JP2015522650A5 - - Google Patents
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- Publication number
- JP2015522650A5 JP2015522650A5 JP2015523576A JP2015523576A JP2015522650A5 JP 2015522650 A5 JP2015522650 A5 JP 2015522650A5 JP 2015523576 A JP2015523576 A JP 2015523576A JP 2015523576 A JP2015523576 A JP 2015523576A JP 2015522650 A5 JP2015522650 A5 JP 2015522650A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutical composition
- composition according
- atom
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 101500021084 Locusta migratoria 5 kDa peptide Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305922.2A EP2689778A1 (en) | 2012-07-27 | 2012-07-27 | Derivatives of azaindoles or diazaindoles for treating pain |
| EP12305922.2 | 2012-07-27 | ||
| PCT/EP2013/065907 WO2014016433A1 (en) | 2012-07-27 | 2013-07-29 | Derivatives of azaindazole or diazaindazole type for treating pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018200317A Division JP6732855B2 (ja) | 2012-07-27 | 2018-10-24 | 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522650A JP2015522650A (ja) | 2015-08-06 |
| JP2015522650A5 true JP2015522650A5 (enExample) | 2016-09-15 |
| JP6456823B2 JP6456823B2 (ja) | 2019-01-23 |
Family
ID=48948392
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015523576A Active JP6456823B2 (ja) | 2012-07-27 | 2013-07-29 | 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 |
| JP2018200317A Active JP6732855B2 (ja) | 2012-07-27 | 2018-10-24 | 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018200317A Active JP6732855B2 (ja) | 2012-07-27 | 2018-10-24 | 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9381195B2 (enExample) |
| EP (2) | EP2689778A1 (enExample) |
| JP (2) | JP6456823B2 (enExample) |
| KR (1) | KR102120505B1 (enExample) |
| CN (1) | CN104684554B (enExample) |
| AU (1) | AU2013294920B2 (enExample) |
| BR (1) | BR112015001502B1 (enExample) |
| CA (1) | CA2879595C (enExample) |
| CY (1) | CY1118478T1 (enExample) |
| DK (1) | DK2877177T3 (enExample) |
| ES (1) | ES2612349T3 (enExample) |
| HR (1) | HRP20170104T1 (enExample) |
| HU (1) | HUE032919T2 (enExample) |
| IL (1) | IL236917A (enExample) |
| LT (1) | LT2877177T (enExample) |
| MA (1) | MA37866B1 (enExample) |
| MX (1) | MX363605B (enExample) |
| MY (1) | MY183398A (enExample) |
| NZ (1) | NZ705253A (enExample) |
| PL (1) | PL2877177T3 (enExample) |
| PT (1) | PT2877177T (enExample) |
| RS (1) | RS55646B1 (enExample) |
| RU (1) | RU2640046C2 (enExample) |
| SI (1) | SI2877177T1 (enExample) |
| TN (1) | TN2015000034A1 (enExample) |
| UA (1) | UA116107C2 (enExample) |
| WO (1) | WO2014016433A1 (enExample) |
| ZA (1) | ZA201501209B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3106463T (pt) | 2008-10-22 | 2018-05-18 | Array Biopharma Inc | Compostos de pirazolo[1,5-]pirimidina substituídos como inibidores de cinase trk |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| RU2735545C2 (ru) | 2010-05-20 | 2020-11-03 | Эррэй Биофарма Инк. | Макроциклические соединения в качестве ингибиторов киназы trk |
| EP2689778A1 (en) * | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindoles or diazaindoles for treating pain |
| WO2015143652A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| US9573948B2 (en) | 2014-10-06 | 2017-02-21 | Flatley Discovery Lab | Triazolopyridine compounds and methods for the treatment of cystic fibrosis |
| EP3218380B1 (en) | 2014-11-16 | 2021-03-17 | Array Biopharma, Inc. | Preparation of a crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| WO2016096709A1 (en) | 2014-12-16 | 2016-06-23 | Eudendron S.R.L. | Heterocyclic derivatives modulating activity of certain protein kinases |
| TN2019000271A1 (en) | 2015-10-26 | 2021-01-07 | Univ Colorado Regents | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| IL304018A (en) | 2016-04-04 | 2023-08-01 | Loxo Oncology Inc | Liquid formulations of (S)-N-(5-((R)-2-(5,2-difluorophenyl)-pyrrolidine-1-yl)-pyrazolo[5,1-A]pyrimidin-3-yl)-3 -hydroxypyrrolidine-1-carboxamide |
| ES2952056T3 (es) | 2016-05-18 | 2023-10-26 | Loxo Oncology Inc | Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| WO2018049271A1 (en) * | 2016-09-09 | 2018-03-15 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| WO2018079759A1 (ja) * | 2016-10-31 | 2018-05-03 | 塩野義製薬株式会社 | ＴｒｋＡ阻害活性を有する縮合複素環および縮合炭素環誘導体 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| WO2019212256A1 (ko) * | 2018-05-02 | 2019-11-07 | 제이더블유중외제약 주식회사 | 신규한 헤테로 사이클 유도체 |
| KR102129114B1 (ko) * | 2018-07-26 | 2020-07-02 | 주식회사 온코파마텍 | TrkA 저해 활성을 갖는 화합물 및 이를 유효성분으로 함유하는 통증의 예방 또는 치료용 약학적 조성물 |
| EP3725777A1 (en) * | 2019-04-17 | 2020-10-21 | Rottapharm Biotech S.r.l. | Benzo- and pyrido-pyrazoles as protein kinase inhibitors |
| CN110105356B (zh) * | 2019-05-31 | 2022-04-01 | 四川国康药业有限公司 | 一种氮杂吲哚类化合物及其制备方法和用途 |
| CN121358733A (zh) * | 2023-05-24 | 2026-01-16 | 长春金赛药业有限责任公司 | Fgfr2/3选择性抑制剂、药物组合物及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE242245T1 (de) * | 1997-03-19 | 2003-06-15 | Basf Ag | Pyrrolo(2,3-d)pyrimidine und ihre verwendung als tyrosinkinase-inhibitoren |
| EP1215208B1 (en) | 1997-10-27 | 2006-07-12 | Agouron Pharmaceuticals, Inc. | 4-Aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
| HUP0301183A3 (en) | 2000-06-22 | 2006-02-28 | Pfizer | Process for the preparation of pyrazolopyrimidinones |
| SE0301906D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | New compounds |
| DE102004061288A1 (de) * | 2004-12-14 | 2006-06-29 | Schering Ag | 3-Amino-Pyrazolo[3,4b]pyridine als Inhibitoren von Proteintyrosinkinasen, deren Herstellung und Verwendung als Arzneimittel |
| AU2006283940A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 MAP kinase inhibitors and methods for using the same |
| WO2008010964A1 (en) | 2006-07-17 | 2008-01-24 | Merck & Co., Inc. | 1-hydroxy naphthyridine compounds as anti-hiv agents |
| ES2509820T3 (es) | 2006-12-20 | 2014-10-20 | Nerviano Medical Sciences S.R.L. | Derivados de indazol como inhibidores de la cinasa para el tratamiento del cáncer |
| US20080194557A1 (en) * | 2007-01-18 | 2008-08-14 | Joseph Barbosa | Methods and compositions for the treatment of pain, inflammation and cancer |
| WO2008112695A2 (en) * | 2007-03-12 | 2008-09-18 | Irm Llc | Pyrazolo [3,4-d] pyrimidines and 1, 2, 5, 6-tetraaza- as- indacenes as protein kinase inhibitors for cancer treatment |
| EA018503B1 (ru) | 2007-07-20 | 2013-08-30 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Замещенные производные индазола, активные как ингибиторы киназы |
| US8354399B2 (en) * | 2008-12-18 | 2013-01-15 | Nerviano Medical Sciences S.R.L. | Substituted indazole derivatives active as kinase inhibitors |
| FR2970967B1 (fr) * | 2011-01-27 | 2013-02-15 | Pf Medicament | Derives de type azaindazole ou diazaindazole comme medicament |
| EP2689778A1 (en) * | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindoles or diazaindoles for treating pain |
-
2012
- 2012-07-27 EP EP12305922.2A patent/EP2689778A1/en not_active Withdrawn
-
2013
- 2013-07-29 MX MX2015001009A patent/MX363605B/es unknown
- 2013-07-29 LT LTEP13745813.9T patent/LT2877177T/lt unknown
- 2013-07-29 AU AU2013294920A patent/AU2013294920B2/en not_active Ceased
- 2013-07-29 SI SI201330496A patent/SI2877177T1/sl unknown
- 2013-07-29 PL PL13745813T patent/PL2877177T3/pl unknown
- 2013-07-29 RU RU2015106434A patent/RU2640046C2/ru active
- 2013-07-29 KR KR1020157004735A patent/KR102120505B1/ko not_active Expired - Fee Related
- 2013-07-29 EP EP13745813.9A patent/EP2877177B1/en active Active
- 2013-07-29 MY MYPI2015700206A patent/MY183398A/en unknown
- 2013-07-29 WO PCT/EP2013/065907 patent/WO2014016433A1/en not_active Ceased
- 2013-07-29 PT PT137458139T patent/PT2877177T/pt unknown
- 2013-07-29 HU HUE13745813A patent/HUE032919T2/hu unknown
- 2013-07-29 UA UAA201501614A patent/UA116107C2/uk unknown
- 2013-07-29 US US14/417,507 patent/US9381195B2/en active Active
- 2013-07-29 DK DK13745813.9T patent/DK2877177T3/en active
- 2013-07-29 CN CN201380049411.3A patent/CN104684554B/zh active Active
- 2013-07-29 RS RS20170095A patent/RS55646B1/sr unknown
- 2013-07-29 ES ES13745813.9T patent/ES2612349T3/es active Active
- 2013-07-29 JP JP2015523576A patent/JP6456823B2/ja active Active
- 2013-07-29 NZ NZ705253A patent/NZ705253A/en unknown
- 2013-07-29 CA CA2879595A patent/CA2879595C/en active Active
- 2013-07-29 BR BR112015001502-6A patent/BR112015001502B1/pt active IP Right Grant
- 2013-07-29 HR HRP20170104TT patent/HRP20170104T1/hr unknown
-
2015
- 2015-01-23 TN TNP2015000034A patent/TN2015000034A1/fr unknown
- 2015-01-25 IL IL236917A patent/IL236917A/en active IP Right Grant
- 2015-02-23 MA MA37866A patent/MA37866B1/fr unknown
- 2015-02-23 ZA ZA2015/01209A patent/ZA201501209B/en unknown
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2017
- 2017-01-23 CY CY20171100091T patent/CY1118478T1/el unknown
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2018
- 2018-10-24 JP JP2018200317A patent/JP6732855B2/ja active Active