JP2013533253A5 - - Google Patents
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- JP2013533253A5 JP2013533253A5 JP2013518241A JP2013518241A JP2013533253A5 JP 2013533253 A5 JP2013533253 A5 JP 2013533253A5 JP 2013518241 A JP2013518241 A JP 2013518241A JP 2013518241 A JP2013518241 A JP 2013518241A JP 2013533253 A5 JP2013533253 A5 JP 2013533253A5
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- JP
- Japan
- Prior art keywords
- carbon atoms
- enantiomer
- atoms
- pharmaceutical composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/827,505 | 2010-06-30 | ||
| US12/827,505 US9610274B2 (en) | 2010-06-30 | 2010-06-30 | Methods for treating bipolar disorder |
| PCT/KR2011/004676 WO2012002687A2 (en) | 2010-06-30 | 2011-06-27 | Methods for treating bipolar disorder |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533253A JP2013533253A (ja) | 2013-08-22 |
| JP2013533253A5 true JP2013533253A5 (enExample) | 2014-08-07 |
| JP5881692B2 JP5881692B2 (ja) | 2016-03-09 |
Family
ID=45400168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518241A Active JP5881692B2 (ja) | 2010-06-30 | 2011-06-27 | 双極性障害を治療する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9610274B2 (enExample) |
| EP (1) | EP2590645B1 (enExample) |
| JP (1) | JP5881692B2 (enExample) |
| KR (1) | KR101828934B1 (enExample) |
| CN (1) | CN102985085B (enExample) |
| AU (1) | AU2011272156B2 (enExample) |
| BR (1) | BR112012033738A2 (enExample) |
| CA (1) | CA2801241C (enExample) |
| ES (1) | ES2654615T3 (enExample) |
| MX (2) | MX2012014686A (enExample) |
| PL (1) | PL2590645T3 (enExample) |
| RU (1) | RU2653408C2 (enExample) |
| WO (1) | WO2012002687A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006254899B2 (en) | 2005-06-08 | 2011-11-24 | Sk Biopharmaceuticals Co., Ltd. | Treatment of sleep-wake disorders |
| RU2567801C2 (ru) | 2009-06-22 | 2015-11-10 | Ск Биофармасъютиклс Ко., Лтд. | Способы лечения и профилактики усталости |
| US9359290B2 (en) | 2013-03-13 | 2016-06-07 | Jazz Pharmaceuticals International Iii Limited | Treatment of cataplexy |
| PL3021838T3 (pl) * | 2013-07-18 | 2021-03-08 | Jazz Pharmaceuticals Ireland Limited | Leczenie otyłości |
| US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
| TWI655179B (zh) | 2014-02-28 | 2019-04-01 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| US10195151B2 (en) * | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| CN120574152A (zh) | 2016-09-06 | 2025-09-02 | 爱尔兰贾兹制药有限公司 | (r)-2-氨基-3-苯丙基氨基甲酸酯盐酸盐的溶剂化物形式的晶体、其制备方法、组合物及用途 |
| MY202185A (en) | 2016-10-06 | 2024-04-15 | Jazz Pharmaceuticals Ireland Ltd | Carbamoyl phenylalaninol compounds and uses therof |
| JP7208139B2 (ja) * | 2016-12-14 | 2023-01-18 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 双極性障害の予防、軽減又は治療のためのカルバメート化合物の使用 |
| EP3630072A4 (en) | 2017-06-02 | 2021-03-10 | Jazz Pharmaceuticals Ireland Limited | METHODS AND COMPOSITIONS FOR TREATMENT OF EXCESSIVE Drowsiness |
| MX2020001146A (es) | 2017-07-31 | 2020-08-20 | Jazz Pharmaceuticals Ireland Ltd | Analogos de carbamoil fenilalaninol y usos de los mismos. |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
| WO2025006965A1 (en) | 2023-06-29 | 2025-01-02 | Axsome Therapeutics, Inc. | Methods of administering solriamfetol to lactating women |
| WO2025165760A1 (en) * | 2024-01-29 | 2025-08-07 | Axsome Therapeutics, Inc. | Phenylalkylamino carbamates for use in the treatment of attention deficit/hyperactivity disorder |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ314570A (en) | 1993-06-10 | 2000-11-24 | Lilly Co Eli | Treatment of emesis using tetrahydrobenz[cd]indole-6-carboxamides |
| KR100197892B1 (ko) * | 1994-09-09 | 1999-06-15 | 남창우 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
| US5756817C1 (en) | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
| KR0173862B1 (ko) | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| IT1275903B1 (it) | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
| KR0173863B1 (ko) | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| DE69618663T2 (de) | 1996-10-10 | 2002-08-14 | Sk Corp., Seoul/Soul | O-carbamoyl-phenylalaninol-zusammensetzungen und ihre pharmazeutisch anwendbaren salzen |
| WO1998017636A1 (en) | 1996-10-22 | 1998-04-30 | Ortho Pharmaceutical Corporation | Phenylalaninol derivatives for the treatment of central nervous system disorders |
| TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| US6294555B1 (en) | 1998-04-28 | 2001-09-25 | Dainippon Pharmaceutical Co., Ltd. | 1-[(1-Substituted-4-piperidinyl)methyl]-4-piperidine derivative, process for producing the same, medicinal compositions containing the same and intermediates of these compounds |
| US20010029262A1 (en) | 1998-06-29 | 2001-10-11 | Sethi Kapil Dev | Method of treatment or prophylaxis |
| TW518218B (en) | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| US20010034320A1 (en) | 2000-01-18 | 2001-10-25 | Hans-Michael Brecht | NK1-receptor antagonists for treating restless legs syndrome |
| AU3113902A (en) | 2000-12-21 | 2002-07-01 | Bristol Myers Squibb Co | Thiazolyl inhibitors of tec family tyrosine kinases |
| US6815464B2 (en) | 2001-02-27 | 2004-11-09 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in the treatment of pain |
| DE60221670T2 (de) | 2001-02-27 | 2008-04-30 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamatverbindungen zur vorbeugung und behandlung von bewegungsstörungen |
| US7259157B2 (en) | 2001-04-03 | 2007-08-21 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists |
| US20040204341A1 (en) | 2001-06-12 | 2004-10-14 | Christopher Allen | Nr2b receptor antagonists for the treatment or prevention of migraines |
| US20040115263A1 (en) | 2002-08-26 | 2004-06-17 | Robertson David W. | Use of bupropion for treating restless legs syndrome |
| JP2006502180A (ja) | 2002-09-20 | 2006-01-19 | ファイザー株式会社 | ５−ｈｔ４レセプターモジュレーターとしてのｎ−置換されたピペリジニル−イミダゾピリジン化合物 |
| WO2004094418A1 (en) | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
| CA2537127C (en) | 2003-09-03 | 2011-04-05 | Pfizer Inc. | Benzimidazolone compounds having 5-ht4 receptor agonistic activity |
| US20050080268A1 (en) | 2003-10-08 | 2005-04-14 | Yong-Moon Choi | Process of preparing O-carbamoyl compounds in the presence of active amine group |
| EP1548011A1 (en) | 2003-12-23 | 2005-06-29 | Neuro3D | Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof |
| WO2005092882A1 (en) | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
| KR20070083826A (ko) | 2004-10-28 | 2007-08-24 | 에스케이 주식회사 | 우울증을 위한 부가 요법 |
| KR100969402B1 (ko) | 2005-04-08 | 2010-07-14 | 화이자 프로덕츠 인크. | Ｉ형 글리신 수송 억제제로서의 비시클릭 [3.1.0]헤테로아릴 아미드 |
| US7598279B2 (en) | 2005-04-22 | 2009-10-06 | Sk Holdings Co., Ltd. | Neurotherapeutic azole compounds |
| AU2006254899B2 (en) * | 2005-06-08 | 2011-11-24 | Sk Biopharmaceuticals Co., Ltd. | Treatment of sleep-wake disorders |
| DE602006012670D1 (de) | 2005-06-22 | 2010-04-15 | Sk Holdings Co Ltd | Behandlung der sexuellen dysfunktion |
| CA2616721C (en) | 2005-07-26 | 2014-01-21 | Janssen Pharmaceutica N.V. | Methods for treating substance-related disorders |
| EP1754476A1 (en) | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| CA2673487A1 (en) | 2006-10-13 | 2008-04-24 | Janssen Pharmaceutica Nv | Phenylalkylamino carbamate compositions |
| HUP0700370A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| RU2567801C2 (ru) | 2009-06-22 | 2015-11-10 | Ск Биофармасъютиклс Ко., Лтд. | Способы лечения и профилактики усталости |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| KR101097605B1 (ko) | 2009-11-04 | 2011-12-22 | 알.에프 에이치아이씨 주식회사 | 도허티 증폭기 |
| WO2011055944A2 (en) | 2009-11-06 | 2011-05-12 | Sk Holdings Co., Ltd. | Methods for treating fibromyalgia syndrome |
| KR101783632B1 (ko) | 2009-11-06 | 2017-10-10 | 에스케이바이오팜 주식회사 | 주의력 결핍/과잉행동 장애(ａｄｈｄ)의 치료 방법 |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
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2010
- 2010-06-30 US US12/827,505 patent/US9610274B2/en active Active
-
2011
- 2011-06-27 BR BR112012033738A patent/BR112012033738A2/pt not_active Application Discontinuation
- 2011-06-27 AU AU2011272156A patent/AU2011272156B2/en active Active
- 2011-06-27 MX MX2012014686A patent/MX2012014686A/es not_active Application Discontinuation
- 2011-06-27 PL PL11801093T patent/PL2590645T3/pl unknown
- 2011-06-27 CN CN201180032698.XA patent/CN102985085B/zh active Active
- 2011-06-27 EP EP11801093.3A patent/EP2590645B1/en active Active
- 2011-06-27 RU RU2012155118A patent/RU2653408C2/ru active
- 2011-06-27 ES ES11801093.3T patent/ES2654615T3/es active Active
- 2011-06-27 CA CA2801241A patent/CA2801241C/en not_active Expired - Fee Related
- 2011-06-27 WO PCT/KR2011/004676 patent/WO2012002687A2/en not_active Ceased
- 2011-06-27 MX MX2016002438A patent/MX360030B/es unknown
- 2011-06-27 JP JP2013518241A patent/JP5881692B2/ja active Active
- 2011-06-27 KR KR1020127032128A patent/KR101828934B1/ko active Active
-
2017
- 2017-02-14 US US15/432,479 patent/US9907777B2/en active Active