JP2012041349A5 - - Google Patents

Download PDF

Info

Publication number
JP2012041349A5
JP2012041349A5 JP2011202172A JP2011202172A JP2012041349A5 JP 2012041349 A5 JP2012041349 A5 JP 2012041349A5 JP 2011202172 A JP2011202172 A JP 2011202172A JP 2011202172 A JP2011202172 A JP 2011202172A JP 2012041349 A5 JP2012041349 A5 JP 2012041349A5
Authority
JP
Japan
Prior art keywords
group
alkyl
hydrogen
covalent bond
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011202172A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012041349A (ja
Filing date
Publication date
Priority claimed from US09/833,914 external-priority patent/US6809105B2/en
Application filed filed Critical
Publication of JP2012041349A publication Critical patent/JP2012041349A/ja
Publication of JP2012041349A5 publication Critical patent/JP2012041349A5/ja
Withdrawn legal-status Critical Current

Links

JP2011202172A 2000-04-27 2011-09-15 ジアザビシクロ系中枢神経系活性薬剤 Withdrawn JP2012041349A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55994300A 2000-04-27 2000-04-27
US09/559,943 2000-04-27
US09/833,914 2001-04-12
US09/833,914 US6809105B2 (en) 2000-04-27 2001-04-12 Diazabicyclic central nervous system active agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2001578437A Division JP4981232B2 (ja) 2000-04-27 2001-04-27 ジアザビシクロ系中枢神経系活性薬剤

Publications (2)

Publication Number Publication Date
JP2012041349A JP2012041349A (ja) 2012-03-01
JP2012041349A5 true JP2012041349A5 (enExample) 2012-12-13

Family

ID=27072208

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001578437A Expired - Fee Related JP4981232B2 (ja) 2000-04-27 2001-04-27 ジアザビシクロ系中枢神経系活性薬剤
JP2011202172A Withdrawn JP2012041349A (ja) 2000-04-27 2011-09-15 ジアザビシクロ系中枢神経系活性薬剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2001578437A Expired - Fee Related JP4981232B2 (ja) 2000-04-27 2001-04-27 ジアザビシクロ系中枢神経系活性薬剤

Country Status (22)

Country Link
EP (3) EP2295437A1 (enExample)
JP (2) JP4981232B2 (enExample)
KR (4) KR100947188B1 (enExample)
CN (3) CN102863441A (enExample)
AR (1) AR030421A1 (enExample)
AU (2) AU2001266559C1 (enExample)
BG (2) BG66151B1 (enExample)
BR (1) BR0107246A (enExample)
CA (2) CA2407094C (enExample)
CZ (4) CZ302038B6 (enExample)
HK (1) HK1054375A1 (enExample)
HU (1) HUP0300602A3 (enExample)
IL (3) IL152231A0 (enExample)
MX (1) MXPA02010594A (enExample)
MY (3) MY137020A (enExample)
NO (1) NO324250B1 (enExample)
NZ (1) NZ521734A (enExample)
PE (1) PE20011305A1 (enExample)
PL (2) PL398491A1 (enExample)
SK (2) SK287658B6 (enExample)
TW (4) TWI311137B (enExample)
WO (1) WO2001081347A2 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU777911B2 (en) 1999-12-10 2004-11-04 Pfizer Products Inc. Pyrrolo(2,3-d)pyrimidine compounds
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
BR0316470A (pt) * 2002-11-21 2005-10-11 Pfizer Prod Inc Derivados de 3-amino-piperadina e métodos de preparação
US7354937B2 (en) 2004-05-21 2008-04-08 Abbott Laboratories (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane
US20040242641A1 (en) * 2003-05-27 2004-12-02 Buckley Michael J. (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US20050261348A1 (en) * 2004-05-21 2005-11-24 Buckley Michael J (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
GB0322140D0 (en) * 2003-09-22 2003-10-22 Pfizer Ltd Combinations
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050171079A1 (en) 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use
JP2007535553A (ja) 2004-04-29 2007-12-06 アボット・ラボラトリーズ アミノ−テトラゾール類縁体および使用方法
US7351833B2 (en) 2004-07-23 2008-04-01 Abbott Laboratories (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate
CA2634305A1 (en) * 2005-12-20 2007-06-28 Marc Chapdelaine Substituted cinnoline derivatives as gabaa-receptor modulators and method for their synthesis
US20070184490A1 (en) * 2006-01-17 2007-08-09 Marleen Verlinden Neuronal nicotinic receptor ligands and their use
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
EP2083921A2 (en) 2006-09-04 2009-08-05 Neurosearch A/S Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8076350B2 (en) 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
WO2008118742A1 (en) 2007-03-23 2008-10-02 Abbott Laboratories Azaadamantane ester and carbamate derivatives and methods of use thereof
CA2691782A1 (en) 2007-09-11 2009-03-19 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole n-oxides
UY31443A1 (es) 2007-10-31 2009-04-30 Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
JP5628043B2 (ja) * 2007-11-21 2014-11-19 アッヴィ・インコーポレイテッド ビアリール置換ジアザビシクロアルカン誘導体
EP2623504A1 (de) 2007-12-07 2013-08-07 Abbott GmbH & Co. KG 5,6-Disubstituierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen
WO2009071687A1 (de) 2007-12-07 2009-06-11 Abbott Gmbh & Co. Kg Amidomethyl-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
CA2707669C (en) 2007-12-07 2016-07-05 Wilfried Braje 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
US8703774B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
MX2010006111A (es) 2007-12-18 2010-06-25 Actelion Pharmaceuticals Ltd Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales.
PT2336125E (pt) 2008-04-11 2013-03-18 Janssen Pharmaceutica Nv Tiazolopiridina-2-iloxi-fenil e tiazolopirazin-2-iloxifenil aminas como moduladores de leucotrieno a4 hidrolase
US8148408B2 (en) * 2008-05-09 2012-04-03 Abbott Laboratories Selective substituted pyridine ligands for neuronal nicotinic receptors
US8263632B2 (en) * 2009-03-24 2012-09-11 Vertex Pharmaceuticals Incoporated Aminopyridine derivatives having Aurora A selective inhibitory action
WO2010132599A1 (en) 2009-05-14 2010-11-18 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
WO2010138600A2 (en) 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
US8268853B2 (en) 2009-06-25 2012-09-18 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
HUE043522T2 (hu) 2009-09-04 2019-08-28 Biogen Ma Inc Bruton tirozinkináz inhibitorok
DK3093291T3 (da) 2009-10-23 2019-07-29 Janssen Pharmaceutica Nv Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer
JP5848251B2 (ja) * 2009-10-23 2016-01-27 ヤンセン ファーマシューティカ エヌ.ベー. オレキシン受容体調節因子としての縮合複素環式化合物
WO2011050200A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
KR101655787B1 (ko) 2014-05-08 2016-09-22 대우조선해양 주식회사 선박의 하이브리드 공기조화시스템 및 그 방법, 그리고 이를 포함하는 선박 또는 해양구조물
KR20160021679A (ko) 2014-08-18 2016-02-26 대우조선해양 주식회사 극저온 환경의 장비용 히팅장치 및 방법 그리고 이를 구비하는 선박
CN107108597B (zh) 2014-10-31 2020-04-17 英立维尔英国有限公司 多巴胺d3受体拮抗剂化合物
IL288321B2 (en) 2016-03-10 2025-08-01 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
EP3487852A1 (en) 2016-07-21 2019-05-29 Biogen MA Inc. Succinate forms and compositions of bruton's tyrosine kinase inhibitors
WO2019057123A1 (zh) * 2017-09-20 2019-03-28 杭州英创医药科技有限公司 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
CR20210240A (es) 2018-11-14 2021-06-08 Janssen Pharmaceutica Nv Métodos sintéticos mejorados para elaborar compuestos heterocíclicos fusionados como moduladores del receptor de orexina
WO2020239073A1 (zh) * 2019-05-30 2020-12-03 中国科学院上海药物研究所 一种并环化合物、其制备方法和用途
CN112047878B (zh) * 2020-10-15 2022-04-19 郑州猫眼农业科技有限公司 4-溴-6-氯吡啶-2-羧酸的制备方法
WO2024189472A1 (en) 2023-03-14 2024-09-19 Janssen Pharmaceutica Nv Improved synthetic methods of making substituted pyrimidine intermediates for synthesis of orexin receptor modulators

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59009705D1 (de) * 1989-04-17 1995-11-02 Bayer Ag Verfahren zur Herstellung von 2,7-Diazabicyclo(3.3.0)octanen.
NL9201810A (nl) 1992-10-19 1994-05-16 Dsm Nv Werkwijze voor de omzetting van een olefine of een olefinemengsel.
NO301165B1 (no) 1992-12-25 1997-09-22 Daiichi Seiyaku Co Bicykliske aminderivater og antibakterielle midler inneholdende disse
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
US5472958A (en) 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
WO1997005139A1 (en) * 1995-07-28 1997-02-13 Abbott Laboratories Furopyridine, thienopyridine, pyrrolopyridine and related pyrimidine, pyridazine and triazine compounds useful in controlling chemical synaptic transmission
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
JPH09172344A (ja) 1995-12-19 1997-06-30 Murata Mfg Co Ltd 圧電共振子
US5733912A (en) 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
KR100589872B1 (ko) * 1997-05-30 2006-06-15 뉴로서치 에이/에스 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법
JP2002502383A (ja) * 1997-05-30 2002-01-22 ニューロサーアチ・アクティーゼルスカブ ニコチンAChレセプターに於けるコリン作動性リガンドとしての9−アザビシクロ(3.3.1)ノン−2−エン及びノナン誘導体
GB9722343D0 (en) * 1997-10-22 1997-12-17 British Telecomm Distributed virtual environment
PL203140B1 (pl) * 1997-10-27 2009-08-31 Neurosearch As Pochodna homopiperazyny, kompozycja farmaceutyczna zawierająca te pochodne i zastosowanie tej pochodnej
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
DK1068208T3 (da) * 1998-04-02 2003-09-01 Targacept Inc Azatricyclo[3.3.1.1]dekanderivater og farmaceutiske sammensætninger, der indeholder dem
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
JP2000026408A (ja) 1998-07-02 2000-01-25 Dai Ichi Seiyaku Co Ltd 対掌体的に純粋なピロリジン誘導体、その塩、それらの製造方法
US6804251B1 (en) 1998-11-12 2004-10-12 Broadcom Corporation System and method for multiplexing data from multiple sources
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
ES2209825T3 (es) * 1999-01-29 2004-07-01 Abbott Laboratories Derivados diazabiciclicos utiles como ligandos del receptor nicotinico de la acetilcolina.
EP1177196B1 (en) * 1999-05-04 2004-03-10 Neurosearch A/S Heteroaryl diazabicycloalkanes, their preparation and use
DK1178982T3 (da) * 1999-05-21 2004-11-08 Abbott Lab Heterocykliske, substituerede aminoazacykliske forbindelser, der er nyttige som midler til centralnervesystemet
ATE289607T1 (de) * 1999-12-14 2005-03-15 Neurosearch As Neue heteroaryl-diazabizykloalkane

Similar Documents

Publication Publication Date Title
JP2012041349A5 (enExample)
JP2011026326A5 (enExample)
JP2013537203A5 (enExample)
UA115320C2 (uk) Інгібітори кінази
JP2016528301A5 (enExample)
JP2007077157A5 (enExample)
JP2011518833A5 (enExample)
PH12015502056A1 (en) Benzothiazole compounds and their pharmaceutical use
JP2010524952A5 (enExample)
EA201490419A1 (ru) Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания
JP2017501237A5 (enExample)
JP2010525056A5 (enExample)
JP2013544860A5 (enExample)
JP2015512931A5 (enExample)
JP2017508782A5 (enExample)
JP2016512520A5 (enExample)
JP2006524660A5 (enExample)
JP2011105738A5 (enExample)
JP2016040288A5 (enExample)
JP2016505637A5 (enExample)
JP2013514367A5 (enExample)
JP2015503609A5 (enExample)
JP2011516610A5 (enExample)
JP2012512863A5 (enExample)
PH12014501278A1 (en) Kinase inhibitors