JP2013513621A5 - - Google Patents

Download PDF

Info

Publication number
JP2013513621A5
JP2013513621A5 JP2012543324A JP2012543324A JP2013513621A5 JP 2013513621 A5 JP2013513621 A5 JP 2013513621A5 JP 2012543324 A JP2012543324 A JP 2012543324A JP 2012543324 A JP2012543324 A JP 2012543324A JP 2013513621 A5 JP2013513621 A5 JP 2013513621A5
Authority
JP
Japan
Prior art keywords
optionally substituted
alkyl
aryl
pharmaceutical composition
rings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012543324A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013513621A (ja
JP5848712B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/059976 external-priority patent/WO2011072275A2/en
Publication of JP2013513621A publication Critical patent/JP2013513621A/ja
Publication of JP2013513621A5 publication Critical patent/JP2013513621A5/ja
Application granted granted Critical
Publication of JP5848712B2 publication Critical patent/JP5848712B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012543324A 2009-12-11 2010-12-10 虚血性疾患および他の疾患を治療するための薬剤および方法 Expired - Fee Related JP5848712B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28595409P 2009-12-11 2009-12-11
US61/285,954 2009-12-11
US31215410P 2010-03-09 2010-03-09
US61/312,154 2010-03-09
PCT/US2010/059976 WO2011072275A2 (en) 2009-12-11 2010-12-10 Agents and methods for treating ischemic and other diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015232476A Division JP2016117713A (ja) 2009-12-11 2015-11-27 虚血性疾患および他の疾患を治療するための薬剤および方法

Publications (3)

Publication Number Publication Date
JP2013513621A JP2013513621A (ja) 2013-04-22
JP2013513621A5 true JP2013513621A5 (enExample) 2014-01-30
JP5848712B2 JP5848712B2 (ja) 2016-01-27

Family

ID=44146214

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012543324A Expired - Fee Related JP5848712B2 (ja) 2009-12-11 2010-12-10 虚血性疾患および他の疾患を治療するための薬剤および方法
JP2015232476A Pending JP2016117713A (ja) 2009-12-11 2015-11-27 虚血性疾患および他の疾患を治療するための薬剤および方法
JP2017222422A Pending JP2018076319A (ja) 2009-12-11 2017-11-20 虚血性疾患および他の疾患を治療するための薬剤および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2015232476A Pending JP2016117713A (ja) 2009-12-11 2015-11-27 虚血性疾患および他の疾患を治療するための薬剤および方法
JP2017222422A Pending JP2018076319A (ja) 2009-12-11 2017-11-20 虚血性疾患および他の疾患を治療するための薬剤および方法

Country Status (6)

Country Link
US (2) US8680137B2 (enExample)
EP (1) EP2521724B1 (enExample)
JP (3) JP5848712B2 (enExample)
AU (1) AU2010327936B2 (enExample)
CA (1) CA2781888C (enExample)
WO (1) WO2011072275A2 (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2884452B2 (ja) 1991-10-09 1999-04-19 清水建設株式会社 セグメントを利用した立坑構築工法
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CA2711558C (en) 2008-01-04 2016-12-13 Intellikine, Inc. Phosphatidyl inositol-3 kinase inhibiting compounds
CN102202677A (zh) 2008-09-03 2011-09-28 阿尔伯维塔公司 治疗疼痛的活性剂和方法
AU2010327936B2 (en) 2009-12-11 2015-08-20 Nono Inc. Agents and methods for treating ischemic and other diseases
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
AU2011202542A1 (en) * 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
WO2012009699A2 (en) 2010-07-16 2012-01-19 Abbott Laboratories Process for preparing antiviral compounds
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
BR112013001138A2 (pt) 2010-07-16 2016-07-05 Abbvie Inc ligantes de fosfina para reações catalíticas
PH12013500907A1 (en) 2010-11-05 2013-07-08 Firmenich Incorporated Compounds useful as modulators of trpm8
EP2642998B1 (en) 2010-11-24 2020-09-16 The Trustees of Columbia University in the City of New York A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease
AU2012205669B2 (en) 2011-01-10 2015-08-20 Infinity Pharmaceuticals Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9334256B2 (en) 2011-06-15 2016-05-10 Nono Inc. Agents and methods for treating ischemic and other diseases
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20130016041A (ko) * 2011-08-04 2013-02-14 재단법인 의약바이오컨버젼스연구단 신규한 아닐린 유도체 및 이의 용도
EP2751093A1 (en) 2011-08-29 2014-07-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2013216885B2 (en) * 2012-02-10 2017-08-03 The Board Of Regents Of The University Of Texas System Modulators of exchange proteins directly activated by cAMP (EPACs)
US9051299B2 (en) 2012-03-29 2015-06-09 Merck Sharp & Dohme Corp. Imidazolyl methyl piperidine T-type calcium channel antagonists
WO2013166037A1 (en) 2012-05-01 2013-11-07 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of eye disorders
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CN103570705B (zh) * 2012-07-18 2017-01-25 中国医学科学院医药生物技术研究所 取代的n‑((1',3'‑杂唑‑4'‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途
WO2014037900A1 (en) 2012-09-07 2014-03-13 Novartis Ag Indole carboxamide derivatives and uses thereof
BR102012024778A2 (pt) * 2012-09-28 2014-08-19 Cristalia Prod Quimicos Farm Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
KR102229478B1 (ko) 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
WO2014079545A1 (en) * 2012-11-20 2014-05-30 Ktb Tumorforschungsgesellschaft Mbh Thioether derivatives as protein kinase inhibitors
EP2733146A1 (en) * 2012-11-20 2014-05-21 KTB Tumorforschungsgesellschaft mbH Thioether derivatives as protein kinase inhibitors
US9296755B2 (en) 2013-01-25 2016-03-29 Glaxosmithkline Intellectual Property Development Limited 3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds and their therapeutic applications
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Flap調節劑
WO2014121055A2 (en) * 2013-02-04 2014-08-07 Janssen Pharmaceutica Nv Flap modulators
WO2014152013A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
WO2014151936A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles, their preparation and use
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
ES2700541T3 (es) 2013-03-14 2019-02-18 Univ Columbia Octahidrociclopentapirroles, su preparación y uso
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015039333A1 (en) * 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
ES2806408T3 (es) * 2013-12-20 2021-02-17 Esteve Pharmaceuticals Sa Compuestos piperidínicos con actividad multimodal contra el dolor
WO2015118167A1 (en) 2014-02-10 2015-08-13 Institut Curie Use of mcoln-1 modulators to regulate cell migration
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
DK4036094T3 (da) 2014-04-30 2026-03-23 Univ Columbia Erstattede 4-fenylpiperidiner, deres fremstilling og anvendelse
US20170273922A1 (en) * 2014-10-03 2017-09-28 The Royal Institution For The Advacement Of Learning/Mcgill University Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
CN107108506B (zh) 2014-10-24 2022-06-21 武田药品工业株式会社 杂环化合物
WO2016077793A1 (en) * 2014-11-14 2016-05-19 Children's Hospital Medical Center Sos1 inhibitors for cancer treatment
DK3097102T3 (en) 2015-03-04 2018-01-22 Gilead Sciences Inc TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS
US9737512B2 (en) 2015-03-11 2017-08-22 The Board Of Regents Of The University Of Texas System Methods and compositions for treating chronic pain
LT3319959T (lt) 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
EP3356356B1 (en) 2015-10-01 2021-05-26 Firmenich Incorporated Compounds useful as modulators of trpm8
WO2017097182A1 (zh) * 2015-12-07 2017-06-15 成都海创药业有限公司 喹啉类化合物及其制备方法和作为尿酸盐转运体抑制剂类药物的用途
MX391135B (es) 2016-06-24 2025-03-21 Infinity Pharmaceuticals Inc Terapias de combinacion.
MA46093A (fr) 2016-09-02 2021-05-19 Gilead Sciences Inc Composés modulateurs du recepteur de type toll
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
CN106565643A (zh) * 2016-10-31 2017-04-19 北京大学 D‑3‑磷酸甘油酸脱氢酶别构抑制剂及其应用
US10722489B2 (en) * 2016-10-31 2020-07-28 Peking University D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof
ES2909086T3 (es) 2017-01-11 2022-05-05 Alkermes Inc Inhibidores bicíclicos de histona desacetilasa
CN106822897B (zh) * 2017-02-17 2018-10-19 河北盛华尔生物医疗科技有限公司 靶向下调trpm7基因表达在提高肺鳞癌化疗敏感性方面的应用
BR112019020252A2 (pt) * 2017-03-31 2020-04-22 Perenna Pharmaceuticals Inc compostos úteis como inibidores de alcat 1
WO2018232160A1 (en) * 2017-06-15 2018-12-20 Belite Bio, Inc Methods of treating metabolic diseases with phenoxyethylamides
EP3638239A4 (en) 2017-06-15 2021-03-10 Belite Bio, Inc METHOD OF TREATMENT OF RBP4-RELATED DISEASES WITH TRIAZOLOPYRIDINES
WO2018232154A1 (en) 2017-06-15 2018-12-20 Belite Bio, Inc Methods of treating metabolic diseases with fused bicyclic pyrazoles
SG11202000970WA (en) 2017-08-07 2020-02-27 Rodin Therapeutics Inc Bicyclic inhibitors of histone deacetylase
PY19106549A (es) * 2018-12-21 2021-07-13 Bayer Ag 1,3,4-oxadiazoles y derivados de éstos como nuevos agentes fungicidas
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
KR20220061093A (ko) 2019-07-08 2022-05-12 벨라이트 바이오 엘엘씨 Rbp4 억제제의 제제 및 사용 방법
AU2020417293A1 (en) 2020-01-03 2022-09-01 Berg Llc Polycyclic amides as UBE2K modulators for treating cancer
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
BR112023000047A2 (pt) 2020-07-02 2023-03-14 Incyte Corp Compostos de ureia tricíclicos como inibidores da v617f da jak2
WO2022006456A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic pyridone compounds as jak2 v617f inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
EP4255893A4 (en) * 2020-12-04 2025-04-23 The Johns Hopkins University COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEUROPATHIC PAIN
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
WO2022148781A1 (en) 2021-01-05 2022-07-14 Institut Curie Combination of mcoln activators and immune checkpoint inhibitors
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
KR102905373B1 (ko) * 2021-04-08 2025-12-29 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 싸이오카보닐 화합물 및 이를 포함하는 약제학적 조성물
CN114685371A (zh) * 2022-03-08 2022-07-01 四川大学 吡唑甲酰胺衍生物及其制备方法和用途
KR20240163688A (ko) 2022-03-17 2024-11-19 인사이트 코포레이션 Jak2 v617f 억제제로서의 삼환계 우레아 화합물
WO2024059524A1 (en) * 2022-09-12 2024-03-21 Hotspot Therapeutics, Inc. Pyrazolylcarboxamide compounds and their use in therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1951499A (en) * 1998-01-06 1999-07-26 General Hospital Corporation, The Use of mek1 inhibitors as protective agents against damage due to ischemia
WO2002008217A2 (en) * 2000-07-21 2002-01-31 Chugai Seiyaku Kabushiki Kaisha COUMARIN DERIVATIVES USEFUL AS TNFα INHIBITORS
ATE388143T1 (de) * 2001-04-24 2008-03-15 Aryx Therapeutics Cumarin derivate und ihre verwendung als anticoagulantien
EP1735296B1 (en) * 2004-04-08 2009-12-09 Aryx Therapeutics Materials and methods for treating coagulation disorders
US20090253782A1 (en) * 2006-07-18 2009-10-08 Ratan Rajiv R Compounds for Enhancing Arginase Activity and Methods of USe Thereof
KR100821683B1 (ko) * 2006-11-01 2008-04-15 우석대학교 산학협력단 이카리사이드 Ⅱ (icariside Ⅱ)를 유효성분으로 하는 혈관 형성 장애 관련 질환의 예방 및 치료용 조성물
AU2008229383B2 (en) * 2007-03-20 2013-09-05 Celgene Corporation 4'-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
AU2010327936B2 (en) * 2009-12-11 2015-08-20 Nono Inc. Agents and methods for treating ischemic and other diseases

Similar Documents

Publication Publication Date Title
JP2011518833A5 (enExample)
JP2012533546A5 (enExample)
JP2014506907A5 (enExample)
JP2013537203A5 (enExample)
WO2009142571A8 (en) Phenyl and benzodioxinyl substituted indazoles derivatives
JP2011105738A5 (enExample)
JP2013508347A5 (enExample)
JP2012255026A5 (enExample)
IL233677A (en) Benzysacazole Compounds Aminopyrazolo-Primidine Converted, Pharmaceuticals Containing Them, and Use of Drug Manufacturing Composition
JP2015143283A5 (enExample)
IL205202A0 (en) Tropane compounds
JP2016040288A5 (enExample)
JP2015512931A5 (enExample)
JP2012041349A5 (enExample)
JP2015504081A5 (enExample)
JP2014513051A5 (enExample)
JP2014534981A5 (enExample)
ATE547417T1 (de) Dihydropyrimidinverbindungen und ihre verwendungen bei der herstellung von medikamenten zur behandlung und prävention antiviraler krankheiten
JP2011527299A5 (enExample)
JP2013533253A5 (enExample)
MY183111A (en) 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
WO2013061004A8 (fr) Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines
WO2011150190A3 (en) Hcv inhibitor compounds and methods of use thereof
JP2010155827A5 (enExample)
FR2997852B1 (fr) Composition cosmetique contenant un acetate d'un compose d'aminoacide.