JP2010524952A5 - - Google Patents
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- Publication number
- JP2010524952A5 JP2010524952A5 JP2010504191A JP2010504191A JP2010524952A5 JP 2010524952 A5 JP2010524952 A5 JP 2010524952A5 JP 2010504191 A JP2010504191 A JP 2010504191A JP 2010504191 A JP2010504191 A JP 2010504191A JP 2010524952 A5 JP2010524952 A5 JP 2010524952A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91192107P | 2007-04-16 | 2007-04-16 | |
| US60/911,921 | 2007-04-16 | ||
| PCT/US2008/060366 WO2008128231A1 (en) | 2007-04-16 | 2008-04-15 | Pyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524952A JP2010524952A (ja) | 2010-07-22 |
| JP2010524952A5 true JP2010524952A5 (enExample) | 2011-06-02 |
| JP5635398B2 JP5635398B2 (ja) | 2014-12-03 |
Family
ID=39854302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504191A Expired - Fee Related JP5635398B2 (ja) | 2007-04-16 | 2008-04-15 | ピリミジン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8349859B2 (enExample) |
| EP (1) | EP2154967B9 (enExample) |
| JP (1) | JP5635398B2 (enExample) |
| KR (1) | KR101424847B1 (enExample) |
| BR (1) | BRPI0809715A2 (enExample) |
| CA (1) | CA2684470C (enExample) |
| DK (1) | DK2154967T5 (enExample) |
| ES (1) | ES2465673T3 (enExample) |
| HR (1) | HRP20140377T2 (enExample) |
| MX (1) | MX2009011199A (enExample) |
| NZ (1) | NZ580671A (enExample) |
| PL (1) | PL2154967T3 (enExample) |
| PT (1) | PT2154967E (enExample) |
| RU (1) | RU2455994C2 (enExample) |
| SI (1) | SI2154967T1 (enExample) |
| TW (1) | TWI484960B (enExample) |
| WO (1) | WO2008128231A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TWI491605B (zh) | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| JP2012197231A (ja) * | 2009-08-06 | 2012-10-18 | Oncotherapy Science Ltd | Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体 |
| US8466155B2 (en) | 2009-10-02 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Pyrimidines |
| CN102070618B (zh) * | 2009-11-23 | 2013-08-21 | 和记黄埔医药（上海）有限公司 | 一种化合物及其晶体 |
| BR112012029647A2 (pt) | 2010-05-21 | 2016-08-02 | Chemilia Ab | novos derivados de pirimidinas |
| EP2395001A1 (en) | 2010-05-21 | 2011-12-14 | Chemilia AB | Novel pyrimidine derivatives |
| EP2433636A1 (en) * | 2010-09-27 | 2012-03-28 | Medizinische Universität Wien | Treatment of Malignant Diseases |
| EP2621276B1 (en) * | 2010-09-30 | 2017-12-27 | Merck Sharp & Dohme Corp. | 2-alkoxy pyrimidine pde10 inhibitors |
| EP2502924A1 (en) | 2011-03-24 | 2012-09-26 | Chemilia AB | Novel pyrimidine derivatives |
| DK2688883T3 (en) | 2011-03-24 | 2016-09-05 | Noviga Res Ab | pyrimidine |
| WO2013054351A1 (en) * | 2011-08-08 | 2013-04-18 | Cadila Healthcare Limited | Heterocyclic compounds |
| EP2711364A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| EP2711365A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| RU2674249C2 (ru) * | 2012-11-05 | 2018-12-06 | НэнтБайо, Инк. | Замещенные производные индол-5-ола и их терапевтическое применение |
| CA2906185A1 (en) | 2013-03-15 | 2014-09-18 | Nantbioscience, Inc. | Substituted indol-5-ol derivatives and their therapeutic applications |
| CN105601573B (zh) * | 2014-11-24 | 2021-07-02 | 中国科学院上海药物研究所 | 2-氨基嘧啶类化合物及其药物组合物和应用 |
| BR112017018183A2 (pt) * | 2015-02-27 | 2018-07-24 | Nantbioscience Inc | derivados de pirimidina como inibidores de quinase e suas aplicações terapêuticas. |
| WO2017190050A1 (en) | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
| TW202115042A (zh) * | 2019-06-21 | 2021-04-16 | 大陸商江蘇豪森藥業集團有限公司 | 芳基磷氧化物類衍生物抑制劑、其製備方法和應用 |
| CN111004221B (zh) * | 2019-12-13 | 2021-02-02 | 长治学院 | 一种嘧啶/苯并咪唑杂合物、制备方法及医药用途 |
| EP4251613A4 (en) * | 2020-11-27 | 2024-11-20 | Allorion Therapeutics Inc. | AMINOHETEROARYL KINASE INHIBITORS |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
| US6235741B1 (en) * | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| KR100838617B1 (ko) | 1999-02-10 | 2008-06-16 | 아스트라제네카 아베 | 혈관형성 억제제로서의 퀴나졸린 유도체 |
| GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6943161B2 (en) * | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
| AU2001237041B9 (en) * | 2000-02-17 | 2005-07-28 | Amgen Inc. | Kinase inhibitors |
| GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AU2001277621A1 (en) * | 2000-08-09 | 2002-03-04 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| CA2432000C (en) * | 2000-12-21 | 2011-03-15 | Glaxo Group Limited | Pyrimidineamines as angiogenesis modulators |
| US20040092750A1 (en) * | 2001-03-01 | 2004-05-13 | Tomoyuki Hasegawa | 2-methylindole-4-acetic acid, process for producing the same, and process for producing intermediate therefor |
| WO2002102783A1 (en) * | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CA2477505A1 (en) | 2002-03-01 | 2003-09-12 | Smithkline Beecham Corporation | Diamino-pyrimidines and their use as angiogenesis inhibitors |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| AR037647A1 (es) | 2002-05-29 | 2004-12-01 | Novartis Ag | Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina |
| EP1515955A4 (en) | 2002-06-17 | 2006-05-03 | Smithkline Beecham Corp | CHEMICAL PROCESS |
| JP2006514989A (ja) * | 2002-07-29 | 2006-05-18 | ライジェル ファーマシューティカルズ | ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療および予防方法 |
| US20060004029A1 (en) * | 2002-08-30 | 2006-01-05 | Akihiko Tsuruoka | Nitrogen-containing aromatic derivatives |
| JP2006503081A (ja) | 2002-10-10 | 2006-01-26 | スミスクライン ビーチャム コーポレーション | 化学化合物 |
| MXPA05005547A (es) | 2002-11-28 | 2005-07-26 | Schering Ag | Pirimidinas inhibidoras de chk, pdk y akt, su produccion y uso como agentes farmaceuticos. |
| US7531553B2 (en) | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
| US7442698B2 (en) | 2003-07-24 | 2008-10-28 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| WO2005026129A1 (en) * | 2003-09-15 | 2005-03-24 | Gpc Biotech Ag | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| GB0321710D0 (en) | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
| US20070105839A1 (en) * | 2003-09-18 | 2007-05-10 | Patricia Imbach | 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| US20050171171A1 (en) * | 2003-11-13 | 2005-08-04 | Ambit Biosciences Corporation | Amide derivatives as FLT-3 modulators |
| US7718697B2 (en) | 2003-12-17 | 2010-05-18 | Alcon, Inc. | Method for treating glaucoma comprising administering α-lipoic acid |
| EA009994B1 (ru) | 2003-12-23 | 2008-06-30 | Пфайзер Инк. | Новые хинолиновые производные |
| DE102004044556A1 (de) * | 2004-09-15 | 2006-03-30 | Bayer Healthcare Ag | Behandlung viraler Infektionen durch selektive Zerstörung virusinfizierter Zellen mit Stresskinase-Inhibitoren |
| US7919487B2 (en) * | 2004-11-10 | 2011-04-05 | Synta Pharmaceuticals Corporation | Heteroaryl compounds |
| US7851466B2 (en) * | 2004-11-19 | 2010-12-14 | Synta Pharmaceuticals Corp. | Pyrimidine compounds and uses thereof |
| KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| WO2006071079A1 (en) | 2004-12-29 | 2006-07-06 | Hanmi Pharm. Co., Ltd. | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof |
| US20060247263A1 (en) * | 2005-04-19 | 2006-11-02 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| WO2007027238A2 (en) * | 2005-05-03 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Jak kinase inhibitors and their uses |
| WO2006138304A2 (en) | 2005-06-14 | 2006-12-28 | Taigen Biotechnology | Pyrimidine compounds |
| US20090149467A1 (en) * | 2005-09-15 | 2009-06-11 | Merck & Co., Inc. | Tyrosine Kinase Inhibitors |
-
2008
- 2008-04-15 NZ NZ580671A patent/NZ580671A/xx not_active IP Right Cessation
- 2008-04-15 BR BRPI0809715-1A patent/BRPI0809715A2/pt not_active Application Discontinuation
- 2008-04-15 PT PT87458816T patent/PT2154967E/pt unknown
- 2008-04-15 CA CA2684470A patent/CA2684470C/en active Active
- 2008-04-15 EP EP08745881.6A patent/EP2154967B9/en active Active
- 2008-04-15 SI SI200831203T patent/SI2154967T1/sl unknown
- 2008-04-15 RU RU2009141982/04A patent/RU2455994C2/ru active
- 2008-04-15 HR HRP20140377AT patent/HRP20140377T2/hr unknown
- 2008-04-15 JP JP2010504191A patent/JP5635398B2/ja not_active Expired - Fee Related
- 2008-04-15 DK DK08745881.6T patent/DK2154967T5/en active
- 2008-04-15 ES ES08745881.6T patent/ES2465673T3/es active Active
- 2008-04-15 PL PL08745881T patent/PL2154967T3/pl unknown
- 2008-04-15 KR KR1020097023882A patent/KR101424847B1/ko not_active Expired - Fee Related
- 2008-04-15 WO PCT/US2008/060366 patent/WO2008128231A1/en not_active Ceased
- 2008-04-15 MX MX2009011199A patent/MX2009011199A/es active IP Right Grant
- 2008-04-15 TW TW097113595A patent/TWI484960B/zh not_active IP Right Cessation
- 2008-04-16 US US12/103,876 patent/US8349859B2/en not_active Expired - Fee Related
-
2012
- 2012-11-08 US US13/672,078 patent/US8901143B2/en active Active
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