|
US4838925A
(en)
|
1986-04-25 |
1989-06-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
|
JP3763997B2
(ja)
|
1999-05-13 |
2006-04-05 |
富士写真フイルム株式会社 |
感熱記録材料
|
|
JP4331823B2
(ja)
|
1999-05-21 |
2009-09-16 |
富士フイルム株式会社 |
ピロロ［１，２−ａ］−１，３，５−トリアジン−４−オン系化合物
|
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
|
JP4070966B2
(ja)
|
2001-06-28 |
2008-04-02 |
株式会社カネボウ化粧品 |
新規ガラクトシルセラミド類縁体及び用途
|
|
JP2005526003A
(ja)
|
2001-10-22 |
2005-09-02 |
ファイザー株式会社 |
５−ｈｔ４受容体調節剤としてのイミダゾピリジン化合物
|
|
EP1481977A4
(en)
|
2002-03-01 |
2006-02-01 |
Astellas Pharma Inc |
NITROGENIC HETEROCYCLIC COMPOUND
|
|
JP2006502180A
(ja)
|
2002-09-20 |
2006-01-19 |
ファイザー株式会社 |
５−ｈｔ４レセプターモジュレーターとしてのｎ−置換されたピペリジニル−イミダゾピリジン化合物
|
|
DOP2003000703A
(es)
|
2002-09-20 |
2004-03-31 |
Pfizer |
Compuestos de imidazopiradina como agonistas del receptor 5-ht4
|
|
AU2003299651A1
(en)
|
2002-12-11 |
2004-06-30 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ［１，５−ａ］ピリミジン誘導体
|
|
WO2004094418A1
(en)
|
2003-04-21 |
2004-11-04 |
Pfizer Inc. |
Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity
|
|
BRPI0416216A
(pt)
|
2003-11-12 |
2006-12-26 |
Amicus Therapeutics Inc |
composto de glicoimidazol e polihidroxiciclohexenila e método para sintetizar composto de glicoimidazol e polihidroxiciclohexenila, métodos para inibir glicocerebrosidase, para aumentar a atividade de glicocerebrosidase e para estabilizar glicocerebrosidade, composição farmacêutica, métodos para inibir uma -glicosidade, e para tratar doença de gaucher, derivado de glicoimidazol e derivados de polihidroxiciclohexilamina
|
|
GB0329214D0
(en)
|
2003-12-17 |
2004-01-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0400812D0
(en)
|
2004-01-14 |
2004-02-18 |
Celltech R&D Ltd |
Novel compounds
|
|
WO2005077953A1
(ja)
|
2004-02-18 |
2005-08-25 |
Banyu Pharmaceutical Co., Ltd. |
含窒素縮合へテロ芳香環誘導体
|
|
AU2005244872B2
(en)
|
2004-05-14 |
2008-09-11 |
Children's Cancer Institute Australia for Medical Research |
Small molecule inhibitors for MRP1 and other multidrug transporters
|
|
WO2005123738A1
(en)
|
2004-06-21 |
2005-12-29 |
F.Hoffmann-La Roche Ag |
Pyrrazolo-pyrimidine derivatives
|
|
WO2006015737A1
(de)
|
2004-08-02 |
2006-02-16 |
Schwarz Pharma Ag |
Carboxamide des indolizins und seiner aza- und diazaderivate
|
|
DE102004049363A1
(de)
|
2004-10-08 |
2006-04-13 |
Henkel Kgaa |
Mittel zum Färben von keratinhaltigen Fasern
|
|
ATE448229T1
(de)
|
2005-01-19 |
2009-11-15 |
Merck & Co Inc |
Bicyclische pyrimidine als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes
|
|
CN101115755B
(zh)
|
2005-02-11 |
2013-01-16 |
弗·哈夫曼-拉罗切有限公司 |
作为mglur2拮抗剂的吡唑并-嘧啶衍生物
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
US7767854B2
(en)
|
2005-04-21 |
2010-08-03 |
Dainippon Sumitomo Pharma Co., Ltd. |
N-substituted phenylacetamide derivative and pharmaceutical composition containing the same
|
|
EP1878727A4
(en)
|
2005-04-28 |
2013-11-13 |
Kyowa Hakko Kirin Co Ltd |
2-AMINOQUINAZOLINE DERIVATIVES
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7723336B2
(en)
|
2005-09-22 |
2010-05-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
|
CN101316847A
(zh)
|
2005-10-06 |
2008-12-03 |
先灵公司 |
用作蛋白激酶抑制剂的吡唑并(1,5a)嘧啶化合物
|
|
WO2007048064A2
(en)
|
2005-10-21 |
2007-04-26 |
Exelixis, Inc. |
Amino-pyrimidines as casein kinase ii (ck2) modulators
|
|
WO2007065664A2
(en)
|
2005-12-08 |
2007-06-14 |
Novartis Ag |
Pyrazolo[1,5-a]pyridine-3-carboxylic acids as ephb and vegfr2 kinase inhibitors
|
|
TW200800997A
(en)
|
2006-03-22 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
|
ATE555788T1
(de)
|
2006-06-23 |
2012-05-15 |
Amicus Therapeutics Inc |
Verfahren zur behandlung neurologischer erkrankungen mittels verstärkung der beta - glucocerebrosidaseaktivität
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
US7553846B2
(en)
|
2006-08-07 |
2009-06-30 |
Albany Molecular Research, Inc. |
2-alkylbenzoxazole carboxamides as 5-HT3 modulators
|
|
AU2007321922A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic matrix metalloprotease inhibitors
|
|
CA2670083A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic metalloprotease inhibitors
|
|
EP2137187A1
(en)
|
2007-03-28 |
2009-12-30 |
Inovacia AB |
Pyrazolo [1,5-a]pyrimidines as inhibitors of stearoyl-coa desaturase
|
|
AR067326A1
(es)
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
BRPI0813216A2
(pt)
|
2007-06-21 |
2014-12-23 |
Irm Llc |
Inibidores de proteínas cinases e métodos para usá-los.
|
|
JP5479105B2
(ja)
|
2007-11-05 |
2014-04-23 |
国立大学法人佐賀大学 |
新規ユビキリン結合性小分子
|
|
WO2009060197A1
(en)
|
2007-11-08 |
2009-05-14 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazopyridazines for use as protein kinase inhibitors
|
|
CA2706946A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
EP2240488B1
(en)
|
2008-02-06 |
2016-11-02 |
Bristol-Myers Squibb Company |
Substituted imidazopyridazines useful as kinase inhibitors
|
|
EP2269990A4
(en)
|
2008-03-25 |
2012-04-18 |
Takeda Pharmaceutical |
Heterocyclic compound
|
|
EA021938B1
(ru)
|
2008-05-01 |
2015-10-30 |
Сертрис Фармасьютикалз, Инк. |
Хинолины и их аналоги в качестве модуляторов сиртуина
|
|
AU2009305203B2
(en)
|
2008-10-14 |
2013-03-07 |
Entasis Therapeutics Limited |
Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
|
|
CN102271515B
(zh)
|
2008-10-31 |
2014-07-02 |
健泰科生物技术公司 |
吡唑并嘧啶jak抑制剂化合物和方法
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
MY162604A
(en)
|
2009-08-17 |
2017-06-30 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
CN102985426B
(zh)
|
2010-07-13 |
2015-10-07 |
弗·哈夫曼-拉罗切有限公司 |
作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
TW201217312A
(en)
|
2010-09-22 |
2012-05-01 |
Gruenenthal Gmbh |
Substituted benzamide compounds
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
CA2820362C
(en)
|
2010-12-08 |
2020-03-24 |
The United States Of America, As Represented By The Secretary, Departmt Of Health And Human Services |
Substituted pyrazolopyrimidines as glucocerebrosidase activators
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
US9169260B2
(en)
|
2011-03-22 |
2015-10-27 |
Merck Sharp & Dohme Corp. |
Amidopyrazole inhibitors of interleukin receptor-associated kinases
|
|
US9845327B2
(en)
*
|
2011-06-22 |
2017-12-19 |
The General Hospital Corporation |
Treatment of proteinopathies
|
|
SI2746265T1
(sl)
|
2011-08-18 |
2016-03-31 |
Nippon Shinyaku Co., Ltd. |
Heterociklični derivat kot zaviralec mikrosomske prostaglandin-e sintaze (mpges)
|
|
PH12014500460A1
(en)
|
2011-09-02 |
2014-04-14 |
Bayer Ip Gmbh |
Substituted annellated pyrimidine and the use thereof
|
|
WO2013059119A1
(en)
|
2011-10-17 |
2013-04-25 |
The Regents Of The University Of Michigan |
Glucosylceramide synthase inhibitors and therapeutic methods using the same
|
|
RU2014120166A
(ru)
|
2011-10-20 |
2015-11-27 |
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи |
Замещенные бициклические аза-гетероциклы и их аналоги в качестве модуляторов сиртуина
|
|
CN104125953A
(zh)
|
2011-12-23 |
2014-10-29 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
US9340549B2
(en)
|
2012-03-05 |
2016-05-17 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
NZ630719A
(en)
|
2012-03-09 |
2017-01-27 |
Lexicon Pharmaceuticals Inc |
Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
|
|
AU2013240187A1
(en)
|
2012-03-28 |
2014-10-30 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Salicylic acid derivatives useful as glucocerebrosidase activators
|
|
MX2014014531A
(es)
|
2012-05-31 |
2015-04-08 |
Hoffmann La Roche |
Derivados de aminoquinazolina y piridopirimidina.
|
|
US9260436B2
(en)
|
2012-06-22 |
2016-02-16 |
Sumitomo Chemical Company, Limited |
Fused heterocyclic compound
|
|
WO2014025651A1
(en)
|
2012-08-06 |
2014-02-13 |
Amgen Inc. |
Chroman derivatives as trpm8 inhibitors
|
|
CN104780764A
(zh)
|
2012-09-05 |
2015-07-15 |
拜尔农作物科学股份公司 |
取代的2-酰氨基苯并咪唑、2-酰氨基苯并噁唑和2-酰氨基苯并噻唑或其盐作为活性物质对抗非生物植物胁迫的用途
|
|
JP6377068B2
(ja)
|
2012-11-16 |
2018-08-22 |
ユニバーシティ・ヘルス・ネットワーク |
ピラゾロピリミジン化合物
|
|
HK1215579A1
(zh)
|
2012-11-29 |
2016-09-02 |
Karyopharm Therapeutics, Inc. |
被取代的2，3-二氫苯並呋喃基化合物和其用途
|
|
SMT202000713T1
(it)
|
2012-12-07 |
2021-03-15 |
Vertex Pharma |
Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro
|
|
KR20140086002A
(ko)
|
2012-12-28 |
2014-07-08 |
한미약품 주식회사 |
Fms 키나아제 저해 활성을 갖는 피리다진 접합고리 유도체
|
|
WO2014141129A2
(en)
|
2013-03-14 |
2014-09-18 |
Grueneberg Dorre A |
Novel methods, compounds, and compositions for inhibition of ros
|
|
EP2970266B1
(en)
|
2013-03-15 |
2018-01-31 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
|
|
JPWO2015012328A1
(ja)
|
2013-07-24 |
2017-03-02 |
武田薬品工業株式会社 |
複素環化合物
|
|
US20160199372A1
(en)
|
2013-08-20 |
2016-07-14 |
Bristol-Myers Squibb Company |
Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia
|
|
TW201542550A
(zh)
|
2013-09-06 |
2015-11-16 |
Lexicon Pharmaceuticals Inc |
吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
|
|
AR097543A1
(es)
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
WO2015073267A1
(en)
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
EP3122726B1
(en)
|
2014-03-27 |
2018-08-29 |
Academisch Medisch Centrum |
N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase
|
|
US9695180B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
|
|
WO2016073889A1
(en)
|
2014-11-06 |
2016-05-12 |
Lysosomal Therapeutics Inc. |
Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
|
|
CN107001379B
(zh)
|
2014-11-06 |
2022-11-01 |
Bial研发投资股份有限公司 |
取代的吡唑并[1,5-a]嘧啶以及它们在治疗医学障碍中的用途
|
|
AU2015342883B2
(en)
|
2014-11-06 |
2020-07-02 |
Bial - R&D Investments, S.A. |
Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
|
|
JP2018525345A
(ja)
|
2015-07-01 |
2018-09-06 |
ノースウェスタン ユニバーシティ |
置換キナゾリン化合物及びグルコセレブロシダーゼ活性の調節のためのその使用
|
|
CN108290894A
(zh)
|
2015-07-01 |
2018-07-17 |
西北大学 |
被取代的4-甲基-吡咯并[1,2-a]嘧啶-8-甲酰胺类化合物及其调节葡糖脑苷脂酶活性的用途
|
|
EP3344632A4
(en)
|
2015-09-04 |
2019-03-20 |
Lysosomal Therapeutics Inc. |
Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders
|
|
TWI744256B
(zh)
|
2015-11-06 |
2021-11-01 |
美商英塞特公司 |
作為ＰＩ３Ｋ-γ抑制劑之雜環化合物
|
|
KR102782807B1
(ko)
|
2015-11-18 |
2025-03-14 |
브리스톨-마이어스 스큅 컴퍼니 |
Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 이미다조피리다진 화합물
|
|
JP6936236B2
(ja)
|
2016-02-18 |
2021-09-15 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
治療化合物、組成物及びその方法の使用
|
|
WO2017176960A1
(en)
|
2016-04-06 |
2017-10-12 |
Lysosomal Therapeutics Inc. |
Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
WO2017176962A1
(en)
|
2016-04-06 |
2017-10-12 |
Lysosomal Therapeutics, Inc. |
Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
US10787454B2
(en)
|
2016-04-06 |
2020-09-29 |
BIAL—BioTech Investments, Inc. |
Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
WO2017192841A1
(en)
*
|
2016-05-04 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
|
|
WO2017192929A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED PYRROLO[1,2-α]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
MX389579B
(es)
|
2016-05-05 |
2025-03-20 |
Bial R&D Invest S A |
IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS
|
|
WO2017192931A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
US20200339587A1
(en)
|
2017-12-21 |
2020-10-29 |
Lysosomal Therapeutics Inc. |
Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof
|