JP2016516043A5 - - Google Patents

Download PDF

Info

Publication number
JP2016516043A5
JP2016516043A5 JP2016502444A JP2016502444A JP2016516043A5 JP 2016516043 A5 JP2016516043 A5 JP 2016516043A5 JP 2016502444 A JP2016502444 A JP 2016502444A JP 2016502444 A JP2016502444 A JP 2016502444A JP 2016516043 A5 JP2016516043 A5 JP 2016516043A5
Authority
JP
Japan
Prior art keywords
optionally substituted
compound
optionally
compound according
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016502444A
Other languages
English (en)
Japanese (ja)
Other versions
JP6562898B2 (ja
JP2016516043A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/027449 external-priority patent/WO2014152536A2/en
Publication of JP2016516043A publication Critical patent/JP2016516043A/ja
Publication of JP2016516043A5 publication Critical patent/JP2016516043A5/ja
Application granted granted Critical
Publication of JP6562898B2 publication Critical patent/JP6562898B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016502444A 2013-03-14 2014-03-14 ロイコトリエンa4加水分解酵素の阻害剤 Active JP6562898B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781168P 2013-03-14 2013-03-14
US61/781,168 2013-03-14
PCT/US2014/027449 WO2014152536A2 (en) 2013-03-14 2014-03-14 Inhibitors of leukotriene a4 hydrolase

Publications (3)

Publication Number Publication Date
JP2016516043A JP2016516043A (ja) 2016-06-02
JP2016516043A5 true JP2016516043A5 (enExample) 2017-04-13
JP6562898B2 JP6562898B2 (ja) 2019-08-21

Family

ID=51581719

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016502444A Active JP6562898B2 (ja) 2013-03-14 2014-03-14 ロイコトリエンa4加水分解酵素の阻害剤

Country Status (10)

Country Link
US (2) US9822106B2 (enExample)
EP (1) EP2968265A4 (enExample)
JP (1) JP6562898B2 (enExample)
KR (1) KR20150131211A (enExample)
AU (2) AU2014239585B2 (enExample)
BR (1) BR112015022227A2 (enExample)
CA (1) CA2906086A1 (enExample)
MX (1) MX2015011676A (enExample)
RU (1) RU2690489C2 (enExample)
WO (1) WO2014152536A2 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT1976828T (lt) 2005-12-29 2017-04-25 Celtaxsys, Inc. Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
WO2014164658A1 (en) 2013-03-12 2014-10-09 Celtaxsys, Inc. Methods of inhibiting leukotriene a4 hydrolase
EP2970309A4 (en) 2013-03-14 2016-11-09 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
WO2017070089A1 (en) 2015-10-19 2017-04-27 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2928856T3 (es) 2015-11-19 2022-11-23 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
WO2017106634A1 (en) 2015-12-17 2017-06-22 Incyte Corporation N-phenyl-pyridine-2-carboxamide derivatives and their use as pd-1/pd-l1 protein/protein interaction modulators
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
TWI850624B (zh) 2015-12-22 2024-08-01 美商英塞特公司 作為免疫調節劑之雜環化合物
ES2906460T3 (es) 2016-05-06 2022-04-18 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
TW201808902A (zh) 2016-05-26 2018-03-16 美商英塞特公司 作為免疫調節劑之雜環化合物
PT3472167T (pt) 2016-06-20 2022-11-11 Incyte Corp Compostos heterocíclicos como imunomoduladores
US20180016260A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
MA46045A (fr) 2016-08-29 2021-04-28 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
CA3045954A1 (en) * 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
RS63710B1 (sr) 2016-12-22 2022-11-30 Incyte Corp Derivati tetrahidro imidazo[4,5-c] piridina kao induktori internalizacije pd-l1
TW201835049A (zh) 2016-12-22 2018-10-01 美商英塞特公司 作為免疫調節劑之雜環化合物
EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
JP7101678B2 (ja) 2016-12-22 2022-07-15 インサイト・コーポレイション 免疫調節剤としての複素環式化合物
US20180179201A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
US10925851B2 (en) 2018-03-15 2021-02-23 Regents Of The University Of Minnesota Use of Tosedostat and related compounds as analgesics
RS66699B1 (sr) 2018-03-30 2025-05-30 Incyte Corp Heterociklična jedinjenja kao imunomodulatori
TW202425987A (zh) 2018-05-11 2024-07-01 美商英塞特公司 作為免疫調節劑之雜環化合物
EP3801559B1 (en) 2018-05-31 2025-01-01 Celltaxis, LLC Method of reducing pulmonary exacerbations in respiratory disease patients
TW202115059A (zh) 2019-08-09 2021-04-16 美商英塞特公司 Pd—1/pd—l1抑制劑之鹽
JP7559059B2 (ja) 2019-09-30 2024-10-01 インサイト・コーポレイション 免疫調節剤としてのピリド[3,2-d]ピリミジン化合物
PH12022551136A1 (en) 2019-11-11 2023-10-09 Incyte Corp Salts and crystalline forms of a pd-1/pd-l1 inhibitor
JP7545570B2 (ja) 2020-08-14 2024-09-04 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Pd—1/pd—l1抑制劑之結晶形式
TW202233616A (zh) 2020-11-06 2022-09-01 美商英塞特公司 用於製備pd-1/pd-l1抑制劑以及其鹽及結晶形式之方法
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6815872A (enExample) 1967-11-22 1969-05-27
US4582833A (en) 1984-04-16 1986-04-15 American Cyanamid Company 2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines
US4576943A (en) 1984-10-09 1986-03-18 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines
US5308852A (en) 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5631401A (en) * 1994-02-09 1997-05-20 Abbott Laboratories Inhibitors of protein farnesyltransferase and squalene synthase
CA2200981A1 (en) * 1994-10-04 1996-04-11 Hisashi Takasugi Urea derivatives and their use as acat-inhibitors
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
CA2246336A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
US5925654A (en) * 1997-03-12 1999-07-20 G.D. Searle & Co. LTA4 , hydrolase inhibitors
US6309561B1 (en) 1997-12-24 2001-10-30 3M Innovative Properties Company Liquid crystal compounds having a chiral fluorinated terminal portion
US6380203B1 (en) 1998-01-14 2002-04-30 Merck & Co., Inc. Angiogenesis inhibitors
US6096745A (en) * 1998-03-25 2000-08-01 Bristol-Myers Squibb Co. Imidazolone anorectic agents: III. heteroaryl derivatives
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
GB9919776D0 (en) 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
CN1356977A (zh) * 1999-05-17 2002-07-03 诺沃挪第克公司 胰高血糖素拮抗剂/反向激动剂
US6699873B1 (en) 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6924313B1 (en) * 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6800651B2 (en) * 2000-02-03 2004-10-05 Eli Lilly And Company Potentiators of glutamate receptors
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
US6451798B2 (en) 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
JP2001354657A (ja) 2000-06-09 2001-12-25 Sds Biotech:Kk 置換ピペラジン誘導体及び農園芸用殺菌剤
DE60114518T2 (de) 2000-07-06 2006-08-10 Fuji Photo Film Co. Ltd., Minamiashigara Flüssigkristallzusammensetzung, die Flüssigkristallmoleküle und Ausrichtungsmittel enthält
WO2002064211A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
CA2439415C (en) 2001-03-02 2011-09-20 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors
AUPR362001A0 (en) 2001-03-08 2001-04-05 Fujisawa Pharmaceutical Co., Ltd. New compound
FR2826011B1 (fr) 2001-06-14 2004-12-10 Oreal Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique
SE0102616D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
WO2003024395A2 (en) 2001-09-14 2003-03-27 Tularik Inc. Linked biaryl compounds
AU2002363236A1 (en) 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
CA2484209C (en) * 2002-05-03 2013-06-11 Exelixis, Inc. Protein kinase modulators and methods of use
PL212616B1 (pl) * 2002-09-19 2012-10-31 Lilly Co Eli Eter diarylowy i kompozycja farmaceutyczna zawierajaca ten eter
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
AU2003290527A1 (en) 2002-10-17 2004-05-04 Decode Genetics Ehf. Susceptibility gene for myocardial infarction
WO2004058683A2 (en) 2002-12-20 2004-07-15 Migenix Corp. Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto
WO2004089410A1 (ja) 2003-04-03 2004-10-21 Kyowa Hakko Kogyo Co., Ltd. 神経因性疼痛の予防及び/または治療剤
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
JP2005008581A (ja) 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ[1,5−a]ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
KR101149379B1 (ko) * 2003-07-28 2012-06-28 얀센 파마슈티카 엔.브이. 벤즈이미다졸, 벤즈티아졸 및 벤즈옥사졸 유도체 및lta4 h 조정자로서의 그의 용도
CA2539276A1 (en) 2003-09-17 2005-03-31 Decode Genetics Ehf. Methods of preventing or treating recurrence of myocardial infarction
JP4795022B2 (ja) * 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
DE10356579A1 (de) 2003-12-04 2005-07-07 Merck Patent Gmbh Aminderivate
SE0303480D0 (sv) 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
WO2005075479A1 (en) 2004-02-04 2005-08-18 Neurosearch A/S Dimeric azacyclic compounds and their use
WO2006033795A2 (en) 2004-09-17 2006-03-30 Wyeth Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth
MX2007012235A (es) * 2005-03-31 2008-03-18 Johnson & Johnson Moduladores de leucotrieno a4 hidrolasa de fenilo y piridilo.
JP2008540395A (ja) * 2005-05-03 2008-11-20 ファイザー・インク アミドレソルシノール化合物
JP2008542365A (ja) * 2005-05-31 2008-11-27 アストラゼネカ・アクチエボラーグ 新規なmchr1アンタゴニスト並びにmchr1媒介状態及び障害の処置のためのそれらの使用
GB0514018D0 (en) 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
SG166769A1 (en) 2005-09-21 2010-12-29 Decode Genetics Ehf Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation
CN1947717B (zh) 2005-10-14 2012-09-26 卓敏 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
DE102005049954A1 (de) 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
LT1976828T (lt) 2005-12-29 2017-04-25 Celtaxsys, Inc. Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
CN102633783A (zh) 2006-02-10 2012-08-15 转化技术制药公司 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
EP1878730A1 (en) * 2006-07-12 2008-01-16 Bayer Schering Pharma Aktiengesellschaft Substituted isoxazolines, pharmaceutical compositions containing the same, methods of preparing the same, and uses of the same
US20100029619A1 (en) 2006-08-04 2010-02-04 Takeda Pharmaceutical Company Limted Fused heterocyclic compound
ES2340223T3 (es) 2006-10-19 2010-05-31 F. Hoffmann-La Roche Ag Aminometil-2-imidazoles con afinidad con los trace receptores asociados amina.
US7893257B2 (en) 2006-12-14 2011-02-22 Janssen Pharmaceutica Nv Process for the preparation of piperazinyl and diazepanyl benzamide derivatives
FR2911140B1 (fr) 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911138B1 (fr) 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911139A1 (fr) 2007-01-05 2008-07-11 Sanofi Aventis Sa Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
BRPI0814403A2 (pt) 2007-07-02 2015-01-27 Hoffmann La Roche Devirados de imidazol como antagonistas de receptor ccr2
WO2009019149A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
AU2008334444B2 (en) 2007-12-12 2011-12-15 Astrazeneca Ab Peptidyl nitriles and use thereof as dipeptidyl peptidase I inhibitors
FR2928070A1 (fr) * 2008-02-27 2009-09-04 Sumitomo Chemical Co Composition agricole, utilisation d'un compose pour sa production et procede pour matriser ou prevenir les maladies des plantes.
US20100029657A1 (en) 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
SI2268646T1 (sl) * 2008-04-11 2013-12-31 Janssen Pharmaceutica N.V. Tiazolopiridin-2-iloksi-fenil in tiazolopirazin-2-iloksi-fenil amini kot modulatorji levkotrien a4 hidrolaze
EP2110374A1 (en) 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
WO2010011912A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Trpv4 antagonists
CN102030700B (zh) * 2009-09-30 2016-06-01 中国医学科学院药物研究所 苯甲酰胺基羧酸类化合物及其制法和药物用途
US8802694B2 (en) 2009-12-07 2014-08-12 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
JP2013047189A (ja) * 2009-12-25 2013-03-07 Kyorin Pharmaceutical Co Ltd 新規パラバン酸誘導体及びそれらを有効成分とする医薬
SG186850A1 (en) 2010-07-29 2013-02-28 Rigel Pharmaceuticals Inc Ampk-activating heterocyclic compounds and methods for using the same
TR201802550T4 (tr) * 2011-03-14 2018-03-21 Boehringer Ingelheim Int Lökotrien üretiminin benzodioksan inhibitörleri.
BR112013023536A2 (pt) 2011-03-15 2016-12-06 Rib X Pharmaceuticals Inc agentes antimicrobianos
ES2557450T3 (es) 2011-05-23 2016-01-26 Janssen Pharmaceutica, N.V. Derivados de ácido picolinamido-propanoico útiles como antagonistas de los receptores de glucagón
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2014164658A1 (en) 2013-03-12 2014-10-09 Celtaxsys, Inc. Methods of inhibiting leukotriene a4 hydrolase
EP2970309A4 (en) 2013-03-14 2016-11-09 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase

Similar Documents

Publication Publication Date Title
JP2016516043A5 (enExample)
JP2016513696A5 (enExample)
JP2016513681A5 (enExample)
JP2016506962A5 (enExample)
JP2015522650A5 (enExample)
JP2014503574A5 (enExample)
JP2015520769A5 (enExample)
JP2016506961A5 (enExample)
JP2013542261A5 (enExample)
JP2019501125A5 (enExample)
JP2011513305A5 (enExample)
JP2015537020A5 (enExample)
JP2014506907A5 (enExample)
JP2016526576A5 (enExample)
JP2017509586A5 (enExample)
RU2015146957A (ru) Производные доластатина 10 и ауристатинов
JP2013512903A5 (enExample)
JP2015500887A5 (enExample)
MX336505B (es) Metodos y composiciones para reducir la grasa y los adipocitos del cuerpo.
EA201391486A1 (ru) Способы и композиции для лечения болезни паркинсона
JP2014508804A5 (enExample)
JP2017526677A5 (enExample)
JP2018527295A5 (enExample)
RU2017116196A (ru) 2-амино-6-(дифторметил)-5,5-дифтор-6-фенил-3,4,5,6-тетрагидропиридины как ингибиторы васе1
JP2013523814A5 (enExample)