 2016-05-04 EP EP21159479.1A patent/EP3896072B1/en active Active
- 2016-05-04 MX MX2017014293A patent/MX383932B/es unknown
- 2016-05-04 WO PCT/EP2016/059975 patent/WO2016180696A1/en not_active Ceased
- 2016-05-04 AU AU2016259677A patent/AU2016259677B2/en active Active
- 2016-05-04 BR BR112017023904-3A patent/BR112017023904A2/pt not_active Application Discontinuation
- 2016-05-04 HU HUE16723965A patent/HUE054724T2/hu unknown
- 2016-05-04 MD MDE20180272T patent/MD3294738T2/ro unknown
- 2016-05-04 MY MYPI2020005593A patent/MY198339A/en unknown
- 2016-05-04 SM SM20210367T patent/SMT202100367T1/it unknown
- 2016-05-04 CN CN201680026606.XA patent/CN107873022B/zh active Active
- 2016-05-04 KR KR1020177031660A patent/KR102610491B1/ko active Active
- 2016-05-04 CR CR20170490A patent/CR20170490A/es unknown
- 2016-05-04 ES ES16723965T patent/ES2877404T3/es active Active
- 2016-05-04 HR HRP20210675TT patent/HRP20210675T1/hr unknown
- 2016-05-04 PL PL16723965T patent/PL3294738T3/pl unknown
- 2016-05-04 CN CN202110222667.6A patent/CN113045476B/zh active Active
- 2016-05-04 CR CR20200152A patent/CR20200152A/es unknown
- 2016-05-04 PE PE2021001440A patent/PE20221579A1/es unknown
- 2016-05-04 UA UAA201909970A patent/UA128183C2/uk unknown
- 2016-05-04 CA CA2981845A patent/CA2981845C/en active Active
- 2016-05-04 EA EA201792429A patent/EA034978B1/ru unknown
- 2016-05-04 DK DK16723965.6T patent/DK3294738T3/da active
- 2016-05-04 UA UAA201711845A patent/UA121332C2/uk unknown
- 2016-05-04 LT LTEP16723965.6T patent/LT3294738T/lt unknown
- 2016-05-04 SG SG10201900315SA patent/SG10201900315SA/en unknown
- 2016-05-04 RS RS20210800A patent/RS62029B1/sr unknown
- 2016-05-04 MX MX2020011156A patent/MX391754B/es unknown
- 2016-05-05 TW TW109121289A patent/TWI744963B/zh active
- 2016-05-05 TW TW105113912A patent/TWI725969B/zh active
- 2016-05-06 UY UY0001036674A patent/UY36674A/es active IP Right Grant
- 2016-05-06 UY UY0001039706A patent/UY39706A/es not_active Application Discontinuation
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2017
- 2017-11-01 SV SV2017005557A patent/SV2017005557A/es unknown
- 2017-11-02 GT GT201700234A patent/GT201700234A/es unknown
- 2017-11-02 PH PH12017502000A patent/PH12017502000B1/en unknown
- 2017-11-05 IL IL255430A patent/IL255430B/en active IP Right Grant
- 2017-11-07 CL CL2017002817A patent/CL2017002817A1/es unknown
- 2017-11-07 EC ECIEPI201773878A patent/ECSP17073878A/es unknown
- 2017-11-07 ZA ZA2017/07524A patent/ZA201707524B/en unknown
- 2017-11-07 NI NI201700137A patent/NI201700137A/es unknown
- 2017-11-30 CO CONC2017/0012381A patent/CO2017012381A2/es unknown
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2020
- 2020-02-20 IL IL272814A patent/IL272814B/en active IP Right Grant
- 2020-04-13 JP JP2020071412A patent/JP6898493B2/ja active Active
- 2020-05-05 ZA ZA2020/02435A patent/ZA202002435B/en unknown
- 2020-05-13 US US15/930,738 patent/US10919854B2/en active Active
- 2020-11-19 AU AU2020273314A patent/AU2020273314B2/en active Active
- 2020-12-31 US US17/139,703 patent/US11827602B2/en active Active
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2021
- 2021-05-10 JO JOP/2021/0109A patent/JOP20210109A1/ar unknown
- 2021-06-09 JP JP2021096927A patent/JP7132399B2/ja active Active
- 2021-07-06 CY CY20211100607T patent/CY1124548T1/el unknown
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2022
- 2022-03-25 EC ECSENADI202223220A patent/ECSP22023220A/es unknown
- 2022-08-24 JP JP2022133239A patent/JP7451626B2/ja active Active
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2023
- 2023-10-19 US US18/490,072 patent/US12172959B2/en active Active
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2024
- 2024-12-19 US US18/987,392 patent/US20250230127A1/en active Pending
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