JP2016534134A5 - - Google Patents
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- JP2016534134A5 JP2016534134A5 JP2016540436A JP2016540436A JP2016534134A5 JP 2016534134 A5 JP2016534134 A5 JP 2016534134A5 JP 2016540436 A JP2016540436 A JP 2016540436A JP 2016540436 A JP2016540436 A JP 2016540436A JP 2016534134 A5 JP2016534134 A5 JP 2016534134A5
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- hydroxy
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- 0 *#Cc(c([C@]1N=O)c2CC1(F)F)ccc2Oc1cc(F)cc(F)c1 Chemical compound *#Cc(c([C@]1N=O)c2CC1(F)F)ccc2Oc1cc(F)cc(F)c1 0.000 description 6
- ZGVWZAJMWJIHNT-HNNXBMFYSA-N CS(c(c([C@@H]1O)c2CC1(F)F)ccc2Oc1cc(F)cc(F)c1)(=O)=O Chemical compound CS(c(c([C@@H]1O)c2CC1(F)F)ccc2Oc1cc(F)cc(F)c1)(=O)=O ZGVWZAJMWJIHNT-HNNXBMFYSA-N 0.000 description 1
- YSQBDUMLHQLQBH-HPGBDJQBSA-N C[S@](c(cc1)c([C@@H](C(C2)(F)F)O)c2c1Oc1cc(C#N)cc(F)c1)(=NC#N)=O Chemical compound C[S@](c(cc1)c([C@@H](C(C2)(F)F)O)c2c1Oc1cc(C#N)cc(F)c1)(=NC#N)=O YSQBDUMLHQLQBH-HPGBDJQBSA-N 0.000 description 1
- KXKBSLFAMIIKMT-UHFFFAOYSA-N OC(C(Cc1c(cc2)Oc(cc3)c(cn[nH]4)c4c3F)(F)F)c1c2S(C(F)(F)F)(=O)=O Chemical compound OC(C(Cc1c(cc2)Oc(cc3)c(cn[nH]4)c4c3F)(F)F)c1c2S(C(F)(F)F)(=O)=O KXKBSLFAMIIKMT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361875674P | 2013-09-09 | 2013-09-09 | |
| US61/875,674 | 2013-09-09 | ||
| US201461978421P | 2014-04-11 | 2014-04-11 | |
| US61/978,421 | 2014-04-11 | ||
| PCT/US2014/054375 WO2015035223A1 (en) | 2013-09-09 | 2014-09-05 | Aryl ethers and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019018100A Division JP6746733B2 (ja) | 2013-09-09 | 2019-02-04 | アリールエーテルおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534134A JP2016534134A (ja) | 2016-11-04 |
| JP2016534134A5 true JP2016534134A5 (enExample) | 2017-10-12 |
| JP6486940B2 JP6486940B2 (ja) | 2019-03-20 |
Family
ID=52628976
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540436A Active JP6486940B2 (ja) | 2013-09-09 | 2014-09-05 | アリールエーテルおよびその使用 |
| JP2019018100A Active JP6746733B2 (ja) | 2013-09-09 | 2019-02-04 | アリールエーテルおよびその使用 |
| JP2019052946A Pending JP2019089855A (ja) | 2013-09-09 | 2019-03-20 | アリールエーテルおよびその使用 |
| JP2019052947A Active JP6918039B2 (ja) | 2013-09-09 | 2019-03-20 | アリールエーテルおよびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019018100A Active JP6746733B2 (ja) | 2013-09-09 | 2019-02-04 | アリールエーテルおよびその使用 |
| JP2019052946A Pending JP2019089855A (ja) | 2013-09-09 | 2019-03-20 | アリールエーテルおよびその使用 |
| JP2019052947A Active JP6918039B2 (ja) | 2013-09-09 | 2019-03-20 | アリールエーテルおよびその使用 |
Country Status (33)
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2900604A1 (en) | 2013-03-15 | 2014-09-25 | Chromocell Corporation | Sodium channel modulators for the treatment of pain |
| MX2016002974A (es) | 2013-09-09 | 2016-06-02 | Peloton Therapeutics Inc | Eteres de arilo y sus usos. |
| AU2014318979B2 (en) | 2013-09-10 | 2019-03-28 | Chromocell Corporation | Sodium channel modulators for the treatment of pain and diabetes |
| ES2737148T3 (es) | 2013-12-16 | 2020-01-10 | Peloton Therapeutics Inc | Análogos de sulfona y sulfoximina cíclicos y usos de los mismos |
| US10098878B2 (en) * | 2014-10-10 | 2018-10-16 | The Board Of Regents Of The University Of Texas System | HIF-2α inhibitors for treating iron overload disorders |
| EP3268362B1 (en) * | 2015-03-11 | 2021-10-20 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| US20180049995A1 (en) * | 2015-03-11 | 2018-02-22 | Peloton Therapeutics, Inc. | Hif-2-alpha inhibitor polymorphs |
| WO2016145045A1 (en) * | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating glioblastoma |
| US10807948B2 (en) * | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| EP3267792A4 (en) * | 2015-03-11 | 2018-09-26 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| WO2016168510A1 (en) * | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| US9796697B2 (en) | 2015-06-12 | 2017-10-24 | Peloton Therapeutics, Inc. | Tricyclic inhibitors of HIF-2-alpha and uses thereof |
| CN105566406A (zh) * | 2015-12-30 | 2016-05-11 | 江西胜富化工有限公司 | 一种氟代脱氧呋喃核糖的制备方法 |
| WO2018031680A1 (en) * | 2016-08-10 | 2018-02-15 | Fronthera U.S. Pharmaceuticals Llc | Novel compounds, uses and methods for their preparation |
| CN110167939B (zh) * | 2017-01-11 | 2021-12-31 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
| WO2018160772A1 (en) | 2017-02-28 | 2018-09-07 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Method of treating obesity, insulin resistance, non-alcoholic fatty liver disease including non-alcoholic steatohepatitis |
| TWI642658B (zh) | 2017-11-01 | 2018-12-01 | 國立臺灣師範大學 | 茚並異喹啉衍生物的製備方法 |
| WO2019100053A1 (en) | 2017-11-20 | 2019-05-23 | University Of Georgia Research Foundation, Inc. | Compositions and methods for modulating hif-2α to improve muscle generation and repair |
| EP3774709A4 (en) * | 2018-03-28 | 2021-12-22 | Peloton Therapeutics, Inc. | METHOD FOR REDUCING INFLAMMATION OF THE DIGESTIVE SYSTEM USING INHIBITORS OF HIF-2-ALPHA |
| CA3100399A1 (en) | 2018-05-18 | 2019-11-21 | Ryvu Therapeutics S.A. | Thiophene derivatives |
| US12171741B2 (en) | 2018-09-11 | 2024-12-24 | Nikang Therapeutics, Inc. | 2,3-dihydrobenzo[b]thiophene derivatives as hypoxia inducible factor-2(alpha) inhibitors |
| WO2020081695A1 (en) | 2018-10-17 | 2020-04-23 | Nikang Therapeutics, Inc. | Indane derivatives as hypoxia inducible factor-2(alpha) inhibitors |
| WO2020092100A1 (en) * | 2018-10-30 | 2020-05-07 | Peloton Therapeutics, Inc. | Solid dispersions and pharmaceutical compositions comprising a substituted indane and methods for the preparation and use thereof |
| CN109776607B (zh) * | 2019-02-21 | 2021-06-04 | 青岛海洋生物医药研究院 | 芳基磷氧类和芳基磷硫类化合物及其制备方法和应用 |
| CN118993939A (zh) * | 2019-04-18 | 2024-11-22 | 尼坎治疗公司 | 作为缺氧可诱导因子-2(α)抑制剂的四氢-1H-环戊二烯并[CD]茚衍生物 |
| PH12022550179A1 (en) | 2019-07-23 | 2022-11-14 | Bayer Ag | Novel heteroaryl-triazole compounds as pesticides |
| WO2021055728A1 (en) | 2019-09-18 | 2021-03-25 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| US11576889B2 (en) | 2019-09-23 | 2023-02-14 | The Board Of Regents Of The University Of Texas System | Methods of identifying and treating patients with HIF-2 inhibitor resistance |
| CR20220230A (es) | 2019-10-28 | 2022-06-15 | Merck Sharp & Dohme | Inhibidores de pequeñas moléculas de mutante g12c de kras |
| WO2021085653A1 (en) | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd. | 4-aminobut-2-enamide derivatives and salts thereof |
| CN112812136B (zh) * | 2019-11-15 | 2022-04-12 | 武汉光谷亚太医药研究院有限公司 | 新型2,3-二氢化茚衍生化合物、制备方法和应用 |
| TW202136248A (zh) | 2019-11-25 | 2021-10-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| US20230024721A1 (en) * | 2019-11-26 | 2023-01-26 | Merck Patent Gmbh | Thiophene derivatives |
| WO2021106231A1 (en) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| KR20220110524A (ko) * | 2019-12-04 | 2022-08-08 | 아르커스 바이오사이언시즈 인코포레이티드 | Hif-2알파의 억제제 |
| CN111214484B (zh) * | 2020-01-21 | 2021-04-06 | 北京工商大学 | 一种共轭聚合物和聚集诱导发光小分子共掺的纳米粒子及其制备方法和应用 |
| CN113387848B (zh) * | 2020-03-12 | 2022-11-22 | 上海交通大学 | 一种制备磺酰胺类化合物的合成工艺 |
| CN115298165B (zh) | 2020-03-19 | 2024-09-17 | 艾库斯生物科学有限公司 | 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物 |
| US11420936B2 (en) | 2020-04-16 | 2022-08-23 | Nikang Therapeutics, Inc. | Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases |
| WO2021215545A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c |
| US20230174518A1 (en) | 2020-04-24 | 2023-06-08 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| TWI891782B (zh) | 2020-05-06 | 2025-08-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基三唑化合物 |
| CN119431335A (zh) * | 2020-06-11 | 2025-02-14 | 贝达药业股份有限公司 | 双环化合物及其应用 |
| WO2021254417A1 (zh) * | 2020-06-17 | 2021-12-23 | 贝达药业股份有限公司 | 双环类化合物及其应用 |
| WO2021261601A1 (ja) | 2020-06-26 | 2021-12-30 | ラクオリア創薬株式会社 | レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬 |
| EP4183395A4 (en) | 2020-07-15 | 2024-07-24 | Taiho Pharmaceutical Co., Ltd. | PYRIMIDINE COMPOUND-CONTAINING COMBINATION FOR USE IN TUMOR TREATMENT |
| WO2022063115A1 (zh) * | 2020-09-24 | 2022-03-31 | 贝达药业股份有限公司 | 双环化合物及其应用 |
| WO2022082329A1 (en) * | 2020-10-19 | 2022-04-28 | Nikang Therapeutics, Inc. | Processes of preparing 3-fluoro-5- ( ( (1s, 2ar) -1, 3, 3, 4, 4-pentafluoro-2a-hydroxy-2, 2a, 3, 4-tetrahydro-1h-cyclopenta [cd] inden-7-yl) oxy) -benzonitrile |
| WO2022082337A1 (en) * | 2020-10-19 | 2022-04-28 | Nikang Therapeutics, Inc. | Process of preparing 3-fluoro-5 ( ( (1r, 2ar) -3, 3, 4, 4-tetrafluoro-1, 2a-dihydroxy-2, 2a, 3, 4-tetrahydro-1h-cyclopenta [cd] inden-7-yl) oxy) benzonitrile |
| WO2022086882A1 (en) | 2020-10-21 | 2022-04-28 | Nikang Therapeutics, Inc. | Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor |
| CN112724167B (zh) * | 2021-01-13 | 2022-11-11 | 湖北恒安芙林药业股份有限公司 | 一种克立硼罗的制备方法 |
| US11827614B2 (en) | 2021-05-21 | 2023-11-28 | Merck Sharp & Dohme Llc | Synthetic pathway to belzutifan and crystalline phases of synthetic intermediates |
| CN117769554A (zh) | 2021-05-28 | 2024-03-26 | 大鹏药品工业株式会社 | Kras突变蛋白的小分子抑制剂 |
| CN113651735B (zh) * | 2021-08-27 | 2022-04-15 | 中国药科大学 | 一种HIF-2α抑制剂PT2385的制备方法 |
| US12145901B1 (en) | 2021-09-17 | 2024-11-19 | Arcus Biosciences, Inc. | Process for preparing tetralin compounds |
| CA3235013A1 (en) * | 2021-10-18 | 2023-04-27 | Jing Lu | Hypoxia inducible factor-2(alpha) inhibitors for the treatment of bladder cancer |
| WO2023160552A1 (zh) * | 2022-02-22 | 2023-08-31 | 南京明德新药研发有限公司 | 一类螺环类化合物及其应用 |
| CN116178223B (zh) * | 2022-04-15 | 2024-12-03 | 上海皓鸿生物医药科技有限公司 | 一种Belzutifan及其中间体的制备方法 |
| CN114656379B (zh) * | 2022-04-27 | 2024-06-04 | 成都道合尔医药技术有限公司 | 一种立他司特中间体的合成方法 |
| CN115611847B (zh) * | 2022-10-13 | 2024-04-30 | 南方科技大学坪山生物医药研究院 | 一种Belzutifan的中间体的制备方法 |
| EP4619386A1 (en) * | 2022-11-14 | 2025-09-24 | F. Hoffmann-La Roche AG | Aryl thioethers as hif-2alpha inhibitors |
| AU2024249981A1 (en) | 2023-04-06 | 2025-10-16 | Pfizer Inc. | Substituted indazole propionic acid derivative compounds and uses thereof as ampk activators |
| TW202515582A (zh) | 2023-08-24 | 2025-04-16 | 日商大塚製藥股份有限公司 | 西區嘧啶(cedazuridine)之固定劑量組合 |
| TW202535891A (zh) | 2023-10-20 | 2025-09-16 | 美商默沙東有限責任公司 | Kras蛋白之小分子抑制劑 |
| CN118005840B (zh) * | 2024-04-08 | 2024-06-14 | 西南石油大学 | 一种热增稠自破胶压裂液稠化剂及其制备方法和应用 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE705530C (de) | 1932-01-23 | 1941-04-30 | Chem Fab Von Heyden Akt Ges | Verfahren zur Darstellung von Polychlorsubstitutionsprodukten des Diphenylaethers |
| FR1574139A (enExample) | 1968-05-06 | 1969-07-11 | ||
| US3905971A (en) * | 1971-03-29 | 1975-09-16 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| JPS4872169A (enExample) | 1971-12-28 | 1973-09-29 | ||
| GB1448696A (en) * | 1973-05-29 | 1976-09-08 | Pfizer | 2-phqnyl-astriazine-3,4-2h,4h-diones |
| GB2017087B (en) | 1978-03-03 | 1982-09-02 | Roussel Lab Ltd | Process for the preparation of xanthone derivatives |
| US4214103A (en) * | 1978-11-30 | 1980-07-22 | Great Lakes Chemical Corporation | Purification of brominated organic products |
| DE2938595A1 (de) * | 1979-09-24 | 1981-04-23 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Verfahren zur herstellung von diphenylaethern |
| US4505929A (en) | 1980-06-12 | 1985-03-19 | The Dow Chemical Company | Sulfur-substituted diphenyl ethers having antiviral activity |
| US4426385A (en) * | 1980-10-16 | 1984-01-17 | Union Carbide Corporation | Insecticidal bicyclooxyphenyl ureas |
| DE3110894A1 (de) * | 1981-03-20 | 1982-09-30 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Neue nitroaniline |
| DE3239449A1 (de) | 1981-10-27 | 1983-05-05 | CIBA-GEIGY AG, 4002 Basel | Phenoxyphenyl- und pyridyloxyphenyl-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| JPS58124758A (ja) | 1982-01-20 | 1983-07-25 | Fujisawa Pharmaceut Co Ltd | ベンゼンスルホンアミド誘導体 |
| DE3209878A1 (de) | 1982-03-18 | 1983-09-29 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Verfahren zur herstellung von diphenylaethern |
| US4665097A (en) * | 1983-03-31 | 1987-05-12 | Union Carbide Corporation | Novel bicyclooxyaryl thioureas and process for preparation |
| US4664097A (en) | 1984-05-09 | 1987-05-12 | The Wistar Institute Of Anatomy & Biology | Nuclear transplantation in the mammalian embryo by microsurgery and cell fusion |
| US4705955A (en) * | 1985-04-02 | 1987-11-10 | Curt Mileikowsky | Radiation therapy for cancer patients |
| JPS635136A (ja) | 1986-06-26 | 1988-01-11 | Mitsubishi Electric Corp | 内燃機関のアイドル回転数制御装置 |
| JPS6351363A (ja) | 1986-08-21 | 1988-03-04 | Tekukemu:Kk | アミノ基を有するジフエニ−ル化合物の製造方法 |
| US5059609A (en) | 1987-10-19 | 1991-10-22 | Pfizer Inc. | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases |
| IL105777A0 (en) | 1992-06-04 | 1993-09-22 | Great Lakes Chemical Corp | Method for the isolation of a partially brominated diphenyl ether product |
| ES2138639T3 (es) | 1993-08-27 | 2000-01-16 | Hoffmann La Roche | Derivados peptidicos de tetrahidronaftaleno. |
| DE4431219A1 (de) * | 1994-09-02 | 1996-03-07 | Bayer Ag | Selektive Herbizide auf Basis von Aryluracilen |
| US6887820B1 (en) | 1995-12-06 | 2005-05-03 | Japan Science And Technology Corporation | Method for producing optically active compounds |
| EP0916637B1 (en) | 1995-12-06 | 2005-04-20 | Japan Science and Technology Agency | Process for preparating optically active compounds |
| AU6829298A (en) | 1997-03-20 | 1998-10-20 | Basf Aktiengesellschaft | Substituted 2-benz(o)ylpyridines, their preparation and their use as herbicides |
| ATE309207T1 (de) | 1999-08-27 | 2005-11-15 | Sugen Inc | Phosphat-mimetika sowie behandlungsmethoden unter verwendung von phosphatase-inhibitoren |
| US20050043227A1 (en) | 2001-04-24 | 2005-02-24 | Veerle Compernolle | Use of hypoxia inducible factor 2alpha for curing neonatal respiratory distress syndrome and as a target for the treatment of pulmonary hypertension |
| EP1471049A4 (en) | 2002-01-30 | 2006-08-16 | Kissei Pharmaceutical | NEW THYROIDIAN HORMONE RECEPTOR LIGAND, MEDICINAL PREPARATIONS CONTAINING THE SAME AND USE THEREOF |
| CA2463464A1 (en) | 2003-04-28 | 2004-10-28 | Auckland Uniservices Limited | Methods of treatment and compositions therefor |
| SE0301906D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | New compounds |
| JP4707560B2 (ja) * | 2003-12-29 | 2011-06-22 | Msd株式会社 | 新規2−ヘテロアリール置換ベンズイミダゾール誘導体 |
| TW200611898A (en) | 2004-05-28 | 2006-04-16 | Speedel Experimenta Ag | Organic compounds |
| EP1791807A1 (en) * | 2004-09-10 | 2007-06-06 | Pfizer Products Incorporated | Therapeutic diphenyl ether ligands |
| MX2007007103A (es) | 2004-12-13 | 2008-03-10 | Lilly Co Eli | Derivados espiro como inhibidores de lipoxigenasa. |
| US7759493B2 (en) | 2005-01-31 | 2010-07-20 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| BRPI0617720A2 (pt) | 2005-10-19 | 2011-08-02 | Hoffmann La Roche | compostos inibidores de nnrt de fenil-acetamida, usos dos referidos compostos e composição farmacêutica que os contém |
| CA2630468C (en) * | 2005-12-05 | 2015-01-20 | Otsuka Pharmaceutical Co., Ltd. | Medicinal drug |
| US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| GB0526445D0 (en) * | 2005-12-23 | 2006-02-08 | Novartis Ag | Organic compounds |
| PL1976828T3 (pl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4 |
| WO2007099423A1 (en) | 2006-03-02 | 2007-09-07 | Pfizer Products Inc. | 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists |
| US20070244071A1 (en) | 2006-03-07 | 2007-10-18 | Mount Sinai Hospital | Treatment of proliferative diseases |
| WO2007136572A2 (en) * | 2006-05-15 | 2007-11-29 | Merck & Co., Inc. | Antidiabetic bicyclic compounds |
| CN101506210A (zh) * | 2006-08-23 | 2009-08-12 | 神经能质公司 | 2-苯氧基嘧啶酮类似物 |
| MX2009010559A (es) | 2007-03-30 | 2009-10-22 | Nippon Shinyaku Co Ltd | Derivados de heteroarilo. |
| CN101058535B (zh) | 2007-05-25 | 2010-07-21 | 复旦大学 | 二(7-羟基-2,3-二氢-1-1h-茚基)醚类及其类似物、合成方法及应用 |
| JP5243537B2 (ja) * | 2007-06-06 | 2013-07-24 | トレント ファーマシューティカルズ リミテッド | 新規化合物 |
| WO2008157273A1 (en) | 2007-06-14 | 2008-12-24 | Smithkline Beecham Corporation | Chemical compounds |
| CN101407467A (zh) * | 2007-10-12 | 2009-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | N-取代芳烃苯胺/多取代二芳基醚类化合物,其制备方法及抗肿瘤应用 |
| EP2231605A1 (en) * | 2007-12-05 | 2010-09-29 | Basf Se | Pyridylmethyl-sulfonamide compounds |
| WO2009093133A1 (en) | 2008-01-25 | 2009-07-30 | Medichem, S.A. | Method for determining the enantiomeric purity of indane derivatives |
| AU2009221375A1 (en) | 2008-03-05 | 2009-09-11 | F. Hoffmann-La Roche Ag | 2-Aminoquinolines |
| US8188098B2 (en) | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
| TWI491605B (zh) * | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| WO2010068794A2 (en) | 2008-12-10 | 2010-06-17 | The General Hospital Corporation | Hif inhibitors and use thereof |
| EA020460B1 (ru) * | 2009-01-12 | 2014-11-28 | Пфайзер Лимитед | Производные сульфонамида |
| CA2754685A1 (en) | 2009-03-11 | 2010-09-16 | Pfizer Inc. | Substituted indazole amides |
| WO2010137620A1 (ja) | 2009-05-27 | 2010-12-02 | 武田薬品工業株式会社 | フェノキシエチルアミン誘導体 |
| US10363229B2 (en) | 2009-06-05 | 2019-07-30 | Joan McInyre Caron | Methods and compositions for the treatment of cancer |
| US8461164B2 (en) | 2009-08-31 | 2013-06-11 | Dow Agrosciences, Llc. | Pteridines and their use as agrochemicals |
| EP2493874A1 (en) | 2009-10-30 | 2012-09-05 | Glaxo Group Limited | Novel crystalline forms of (3r,6r) -3- (2, 3 -dihydro- 1h- inden- 2 -yl) - 1 - [ (1r) - 1 - (2, 6 - dimethyl - 3 - pyridinyl) - 2 - (4 -morpholinyl) -2-oxoethyl]-6- [(1s) - 1 -methylpropyl]-2,5- piperazinedione |
| US8853277B2 (en) * | 2009-11-30 | 2014-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC) |
| JP4902819B1 (ja) * | 2010-02-26 | 2012-03-21 | 株式会社日本触媒 | フタロシアニン誘導体 |
| GB201005589D0 (en) * | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
| US9024041B2 (en) * | 2010-04-08 | 2015-05-05 | Respivert Ltd. | P38 MAP kinase inhibitors |
| WO2011133659A2 (en) | 2010-04-20 | 2011-10-27 | Emory University | Inhibitors of hif and angiogenesis |
| US8853423B2 (en) | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| KR101760158B1 (ko) | 2010-07-29 | 2017-07-20 | 아스텔라스세이야쿠 가부시키가이샤 | 축환 피리딘 화합물 |
| EP2502917A1 (en) | 2011-03-17 | 2012-09-26 | Santhera Pharmaceuticals (Schweiz) AG | Solid state crystalline forms of 4-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole |
| MX2013014310A (es) | 2011-06-06 | 2014-01-23 | Akebia Therapeutics Inc | Compuestos y composiciones para estabilizar el factor-2 alfa inducible por hipoxia como un metodo para tratar el cancer. |
| UY34200A (es) | 2011-07-21 | 2013-02-28 | Bayer Ip Gmbh | 3-(fluorovinil)pirazoles y su uso |
| AU2012313094B2 (en) | 2011-09-22 | 2017-02-02 | Intervet International B.V. | Pyrazole carboxamides as janus kinase inhibitors |
| HK1203946A1 (en) | 2011-10-17 | 2015-11-06 | Bayer Intellectual Property Gmbh | Substituted oxadiazolyl pyridinones and oxadiazolyl pyridazinones as hif inhibitors |
| EP2773641B1 (en) * | 2011-10-31 | 2017-09-27 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| HK1202543A1 (en) | 2012-01-28 | 2015-10-02 | Merck Patent Gmbh | Azaheterocyclic compounds |
| JP6198715B2 (ja) | 2012-03-06 | 2017-09-20 | 武田薬品工業株式会社 | 三環性化合物 |
| DK2865663T3 (en) | 2012-06-21 | 2017-06-19 | Eisai R&D Man Co Ltd | HIS UNKNOWN INDANSULPHAMIDE DERIVATIVES |
| WO2014031933A2 (en) | 2012-08-24 | 2014-02-27 | Philip Jones | Heterocyclic modulators of hif activity for treatment of disease |
| WO2014031928A2 (en) | 2012-08-24 | 2014-02-27 | Philip Jones | Heterocyclic modulators of hif activity for treatment of disease |
| US20140128365A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| EP2919770A4 (en) | 2012-11-14 | 2017-03-08 | The Board of Regents of The University of Texas System | Inhibition of hif-2 heterodimerization with hif1 (arnt) |
| BR112015009376A2 (pt) * | 2012-11-28 | 2017-07-04 | Boehringer Ingelheim Int | ácidos indaniloxidihidrobenzofuranilacéticos |
| JP6283862B2 (ja) * | 2012-12-07 | 2018-02-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規インダニルオキシジヒドロベンゾフラニル酢酸 |
| MX2016002974A (es) | 2013-09-09 | 2016-06-02 | Peloton Therapeutics Inc | Eteres de arilo y sus usos. |
| ES2737148T3 (es) | 2013-12-16 | 2020-01-10 | Peloton Therapeutics Inc | Análogos de sulfona y sulfoximina cíclicos y usos de los mismos |
| EP3267792A4 (en) | 2015-03-11 | 2018-09-26 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| WO2016145045A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating glioblastoma |
| US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| EP3268362B1 (en) | 2015-03-11 | 2021-10-20 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| US20180049995A1 (en) | 2015-03-11 | 2018-02-22 | Peloton Therapeutics, Inc. | Hif-2-alpha inhibitor polymorphs |
| WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| US9796697B2 (en) | 2015-06-12 | 2017-10-24 | Peloton Therapeutics, Inc. | Tricyclic inhibitors of HIF-2-alpha and uses thereof |
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