|
US4838925A
(en)
|
1986-04-25 |
1989-06-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
|
JP3763997B2
(ja)
|
1999-05-13 |
2006-04-05 |
富士写真フイルム株式会社 |
感熱記録材料
|
|
JP4331823B2
(ja)
|
1999-05-21 |
2009-09-16 |
富士フイルム株式会社 |
ピロロ［１，２−ａ］−１，３，５−トリアジン−４−オン系化合物
|
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
|
JP4070966B2
(ja)
|
2001-06-28 |
2008-04-02 |
株式会社カネボウ化粧品 |
新規ガラクトシルセラミド類縁体及び用途
|
|
WO2003035649A1
(en)
|
2001-10-22 |
2003-05-01 |
Pfizer Japan Inc. |
Imidazopyridine compounds as 5-ht4 receptor modulators
|
|
CA2476757A1
(en)
|
2002-03-01 |
2003-09-12 |
Yamanouchi Pharmaceutical Co., Ltd. |
Nitrogen-containing heterocyclic compound
|
|
DOP2003000703A
(es)
|
2002-09-20 |
2004-03-31 |
Pfizer |
Compuestos de imidazopiradina como agonistas del receptor 5-ht4
|
|
MXPA05003065A
(es)
|
2002-09-20 |
2005-05-27 |
Pfizer |
Compuestos de piperidinil-imidazopiridina n-sustituidos como moduladores del receptor 5-ht4.
|
|
US7550470B2
(en)
|
2002-12-11 |
2009-06-23 |
Merck & Co. Inc. |
Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors
|
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ［１，５−ａ］ピリミジン誘導体
|
|
EP1620435A1
(en)
|
2003-04-21 |
2006-02-01 |
Pfizer Inc. |
IMADAZOPYRIDINE COMPOUNDS HAVING 5-HT sb 4 /sb RECEPTOR AGONISTIC ACTIVITY AND 5-HT sb 3 /sb RECEPTOR ANTAGONISTIC ACTIVITY
|
|
CA2545435C
(en)
|
2003-11-12 |
2014-08-19 |
Amicus Therapeutics Inc. |
Hydroxy piperidine derivatives to treat gaucher disease
|
|
GB0329214D0
(en)
|
2003-12-17 |
2004-01-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0400812D0
(en)
|
2004-01-14 |
2004-02-18 |
Celltech R&D Ltd |
Novel compounds
|
|
EP1719756A4
(en)
|
2004-02-18 |
2007-09-26 |
Banyu Pharma Co Ltd |
DERIVATIVE NITROGENOUS, CONDENSED HETEROAROMATIC RING
|
|
NZ551424A
(en)
|
2004-05-14 |
2009-10-30 |
Childrenaes Cancer Inst Austra |
Small molecule inhibitors for MRP1 and other multidrug transporters
|
|
ATE383361T1
(de)
|
2004-06-21 |
2008-01-15 |
Hoffmann La Roche |
Pyrrazolopyrimidinderivate
|
|
EP1778685B1
(de)
|
2004-08-02 |
2008-03-26 |
Schwarz Pharma Ag |
Carboxamide des indolizins und seiner aza- und diazaderivate
|
|
DE102004049363A1
(de)
*
|
2004-10-08 |
2006-04-13 |
Henkel Kgaa |
Mittel zum Färben von keratinhaltigen Fasern
|
|
CN101107251A
(zh)
|
2005-01-19 |
2008-01-16 |
默克公司 |
用于治疗或预防糖尿病的作为二肽基肽酶-ⅳ抑制剂的双环嘧啶类
|
|
WO2006084835A1
(en)
*
|
2005-02-10 |
2006-08-17 |
Ferrer Internacional, S. A. |
N-(3-(imidazo [1,5-a]pyrimidin-4-yl)phenyl]-sulfonamides and n-[3-(imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides and their use as gabaa receptor modulators
|
|
ES2365406T3
(es)
|
2005-02-11 |
2011-10-04 |
F. Hoffmann-La Roche Ag |
Derivados de pirazolo-pirimidina como antagonistas de mglur2.
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
AU2006240769A1
(en)
|
2005-04-21 |
2006-11-02 |
Dainippon Sumitomo Pharma Co., Ltd. |
N-substituted phenylacetamide derivative and pharmaceutical composition comprising the same
|
|
EP1878727A4
(en)
|
2005-04-28 |
2013-11-13 |
Kyowa Hakko Kirin Co Ltd |
2-AMINOQUINAZOLINE DERIVATIVES
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7723336B2
(en)
|
2005-09-22 |
2010-05-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
|
WO2007044407A2
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Pyrazolo (1 , 5a) pyrimidines as protein kinase inhibitors
|
|
ATE517874T1
(de)
|
2005-10-21 |
2011-08-15 |
Exelixis Inc |
Pyrimidinone als modulatoren von caseinkinase ii (ck2)
|
|
JP2009518340A
(ja)
|
2005-12-08 |
2009-05-07 |
ノバルティス アクチエンゲゼルシャフト |
ＥｐｈＢおよびＶＥＧＦＲ２キナーゼ阻害剤としてのピラゾロ［１，５−ａ］ピリジン−３−カルボン酸
|
|
TW200800997A
(en)
|
2006-03-22 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
|
ATE555788T1
(de)
|
2006-06-23 |
2012-05-15 |
Amicus Therapeutics Inc |
Verfahren zur behandlung neurologischer erkrankungen mittels verstärkung der beta - glucocerebrosidaseaktivität
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
WO2008019363A2
(en)
|
2006-08-07 |
2008-02-14 |
Albany Molecular Research, Inc. |
2-alkylbenzoxazole carboxamides as 5ht3 modulators
|
|
CA2670044A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic matrix metalloprotease inhibitors
|
|
US20080176870A1
(en)
|
2006-11-20 |
2008-07-24 |
Bert Nolte |
Heterobicyclic metalloprotease inhibitors
|
|
CA2682016A1
(en)
|
2007-03-28 |
2008-10-02 |
Inovacia Ab |
Pyrazolo [1,5-a]pyrimidines as inhibitors of stearoyl-coa desaturase
|
|
AR067326A1
(es)
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
JP2010530438A
(ja)
|
2007-06-21 |
2010-09-09 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
プロテインキナーゼ阻害剤およびその使用法
|
|
JP5479105B2
(ja)
|
2007-11-05 |
2014-04-23 |
国立大学法人佐賀大学 |
新規ユビキリン結合性小分子
|
|
EP2217601A1
(en)
|
2007-11-08 |
2010-08-18 |
Centro Nacional de Investigaciones Oncológicas (CNIO) |
Imidazopyridazines for use as protein kinase inhibitors
|
|
CA2706946A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
JP5394404B2
(ja)
|
2008-02-06 |
2014-01-22 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用な置換イミダゾピリダジン類
|
|
EP2269990A4
(en)
|
2008-03-25 |
2012-04-18 |
Takeda Pharmaceutical |
Heterocyclic compound
|
|
EA021938B1
(ru)
|
2008-05-01 |
2015-10-30 |
Сертрис Фармасьютикалз, Инк. |
Хинолины и их аналоги в качестве модуляторов сиртуина
|
|
ES2565611T3
(es)
|
2008-10-14 |
2016-04-05 |
Entasis Therapeutics Limited |
Compuestos heteroaromáticos espirocíclicos y condensados para el tratamiento de infecciones bacterianas
|
|
JP5769199B2
(ja)
|
2008-10-31 |
2015-08-26 |
ジェネンテック， インコーポレイテッド |
ピラゾロピリミジンｊａｋ阻害剤化合物と方法
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
UA111579C2
(uk)
|
2009-08-17 |
2016-05-25 |
Інтеллікіне Ллк |
ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
|
|
CA2802641C
(en)
|
2010-07-13 |
2019-03-12 |
Nidhi Arora |
Pyrazolo [1, 5a] pyrimidine and thieno [3, 2b] pyrimidine derivatives as irak4 modulators
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
TW201217312A
(en)
|
2010-09-22 |
2012-05-01 |
Gruenenthal Gmbh |
Substituted benzamide compounds
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
BR112013014242B1
(pt)
*
|
2010-12-08 |
2022-02-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Composição farmacêutica e composto ou seu sal farmaceuticamente aceitável
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
EP2688872A4
(en)
|
2011-03-22 |
2014-08-27 |
Merck Sharp & Dohme |
AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES
|
|
JP6061922B2
(ja)
|
2011-06-22 |
2017-01-18 |
ザ ジェネラル ホスピタル コーポレイション |
プロテイノパチーの処置方法
|
|
CA2844794C
(en)
|
2011-08-18 |
2018-02-20 |
Nippon Shinyaku Co., Ltd. |
Heterocyclic derivatives with mpges-1 inhibitory activity
|
|
US8859569B2
(en)
|
2011-09-02 |
2014-10-14 |
Bayer Pharma Aktiengesellschaft |
Substituted annellated pyrimidines and use thereof
|
|
US8961959B2
(en)
|
2011-10-17 |
2015-02-24 |
The Regents Of The University Of Michigan |
Glucosylceramide synthase inhibitors and therapeutic methods using the same
|
|
KR20140077963A
(ko)
|
2011-10-20 |
2014-06-24 |
글락소스미스클라인 엘엘씨 |
시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
|
|
JP2015503519A
(ja)
|
2011-12-23 |
2015-02-02 |
ノバルティス アーゲー |
Ｂｃｌ２と結合相手の相互作用を阻害するための化合物
|
|
US9340549B2
(en)
|
2012-03-05 |
2016-05-17 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
KR102085121B1
(ko)
|
2012-03-09 |
2020-03-05 |
렉시컨 파마슈티컬스 인코퍼레이티드 |
이미다조[1,2-b]피리다진계 화합물, 그를 포함하는 조성물 및 그의 용도
|
|
HUE036040T2
(hu)
|
2012-03-09 |
2018-06-28 |
Lexicon Pharmaceuticals Inc |
Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére
|
|
CA2868484A1
(en)
|
2012-03-28 |
2013-10-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Salicylic acid derivatives useful as glucocerebrosidase activators
|
|
EP2855459B1
(en)
|
2012-05-31 |
2020-04-29 |
F.Hoffmann-La Roche Ag |
Aminoquinazoline and pyridopyrimidine derivatives
|
|
BR112014030147B1
(pt)
|
2012-06-22 |
2019-10-15 |
Sumitomo Chemical Company, Limited |
Compostos heterocíclicos fundidos, composição e método para controlar pestes
|
|
WO2014025651A1
(en)
|
2012-08-06 |
2014-02-13 |
Amgen Inc. |
Chroman derivatives as trpm8 inhibitors
|
|
BR112015004858A2
(pt)
|
2012-09-05 |
2017-07-04 |
Bayer Cropscience Ag |
uso de 2-amidobenzimidazóis, 2-amidobenzoxazóis e 2-amidobenzotiazóis substituídos ou sais dos mesmos como substâncias ativas contra estresse abiótico em plantas
|
|
US9573954B2
(en)
|
2012-11-16 |
2017-02-21 |
University Health Network |
Pyrazolopyrimidine compounds
|
|
EP2925750A1
(en)
|
2012-11-29 |
2015-10-07 |
Karyopharm Therapeutics, Inc. |
Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
|
|
PL3808749T3
(pl)
|
2012-12-07 |
2023-07-10 |
Vertex Pharmaceuticals Incorporated |
Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych
|
|
KR20140086002A
(ko)
|
2012-12-28 |
2014-07-08 |
한미약품 주식회사 |
Fms 키나아제 저해 활성을 갖는 피리다진 접합고리 유도체
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
EP2970266B1
(en)
|
2013-03-15 |
2018-01-31 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
|
|
EP3026051A4
(en)
|
2013-07-24 |
2017-03-08 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
EP3035921A1
(en)
|
2013-08-20 |
2016-06-29 |
Bristol-Myers Squibb Company |
Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia
|
|
TW201605866A
(zh)
|
2013-08-23 |
2016-02-16 |
英塞特公司 |
可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物
|
|
TW201542550A
(zh)
|
2013-09-06 |
2015-11-16 |
Lexicon Pharmaceuticals Inc |
吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
|
|
AR097543A1
(es)
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
WO2015073267A1
(en)
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
WO2015147639A1
(en)
|
2014-03-27 |
2015-10-01 |
Academisch Medisch Centrum |
N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase
|
|
US9695180B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
|
|
KR102662215B1
(ko)
|
2014-11-06 |
2024-05-02 |
비알 - 알&디 인베스트먼츠, 에스.에이. |
치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도
|
|
US20170333435A1
(en)
|
2014-11-06 |
2017-11-23 |
Lysosomal Therapeutics Inc. |
Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
|
|
WO2016073891A1
(en)
|
2014-11-06 |
2016-05-12 |
Lysosomal Therapeutics Inc. |
Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
|
|
US10167270B2
(en)
|
2015-07-01 |
2019-01-01 |
Northwestern University |
Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
|
|
EP3317282B1
(en)
*
|
2015-07-01 |
2020-12-09 |
Northwestern University |
Substituted 4-methyl-pyrrolo[1.2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
|
|
US20190092789A1
(en)
|
2015-09-04 |
2019-03-28 |
Lysosomal Therapeutics Inc. |
Heterobicyclic pyrimidinone compounds and their use in the treatment of medical disorders
|
|
SI3371190T1
(sl)
|
2015-11-06 |
2022-08-31 |
Incyte Corporation |
Heterociklične spojine kot inhibitorji PI3K gama
|
|
US10479793B2
(en)
|
2015-11-18 |
2019-11-19 |
Bristol-Myers Squibb Company |
Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
|
|
CN108473501B
(zh)
|
2016-02-18 |
2021-07-16 |
豪夫迈·罗氏有限公司 |
治疗化合物、其组合物及使用方法
|
|
US11192892B2
(en)
|
2016-04-06 |
2021-12-07 |
Bial—R&D Investments, S.A. |
Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders
|
|
WO2017176961A1
(en)
|
2016-04-06 |
2017-10-12 |
Lysosomal Therapeutics Inc. |
Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
JP7034935B2
(ja)
*
|
2016-04-06 |
2022-03-14 |
リソソーマル・セラピューティクス・インコーポレイテッド |
ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
|
|
WO2017192841A1
(en)
|
2016-05-04 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
|
|
WO2017192930A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
US11345698B2
(en)
|
2016-05-05 |
2022-05-31 |
Bial—R&D Investments, S.A. |
Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders
|
|
US20190389865A1
(en)
|
2016-05-05 |
2019-12-26 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED PYRROLO[1,2-a]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
EP3728265A1
(en)
|
2017-12-21 |
2020-10-28 |
BIAL - BioTech Investments, Inc. |
Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof
|