|
US4838925A
(en)
|
1986-04-25 |
1989-06-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
|
JP3763997B2
(ja)
|
1999-05-13 |
2006-04-05 |
富士写真フイルム株式会社 |
感熱記録材料
|
|
JP4331823B2
(ja)
|
1999-05-21 |
2009-09-16 |
富士フイルム株式会社 |
ピロロ[1,2−a]−1,3,5−トリアジン−4−オン系化合物
|
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
|
JP4070966B2
(ja)
|
2001-06-28 |
2008-04-02 |
株式会社カネボウ化粧品 |
新規ガラクトシルセラミド類縁体及び用途
|
|
JP2005526003A
(ja)
|
2001-10-22 |
2005-09-02 |
ファイザー株式会社 |
5−ht4受容体調節剤としてのイミダゾピリジン化合物
|
|
EP1481977A4
(en)
|
2002-03-01 |
2006-02-01 |
Astellas Pharma Inc |
NITROGENIC HETEROCYCLIC COMPOUND
|
|
BR0314584A
(pt)
|
2002-09-20 |
2005-08-09 |
Pfizer |
Compostos piperidinil-imidazopiridina n-substituìda como moduladores e receptores 5-ht4
|
|
DOP2003000703A
(es)
|
2002-09-20 |
2004-03-31 |
Pfizer |
Compuestos de imidazopiradina como agonistas del receptor 5-ht4
|
|
AU2003299651A1
(en)
|
2002-12-11 |
2004-06-30 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ[1,5−a]ピリミジン誘導体
|
|
EP1620435A1
(en)
|
2003-04-21 |
2006-02-01 |
Pfizer Inc. |
IMADAZOPYRIDINE COMPOUNDS HAVING 5-HT sb 4 /sb RECEPTOR AGONISTIC ACTIVITY AND 5-HT sb 3 /sb RECEPTOR ANTAGONISTIC ACTIVITY
|
|
EP1682134A4
(en)
|
2003-11-12 |
2008-10-15 |
Amicus Therapeutics Inc |
GLUCOIMIDAZOLE AND POLYHYDROXYCYCLOHEXENYL-AMINE DERIVATIVES FOR THE TREATMENT OF GAUCHER DISEASE
|
|
GB0329214D0
(en)
|
2003-12-17 |
2004-01-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0400812D0
(en)
|
2004-01-14 |
2004-02-18 |
Celltech R&D Ltd |
Novel compounds
|
|
CN1922183B
(zh)
|
2004-02-18 |
2010-05-26 |
万有制药株式会社 |
含氮的稠合杂芳环衍生物
|
|
WO2005113004A2
(en)
|
2004-05-14 |
2005-12-01 |
The Cleveland Clinic Founfation |
Small molecule inhibitors for mrp1 and other multidrug transporters
|
|
AU2005254657B2
(en)
|
2004-06-21 |
2011-03-17 |
F. Hoffmann-La Roche Ag |
Pyrrazolo-pyrimidine derivatives
|
|
MX2007001341A
(es)
|
2004-08-02 |
2007-04-23 |
Sanol Arznei Schwarz Gmbh |
Carboxamidas de indolizina y sus derivados aza y diaza.
|
|
DE102004049363A1
(de)
|
2004-10-08 |
2006-04-13 |
Henkel Kgaa |
Mittel zum Färben von keratinhaltigen Fasern
|
|
WO2006078676A2
(en)
|
2005-01-19 |
2006-07-27 |
Merck & Co., Inc. |
Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
|
KR100968291B1
(ko)
|
2005-02-11 |
2010-07-07 |
에프. 호프만-라 로슈 아게 |
Mglur2 길항제로서의 피라졸로-피리미딘 유도체
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
KR20070122541A
(ko)
|
2005-04-21 |
2007-12-31 |
다이닛본 스미토모 세이야꾸 가부시끼가이샤 |
N-치환 페닐아세트아미드 유도체 및 그것을 포함하는의약조성물
|
|
EP1878727A4
(en)
|
2005-04-28 |
2013-11-13 |
Kyowa Hakko Kirin Co Ltd |
2-AMINOQUINAZOLINE DERIVATIVES
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7723336B2
(en)
|
2005-09-22 |
2010-05-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
|
JP5102212B2
(ja)
|
2005-10-06 |
2012-12-19 |
メルク・シャープ・アンド・ドーム・コーポレーション |
プロテインキナーゼインヒビターとしてのピラゾロピリミジン
|
|
WO2007048066A2
(en)
|
2005-10-21 |
2007-04-26 |
Exelixis, Inc. |
Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators
|
|
BRPI0619517A2
(pt)
|
2005-12-08 |
2011-10-04 |
Novartis Ag |
ácidos pirazolo[1,5-a]piridina-3-carboxìlicos como inibidores de ephb e vegfr2 cinase
|
|
TW200800997A
(en)
|
2006-03-22 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
|
DK2040548T3
(da)
|
2006-06-23 |
2012-08-13 |
Amicus Therapeutics Inc |
Fremgangsmåde til behandling af neurologiske forstyrrelser ved forøgelse af aktiviteten af beta-glucocerebrosidase
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
WO2008019363A2
(en)
|
2006-08-07 |
2008-02-14 |
Albany Molecular Research, Inc. |
2-alkylbenzoxazole carboxamides as 5ht3 modulators
|
|
US20080176870A1
(en)
|
2006-11-20 |
2008-07-24 |
Bert Nolte |
Heterobicyclic metalloprotease inhibitors
|
|
EP2094707A1
(en)
|
2006-11-20 |
2009-09-02 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic matrix metalloprotease inhibitors
|
|
US20080255153A1
(en)
|
2007-03-28 |
2008-10-16 |
Biovitrum Ab (Publ) |
New compounds
|
|
AR067326A1
(es)
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
BRPI0813216A2
(pt)
|
2007-06-21 |
2014-12-23 |
Irm Llc |
Inibidores de proteínas cinases e métodos para usá-los.
|
|
JP5479105B2
(ja)
|
2007-11-05 |
2014-04-23 |
国立大学法人佐賀大学 |
新規ユビキリン結合性小分子
|
|
US20110046127A1
(en)
|
2007-11-08 |
2011-02-24 |
Paolo Pevarello |
Imidazopyridazines for Use as Protein Kinase Inhibitors
|
|
WO2009070567A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
JP5394404B2
(ja)
|
2008-02-06 |
2014-01-22 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用な置換イミダゾピリダジン類
|
|
EP2269990A4
(en)
|
2008-03-25 |
2012-04-18 |
Takeda Pharmaceutical |
Heterocyclic compound
|
|
CA2723135A1
(en)
|
2008-05-01 |
2009-11-05 |
Sirtris Pharmaceuticals, Inc. |
Quenolines and related analogs as sirtuin modulators
|
|
JP5749169B2
(ja)
|
2008-10-14 |
2015-07-15 |
アストラゼネカ アクチボラグ |
細菌感染の処置用の縮合スピロ環式ヘテロ芳香族化合物
|
|
AU2009308675A1
(en)
|
2008-10-31 |
2010-05-06 |
Genentech, Inc. |
Pyrazolopyrimidine JAK inhibitor compounds and methods
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
ES2709108T3
(es)
|
2009-08-17 |
2019-04-15 |
Intellikine Llc |
Compuestos heterocíclicos y usos de los mismos
|
|
BR112013000868A2
(pt)
|
2010-07-13 |
2016-05-17 |
Hoffmann La Roche |
derivados de pirazol [1,5a] e tieno [3,2b] pirimidina como modulares de irak4
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
TW201217312A
(en)
|
2010-09-22 |
2012-05-01 |
Gruenenthal Gmbh |
Substituted benzamide compounds
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
ES2681218T3
(es)
|
2010-12-08 |
2018-09-12 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Pirazolopirimidinas sustituidas como activadoras de la glucocerebrosidasa
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
EP2688872A4
(en)
|
2011-03-22 |
2014-08-27 |
Merck Sharp & Dohme |
AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES
|
|
CA2840224C
(en)
|
2011-06-22 |
2019-08-13 |
The General Hospital Corporation |
Treatment of proteinopathies
|
|
HRP20160118T1
(hr)
|
2011-08-18 |
2016-02-26 |
Nippon Shinyaku Co., Ltd. |
HETEROCIKLIÄŚKI DERIVAT KAO INHIBITOR MIKROSOMSKIH SINTAZA PROSTAGLANDINA E (mPGEs)
|
|
KR20140068112A
(ko)
|
2011-09-02 |
2014-06-05 |
바이엘 인텔렉쳐 프로퍼티 게엠베하 |
치환된 융합 피리미딘 및 그의 용도
|
|
US8961959B2
(en)
|
2011-10-17 |
2015-02-24 |
The Regents Of The University Of Michigan |
Glucosylceramide synthase inhibitors and therapeutic methods using the same
|
|
CN104394869A
(zh)
|
2011-10-20 |
2015-03-04 |
葛兰素史密斯克莱有限责任公司 |
用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物
|
|
AU2012355624A1
(en)
|
2011-12-23 |
2014-07-17 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
|
EP2822944A1
(en)
|
2012-03-05 |
2015-01-14 |
Amgen, Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
EP2822559B1
(en)
|
2012-03-09 |
2018-05-02 |
Lexicon Pharmaceuticals, Inc. |
Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and uses thereof
|
|
AU2013240187A1
(en)
|
2012-03-28 |
2014-10-30 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Salicylic acid derivatives useful as glucocerebrosidase activators
|
|
RU2014149684A
(ru)
|
2012-05-31 |
2016-07-20 |
Ф. Хоффманн-Ля Рош Аг |
Производные аминохиназолина и пиридопиримидина
|
|
BR112014030147B1
(pt)
|
2012-06-22 |
2019-10-15 |
Sumitomo Chemical Company, Limited |
Compostos heterocíclicos fundidos, composição e método para controlar pestes
|
|
WO2014025651A1
(en)
|
2012-08-06 |
2014-02-13 |
Amgen Inc. |
Chroman derivatives as trpm8 inhibitors
|
|
AU2013311826A1
(en)
|
2012-09-05 |
2015-03-26 |
Bayer Cropscience Ag |
Use of substituted 2-amidobenzimidazoles, 2-amidobenzoxazoles and 2-amidobenzothiazoles or salts thereof as active substances against abiotic plant stress
|
|
NZ707432A
(en)
|
2012-11-16 |
2020-01-31 |
Univ Health Network |
Pyrazolopyrimidine compounds
|
|
WO2014085607A1
(en)
|
2012-11-29 |
2014-06-05 |
Karyopharm Therapeutics Inc. |
Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
|
|
US9340546B2
(en)
|
2012-12-07 |
2016-05-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
KR20140086002A
(ko)
|
2012-12-28 |
2014-07-08 |
한미약품 주식회사 |
Fms 키나아제 저해 활성을 갖는 피리다진 접합고리 유도체
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
US9718816B2
(en)
|
2013-03-15 |
2017-08-01 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof
|
|
WO2015012328A1
(ja)
|
2013-07-24 |
2015-01-29 |
武田薬品工業株式会社 |
複素環化合物
|
|
WO2015026574A1
(en)
|
2013-08-20 |
2015-02-26 |
Bristol-Myers Squibb Company |
Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia
|
|
TW201542550A
(zh)
|
2013-09-06 |
2015-11-16 |
Lexicon Pharmaceuticals Inc |
吡唑并[1,5-a]嘧啶基化合物、包含彼之組合物以及使用彼之方法
|
|
AR097543A1
(es)
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
WO2015073267A1
(en)
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
ES2687843T3
(es)
|
2014-03-27 |
2018-10-29 |
Academisch Medisch Centrum |
Iminoazúcares N-(5-((aril o heteroril)metiloxi)pentil)-sustituidos como inhibidores de glucosilceramida sintasa
|
|
WO2016007736A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyrazines as lsd1 inhibitors
|
|
SMT202400187T1
(it)
|
2014-11-06 |
2024-07-09 |
Bial R&D Investments S A |
Pirazolo(1,5-a)pirimidine sostituite e loro utilizzo nel trattamento di disturbi medici
|
|
WO2016073891A1
(en)
*
|
2014-11-06 |
2016-05-12 |
Lysosomal Therapeutics Inc. |
Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
|
|
ES2958391T3
(es)
|
2014-11-06 |
2024-02-08 |
Bial R&D Invest S A |
Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
|
|
WO2017004408A1
(en)
*
|
2015-07-01 |
2017-01-05 |
Northwestern University |
Substituted 4-methyl-pyrrolo[1.2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
|
|
JP2018525345A
(ja)
|
2015-07-01 |
2018-09-06 |
ノースウェスタン ユニバーシティ |
置換キナゾリン化合物及びグルコセレブロシダーゼ活性の調節のためのその使用
|
|
WO2017040877A1
(en)
|
2015-09-04 |
2017-03-09 |
Lysosomal Therapeutics Inc. |
Heterobicyclic pyrimidinone compounds and their use in the treatment of medical disorders
|
|
LT3371190T
(lt)
|
2015-11-06 |
2022-08-10 |
Incyte Corporation |
Heterocikliniai junginiai, kaip pi3k-gama inhibitoriai
|
|
KR102782807B1
(ko)
|
2015-11-18 |
2025-03-14 |
브리스톨-마이어스 스큅 컴퍼니 |
Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 이미다조피리다진 화합물
|
|
CN108473501B
(zh)
|
2016-02-18 |
2021-07-16 |
豪夫迈·罗氏有限公司 |
治疗化合物、其组合物及使用方法
|
|
EP3440081A4
(en)
|
2016-04-06 |
2019-09-18 |
Lysosomal Therapeutics Inc. |
PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
|
|
SG11201808830YA
(en)
|
2016-04-06 |
2018-11-29 |
Lysosomal Therapeutics Inc |
Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
CA3020305A1
(en)
|
2016-04-06 |
2017-10-12 |
Lysosomal Therapeutics Inc. |
Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
WO2017192841A1
(en)
*
|
2016-05-04 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
|
|
JP7164774B2
(ja)
|
2016-05-05 |
2022-11-02 |
ビアル-アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ |
置換イミダゾ[1,2-b]ピリダジン、置換イミダゾ[1,5-b]ピリダジン、関連化合物、および医学的障害の治療におけるその使用
|
|
WO2017192931A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
WO2017192929A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED PYRROLO[1,2-α]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
JP2021506920A
(ja)
|
2017-12-21 |
2021-02-22 |
リソソーマル・セラピューティクス・インコーポレイテッドLysosomal Therapeutics Inc. |
結晶性の置換シクロヘキシルピラゾロ[1,5−a]ピリミジニルカルボキサミド化合物およびその治療的使用
|