JP2015501783A5 - - Google Patents
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- Publication number
- JP2015501783A5 JP2015501783A5 JP2014539998A JP2014539998A JP2015501783A5 JP 2015501783 A5 JP2015501783 A5 JP 2015501783A5 JP 2014539998 A JP2014539998 A JP 2014539998A JP 2014539998 A JP2014539998 A JP 2014539998A JP 2015501783 A5 JP2015501783 A5 JP 2015501783A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- pharmaceutical composition
- following formula
- acceptable carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- YFISEEHEDYLAHH-UHFFFAOYSA-N Cc1ncc(CCc2cc3nc(C(N)=O)cc(-c(ccc(OC)c4)c4F)c3cc2)cn1 Chemical compound Cc1ncc(CCc2cc3nc(C(N)=O)cc(-c(ccc(OC)c4)c4F)c3cc2)cn1 YFISEEHEDYLAHH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161555227P | 2011-11-03 | 2011-11-03 | |
| US61/555,227 | 2011-11-03 | ||
| US201261672334P | 2012-07-17 | 2012-07-17 | |
| US61/672,334 | 2012-07-17 | ||
| PCT/US2012/062027 WO2013066736A1 (en) | 2011-11-03 | 2012-10-26 | QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015242916A Division JP6114809B2 (ja) | 2011-11-03 | 2015-12-14 | ｍＧｌｕＲ２−陰性アロステリック調節因子としてのキノリンカルボキサミドおよびキノリンカルボニトリル誘導体、組成物、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501783A JP2015501783A (ja) | 2015-01-19 |
| JP2015501783A5 true JP2015501783A5 (enExample) | 2015-12-24 |
| JP5857136B2 JP5857136B2 (ja) | 2016-02-10 |
Family
ID=48192643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539998A Expired - Fee Related JP5857136B2 (ja) | 2011-11-03 | 2012-10-26 | ｍＧｌｕＲ２−陰性アロステリック調節因子としてのキノリンカルボキサミドおよびキノリンカルボニトリル誘導体、組成物、およびその使用 |
| JP2015242916A Expired - Fee Related JP6114809B2 (ja) | 2011-11-03 | 2015-12-14 | ｍＧｌｕＲ２−陰性アロステリック調節因子としてのキノリンカルボキサミドおよびキノリンカルボニトリル誘導体、組成物、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015242916A Expired - Fee Related JP6114809B2 (ja) | 2011-11-03 | 2015-12-14 | ｍＧｌｕＲ２−陰性アロステリック調節因子としてのキノリンカルボキサミドおよびキノリンカルボニトリル誘導体、組成物、およびその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9278960B2 (enExample) |
| EP (1) | EP2775841B1 (enExample) |
| JP (2) | JP5857136B2 (enExample) |
| KR (1) | KR20140088887A (enExample) |
| CN (1) | CN104010504B (enExample) |
| AR (1) | AR088611A1 (enExample) |
| AU (2) | AU2012332895B2 (enExample) |
| CA (1) | CA2853923A1 (enExample) |
| CO (1) | CO6950474A2 (enExample) |
| IL (1) | IL232291A0 (enExample) |
| IN (1) | IN2014CN03234A (enExample) |
| MX (1) | MX344308B (enExample) |
| MY (1) | MY167423A (enExample) |
| RU (1) | RU2610262C2 (enExample) |
| TW (1) | TWI605040B (enExample) |
| WO (1) | WO2013066736A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066736A1 (en) * | 2011-11-03 | 2013-05-10 | Merck Sharp & Dohme Corp. | QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JP6377245B2 (ja) * | 2014-03-24 | 2018-08-22 | グアンドン ジョンシェン ファーマシューティカル カンパニー リミテッド | Ｓｍｏ阻害剤としてのキノリン誘導体 |
| JO3601B1 (ar) | 2014-08-01 | 2020-07-05 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JOP20150177B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| RU2696135C2 (ru) | 2014-08-01 | 2019-07-31 | Янссен Фармацевтика Нв | 6,7-ДИГИДРОПИРАЗОЛО[1,5-α]ПИРАЗИН-4(5Н)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2 |
| JOP20150179B1 (ar) * | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| ES2707525T3 (es) | 2014-08-01 | 2019-04-03 | Janssen Pharmaceutica Nv | Compuestos de 6,7-dihidropirazolo[1,5-a]pirazin-4(5H)-ona y su uso como moduladores alostéricos negativos de receptores de mGlu2 |
| WO2016029454A1 (en) | 2014-08-29 | 2016-03-03 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
| EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| JP6861154B2 (ja) | 2014-12-03 | 2021-04-21 | ヤンセン ファーマシューティカ エヌ．ベー． | 放射標識されたｍＧｌｕＲ２ ＰＥＴリガンド |
| EP3227295B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | 6,7-dihydropyrazolo[1,5- ]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglu2 receptors |
| US10538491B2 (en) | 2015-03-16 | 2020-01-21 | Vanderbilt University | 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators |
| RU2748884C2 (ru) * | 2015-07-20 | 2021-06-01 | Джензим Корпорейшн | Ингибиторы рецептора колониестимулирующего фактора-1 (csf-1r) |
| JP6916175B2 (ja) | 2015-10-26 | 2021-08-11 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての縮合二環式ヘテロ環誘導体 |
| SMT202000591T1 (it) | 2015-12-18 | 2020-11-10 | Janssen Pharmaceutica Nv | Ligandi pet radiomarcati mglur 2/3 |
| ES2820823T3 (es) | 2015-12-18 | 2021-04-22 | Janssen Pharmaceutica Nv | Ligandos PET mGluR2/3 radiomarcados |
| GEP20217279B (en) * | 2016-09-27 | 2021-08-10 | Merck Sharp & Dohme | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND THEIR USE |
| SG11202004484UA (en) | 2017-11-24 | 2020-06-29 | Sumitomo Dainippon Pharma Co Ltd | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF |
| CN108689957B (zh) * | 2018-07-23 | 2020-07-03 | 南京药石科技股份有限公司 | 一种2r/2s-三氟甲基吗啉及其盐酸盐的制备方法和应用 |
| WO2020097389A1 (en) * | 2018-11-09 | 2020-05-14 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| CA3137025A1 (en) | 2019-04-16 | 2020-10-22 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| US12304899B2 (en) | 2019-05-30 | 2025-05-20 | Merck Sharp & Dohme Llc | Factor XI activation inhibitors |
| AU2020299705A1 (en) | 2019-07-01 | 2021-12-09 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a D1 positive allosteric modulator |
| CN110256342B (zh) * | 2019-07-16 | 2022-06-07 | 河南省科学院化学研究所有限公司 | 一种2-氰基喹啉衍生物的合成方法 |
| JP2024500919A (ja) | 2020-12-23 | 2024-01-10 | ジェンザイム・コーポレーション | 重水素化コロニー刺激因子－１受容体（ｃｓｆ－１ｒ）阻害剤 |
| WO2024112853A1 (en) * | 2022-11-24 | 2024-05-30 | Exelixis, Inc. | Compounds that inhibit pkmyt1 |
| TW202519226A (zh) * | 2023-11-08 | 2025-05-16 | 美商艾克塞里克斯公司 | 使用抑制ｐｋｍｙｔ１之化合物治療癌症之方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0551831A1 (de) * | 1992-01-15 | 1993-07-21 | Hoechst Schering AgrEvo GmbH | Verfahren zur Herstellung substituierter 2-Cyanopyridine |
| US5552437A (en) | 1994-10-27 | 1996-09-03 | Merck Frosst Canada, Inc. | Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis |
| US5576338A (en) | 1995-02-15 | 1996-11-19 | Merck Frosst Canada, Inc. | Bis (biaryl) compounds as inhibitors of leukotriene biosynthesis |
| GB9524137D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| JPH115772A (ja) * | 1997-04-25 | 1999-01-12 | Takeda Chem Ind Ltd | アミド誘導体、その製造法および用途 |
| US6340704B1 (en) * | 1997-04-25 | 2002-01-22 | Takeda Chemical Industries, Ltd. | Cell differentiation inducing amide derivatives, their production and use |
| DE60009116T2 (de) * | 1999-10-15 | 2005-02-17 | F. Hoffmann-La Roche Ag | Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten |
| TWI328009B (en) * | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| CA2532036A1 (en) * | 2003-07-11 | 2005-02-03 | Merck & Co., Inc. | Methods for identifying cell surface receptor protein modulators |
| EP1667683A4 (en) | 2003-09-23 | 2009-04-29 | Merck & Co Inc | QUINOLINE POTASSIUM CHANNEL INHIBITORS |
| CA2585210A1 (en) * | 2004-10-28 | 2006-05-11 | Merck & Co., Inc. | Pyrimidine and quinoline potentiators of metabotropic glutamate receptors |
| JP2009510132A (ja) * | 2005-10-05 | 2009-03-12 | メルク フロスト カナダ リミテツド | ロイコトリエン生合成の阻害剤としての置換キノリン |
| AR065093A1 (es) * | 2007-02-05 | 2009-05-13 | Merck Frosst Canada Ltd | Compuestos farmacéuticos inhibidores de la biosintesis de leucotrienos |
| GEP20125524B (en) * | 2007-06-18 | 2012-05-25 | Richter Gedeon Nyrt | Sulfonyl-quinoline derivatives |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| WO2012083866A1 (en) | 2010-12-22 | 2012-06-28 | The Hong Kong Polytechnic University | Quinoline derivatives as anti-cancer agents |
| WO2013066736A1 (en) | 2011-11-03 | 2013-05-10 | Merck Sharp & Dohme Corp. | QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
-
2012
- 2012-10-26 WO PCT/US2012/062027 patent/WO2013066736A1/en not_active Ceased
- 2012-10-26 US US14/356,080 patent/US9278960B2/en active Active
- 2012-10-26 AU AU2012332895A patent/AU2012332895B2/en not_active Ceased
- 2012-10-26 JP JP2014539998A patent/JP5857136B2/ja not_active Expired - Fee Related
- 2012-10-26 EP EP12846579.6A patent/EP2775841B1/en active Active
- 2012-10-26 MY MYPI2014001269A patent/MY167423A/en unknown
- 2012-10-26 MX MX2014005415A patent/MX344308B/es active IP Right Grant
- 2012-10-26 RU RU2014122335A patent/RU2610262C2/ru not_active IP Right Cessation
- 2012-10-26 CN CN201280065879.7A patent/CN104010504B/zh not_active Expired - Fee Related
- 2012-10-26 KR KR1020147014513A patent/KR20140088887A/ko not_active Withdrawn
- 2012-10-26 IN IN3234CHN2014 patent/IN2014CN03234A/en unknown
- 2012-10-26 CA CA2853923A patent/CA2853923A1/en not_active Abandoned
- 2012-11-01 AR ARP120104094A patent/AR088611A1/es unknown
- 2012-11-02 TW TW101140837A patent/TWI605040B/zh not_active IP Right Cessation
-
2014
- 2014-04-28 IL IL232291A patent/IL232291A0/en unknown
- 2014-04-30 CO CO14093156A patent/CO6950474A2/es unknown
-
2015
- 2015-12-14 JP JP2015242916A patent/JP6114809B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-17 AU AU2016200998A patent/AU2016200998B2/en not_active Ceased
- 2016-02-18 US US15/047,224 patent/US9636337B2/en active Active
- 2016-02-18 US US15/047,213 patent/US9663506B2/en active Active
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