|
US4838925A
(en)
|
1986-04-25 |
1989-06-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
|
JP3763997B2
(ja)
|
1999-05-13 |
2006-04-05 |
富士写真フイルム株式会社 |
感熱記録材料
|
|
JP4331823B2
(ja)
|
1999-05-21 |
2009-09-16 |
富士フイルム株式会社 |
ピロロ［１，２−ａ］−１，３，５−トリアジン−４−オン系化合物
|
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
|
JP4070966B2
(ja)
|
2001-06-28 |
2008-04-02 |
株式会社カネボウ化粧品 |
新規ガラクトシルセラミド類縁体及び用途
|
|
EP1440071B1
(en)
|
2001-10-22 |
2005-10-26 |
Pfizer Inc. |
Imidazopyridine compounds as 5-ht 4? receptor modulators
|
|
AU2003211424A1
(en)
|
2002-03-01 |
2003-09-16 |
Yamanouchi Pharmaceutical Co., Ltd. |
Nitrogen-containing heterocyclic compound
|
|
AU2003259482A1
(en)
|
2002-09-20 |
2004-04-08 |
Pfizer Japan Inc. |
N-substituted piperidinyl-imidazopyridine compounds as 5-ht4 receptor modulators
|
|
DOP2003000703A
(es)
|
2002-09-20 |
2004-03-31 |
Pfizer |
Compuestos de imidazopiradina como agonistas del receptor 5-ht4
|
|
WO2004052315A2
(en)
|
2002-12-11 |
2004-06-24 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ［１，５−ａ］ピリミジン誘導体
|
|
MXPA05011270A
(es)
|
2003-04-21 |
2006-01-24 |
Pfizer |
Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3.
|
|
AU2004289327A1
(en)
|
2003-11-12 |
2005-05-26 |
Amicus Therapeutics Inc. |
Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat Gaucher disease
|
|
GB0329214D0
(en)
|
2003-12-17 |
2004-01-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0400812D0
(en)
|
2004-01-14 |
2004-02-18 |
Celltech R&D Ltd |
Novel compounds
|
|
JPWO2005077953A1
(ja)
|
2004-02-18 |
2007-10-18 |
萬有製薬株式会社 |
含窒素縮合ヘテロ芳香環誘導体
|
|
EP1753422B1
(en)
|
2004-05-14 |
2008-05-28 |
The Cleveland Clinic Foundation |
Small molecule inhibitors for mrp1 and other multidrug transporters
|
|
WO2005123738A1
(en)
|
2004-06-21 |
2005-12-29 |
F.Hoffmann-La Roche Ag |
Pyrrazolo-pyrimidine derivatives
|
|
CA2568850A1
(en)
|
2004-08-02 |
2006-02-16 |
Schwarz Pharma Ag |
Indolizine carboxamides and the aza and diaza derivatives thereof
|
|
DE102004049363A1
(de)
|
2004-10-08 |
2006-04-13 |
Henkel Kgaa |
Mittel zum Färben von keratinhaltigen Fasern
|
|
CA2593264C
(en)
|
2005-01-19 |
2012-09-25 |
Merck & Co., Inc. |
Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
|
AU2006212457B2
(en)
|
2005-02-11 |
2011-04-14 |
F. Hoffmann-La Roche Ag |
Pyrazolo-pyrimidine derivatives as mGLuR2 antagonists
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
TW200720231A
(en)
|
2005-04-21 |
2007-06-01 |
Dainippon Sumitomo Pharma Co |
An n-substituted phenylacetamide derivative and a pharmaceutical composition thereof
|
|
US7906522B2
(en)
|
2005-04-28 |
2011-03-15 |
Kyowa Hakko Kirin Co., Ltd |
2-aminoquinazoline derivatives
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7723336B2
(en)
|
2005-09-22 |
2010-05-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
|
JP5102212B2
(ja)
|
2005-10-06 |
2012-12-19 |
メルク・シャープ・アンド・ドーム・コーポレーション |
プロテインキナーゼインヒビターとしてのピラゾロピリミジン
|
|
CA2626789A1
(en)
|
2005-10-21 |
2007-04-26 |
Exelixis, Inc. |
Pyrimidinones as casein kinase ii (ck2) modulators
|
|
WO2007065664A2
(en)
|
2005-12-08 |
2007-06-14 |
Novartis Ag |
Pyrazolo[1,5-a]pyridine-3-carboxylic acids as ephb and vegfr2 kinase inhibitors
|
|
TW200800997A
(en)
|
2006-03-22 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
|
BRPI0713442A2
(pt)
|
2006-06-23 |
2012-03-06 |
Amicus Therapeutics, Inc. |
Método para o tratamento de desrodens neurológicas, pelo aumento da atividade de b-glicocerebrosidase
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
US7553846B2
(en)
|
2006-08-07 |
2009-06-30 |
Albany Molecular Research, Inc. |
2-alkylbenzoxazole carboxamides as 5-HT3 modulators
|
|
EP2094707A1
(en)
|
2006-11-20 |
2009-09-02 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic matrix metalloprotease inhibitors
|
|
US20080176870A1
(en)
|
2006-11-20 |
2008-07-24 |
Bert Nolte |
Heterobicyclic metalloprotease inhibitors
|
|
WO2008116898A1
(en)
|
2007-03-28 |
2008-10-02 |
Biovitrum Ab (Publ) |
Pyrazolo [1,5-a]pyrimidines as inhibitors of stearoyl-coa desaturase
|
|
AR067326A1
(es)
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
US20110053932A1
(en)
|
2007-06-21 |
2011-03-03 |
Irm Llc |
Protein Kinase Inhibitors and Methods for Using Thereof
|
|
WO2009060835A1
(ja)
|
2007-11-05 |
2009-05-14 |
Kyoto University |
新規ユビキリン結合性小分子
|
|
WO2009060197A1
(en)
|
2007-11-08 |
2009-05-14 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazopyridazines for use as protein kinase inhibitors
|
|
CA2706946A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
US8389527B2
(en)
|
2008-02-06 |
2013-03-05 |
Bristol-Myers Squibb Company |
Substituted imidazopyridazines useful as kinase inhibitors
|
|
US20110118236A1
(en)
|
2008-03-25 |
2011-05-19 |
Michiyo Mochizuki |
Heterocyclic compound
|
|
ES2586459T3
(es)
|
2008-05-01 |
2016-10-14 |
Glaxosmithkline Llc |
Quinolinas y análogos relacionados como moduladores de sirtuina
|
|
EA201100613A1
(ru)
|
2008-10-14 |
2011-12-30 |
Астразенека Аб |
Конденсированные, спироциклические гетероароматические соединения для лечения бактериальных инфекций
|
|
MX2011004494A
(es)
|
2008-10-31 |
2011-05-24 |
Genentech Inc |
Compuestos de pirazolopirimidina inhibidores de jak y metodos.
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
NZ598220A
(en)
|
2009-08-17 |
2014-02-28 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
RU2604062C2
(ru)
|
2010-07-13 |
2016-12-10 |
Ф.Хоффманн-Ля Рош Аг |
ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА И ТИЕНО[3,2-b]ПИРИМИДИНА В КАЧЕСТВЕ МОДУЛЯТОРОВ IRAK-4
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
TW201217312A
(en)
|
2010-09-22 |
2012-05-01 |
Gruenenthal Gmbh |
Substituted benzamide compounds
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
EP3366688B1
(en)
|
2010-12-08 |
2022-02-09 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Substituted pyrazolopyrimidines as glucocerebrosidase activators
|
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
|
WO2012129258A1
(en)
|
2011-03-22 |
2012-09-27 |
Merck Sharp & Dohme Corp. |
Amidopyrazole inhibitors of interleukin receptor-associated kinases
|
|
WO2012177997A1
(en)
|
2011-06-22 |
2012-12-27 |
The General Hospital Corporation |
Treatment of proteinopathies
|
|
PT2746265E
(pt)
|
2011-08-18 |
2016-03-11 |
Nippon Shinyaku Co Ltd |
Derivado heterocíclico como inibidor de pronstaglandina-sintase microssomal (mpge)
|
|
JP6054967B2
(ja)
|
2011-09-02 |
2016-12-27 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ |
置換アネレート化ピリミジンおよびその使用
|
|
WO2013059119A1
(en)
|
2011-10-17 |
2013-04-25 |
The Regents Of The University Of Michigan |
Glucosylceramide synthase inhibitors and therapeutic methods using the same
|
|
JP6073343B2
(ja)
|
2011-10-20 |
2017-02-01 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ |
サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
|
|
BR112014015339A2
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos para inibição da interação de bcl2 com parceiros de ligação
|
|
US9340549B2
(en)
|
2012-03-05 |
2016-05-17 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
EP2822559B1
(en)
|
2012-03-09 |
2018-05-02 |
Lexicon Pharmaceuticals, Inc. |
Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and uses thereof
|
|
JP2015512913A
(ja)
|
2012-03-28 |
2015-04-30 |
ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
グルコセレブロシダーゼ活性剤として有用なサリチル酸誘導体
|
|
CA2870407A1
(en)
|
2012-05-31 |
2013-12-05 |
F. Hoffmann-La Roche Ag |
Aminoquinazoline and pyridopyrimidine derivatives
|
|
US9260436B2
(en)
|
2012-06-22 |
2016-02-16 |
Sumitomo Chemical Company, Limited |
Fused heterocyclic compound
|
|
WO2014025651A1
(en)
|
2012-08-06 |
2014-02-13 |
Amgen Inc. |
Chroman derivatives as trpm8 inhibitors
|
|
WO2014037340A1
(de)
|
2012-09-05 |
2014-03-13 |
Bayer Cropscience Ag |
Verwendung substituierter 2-amidobenzimidazole, 2-amidobenzoxazole und 2-amidobenzothiazole oder deren salze als wirkstoffe gegen abiotischen pflanzenstress
|
|
AU2013344716B2
(en)
|
2012-11-16 |
2018-03-01 |
University Health Network |
Pyrazolopyrimidine compounds
|
|
US9938258B2
(en)
|
2012-11-29 |
2018-04-10 |
Karyopharm Therapeutics Inc. |
Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
|
|
LT3486245T
(lt)
|
2012-12-07 |
2021-08-25 |
Vertex Pharmaceuticals Incorporated |
2-amino-n-(piperidin-1-il-piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamidas, kaip atr kinazės inhibitorius
|
|
KR20140086002A
(ko)
|
2012-12-28 |
2014-07-08 |
한미약품 주식회사 |
Fms 키나아제 저해 활성을 갖는 피리다진 접합고리 유도체
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
US9718816B2
(en)
|
2013-03-15 |
2017-08-01 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof
|
|
JPWO2015012328A1
(ja)
|
2013-07-24 |
2017-03-02 |
武田薬品工業株式会社 |
複素環化合物
|
|
WO2015026574A1
(en)
|
2013-08-20 |
2015-02-26 |
Bristol-Myers Squibb Company |
Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia
|
|
AR097543A1
(es)
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
TW201542550A
(zh)
|
2013-09-06 |
2015-11-16 |
Lexicon Pharmaceuticals Inc |
吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
|
|
WO2015073267A1
(en)
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
DK3461812T3
(da)
|
2014-03-27 |
2021-12-20 |
Acad Medisch Ct |
N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase
|
|
WO2016007736A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyrazines as lsd1 inhibitors
|
|
CA2966581A1
(en)
|
2014-11-06 |
2016-05-12 |
Lysosomal Therapeutics Inc. |
Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
|
|
US20170333435A1
(en)
|
2014-11-06 |
2017-11-23 |
Lysosomal Therapeutics Inc. |
Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
|
|
IL252053B2
(en)
|
2014-11-06 |
2024-04-01 |
Lysosomal Therapeutics Inc |
SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
JP2018522872A
(ja)
*
|
2015-07-01 |
2018-08-16 |
ノースウェスタン ユニバーシティ |
置換４−メチルピロロ［１，２−ａ］ピリミジン−８−カルボキサミド化合物及びグルコセレブロシダーゼ活性の調節のためのその使用
|
|
WO2017004405A1
(en)
|
2015-07-01 |
2017-01-05 |
Northwestern University |
Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
|
|
EP3344632A4
(en)
|
2015-09-04 |
2019-03-20 |
Lysosomal Therapeutics Inc. |
Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders
|
|
TWI744256B
(zh)
|
2015-11-06 |
2021-11-01 |
美商英塞特公司 |
作為ＰＩ３Ｋ-γ抑制劑之雜環化合物
|
|
KR102782807B1
(ko)
|
2015-11-18 |
2025-03-14 |
브리스톨-마이어스 스큅 컴퍼니 |
Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 이미다조피리다진 화합물
|
|
WO2017140825A1
(en)
|
2016-02-18 |
2017-08-24 |
F. Hoffmann-La Roche Ag |
Therapeutic compounds, compositions and methods of use thereof
|
|
EP3440081A4
(en)
|
2016-04-06 |
2019-09-18 |
Lysosomal Therapeutics Inc. |
PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
|
|
CA3020305A1
(en)
|
2016-04-06 |
2017-10-12 |
Lysosomal Therapeutics Inc. |
Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
MX2018012211A
(es)
|
2016-04-06 |
2019-03-28 |
Lysosomal Therapeutics Inc |
Compuestos de pirazol[1,5-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos.
|
|
WO2017192841A1
(en)
|
2016-05-04 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
|
|
EP3452481A4
(en)
|
2016-05-05 |
2020-02-26 |
Lysosomal Therapeutics Inc. |
IMIDAZO [1,2-B] SUBSTITUTED PYRIDAZINES, IMIDAZO [1,5-B] SUBSTITUTED PYRIDAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL CONDITIONS
|
|
WO2017192931A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
US20190389865A1
(en)
|
2016-05-05 |
2019-12-26 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED PYRROLO[1,2-a]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
WO2019126776A1
(en)
|
2017-12-21 |
2019-06-27 |
Lysosomal Therapeutics Inc. |
Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof
|