JP2017501237A5 - - Google Patents
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- Publication number
- JP2017501237A5 JP2017501237A5 JP2016562466A JP2016562466A JP2017501237A5 JP 2017501237 A5 JP2017501237 A5 JP 2017501237A5 JP 2016562466 A JP2016562466 A JP 2016562466A JP 2016562466 A JP2016562466 A JP 2016562466A JP 2017501237 A5 JP2017501237 A5 JP 2017501237A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- cycloalkyl
- membered
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 63
- 229910052739 hydrogen Inorganic materials 0.000 claims 42
- 239000001257 hydrogen Substances 0.000 claims 40
- 125000005842 heteroatom Chemical group 0.000 claims 33
- 229910052760 oxygen Inorganic materials 0.000 claims 30
- 229910052717 sulfur Inorganic materials 0.000 claims 30
- 125000004432 carbon atom Chemical group C* 0.000 claims 27
- 125000000623 heterocyclic group Chemical group 0.000 claims 25
- 150000002431 hydrogen Chemical class 0.000 claims 25
- 125000005843 halogen group Chemical group 0.000 claims 22
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 10
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 125000002837 carbocyclic group Chemical group 0.000 claims 5
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- -1 substituted Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 0 C*C(C)(C(F)(F)F)C(F)(F)F Chemical compound C*C(C)(C(F)(F)F)C(F)(F)F 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923904P | 2014-01-06 | 2014-01-06 | |
| US61/923,904 | 2014-01-06 | ||
| PCT/US2015/010090 WO2015103510A1 (en) | 2014-01-06 | 2015-01-05 | Heterocyclic sulfone as ror-gamma modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501237A JP2017501237A (ja) | 2017-01-12 |
| JP2017501237A5 true JP2017501237A5 (enExample) | 2018-01-25 |
| JP6476205B2 JP6476205B2 (ja) | 2019-02-27 |
Family
ID=52392247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562466A Expired - Fee Related JP6476205B2 (ja) | 2014-01-06 | 2015-01-05 | ＲＯＲγ修飾因子としてのヘテロ環式スルホン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9637455B2 (enExample) |
| EP (1) | EP3092221B1 (enExample) |
| JP (1) | JP6476205B2 (enExample) |
| CN (1) | CN106061956B (enExample) |
| ES (1) | ES2705400T3 (enExample) |
| WO (1) | WO2015103510A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
| EP3046906B1 (en) | 2013-09-20 | 2017-08-16 | Bristol-Myers Squibb Company | Ror gamma modulators |
| EA030849B1 (ru) | 2014-01-06 | 2018-10-31 | Бристол-Маерс Сквибб Компани | ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ |
| WO2015103510A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Heterocyclic sulfone as ror-gamma modulators |
| CN106061947B (zh) * | 2014-01-06 | 2019-12-03 | 百时美施贵宝公司 | 环己基砜RORγ调节剂 |
| ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
| JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
| SMT201900082T1 (it) | 2014-10-30 | 2019-02-28 | Janssen Pharmaceutica Nv | Tiazoli come modulatori di roryt |
| PT3212642T (pt) | 2014-10-30 | 2019-12-19 | Janssen Pharmaceutica Nv | Tiazóis com amida substituída como moduladores de rorgammat |
| CN107709295B (zh) | 2015-05-07 | 2021-05-04 | 百时美施贵宝公司 | 作为RORγ调节剂的三环砜类 |
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| TW201821404A (zh) | 2016-11-09 | 2018-06-16 | 美商必治妥美雅史谷比公司 | 作為ROR γ調節劑之三環碸 |
| ES2928246T3 (es) | 2018-06-18 | 2022-11-16 | Janssen Pharmaceutica Nv | 6-aminopiridin-3-il pirazoles como moduladores de RORyt |
| CA3103929A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl substituted pyrazoles as modulators of roryt |
| EP3807261B1 (en) | 2018-06-18 | 2022-07-13 | Janssen Pharmaceutica NV | Pyridinyl pyrazoles as modulators of roryt |
| CN112334450A (zh) | 2018-06-18 | 2021-02-05 | 詹森药业有限公司 | 作为RORγt的调节剂的苯基和吡啶基取代的咪唑 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE735866C (de) | 1941-01-17 | 1943-06-11 | Ig Farbenindustrie Ag | Verfahren zur Darstellung von Aminoalkylsulfonverbindungen |
| US2802013A (en) | 1954-02-12 | 1957-08-06 | Searle & Co | 2-(oxo and imino)-3-(phenyl and halophenyl)-tetrahydrofuransulfones and processes for the manufacture thereof |
| US3016403A (en) * | 1955-07-29 | 1962-01-09 | Searle & Co | 1-aryl-3-hydroxypropyl sulfones and processes |
| US2812330A (en) | 1956-05-02 | 1957-11-05 | Searle & Co | Sulfone derivatives of 2, 6-piperidinedione |
| GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| RU2304140C2 (ru) * | 2001-12-27 | 2007-08-10 | Дайити Фармасьютикал Ко., Лтд. | ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА |
| WO2010019392A1 (en) * | 2008-08-13 | 2010-02-18 | Merck Sharp & Dohme Corp. | Purine derivatives for treatment of alzheimer's disease |
| US20130190356A1 (en) | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| WO2013169588A1 (en) * | 2012-05-08 | 2013-11-14 | Merck Sharp & Dohme Corp. | BICYCLIC SULFONE COMPOUNDS FOR INHIBITION OF RORy ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2014028669A1 (en) * | 2012-08-15 | 2014-02-20 | Biogen Idec Ma Inc. | Novel compounds for modulation of ror-gamma activity |
| US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
| EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
| EP3046906B1 (en) | 2013-09-20 | 2017-08-16 | Bristol-Myers Squibb Company | Ror gamma modulators |
| EA030849B1 (ru) | 2014-01-06 | 2018-10-31 | Бристол-Маерс Сквибб Компани | ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ |
| CN106061947B (zh) | 2014-01-06 | 2019-12-03 | 百时美施贵宝公司 | 环己基砜RORγ调节剂 |
| ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
| WO2015103510A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Heterocyclic sulfone as ror-gamma modulators |
-
2015
- 2015-01-05 WO PCT/US2015/010090 patent/WO2015103510A1/en not_active Ceased
- 2015-01-05 US US15/109,727 patent/US9637455B2/en active Active
- 2015-01-05 EP EP15700818.6A patent/EP3092221B1/en not_active Not-in-force
- 2015-01-05 JP JP2016562466A patent/JP6476205B2/ja not_active Expired - Fee Related
- 2015-01-05 ES ES15700818T patent/ES2705400T3/es active Active
- 2015-01-05 CN CN201580011973.8A patent/CN106061956B/zh not_active Expired - Fee Related
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