JOP20150179B1 - مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 - Google Patents

مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2

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Publication number
JOP20150179B1
JOP20150179B1 JOP/2015/0179A JOP20150179A JOP20150179B1 JO P20150179 B1 JOP20150179 B1 JO P20150179B1 JO P20150179 A JOP20150179 A JO P20150179A JO P20150179 B1 JOP20150179 B1 JO P20150179B1
Authority
JO
Jordan
Prior art keywords
dihydropyrazolo
pyrazin
compounds
allosteric modulators
negative allosteric
Prior art date
Application number
JOP/2015/0179A
Other languages
English (en)
Inventor
Gool Michiel Luc Maria Van
Diego Sergio-Alvar Alonso-De
José Ignacio Andrés-Gil
?Scar Delgado-Gonz?Lez
Andrés Avelino Trabanco-Su?Rez
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of JOP20150179B1 publication Critical patent/JOP20150179B1/ar

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

يتعلق الاختراع الحالي بمشتقات 6 ، 7 ثاني هيدرو بيرازولوandnbsp; [andnbsp; 1، 5 الفاandnbsp; ] بيرازين andndash; 4 (5 يد) andndash; اون بصفتها منظمات الوسترية سلبية لمستقبل جلوتاميت ميتاتروبي نوع فرعي 2.
JOP/2015/0179A 2014-08-01 2015-07-27 مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 JOP20150179B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14179598 2014-08-01

Publications (1)

Publication Number Publication Date
JOP20150179B1 true JOP20150179B1 (ar) 2021-08-17

Family

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JOP/2015/0179A JOP20150179B1 (ar) 2014-08-01 2015-07-27 مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2

Country Status (33)

Country Link
US (3) US10005786B2 (ar)
EP (1) EP3177623B1 (ar)
JP (1) JP6662846B2 (ar)
KR (1) KR102531689B1 (ar)
CN (1) CN106573936B (ar)
AR (1) AR101392A1 (ar)
AU (1) AU2015295298B2 (ar)
BR (1) BR112017001726A2 (ar)
CA (1) CA2954093C (ar)
CL (1) CL2017000192A1 (ar)
CY (1) CY1121649T1 (ar)
DK (1) DK3177623T3 (ar)
EA (1) EA031087B1 (ar)
ES (1) ES2708215T3 (ar)
HR (1) HRP20181997T1 (ar)
HU (1) HUE042871T2 (ar)
IL (1) IL250298A0 (ar)
JO (1) JOP20150179B1 (ar)
LT (1) LT3177623T (ar)
MA (1) MA39582B1 (ar)
ME (1) ME03320B (ar)
MX (1) MX2017001452A (ar)
NZ (1) NZ728122A (ar)
PH (1) PH12017500161A1 (ar)
PL (1) PL3177623T3 (ar)
PT (1) PT3177623T (ar)
RS (1) RS58279B1 (ar)
SG (1) SG11201700638YA (ar)
SI (1) SI3177623T1 (ar)
TR (1) TR201901074T4 (ar)
TW (1) TWI696624B (ar)
WO (1) WO2016016380A1 (ar)
ZA (1) ZA201700759B (ar)

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TR201901074T4 (tr) 2019-02-21
WO2016016380A8 (en) 2017-01-19
PL3177623T3 (pl) 2019-04-30
HUE042871T2 (hu) 2019-07-29
US20180256569A1 (en) 2018-09-13
LT3177623T (lt) 2019-02-11
US10512646B2 (en) 2019-12-24
MX2017001452A (es) 2017-05-09
PH12017500161A1 (en) 2017-06-28
WO2016016380A1 (en) 2016-02-04
AR101392A1 (es) 2016-12-14
EP3177623B1 (en) 2018-11-07
SG11201700638YA (en) 2017-02-27
EA201692540A1 (ru) 2017-05-31
KR102531689B1 (ko) 2023-05-10
CA2954093A1 (en) 2016-02-04
AU2015295298A1 (en) 2017-01-12
CL2017000192A1 (es) 2017-07-28
EA031087B1 (ru) 2018-11-30
TWI696624B (zh) 2020-06-21
PT3177623T (pt) 2019-02-01
CN106573936A (zh) 2017-04-19
MA39582A1 (fr) 2018-06-29
US10005786B2 (en) 2018-06-26
CN106573936B (zh) 2020-01-07
CA2954093C (en) 2022-11-29
ES2708215T3 (es) 2019-04-09
HRP20181997T1 (hr) 2019-01-25
US20170217972A1 (en) 2017-08-03
ZA201700759B (en) 2018-12-19
US20200121677A1 (en) 2020-04-23
NZ728122A (en) 2022-07-29
RS58279B1 (sr) 2019-03-29
KR20170031247A (ko) 2017-03-20
AU2015295298B2 (en) 2019-07-11
JP2017522340A (ja) 2017-08-10
IL250298A0 (en) 2017-03-30
CY1121649T1 (el) 2020-07-31
EP3177623A1 (en) 2017-06-14
DK3177623T3 (en) 2019-02-25
SI3177623T1 (sl) 2019-01-31
ME03320B (me) 2019-10-20
MA39582B1 (fr) 2019-10-31
BR112017001726A2 (pt) 2017-11-21
TW201617346A (zh) 2016-05-16
JP6662846B2 (ja) 2020-03-11

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