JP2020502092A5 - - Google Patents
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- Publication number
- JP2020502092A5 JP2020502092A5 JP2019530500A JP2019530500A JP2020502092A5 JP 2020502092 A5 JP2020502092 A5 JP 2020502092A5 JP 2019530500 A JP2019530500 A JP 2019530500A JP 2019530500 A JP2019530500 A JP 2019530500A JP 2020502092 A5 JP2020502092 A5 JP 2020502092A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- haloalkyl
- cycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GEGDLANPARTRKE-UHFFFAOYSA-N CN1C=COCC1 Chemical compound CN1C=COCC1 GEGDLANPARTRKE-UHFFFAOYSA-N 0.000 description 1
- RXYPXQSKLGGKOL-UHFFFAOYSA-N CN1CCN(C)CC1 Chemical compound CN1CCN(C)CC1 RXYPXQSKLGGKOL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662431504P | 2016-12-08 | 2016-12-08 | |
| US62/431,504 | 2016-12-08 | ||
| PCT/US2017/065385 WO2018107072A1 (en) | 2016-12-08 | 2017-12-08 | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502092A JP2020502092A (ja) | 2020-01-23 |
| JP2020502092A5 true JP2020502092A5 (enExample) | 2021-01-21 |
| JP7128816B2 JP7128816B2 (ja) | 2022-08-31 |
Family
ID=62492159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530500A Expired - Fee Related JP7128816B2 (ja) | 2016-12-08 | 2017-12-08 | 疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10093664B2 (enExample) |
| EP (1) | EP3551610B1 (enExample) |
| JP (1) | JP7128816B2 (enExample) |
| KR (1) | KR20190087622A (enExample) |
| CN (1) | CN110191878B (enExample) |
| AU (1) | AU2017371084B2 (enExample) |
| BR (1) | BR112019011801A2 (enExample) |
| CA (1) | CA3045947A1 (enExample) |
| CL (1) | CL2019001539A1 (enExample) |
| CO (1) | CO2019006785A2 (enExample) |
| EA (1) | EA201991375A1 (enExample) |
| EC (1) | ECSP19048477A (enExample) |
| ES (1) | ES2895257T3 (enExample) |
| IL (1) | IL267121B (enExample) |
| MX (1) | MX386838B (enExample) |
| WO (1) | WO2018107072A1 (enExample) |
| ZA (1) | ZA201904402B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3045947A1 (en) | 2016-12-08 | 2018-06-14 | Michael J. Soth | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
| IL301709B2 (en) | 2017-08-09 | 2025-07-01 | Denali Therapeutics Inc | Compounds, compositions and methods |
| TW201920129A (zh) | 2017-09-01 | 2019-06-01 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| US20190382396A1 (en) * | 2018-06-13 | 2019-12-19 | Board Of Regents, The University Of Texas System | Salts of bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
| GB201811165D0 (en) * | 2018-07-06 | 2018-08-29 | Metrion Biosciences Ltd | Novel compounds |
| WO2020027723A1 (en) * | 2018-08-01 | 2020-02-06 | Agency For Science, Technology And Research | Bicyclic compounds as kinase modulators, methods and uses thereof |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CA3123215C (en) | 2018-12-19 | 2024-04-02 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
| CR20210426A (es) | 2019-02-13 | 2021-09-30 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| IL291665B2 (en) * | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| EP4208455A1 (en) | 2020-09-02 | 2023-07-12 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Lzk-targeting degraders and methods of use |
| TW202241857A (zh) | 2020-12-18 | 2022-11-01 | 美商戴納立製藥公司 | 化合物之固體形式 |
| WO2023034808A1 (en) | 2021-09-01 | 2023-03-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mixed lineage kinase inhibitors and methods of use |
| CN115974795A (zh) * | 2022-12-26 | 2023-04-18 | 杭州师范大学 | 一种含全氟烷基和n杂环二取代双环[1.1.1]戊烷及其合成方法 |
| EP4750781A1 (en) | 2023-07-27 | 2026-06-03 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | New map4k1 inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7332476B2 (en) | 2003-04-25 | 2008-02-19 | Novartis Ag | Pyridyl substituted ketolide antibiotics |
| TW200944520A (en) | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| EP2651930B1 (en) | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
| JP6267193B2 (ja) | 2012-05-22 | 2018-01-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換ジピリジルアミン類及びそれらの使用 |
| MX2015009270A (es) * | 2013-01-18 | 2015-10-30 | Hoffmann La Roche | Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk). |
| CN104119340A (zh) | 2013-01-22 | 2014-10-29 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
| TWI710558B (zh) | 2013-05-01 | 2020-11-21 | 瑞士商赫孚孟拉羅股份公司 | 二雜芳基化合物及其用途 |
| RU2015147601A (ru) | 2013-05-01 | 2017-06-05 | Ф. Хоффманн-Ля Рош Аг | С-связанные гетероциклоалкилзамещенные пиримидины и их применения |
| MX2016008110A (es) | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
| CN106232567B (zh) * | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| US9307840B2 (en) | 2014-07-01 | 2016-04-12 | Carlos Arturo Restrepo | Foldable and portable lounge chair having an integrated lockable storage compartment |
| JP6836998B2 (ja) * | 2015-03-02 | 2021-03-03 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ＴＧＦ−β阻害剤 |
| EP3277690B1 (en) * | 2015-04-03 | 2020-02-26 | Recurium IP Holdings, LLC | Spirocyclic compounds |
| MX2019002444A (es) | 2016-08-29 | 2019-09-02 | Univ Texas | Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades. |
| CA3045947A1 (en) | 2016-12-08 | 2018-06-14 | Michael J. Soth | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
-
2017
- 2017-12-08 CA CA3045947A patent/CA3045947A1/en active Pending
- 2017-12-08 WO PCT/US2017/065385 patent/WO2018107072A1/en not_active Ceased
- 2017-12-08 AU AU2017371084A patent/AU2017371084B2/en not_active Ceased
- 2017-12-08 EP EP17879488.9A patent/EP3551610B1/en active Active
- 2017-12-08 KR KR1020197019246A patent/KR20190087622A/ko not_active Abandoned
- 2017-12-08 MX MX2019006645A patent/MX386838B/es unknown
- 2017-12-08 CN CN201780082917.2A patent/CN110191878B/zh not_active Expired - Fee Related
- 2017-12-08 ES ES17879488T patent/ES2895257T3/es active Active
- 2017-12-08 BR BR112019011801-2A patent/BR112019011801A2/pt not_active IP Right Cessation
- 2017-12-08 US US15/836,442 patent/US10093664B2/en active Active
- 2017-12-08 JP JP2019530500A patent/JP7128816B2/ja not_active Expired - Fee Related
- 2017-12-08 EA EA201991375A patent/EA201991375A1/ru unknown
-
2018
- 2018-09-04 US US16/121,198 patent/US10428057B2/en active Active
-
2019
- 2019-06-05 CL CL2019001539A patent/CL2019001539A1/es unknown
- 2019-06-05 IL IL267121A patent/IL267121B/en unknown
- 2019-06-26 CO CONC2019/0006785A patent/CO2019006785A2/es unknown
- 2019-07-04 ZA ZA2019/04402A patent/ZA201904402B/en unknown
- 2019-07-08 EC ECSENADI201948477A patent/ECSP19048477A/es unknown
-
2022
- 2022-03-10 US US17/654,301 patent/US20220267311A1/en not_active Abandoned