JP2015535839A5 - - Google Patents
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- Publication number
- JP2015535839A5 JP2015535839A5 JP2015533635A JP2015533635A JP2015535839A5 JP 2015535839 A5 JP2015535839 A5 JP 2015535839A5 JP 2015533635 A JP2015533635 A JP 2015533635A JP 2015533635 A JP2015533635 A JP 2015533635A JP 2015535839 A5 JP2015535839 A5 JP 2015535839A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carboxylic acid
- compound
- amino
- heteroarylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(*/C1=C\CC#CCCC1)OC(C(N)=*)=C(C)NN=C(N)N Chemical compound CC(*/C1=C\CC#CCCC1)OC(C(N)=*)=C(C)NN=C(N)N 0.000 description 4
- QKFLVZGGHLUMLZ-OEMAIJDKSA-N CCCCN[C@@](C1)(C1(C)OCc1cccnc1)N/C=N/CN Chemical compound CCCCN[C@@](C1)(C1(C)OCc1cccnc1)N/C=N/CN QKFLVZGGHLUMLZ-OEMAIJDKSA-N 0.000 description 1
- TVZORZUMEIQISH-UHFFFAOYSA-N COC1=CC=C(CCCO)CC1 Chemical compound COC1=CC=C(CCCO)CC1 TVZORZUMEIQISH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306196.2A EP2712866A1 (en) | 2012-10-01 | 2012-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections |
| EP12306196.2 | 2012-10-01 | ||
| PCT/EP2013/070488 WO2014053516A1 (en) | 2012-10-01 | 2013-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535839A JP2015535839A (ja) | 2015-12-17 |
| JP2015535839A5 true JP2015535839A5 (enExample) | 2016-11-10 |
| JP6298998B2 JP6298998B2 (ja) | 2018-03-28 |
Family
ID=46982496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533635A Expired - Fee Related JP6298998B2 (ja) | 2012-10-01 | 2013-10-01 | ウイルス感染を治療するための１，２，４−トリアジン誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9416114B2 (enExample) |
| EP (2) | EP2712866A1 (enExample) |
| JP (1) | JP6298998B2 (enExample) |
| KR (1) | KR102138393B1 (enExample) |
| CN (1) | CN104812747B (enExample) |
| AU (1) | AU2013326579B2 (enExample) |
| BR (1) | BR112015007310B1 (enExample) |
| CA (1) | CA2886630C (enExample) |
| CL (1) | CL2015000787A1 (enExample) |
| EA (1) | EA026236B1 (enExample) |
| ES (1) | ES2616496T3 (enExample) |
| IL (1) | IL237871A (enExample) |
| IN (1) | IN2015DN03327A (enExample) |
| MX (1) | MX348229B (enExample) |
| MY (1) | MY182558A (enExample) |
| NZ (1) | NZ706354A (enExample) |
| PH (1) | PH12015500724A1 (enExample) |
| SG (1) | SG11201502522WA (enExample) |
| UA (1) | UA114644C2 (enExample) |
| WO (1) | WO2014053516A1 (enExample) |
| ZA (1) | ZA201502240B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101946499B1 (ko) | 2011-04-08 | 2019-02-11 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 치료를 위한 피리미딘 유도체 |
| UA116083C2 (uk) | 2011-11-09 | 2018-02-12 | ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі | Похідні пурину для лікування вірусних інфекцій |
| PT2872515T (pt) | 2012-07-13 | 2016-07-27 | Janssen Sciences Ireland Uc | Purinas macrocíclicas para o tratamento de infeções virais |
| EA035327B1 (ru) | 2012-10-10 | 2020-05-28 | Янссен Сайенсиз Айрлэнд Юси | Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний |
| ES2655843T3 (es) | 2012-11-16 | 2018-02-21 | Janssen Sciences Ireland Uc | Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas |
| MY191389A (en) | 2013-02-21 | 2022-06-22 | Janssen Sciences Ireland Uc | 2-aminopyrimidine derivatives for the treatment of viral infections |
| CN105338983B (zh) | 2013-03-29 | 2019-10-25 | 爱尔兰詹森科学公司 | 用于治疗病毒感染的大环脱氮-嘌呤酮 |
| JP6377139B2 (ja) | 2013-05-24 | 2018-08-22 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症およびさらなる疾患の処置のためのピリドン誘導体 |
| JP6763769B2 (ja) | 2013-06-27 | 2020-09-30 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ウイルス感染症および他の疾病の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体 |
| MX368625B (es) | 2013-07-30 | 2019-10-08 | Janssen Sciences Ireland Uc | Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales. |
| SG11201811448RA (en) | 2016-07-01 | 2019-01-30 | Janssen Sciences Ireland Unlimited Co | Dihydropyranopyrimidines for the treatment of viral infections |
| KR102450287B1 (ko) * | 2016-09-29 | 2022-09-30 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그 |
| TW202415645A (zh) | 2018-03-01 | 2024-04-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| BR112021015577A8 (pt) | 2019-02-08 | 2021-10-05 | Research & Business Found Sungkyunkwan Univ | Complexo-colesterol agonista do receptor toll-like 7/8, composição de nanopartícula, composição adjuvante, composição de vacina, composição para regular uma função imunológica, composição farmacêutica e uso do complexo |
| EP4115901A4 (en) | 2020-03-02 | 2024-04-10 | Progeneer Inc. | Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof |
| EP4194008A4 (en) | 2020-08-04 | 2025-01-08 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| WO2022031021A1 (ko) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | 동력학적 제어가 가능한 아주번트를 포함하는 mrna 백신 |
| EP4194010A4 (en) | 2020-08-04 | 2025-03-26 | Progeneer Inc. | Conjugate of a functional drug and a toll-like receptor 7 or 8 agonist with a temporarily inactivated drug site, and use thereof |
| WO2024151953A1 (en) * | 2023-01-15 | 2024-07-18 | Viradem Inc. | Compounds and methods for treating diseases caused by sars-cov-2 and other coronaviruses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485531A1 (fr) * | 1980-06-25 | 1981-12-31 | Fabre Sa Pierre | Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| TW552261B (en) | 1996-07-03 | 2003-09-11 | Japan Energy Corp | Novel purine derivative |
| CA2311742C (en) | 1997-11-28 | 2009-06-16 | Sumitomo Pharmaceuticals Co., Ltd. | 6-amino-9-benzyl-8-hydroxypurine derivatives |
| RU2401833C2 (ru) * | 2004-08-10 | 2010-10-20 | Янссен Фармацевтика Н.В. | Производные 1, 2, 4-триазин-6-она, ингибирующие вич |
| MX2007013780A (es) | 2005-05-04 | 2008-02-05 | Pfizer Ltd | Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c. |
| ES2612890T3 (es) * | 2005-09-01 | 2017-05-19 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P2X2/3 |
| RU2352565C1 (ru) * | 2007-10-08 | 2009-04-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения |
| PE20091236A1 (es) * | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| WO2012067269A1 (en) * | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Aminoalkoxyphenyl compounds and their use in the treatment of disease |
-
2012
- 2012-10-01 EP EP12306196.2A patent/EP2712866A1/en not_active Withdrawn
-
2013
- 2013-10-01 KR KR1020157009515A patent/KR102138393B1/ko not_active Expired - Fee Related
- 2013-10-01 NZ NZ706354A patent/NZ706354A/en not_active IP Right Cessation
- 2013-10-01 AU AU2013326579A patent/AU2013326579B2/en not_active Ceased
- 2013-10-01 UA UAA201504222A patent/UA114644C2/uk unknown
- 2013-10-01 BR BR112015007310-7A patent/BR112015007310B1/pt not_active IP Right Cessation
- 2013-10-01 US US14/432,269 patent/US9416114B2/en active Active
- 2013-10-01 CA CA2886630A patent/CA2886630C/en active Active
- 2013-10-01 MY MYPI2015000804A patent/MY182558A/en unknown
- 2013-10-01 SG SG11201502522WA patent/SG11201502522WA/en unknown
- 2013-10-01 IN IN3327DEN2015 patent/IN2015DN03327A/en unknown
- 2013-10-01 EA EA201500383A patent/EA026236B1/ru not_active IP Right Cessation
- 2013-10-01 JP JP2015533635A patent/JP6298998B2/ja not_active Expired - Fee Related
- 2013-10-01 ES ES13773690.6T patent/ES2616496T3/es active Active
- 2013-10-01 EP EP13773690.6A patent/EP2903976B1/en active Active
- 2013-10-01 WO PCT/EP2013/070488 patent/WO2014053516A1/en not_active Ceased
- 2013-10-01 MX MX2015004160A patent/MX348229B/es active IP Right Grant
- 2013-10-01 CN CN201380050972.5A patent/CN104812747B/zh not_active Expired - Fee Related
-
2015
- 2015-03-22 IL IL237871A patent/IL237871A/en active IP Right Grant
- 2015-03-30 CL CL2015000787A patent/CL2015000787A1/es unknown
- 2015-03-31 ZA ZA2015/02240A patent/ZA201502240B/en unknown
- 2015-03-31 PH PH12015500724A patent/PH12015500724A1/en unknown