JP2016519165A5 - - Google Patents
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- Publication number
- JP2016519165A5 JP2016519165A5 JP2016515318A JP2016515318A JP2016519165A5 JP 2016519165 A5 JP2016519165 A5 JP 2016519165A5 JP 2016515318 A JP2016515318 A JP 2016515318A JP 2016515318 A JP2016515318 A JP 2016515318A JP 2016519165 A5 JP2016519165 A5 JP 2016519165A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- methyl
- nitrogen atoms
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920006395 saturated elastomer Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- -1 1,3-dimethyl-2,6-dioxo-2,3-dihydro -1H- purine -7 (6H) - yl Chemical group 0.000 description 4
- 239000013067 intermediate product Substances 0.000 description 4
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 4
- 238000006751 Mitsunobu reaction Methods 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- WZBKGWBHAPBSBF-UHFFFAOYSA-N 1,3,8-trimethyl-7h-purine-2,6-dione Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=C(C)N2 WZBKGWBHAPBSBF-UHFFFAOYSA-N 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1309333.1 | 2013-05-23 | ||
| GBGB1309333.1A GB201309333D0 (en) | 2013-05-23 | 2013-05-23 | Purine diones as WNT pathway modulators |
| PCT/SG2014/000217 WO2014189466A1 (en) | 2013-05-23 | 2014-05-19 | Purine diones as wnt pathway modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519165A JP2016519165A (ja) | 2016-06-30 |
| JP2016519165A5 true JP2016519165A5 (enExample) | 2017-04-06 |
| JP6506742B2 JP6506742B2 (ja) | 2019-04-24 |
Family
ID=48784655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515318A Active JP6506742B2 (ja) | 2013-05-23 | 2014-05-19 | Ｗｎｔ経路モジュレーターとしてのプリンジオン |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9926320B2 (enExample) |
| EP (1) | EP2999699B1 (enExample) |
| JP (1) | JP6506742B2 (enExample) |
| KR (2) | KR102062262B1 (enExample) |
| CN (2) | CN105452248A (enExample) |
| AU (2) | AU2014269134B2 (enExample) |
| BR (1) | BR112015029182B1 (enExample) |
| CA (1) | CA2912757C (enExample) |
| DK (1) | DK2999699T3 (enExample) |
| ES (1) | ES2802923T3 (enExample) |
| GB (1) | GB201309333D0 (enExample) |
| SG (1) | SG11201509593TA (enExample) |
| WO (1) | WO2014189466A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
| GB201322334D0 (en) * | 2013-12-17 | 2014-01-29 | Agency Science Tech & Res | Maleimide derivatives as modulators of WNT pathway |
| TWI676626B (zh) * | 2014-04-23 | 2019-11-11 | 美商美國禮來大藥廠 | 抑制瞬時受體電位ａ１離子通道 |
| RS60192B1 (sr) | 2014-09-19 | 2020-06-30 | Lilly Co Eli | Inhibicija jonskog kanala a1 za prolazni receptorski potencijal |
| CN105440034B (zh) * | 2015-11-16 | 2017-08-15 | 山东罗欣药业集团股份有限公司 | 一种利格列汀及其中间体的制备方法 |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| CN106632332B (zh) * | 2016-09-26 | 2018-07-06 | 杭州新博思生物医药有限公司 | 一种伊曲茶碱的制备方法 |
| WO2019054941A1 (en) | 2017-09-14 | 2019-03-21 | Agency For Science, Technology And Research | MODULATORS OF THE WNT PATH |
| EA202091604A1 (ru) | 2018-01-31 | 2020-10-26 | Эли Лилли Энд Компани | Ингибирование ионного канала a1 с транзиторным рецепторным потенциалом |
| US10961534B2 (en) | 2018-07-13 | 2021-03-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating porphyria |
| US12534762B2 (en) | 2018-09-28 | 2026-01-27 | Children's Medical Center Corporation | Treating atopic dermatitis by targeting the WNT pathway |
| CN114072131B (zh) * | 2019-05-22 | 2024-03-19 | 新加坡科技研究局 | 口服制剂、其制备方法及其用途 |
| US20220211715A1 (en) * | 2019-05-22 | 2022-07-07 | Agency For Science, Technology And Research | Pharmaceutical combination |
| WO2021004467A1 (zh) * | 2019-07-08 | 2021-01-14 | 南京明德新药研发有限公司 | 作为porcupine抑制剂的化合物及其应用 |
| EP4069243A4 (en) * | 2020-01-08 | 2023-12-27 | Agency for Science, Technology and Research | COMBINATION THERAPY |
| AU2022297176A1 (en) | 2021-06-25 | 2024-01-04 | Korea Research Institute Of Chemical Technology | Novel bifunctional heterocyclic compound having btk degradation function via ubiquitin proteasome pathway, and use thereof |
| JP7784542B2 (ja) * | 2021-10-29 | 2025-12-11 | ジアンスー カニョン ファーマシューティカル カンパニー リミテッド | ５－置換のピリジン－２（１ｈ）－オン系化合物及びその使用 |
| CN114671875A (zh) * | 2022-04-27 | 2022-06-28 | 成都施贝康生物医药科技有限公司 | 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途 |
| CN120737092B (zh) * | 2025-09-05 | 2025-11-14 | 利诚检测认证集团股份有限公司 | 别嘌醇半抗原及其制备方法、人工抗原、抗体及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71971C2 (en) | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| TW201900217A (zh) | 2005-12-22 | 2019-01-01 | 美商海卓勒生物科學公司 | 用於調節ｔｒｐａ１功能之化合物 |
| SI3184527T1 (sl) * | 2007-06-22 | 2020-03-31 | Eli Lilly And Company | Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala |
| CN101909630A (zh) * | 2007-11-02 | 2010-12-08 | 新加坡科技研究局 | 预防和治疗肿瘤的方法和化合物 |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US20120108614A1 (en) | 2008-05-14 | 2012-05-03 | Chong Jayhong A | Compounds and compositions for treating chemical warfare agent-induced injuries |
| US20120046305A1 (en) | 2008-09-24 | 2012-02-23 | Moran Magdalene M | Methods and compositions for treating respiratory disorders |
| TW201026700A (en) | 2008-12-22 | 2010-07-16 | Hydra Biosciences Inc | Compositions useful for treating disorders related to TRPA1 |
| UA103918C2 (en) * | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| US8993612B2 (en) * | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| UY33469A (es) | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
| AR084294A1 (es) | 2010-12-20 | 2013-05-08 | Glenmark Pharmaceuticals Sa | Compuestos de 2-amino-4-ariltiazol, metodos para su sintesis y uso como antagonista de trpa1 |
| CA2836856A1 (en) * | 2011-06-13 | 2012-12-20 | Glenmark Pharmaceuticals, S.A. | Treatment of respiratory disorders using trpa1 antagonists |
| JP5659098B2 (ja) * | 2011-07-19 | 2015-01-28 | 株式会社東芝 | 半導体装置の製造方法 |
| JP2014521634A (ja) | 2011-07-25 | 2014-08-28 | グレンマーク ファーマシューティカルズ， エセ．アー． | Ｔｒｐａ１アンタゴニスト及びステロイドを含む医薬組成物 |
| JP2014521724A (ja) * | 2011-08-09 | 2014-08-28 | ハイドラ バイオサイエンシズ インコーポレイテッド | 一過性受容器電位イオンチャネルｔｒｐａ１の阻害 |
| EP3473099A1 (en) * | 2011-09-14 | 2019-04-24 | Samumed, LLC | Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| JP6377054B2 (ja) | 2012-05-11 | 2018-08-22 | リセット セラピューティークス， インコーポレイテッド | クリプトクロム調節薬としてのカルバゾール含有スルホンアミド |
| GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
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2013
- 2013-05-23 GB GBGB1309333.1A patent/GB201309333D0/en not_active Ceased
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2014
- 2014-05-19 CN CN201480041283.2A patent/CN105452248A/zh active Pending
- 2014-05-19 AU AU2014269134A patent/AU2014269134B2/en active Active
- 2014-05-19 ES ES14801575T patent/ES2802923T3/es active Active
- 2014-05-19 WO PCT/SG2014/000217 patent/WO2014189466A1/en not_active Ceased
- 2014-05-19 SG SG11201509593TA patent/SG11201509593TA/en unknown
- 2014-05-19 JP JP2016515318A patent/JP6506742B2/ja active Active
- 2014-05-19 DK DK14801575.3T patent/DK2999699T3/da active
- 2014-05-19 BR BR112015029182-1A patent/BR112015029182B1/pt active IP Right Grant
- 2014-05-19 US US14/893,172 patent/US9926320B2/en active Active
- 2014-05-19 EP EP14801575.3A patent/EP2999699B1/en active Active
- 2014-05-19 CA CA2912757A patent/CA2912757C/en active Active
- 2014-05-19 KR KR1020157035961A patent/KR102062262B1/ko active Active
- 2014-05-19 CN CN201910142080.7A patent/CN109776537B/zh active Active
- 2014-05-19 KR KR1020197038593A patent/KR102153989B1/ko active Active
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2017
- 2017-08-03 US US15/668,260 patent/US10472360B2/en active Active
- 2017-08-28 AU AU2017219132A patent/AU2017219132B2/en active Active
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2018
- 2018-02-20 US US15/899,675 patent/US10526335B2/en active Active
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2019
- 2019-12-16 US US16/716,268 patent/US10844063B2/en active Active
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2020
- 2020-11-20 US US17/100,474 patent/US11555037B2/en active Active
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2022
- 2022-12-08 US US18/077,921 patent/US12559495B2/en active Active