JP2011504903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011504903A5 JP2011504903A5 JP2010535355A JP2010535355A JP2011504903A5 JP 2011504903 A5 JP2011504903 A5 JP 2011504903A5 JP 2010535355 A JP2010535355 A JP 2010535355A JP 2010535355 A JP2010535355 A JP 2010535355A JP 2011504903 A5 JP2011504903 A5 JP 2011504903A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- dipeptidyl peptidase
- pharmaceutical composition
- acid addition
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 6
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 6
- 230000001404 mediated effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 2
- 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US484607P | 2007-11-30 | 2007-11-30 | |
| US60/004,846 | 2007-11-30 | ||
| PCT/EP2008/066159 WO2009068531A2 (en) | 2007-11-30 | 2008-11-25 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011504903A JP2011504903A (ja) | 2011-02-17 |
| JP2011504903A5 true JP2011504903A5 (enExample) | 2013-10-03 |
| JP5401465B2 JP5401465B2 (ja) | 2014-01-29 |
Family
ID=40679052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535355A Expired - Fee Related JP5401465B2 (ja) | 2007-11-30 | 2008-11-25 | 有機化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8252751B2 (enExample) |
| EP (1) | EP2247602B1 (enExample) |
| JP (1) | JP5401465B2 (enExample) |
| KR (1) | KR20100092461A (enExample) |
| CN (1) | CN101918423B (enExample) |
| AU (1) | AU2008328845C1 (enExample) |
| CA (1) | CA2704493A1 (enExample) |
| ES (1) | ES2418440T3 (enExample) |
| MX (1) | MX2010005914A (enExample) |
| PL (1) | PL2247602T3 (enExample) |
| PT (1) | PT2247602E (enExample) |
| RU (2) | RU2489439C2 (enExample) |
| WO (1) | WO2009068531A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5686413B2 (ja) | 2009-12-22 | 2015-03-18 | 塩野義製薬株式会社 | アダマンタンアミン誘導体 |
| CN101798270B (zh) * | 2010-02-25 | 2013-04-17 | 东华大学 | 一种3-氨基-1-金刚烷醇的制备方法 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| CN103209957A (zh) | 2010-08-09 | 2013-07-17 | 盐野义制药株式会社 | 氨基金刚烷氨基甲酸酯衍生物的制备方法 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| IN2012MU01383A (enExample) * | 2012-05-04 | 2014-02-28 | ||
| JP5929555B2 (ja) * | 2012-06-28 | 2016-06-08 | 三菱瓦斯化学株式会社 | ヒドロキシアダマンタンカルボン酸化合物の製造方法 |
| IN2015DN03795A (enExample) | 2012-10-24 | 2015-10-02 | Inserm Inst Nat De La Santé Et De La Rech Médicale | |
| CN103804267B (zh) * | 2014-02-21 | 2016-06-08 | 张家港威胜生物医药有限公司 | 一种维达列汀的合成工艺 |
| CN105439873A (zh) * | 2014-08-20 | 2016-03-30 | 天津药物研究院 | 3-羟基-1-金刚烷胺的制备方法 |
| US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| CN104744334A (zh) * | 2015-03-25 | 2015-07-01 | 合肥创新医药技术有限公司 | 维格列汀的制备方法 |
| CN107311907A (zh) * | 2017-07-29 | 2017-11-03 | 合肥创新医药技术有限公司 | 一种维格列汀异构体杂质的制备方法 |
| CN111138334A (zh) * | 2020-01-13 | 2020-05-12 | 天津民祥生物医药股份有限公司 | 一种维格列汀的制备方法 |
| JP7349475B2 (ja) | 2021-06-22 | 2023-09-22 | シャープ株式会社 | リレー制御回路および電源回路 |
| EP4532466A1 (en) * | 2022-06-03 | 2025-04-09 | Universiteit Antwerpen | Dpp9 binding compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| US6683056B2 (en) * | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| US6555519B2 (en) * | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
| US6995183B2 (en) * | 2003-08-01 | 2006-02-07 | Bristol Myers Squibb Company | Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods |
| US7871982B2 (en) * | 2005-12-09 | 2011-01-18 | Meiji Seika Kaisha, Ltd. | Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient |
-
2008
- 2008-11-25 EP EP08853345A patent/EP2247602B1/en not_active Not-in-force
- 2008-11-25 AU AU2008328845A patent/AU2008328845C1/en not_active Ceased
- 2008-11-25 ES ES08853345T patent/ES2418440T3/es active Active
- 2008-11-25 PL PL08853345T patent/PL2247602T3/pl unknown
- 2008-11-25 MX MX2010005914A patent/MX2010005914A/es active IP Right Grant
- 2008-11-25 US US12/744,510 patent/US8252751B2/en not_active Expired - Fee Related
- 2008-11-25 JP JP2010535355A patent/JP5401465B2/ja not_active Expired - Fee Related
- 2008-11-25 CA CA2704493A patent/CA2704493A1/en not_active Abandoned
- 2008-11-25 PT PT88533450T patent/PT2247602E/pt unknown
- 2008-11-25 RU RU2010126056/04A patent/RU2489439C2/ru not_active IP Right Cessation
- 2008-11-25 CN CN2008801181558A patent/CN101918423B/zh not_active Expired - Fee Related
- 2008-11-25 KR KR1020107011725A patent/KR20100092461A/ko not_active Ceased
- 2008-11-25 WO PCT/EP2008/066159 patent/WO2009068531A2/en not_active Ceased
-
2012
- 2012-07-27 US US13/560,421 patent/US8569250B2/en not_active Expired - Fee Related
-
2013
- 2013-04-24 RU RU2013119129/04A patent/RU2013119129A/ru not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011504903A5 (enExample) | ||
| RU2013119129A (ru) | Органические соединения | |
| JP2005112864A5 (enExample) | ||
| JP2013508279A5 (enExample) | ||
| EP1857457A3 (en) | Benzimidazole derivative and its use as AII receptor antagonist | |
| JP2011502958A5 (enExample) | ||
| JP2008535902A5 (enExample) | ||
| JP2013533253A5 (enExample) | ||
| JP2013537203A5 (enExample) | ||
| JP2008195730A5 (enExample) | ||
| JP2005539088A5 (enExample) | ||
| JP2009526034A5 (enExample) | ||
| JP2012533546A5 (enExample) | ||
| JP2008520742A5 (enExample) | ||
| JP2014508811A5 (enExample) | ||
| JP2008513498A5 (enExample) | ||
| JP2013512277A5 (enExample) | ||
| JP2009535307A5 (enExample) | ||
| JP2011516511A5 (enExample) | ||
| JP2011526917A5 (enExample) | ||
| JP2013506674A5 (enExample) | ||
| JP2014505107A5 (enExample) | ||
| DE602008001725D1 (de) | 1-(1-benzylpiperidin-4-yl)benzimidazol-5-carbonsäurederivate zur behandlung von diabetes mellitus | |
| JP2006501201A5 (enExample) | ||
| JPWO2023195529A5 (enExample) |