JP2013531008A5 - - Google Patents
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- JP2013531008A5 JP2013531008A5 JP2013518242A JP2013518242A JP2013531008A5 JP 2013531008 A5 JP2013531008 A5 JP 2013531008A5 JP 2013518242 A JP2013518242 A JP 2013518242A JP 2013518242 A JP2013518242 A JP 2013518242A JP 2013531008 A5 JP2013531008 A5 JP 2013531008A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- enantiomer
- pharmaceutical composition
- composition according
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 5
- 208000005793 Restless legs syndrome Diseases 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 206010061224 Limb discomfort Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 230000035807 sensation Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000022925 sleep disturbance Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/827,529 US8623913B2 (en) | 2010-06-30 | 2010-06-30 | Methods for treating restless legs syndrome |
| US12/827,529 | 2010-06-30 | ||
| PCT/KR2011/004677 WO2012002688A2 (en) | 2010-06-30 | 2011-06-27 | Methods of treating restless legs syndrome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531008A JP2013531008A (ja) | 2013-08-01 |
| JP2013531008A5 true JP2013531008A5 (enExample) | 2014-08-07 |
| JP5921539B2 JP5921539B2 (ja) | 2016-05-24 |
Family
ID=45400169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518242A Active JP5921539B2 (ja) | 2010-06-30 | 2011-06-27 | 下肢静止不能症候群を治療する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8623913B2 (enExample) |
| EP (1) | EP2588099B1 (enExample) |
| JP (1) | JP5921539B2 (enExample) |
| KR (1) | KR101785072B1 (enExample) |
| CN (1) | CN103025326B (enExample) |
| CA (1) | CA2801243C (enExample) |
| ES (1) | ES2638074T3 (enExample) |
| WO (1) | WO2012002688A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0613697A2 (pt) | 2005-06-08 | 2011-01-25 | Sk Holdings Co Ltd | tratamento de distúrbios de sono-vigìlia |
| KR102021075B1 (ko) | 2009-06-22 | 2019-11-04 | 에스케이바이오팜 주식회사 | 피로의 치료 또는 예방 방법 |
| WO2011055944A2 (en) * | 2009-11-06 | 2011-05-12 | Sk Holdings Co., Ltd. | Methods for treating fibromyalgia syndrome |
| BR112012010670A2 (pt) | 2009-11-06 | 2016-04-12 | Sk Biopharmaceuticals Co Ltd | métodos para tratamento de distúrbio de défict de atenção/hiperatividade |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| GB201221329D0 (en) | 2012-11-27 | 2013-01-09 | Avexxin As | Dermatitis treatment |
| MY177740A (en) | 2013-03-13 | 2020-09-23 | Sk Biopharmaceuticals Co Ltd | Treatment of cataplexy |
| TW201919605A (zh) | 2013-07-18 | 2019-06-01 | 南韓商愛思開生物製藥股份有限公司 | 肥胖之治療 |
| US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
| TWI698415B (zh) * | 2014-02-28 | 2020-07-11 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| CN121202730A (zh) | 2016-09-06 | 2025-12-26 | 爱尔兰贾兹制药有限公司 | (r)-2-氨基-3-苯丙基氨基甲酸酯盐酸盐的制备方法、其组合物及用途 |
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| WO2018055062A1 (en) | 2016-09-21 | 2018-03-29 | Avexxin As | Pharmaceutical composition |
| WO2018067971A1 (en) * | 2016-10-06 | 2018-04-12 | Jazz Pharmaceuticals International Iii Limited | Carbamoyl phenylalaninol compounds and uses therof |
| BR112019025286A2 (pt) | 2017-06-02 | 2020-06-23 | Jazz Pharmaceuticals Ireland Limited | Métodos e composições para tratamento de sonolência excessiva |
| CA3071779A1 (en) | 2017-07-31 | 2019-02-07 | Jazz Pharmaceuticals Ireland Limited | Carbamoyl phenylalaninol analogs and uses thereof |
| US11283085B1 (en) | 2020-03-06 | 2022-03-22 | Bloom Energy Corporation | Low VOC ink compositions and methods of forming fuel cell system components using the same |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
| US11515543B1 (en) | 2020-06-03 | 2022-11-29 | Bloom Energy Corporation | Aqueous fuel cell system component ink compositions and methods of forming fuel cell system components using the same |
| WO2025006965A1 (en) | 2023-06-29 | 2025-01-02 | Axsome Therapeutics, Inc. | Methods of administering solriamfetol to lactating women |
| US12201783B1 (en) * | 2023-09-05 | 2025-01-21 | Steven F Pichette | Use of blue-light filtering eyeglasses for treatment of restless legs syndrome |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100197892B1 (ko) * | 1994-09-09 | 1999-06-15 | 남창우 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
| US5756817C1 (en) | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
| KR0173862B1 (ko) | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| IT1275903B1 (it) | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
| KR0173863B1 (ko) | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| CN1076016C (zh) | 1996-10-10 | 2001-12-12 | Sk株式会社 | O－氨基甲酰基－苯丙胺醇化合物、其药学上有用的盐和它们的制备方法 |
| TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| WO1999055674A1 (en) | 1998-04-28 | 1999-11-04 | Dainippon Pharmaceutical Co., Ltd. | 1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds |
| US20010029262A1 (en) | 1998-06-29 | 2001-10-11 | Sethi Kapil Dev | Method of treatment or prophylaxis |
| TW518218B (en) | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| US20010034320A1 (en) | 2000-01-18 | 2001-10-25 | Hans-Michael Brecht | NK1-receptor antagonists for treating restless legs syndrome |
| EP1347971B1 (en) | 2000-12-21 | 2006-03-01 | Bristol-Myers Squibb Company | Thiazolyl inhibitors of tec family tyrosine kinases |
| ES2356617T3 (es) | 2001-02-27 | 2011-04-11 | Ortho-Mcneil Pharmaceutical, Inc. | Compuestos de carbamato para su uso en el tratamiento del dolor. |
| PT1411917E (pt) * | 2001-02-27 | 2007-09-17 | Ortho Mcneil Pharm Inc | ''compostos carbamatos para utilização na prevenção ou tratamento de distúrbios do movimento'' |
| AU2002338334B8 (en) | 2001-04-03 | 2008-09-18 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists |
| EP1399160A4 (en) | 2001-06-12 | 2004-08-25 | Merck & Co Inc | NR2B RECEPTOR ANTAGONISTS FOR TREATING OR PREVENTING MIGRAINE |
| US20040115263A1 (en) * | 2002-08-26 | 2004-06-17 | Robertson David W. | Use of bupropion for treating restless legs syndrome |
| AU2003259482A1 (en) | 2002-09-20 | 2004-04-08 | Pfizer Japan Inc. | N-substituted piperidinyl-imidazopyridine compounds as 5-ht4 receptor modulators |
| EP1620435A1 (en) | 2003-04-21 | 2006-02-01 | Pfizer Inc. | IMADAZOPYRIDINE COMPOUNDS HAVING 5-HT sb 4 /sb RECEPTOR AGONISTIC ACTIVITY AND 5-HT sb 3 /sb RECEPTOR ANTAGONISTIC ACTIVITY |
| DK1664036T3 (da) | 2003-09-03 | 2012-02-13 | Pfizer | Benzimidazolonforbindelser med 5-HT4-receptoragonistisk virkning |
| EP1548011A1 (en) | 2003-12-23 | 2005-06-29 | Neuro3D | Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof |
| WO2005092882A1 (en) | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
| BRPI0518233A2 (pt) | 2004-10-28 | 2008-11-11 | Sk Corp | terapia adjunta para depressço |
| CA2603939C (en) | 2005-04-08 | 2013-08-27 | Pfizer Products Inc. | Bicyclic [3.1.0] heteroaryl amides as type i glycine transport inhibitors |
| US7598279B2 (en) | 2005-04-22 | 2009-10-06 | Sk Holdings Co., Ltd. | Neurotherapeutic azole compounds |
| BRPI0613697A2 (pt) * | 2005-06-08 | 2011-01-25 | Sk Holdings Co Ltd | tratamento de distúrbios de sono-vigìlia |
| EP1754476A1 (en) | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| EA200970377A1 (ru) * | 2006-10-13 | 2009-10-30 | Янссен Фармацевтика Нв | Композиции фенилалкиламинокарбамата |
| US7377267B2 (en) * | 2006-10-30 | 2008-05-27 | Ford Global Technologies, Llc | Injection strategy to maximize efficiency in gaseous engine |
| CN101317949A (zh) * | 2008-07-15 | 2008-12-10 | 洛阳梓生科技开发有限公司 | 一种补血调经养血柔肝胶囊的制作方法 |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| KR102021075B1 (ko) | 2009-06-22 | 2019-11-04 | 에스케이바이오팜 주식회사 | 피로의 치료 또는 예방 방법 |
-
2010
- 2010-06-30 US US12/827,529 patent/US8623913B2/en active Active
-
2011
- 2011-06-27 ES ES11801094.1T patent/ES2638074T3/es active Active
- 2011-06-27 WO PCT/KR2011/004677 patent/WO2012002688A2/en not_active Ceased
- 2011-06-27 CN CN201180032680.XA patent/CN103025326B/zh active Active
- 2011-06-27 KR KR1020127032127A patent/KR101785072B1/ko active Active
- 2011-06-27 EP EP11801094.1A patent/EP2588099B1/en active Active
- 2011-06-27 JP JP2013518242A patent/JP5921539B2/ja active Active
- 2011-06-27 CA CA2801243A patent/CA2801243C/en not_active Expired - Fee Related
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