|
US3598122A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US4144317A
(en)
|
1975-05-30 |
1979-03-13 |
Alza Corporation |
Device consisting of copolymer having acetoxy groups for delivering drugs
|
|
US4262003A
(en)
|
1975-12-08 |
1981-04-14 |
Alza Corporation |
Method and therapeutic system for administering scopolamine transdermally
|
|
US4201211A
(en)
|
1977-07-12 |
1980-05-06 |
Alza Corporation |
Therapeutic system for administering clonidine transdermally
|
|
US4525586A
(en)
|
1980-02-28 |
1985-06-25 |
The Upjohn Company |
Composition and process
|
|
US4338457A
(en)
|
1980-02-28 |
1982-07-06 |
The Upjohn Company |
Composition and process
|
|
US4306075A
(en)
|
1980-03-28 |
1981-12-15 |
The Upjohn Company |
Composition and process
|
|
US4420632A
(en)
|
1980-04-15 |
1983-12-13 |
The Upjohn Company |
Composition and process
|
|
US4306076A
(en)
|
1980-04-23 |
1981-12-15 |
The Upjohn Company |
Inter-phenylene CBA compounds
|
|
US4349689A
(en)
|
1980-12-22 |
1982-09-14 |
The Upjohn Company |
Methano carbacyclin analogs
|
|
US4379454A
(en)
|
1981-02-17 |
1983-04-12 |
Alza Corporation |
Dosage for coadministering drug and percutaneous absorption enhancer
|
|
DE3333240A1
(de)
|
1983-09-12 |
1985-03-28 |
Schering AG, 1000 Berlin und 4709 Bergkamen |
Mittel zur transdermalen applikation von arzneimittelwirkstoffen
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
US4683330A
(en)
|
1984-03-08 |
1987-07-28 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
ES2045437T3
(es)
|
1988-06-17 |
1994-01-16 |
Wellcome Found |
Analogos de prostaglandinas para empleo en medicina.
|
|
GB8824187D0
(en)
|
1988-10-14 |
1988-11-23 |
Wellcome Found |
Compounds for use in medicine
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
US5088977A
(en)
|
1988-12-21 |
1992-02-18 |
Drug Delivery Systems Inc. |
Electrical transdermal drug applicator with counteractor and method of drug delivery
|
|
GB9011588D0
(en)
*
|
1990-05-24 |
1990-07-11 |
Wellcome Found |
Prostaglandin analogues for use in medicine
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5869505A
(en)
|
1993-02-02 |
1999-02-09 |
Keenan; Robert M. |
Nicotine metabolites and nicotine dependence
|
|
US5853751A
(en)
|
1993-06-23 |
1998-12-29 |
Masiz; John J. |
Molecular transdermal transport system
|
|
US5797898A
(en)
|
1996-07-02 |
1998-08-25 |
Massachusetts Institute Of Technology |
Microchip drug delivery devices
|
|
IN184589B
(enExample)
|
1996-10-16 |
2000-09-09 |
Alza Corp |
|
|
WO2000057701A1
(en)
|
1999-03-31 |
2000-10-05 |
United Therapeutics Corporation |
Prostaglandin compounds, compositions and methods of treating peripheral vascular disease and pulmonary hypertension
|
|
US20020004065A1
(en)
|
2000-01-20 |
2002-01-10 |
David Kanios |
Compositions and methods to effect the release profile in the transdermal administration of active agents
|
|
US6242482B1
(en)
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6635274B1
(en)
|
2000-10-27 |
2003-10-21 |
Biochemics, Inc. |
Solution-based transdermal drug delivery system
|
|
US6700025B2
(en)
|
2001-01-05 |
2004-03-02 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US6803386B2
(en)
|
2002-01-16 |
2004-10-12 |
United Therapeutics Corporation |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
|
|
US8246979B2
(en)
|
2002-07-30 |
2012-08-21 |
Ucb Pharma Gmbh |
Transdermal delivery system for the administration of rotigotine
|
|
CN102697790A
(zh)
|
2003-05-22 |
2012-10-03 |
联合治疗公司 |
化合物和释放前列环素类似物的方法
|
|
WO2005009510A2
(en)
|
2003-07-23 |
2005-02-03 |
The Regents Of The University Of California |
Penetration enhancer combinations for transdermal delivery
|
|
US7375139B2
(en)
|
2003-08-18 |
2008-05-20 |
Aldred Katherine M |
Transdermal method and apparatus
|
|
JP2005120069A
(ja)
|
2003-10-13 |
2005-05-12 |
Anges Mg Inc |
炎症性疾患治療薬
|
|
CN101647792B
(zh)
|
2003-12-16 |
2012-11-28 |
联合治疗公司 |
曲前列环素在制备治疗和预防缺血性损害的药物中的用途
|
|
EP1696932B1
(en)
|
2003-12-16 |
2009-09-02 |
United Therapeutics Corporation |
Use of treprostinil to improve kidney functions
|
|
US7879909B2
(en)
|
2004-04-12 |
2011-02-01 |
United Therapeutics Corporation |
Use of Treprostinil to treat neuropathic diabetic foot ulcers
|
|
WO2006015299A2
(en)
|
2004-07-30 |
2006-02-09 |
Microchips, Inc. |
Multi-reservoir device for transdermal drug delivery and sensing
|
|
ES2596809T3
(es)
|
2004-10-08 |
2017-01-12 |
Noven Pharmaceuticals, Inc. |
Dispositivo de administración transdérmica de fármacos que incluye un refuerzo oclusivo
|
|
US8623917B2
(en)
|
2005-06-02 |
2014-01-07 |
The Regents Of The University Of Colorado, A Body Corporate |
Uses of prostacyclin analogs
|
|
US8435944B2
(en)
|
2005-06-03 |
2013-05-07 |
Acrux Dds Pty Ltd. |
Method and composition for transdermal drug delivery
|
|
US20080319092A1
(en)
|
2005-08-05 |
2008-12-25 |
Nuvo Research Inc. |
Transdermal Drug Delivery Formulation
|
|
CA2633588A1
(en)
|
2005-12-20 |
2007-08-23 |
Teikoku Pharma Usa, Inc. |
Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same
|
|
ES2657628T3
(es)
|
2006-02-28 |
2018-03-06 |
Kodiak Sciences Inc. |
Conjugados poliméricos que contienen acriloiloxietilfosforilcolina y su preparación
|
|
US9642912B2
(en)
|
2006-03-06 |
2017-05-09 |
Crescita Therapeutics Inc. |
Topical formulations for treating skin conditions
|
|
US9308181B2
(en)
|
2006-03-06 |
2016-04-12 |
Nuvo Research Inc. |
Topical formulations, systems and methods
|
|
US8747897B2
(en)
|
2006-04-27 |
2014-06-10 |
Supernus Pharmaceuticals, Inc. |
Osmotic drug delivery system
|
|
ES2707548T3
(es)
|
2006-05-15 |
2019-04-04 |
United Therapeutics Corp |
Administración de treprostinil utilizando un inhalador de dosis medida
|
|
WO2008002929A2
(en)
|
2006-06-26 |
2008-01-03 |
Inverseon, Inc. |
Heterologous cross-sensitization for improved agonist activity
|
|
WO2008049000A2
(en)
|
2006-10-18 |
2008-04-24 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
US20080280986A1
(en)
|
2007-02-09 |
2008-11-13 |
United Therapeutics Corporation |
Treprostinil treatment for interstitial lung disease and asthma
|
|
AU2008275179B2
(en)
|
2007-07-11 |
2013-09-12 |
Lexicon Pharmaceuticals, Inc. |
Methods and compositions for treating pulmonary hypertension and related diseases and disorders
|
|
EP2252570B1
(en)
|
2007-12-17 |
2017-04-05 |
United Therapeutics Corporation |
An improved process to prepare treprostinil, the active ingredient in remodulin ®
|
|
JP5688009B2
(ja)
|
2008-03-31 |
2015-03-25 |
日東電工株式会社 |
浸透物送達システム及びその使用方法
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
KR102080429B1
(ko)
|
2008-06-26 |
2020-02-21 |
안테리오스, 인코퍼레이티드 |
경피 운반
|
|
US20110294815A1
(en)
|
2008-06-27 |
2011-12-01 |
Harbeson Scott L |
Prostacyclin analogs
|
|
SMT201700592T1
(it)
|
2008-08-13 |
2018-03-08 |
Actelion Pharmaceuticals Ltd |
Composizioni terapeutiche contenenti macitentan
|
|
CN102271685A
(zh)
|
2008-12-30 |
2011-12-07 |
斯若姆博洛捷克有限公司 |
鉴定发展成器官功能衰竭的风险提高的危重患者的方法及用于其治疗的化合物
|
|
CN102421288B
(zh)
|
2009-05-07 |
2015-04-22 |
联合治疗公司 |
前列环素类似物的固体剂型
|
|
JP6087147B2
(ja)
|
2009-06-22 |
2017-03-01 |
ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ |
プロスタグランジンの精製方法
|
|
SG178315A1
(en)
|
2009-08-07 |
2012-03-29 |
Scipharm Sarl |
Composition for the treatment of cystic fibrosis
|
|
US9327105B2
(en)
|
2010-03-26 |
2016-05-03 |
Itrace Biomedical Inc. |
Active transdermal drug delivery system and the method thereof
|
|
US8557961B2
(en)
|
2010-04-02 |
2013-10-15 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
WO2011134478A2
(en)
|
2010-04-29 |
2011-11-03 |
Thrombologic Aps |
Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof
|
|
JP6046034B2
(ja)
|
2010-06-03 |
2016-12-14 |
ユナイテッド セラピューティクス コーポレイション |
トレプロスチニルの製造
|
|
WO2012006273A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
JP2013543491A
(ja)
*
|
2010-10-01 |
2013-12-05 |
リグスホスピタル |
急性外傷性凝固障害及び蘇生した心停止の予防または処置に使用するための血管内皮の完全性を調節または保存できる化合物
|
|
CA2726599C
(en)
|
2010-12-30 |
2017-07-25 |
Alphora Research Inc. |
Process for treprostinil salt preparation
|
|
WO2012095511A1
(en)
|
2011-01-13 |
2012-07-19 |
Scipharm Sàrl |
Method for enhancing engraftment of haematopoetic stem cells
|
|
JP2014503586A
(ja)
|
2011-01-24 |
2014-02-13 |
アンテリオス， インコーポレイテッド |
油組成物
|
|
HUE031652T2
(en)
|
2011-02-07 |
2017-07-28 |
Scipharm Sarl |
New composition for treating cystic fibrosis
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
CA2832992A1
(en)
|
2011-04-19 |
2012-10-26 |
Rigshospitalet |
Prostacyclin and analogs thereof administered during surgery for prevention and treatment of capillary leakage
|
|
WO2013022846A2
(en)
|
2011-08-05 |
2013-02-14 |
Cardero Therapeutics, Inc. |
Flavonoid compounds
|
|
KR101997939B1
(ko)
|
2011-08-12 |
2019-07-08 |
아센디스 파마 에이에스 |
담체-연결된 트레프로스티닐 전구약물
|
|
CN103874480A
(zh)
|
2011-08-12 |
2014-06-18 |
阿森迪斯药物股份有限公司 |
前列环素的缓释组合物
|
|
EP3643306A3
(en)
|
2011-08-12 |
2020-08-26 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
CN103193626B
(zh)
|
2012-01-10 |
2016-05-11 |
上海天伟生物制药有限公司 |
一种前列腺素类似物的晶型及其制备方法和用途
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
WO2013143548A1
(en)
|
2012-03-30 |
2013-10-03 |
Rigshospitalet |
Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
|
|
US20150087688A1
(en)
|
2012-04-25 |
2015-03-26 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
|
LT2674413T
(lt)
|
2012-06-15 |
2017-09-25 |
Scipharm Sąrl |
Treprostinilo ir jo darinių gavimo būdas
|
|
JP6901823B2
(ja)
|
2012-08-01 |
2021-07-14 |
ユナイテッド セラピューティクス コーポレイション |
間葉系幹細胞による肺動脈性高血圧症の処置
|
|
WO2014089385A2
(en)
|
2012-12-07 |
2014-06-12 |
Cayman Chemical Company Incorporated |
Methods of synthesizing a prostacyclin analog
|
|
EP3415150B1
(en)
|
2013-01-09 |
2021-08-18 |
United Therapeutics Corporation |
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
|
|
US9203373B2
(en)
*
|
2013-01-11 |
2015-12-01 |
Qualcomm Incorporated |
Diplexer design using through glass via technology
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
ES2927844T3
(es)
|
2013-01-11 |
2022-11-11 |
Corsair Pharma Inc |
Profármacos de treprostinil
|
|
US20140275616A1
(en)
|
2013-03-15 |
2014-09-18 |
United Therapeutics Corporation |
Salts of treprostinil
|
|
WO2014160638A1
(en)
|
2013-03-25 |
2014-10-02 |
United Therapeutics Corporation |
Process of making prostacyclin compounds with linker thiol and pegylated forms
|
|
CA2911172C
(en)
|
2013-04-30 |
2021-10-19 |
United Therapeutics Corporation |
Controlled release pharmaceutical formulations
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
FR3008320B1
(fr)
|
2013-07-15 |
2018-04-20 |
Centre Hospitalier Univ Grenoble |
Dispositif de prevention ou de traitement d'une ulceration cutanee
|
|
CN108947843A
(zh)
|
2013-10-25 |
2018-12-07 |
英斯梅德股份有限公司 |
前列环素化合物、其组合物及使用方法
|
|
EP3068752A1
(en)
|
2013-11-13 |
2016-09-21 |
Cayman Chemical Company Incorporated |
Amine salts of a prostacyclin analog
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
JO3624B1
(ar)
|
2014-05-08 |
2020-08-27 |
Lilly Co Eli |
تركيبات إنسولين سريعة المفعول
|
|
JP6561109B2
(ja)
|
2014-07-16 |
2019-08-14 |
コルセア ファーマ インコーポレイテッド |
トレプロスチニル誘導体化合物およびその使用方法
|
|
US20160045470A1
(en)
|
2014-08-12 |
2016-02-18 |
Dr. Reddy's Laboratories Limited |
Amorphous solid dispersion of treprostinil diethanolamine
|
|
HU231184B1
(hu)
|
2014-10-08 |
2021-07-28 |
CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. |
Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
|
|
US10343979B2
(en)
|
2014-11-18 |
2019-07-09 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
|
TWI540121B
(zh)
|
2014-12-01 |
2016-07-01 |
臺灣永光化學工業股份有限公司 |
曲前列環素二乙醇胺之合成方法及新穎中間體
|
|
EA201791696A1
(ru)
|
2015-01-27 |
2017-11-30 |
Сифарм Сарл |
Композиция для лечения веноокклюзионной болезни печени
|
|
US20160243064A1
(en)
|
2015-02-21 |
2016-08-25 |
Gavis Pharmaceuticals |
Novel oral pharmaceutical compositions of treprostinil
|
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
US9394227B1
(en)
|
2015-06-17 |
2016-07-19 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
US9643911B2
(en)
|
2015-06-17 |
2017-05-09 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
CA3045917A1
(en)
|
2016-12-05 |
2018-06-14 |
Corsair Pharma, Inc. |
Dermal and transdermal administration of treprostinil and salts thereof
|
|
JP6556217B2
(ja)
*
|
2017-12-20 |
2019-08-07 |
三菱電機株式会社 |
流量検出装置
|
|
JP2020011957A
(ja)
|
2019-07-22 |
2020-01-23 |
コルセア ファーマ インコーポレイテッド |
トレプロスチニル誘導体化合物およびその使用方法
|