JP2016518317A5 - - Google Patents
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- Publication number
- JP2016518317A5 JP2016518317A5 JP2016500700A JP2016500700A JP2016518317A5 JP 2016518317 A5 JP2016518317 A5 JP 2016518317A5 JP 2016500700 A JP2016500700 A JP 2016500700A JP 2016500700 A JP2016500700 A JP 2016500700A JP 2016518317 A5 JP2016518317 A5 JP 2016518317A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- compound according
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)CC(CC1)=CC=C1C(C)* Chemical compound CC(C)CC(CC1)=CC=C1C(C)* 0.000 description 2
- DAIXZZSTPFEPSI-UHFFFAOYSA-N CC(C)(C(C1)(C2)CC12N)S Chemical compound CC(C)(C(C1)(C2)CC12N)S DAIXZZSTPFEPSI-UHFFFAOYSA-N 0.000 description 1
- FZUVPMJBKAKQBZ-UHFFFAOYSA-N CC(NC(C1)(C2)CC12N)=O Chemical compound CC(NC(C1)(C2)CC12N)=O FZUVPMJBKAKQBZ-UHFFFAOYSA-N 0.000 description 1
- IGSUQDHPOFVGAJ-UHFFFAOYSA-N CC(NC(C1)(C2)CC12OC(C)=O)=O Chemical compound CC(NC(C1)(C2)CC12OC(C)=O)=O IGSUQDHPOFVGAJ-UHFFFAOYSA-N 0.000 description 1
- CRJXXQOBEODWHG-UHFFFAOYSA-N CC(NC(C1)(C2)CC12OC(C1C(OC(C)=O)=CC=CC1)=O)=O Chemical compound CC(NC(C1)(C2)CC12OC(C1C(OC(C)=O)=CC=CC1)=O)=O CRJXXQOBEODWHG-UHFFFAOYSA-N 0.000 description 1
- NITXXARKEONICI-UHFFFAOYSA-N CC(NC1(C2)CC2C1)=O Chemical compound CC(NC1(C2)CC2C1)=O NITXXARKEONICI-UHFFFAOYSA-N 0.000 description 1
- TZBUTPHPKDVPKK-UHFFFAOYSA-N CCOC(C1)(C2)C(CC(NC(C3)(C4)CC34O)=O)C12NC(C)=O Chemical compound CCOC(C1)(C2)C(CC(NC(C3)(C4)CC34O)=O)C12NC(C)=O TZBUTPHPKDVPKK-UHFFFAOYSA-N 0.000 description 1
- AALJTAHBKGMKLZ-UHFFFAOYSA-N CCOC1(CCN)C(CC(N(C)C(C2)(C3)CC23O)=O)CC1 Chemical compound CCOC1(CCN)C(CC(N(C)C(C2)(C3)CC23O)=O)CC1 AALJTAHBKGMKLZ-UHFFFAOYSA-N 0.000 description 1
- SSEYVRNQWOYZBO-UHFFFAOYSA-N NC(C1)(C2)CC12OC=O Chemical compound NC(C1)(C2)CC12OC=O SSEYVRNQWOYZBO-UHFFFAOYSA-N 0.000 description 1
- DTMCAPQJLBMVNQ-UHFFFAOYSA-N OC1(CCNC(C(F)(F)F)=O)CCC1 Chemical compound OC1(CCNC(C(F)(F)F)=O)CCC1 DTMCAPQJLBMVNQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781580P | 2013-03-14 | 2013-03-14 | |
| US61/781,580 | 2013-03-14 | ||
| PCT/US2014/021038 WO2014149819A1 (en) | 2013-03-14 | 2014-03-06 | Bicyclic analgesic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518317A JP2016518317A (ja) | 2016-06-23 |
| JP2016518317A5 true JP2016518317A5 (enExample) | 2017-04-13 |
| JP6506248B2 JP6506248B2 (ja) | 2019-04-24 |
Family
ID=51530018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500700A Expired - Fee Related JP6506248B2 (ja) | 2013-03-14 | 2014-03-06 | 二環式鎮痛化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US9447025B2 (enExample) |
| EP (1) | EP2970104B1 (enExample) |
| JP (1) | JP6506248B2 (enExample) |
| KR (1) | KR102243637B1 (enExample) |
| AR (1) | AR095036A1 (enExample) |
| CA (1) | CA2903431C (enExample) |
| TW (1) | TWI630194B (enExample) |
| WO (1) | WO2014149819A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9447025B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
| CN106232567B (zh) | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| CN106999451B (zh) * | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| EP3277690B1 (en) * | 2015-04-03 | 2020-02-26 | Recurium IP Holdings, LLC | Spirocyclic compounds |
| US20190060257A1 (en) * | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
| KR20190075931A (ko) | 2016-10-05 | 2019-07-01 | 제노 로얄티즈 앤 마일스톤즈, 엘엘씨 | 스피로 고리 화합물 |
| EP3628043A4 (en) * | 2017-05-15 | 2021-04-28 | Recurium IP Holdings, LLC | ANALGESIC COMPOUNDS |
| IL301709B2 (en) * | 2017-08-09 | 2025-07-01 | Denali Therapeutics Inc | Compounds, compositions and methods |
| TW201920129A (zh) | 2017-09-01 | 2019-06-01 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| US11478461B2 (en) | 2018-04-19 | 2022-10-25 | Merck Sharp & Dohme Llc | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| CR20210426A (es) | 2019-02-13 | 2021-09-30 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| TW202241857A (zh) | 2020-12-18 | 2022-11-01 | 美商戴納立製藥公司 | 化合物之固體形式 |
| WO2026004939A1 (ja) * | 2024-06-28 | 2026-01-02 | キッセイ薬品工業株式会社 | ジ置換ビシクロ［１．１．１］ペンタン化合物 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL54795A (en) * | 1978-05-26 | 1980-10-26 | Yeda Res & Dev | Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types |
| EP0449831A4 (en) | 1988-06-03 | 1992-05-20 | Board Of Regents The University Of Texas System | Compounds and methods based on 1.1.1)propellane |
| AU626949B2 (en) | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| AU4743890A (en) | 1988-12-06 | 1990-06-26 | Upjohn Company, The | Antibacterial quinolone compounds |
| US5262417A (en) | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| IL138342A0 (en) | 1998-03-17 | 2001-10-31 | Pfizer Prod Inc | Bicyclo[2.2.1] heptanes and related compounds |
| AU3898000A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of neuropathic pain or fibromyalgia |
| DE10025946A1 (de) | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
| EP1289558A2 (en) | 2000-05-31 | 2003-03-12 | Warner-Lambert Company Llc | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| DE10164348A1 (de) | 2001-12-28 | 2003-07-17 | Basf Ag | Verfahren zur Herstellung von 1-Methoypropanol-2 |
| AP2331A (en) | 2003-12-22 | 2011-12-05 | Pfizer | Triazole derivatives as vasopressin antagonists. |
| WO2006024018A2 (en) | 2004-08-24 | 2006-03-02 | Neuromolecular Pharmaceuticals, Inc. | Compositions for treating nociceptive pain |
| US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
| JP2008120797A (ja) | 2006-10-19 | 2008-05-29 | Dainippon Sumitomo Pharma Co Ltd | Ｎ−置換フェニルアセトアミド誘導体からなる医薬 |
| EP2102164B1 (en) | 2006-12-27 | 2010-12-01 | Sanofi-Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| WO2008096218A1 (en) | 2007-02-06 | 2008-08-14 | Pfizer Inc. | 2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer |
| DK2217597T3 (da) | 2007-10-01 | 2011-06-20 | Comentis Inc | Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom |
| EP2307377A1 (en) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| NZ598269A (en) | 2009-09-18 | 2014-12-24 | Zalicus Pharmaceuticals Ltd | Aryl sulphone derivatives as calcium channel blockers |
| CA2804147A1 (en) | 2010-06-30 | 2012-01-05 | Upsher-Smith Laboratories, Inc. | Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid |
| RU2013120966A (ru) | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| EP2694509B1 (en) | 2011-04-05 | 2016-05-18 | Pfizer Limited | Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of tropomyosin-related kinases |
| EA022375B1 (ru) | 2011-04-22 | 2015-12-30 | Пфайзер Инк. | ПРОИЗВОДНЫЕ ПИРАЗОЛОСПИРОКЕТОНОВ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ |
| TWI548621B (zh) | 2011-04-22 | 2016-09-11 | 標誌製藥公司 | 經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法 |
| BR112014002472A2 (pt) | 2011-08-12 | 2017-04-11 | Nissan Chemical Ind Ltd | "compostos heterocíclicos tricíclicos, seu uso, agente terapêutico para reumatismo articular e medicamento" |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9493481B2 (en) | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
| EP2842553A4 (en) | 2012-04-27 | 2015-12-09 | Nippon Zoki Pharmaceutical Co | ANALGESIC |
| US9447025B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| US20160076098A1 (en) | 2013-04-12 | 2016-03-17 | Drexel University | Methods of diagnosing and treating chronic pain |
| AU2014301295C1 (en) | 2013-06-28 | 2018-03-15 | Evotec International Gmbh | Sulfoximine substituted quinazolines and their use as MNK1 and/or MNK2 kinase inhibitors |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| MX2016001855A (es) | 2013-08-12 | 2016-05-24 | Hoffmann La Roche | Nuevos aza-oxo-indoles para el tratamiento y profilaxis de la infeccion por virus sincitial respiratorio. |
| US10329270B2 (en) | 2013-10-21 | 2019-06-25 | Merck Patent Gmbh | Heteroaryl compounds as BTK inhibitors and uses thereof |
| CN103588668A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 化合物 |
| CN103588672A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 一种治疗癌性疼痛的药物 |
| US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
| RU2016129380A (ru) | 2013-12-20 | 2018-01-25 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием |
| CN106232567B (zh) | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| US9649309B2 (en) | 2014-04-11 | 2017-05-16 | The University Of North Carolina At Chapel Hill | Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity |
| US20170197939A1 (en) | 2014-04-15 | 2017-07-13 | Pfizer Inc. | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety |
| CA2945212A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| BR112017002001B1 (pt) | 2014-07-31 | 2022-10-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compostos e composição farmacêutica |
| CN106999451B (zh) | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| US20190060257A1 (en) | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
-
2014
- 2014-03-06 US US14/199,567 patent/US9447025B2/en active Active
- 2014-03-06 AR ARP140100734A patent/AR095036A1/es unknown
- 2014-03-06 WO PCT/US2014/021038 patent/WO2014149819A1/en not_active Ceased
- 2014-03-06 TW TW103107738A patent/TWI630194B/zh not_active IP Right Cessation
- 2014-03-06 US US14/439,636 patent/US9447026B2/en active Active
- 2014-03-06 KR KR1020157029086A patent/KR102243637B1/ko not_active Expired - Fee Related
- 2014-03-06 JP JP2016500700A patent/JP6506248B2/ja not_active Expired - Fee Related
- 2014-03-06 EP EP14769979.7A patent/EP2970104B1/en active Active
- 2014-03-06 CA CA2903431A patent/CA2903431C/en active Active
-
2016
- 2016-08-17 US US15/239,446 patent/US9693975B2/en not_active Expired - Fee Related
- 2016-09-12 US US15/262,852 patent/US9724316B2/en not_active Expired - Fee Related
-
2017
- 2017-06-26 US US15/633,480 patent/US10251851B2/en active Active
-
2019
- 2019-04-08 US US16/378,422 patent/US20190298668A1/en not_active Abandoned
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