EA033446B1 - Гетероциклическое соединение для лечения дегенерации желтого пятна и/или болезни штаргардта - Google Patents
Гетероциклическое соединение для лечения дегенерации желтого пятна и/или болезни штаргардтаInfo
- Publication number
- EA033446B1 EA033446B1 EA201790912A EA201790912A EA033446B1 EA 033446 B1 EA033446 B1 EA 033446B1 EA 201790912 A EA201790912 A EA 201790912A EA 201790912 A EA201790912 A EA 201790912A EA 033446 B1 EA033446 B1 EA 033446B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- stargardt
- disease
- macular degeneration
- heterocyclic compound
- treating macular
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
Abstract
Предложено гетероциклическое соединение формулы (I), обладающее превосходным RBP4-понижающим действием, которое может быть использовано в качестве лекарственного средства, которое представляет собой профилактическое или терапевтическое средство для лечения дегенерации желтого пятна и/или болезни Штаргардта:где каждый символ имеет значения, определенные в описании, или его соль.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014217770 | 2014-10-24 | ||
PCT/JP2015/079782 WO2016063933A1 (ja) | 2014-10-24 | 2015-10-22 | 複素環化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201790912A1 EA201790912A1 (ru) | 2017-09-29 |
EA033446B1 true EA033446B1 (ru) | 2019-10-31 |
Family
ID=55760964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790912A EA033446B1 (ru) | 2014-10-24 | 2015-10-22 | Гетероциклическое соединение для лечения дегенерации желтого пятна и/или болезни штаргардта |
Country Status (37)
Country | Link |
---|---|
US (4) | US10214498B2 (ru) |
EP (2) | EP3210973B1 (ru) |
JP (2) | JP6588027B2 (ru) |
KR (1) | KR102490156B1 (ru) |
CN (2) | CN115197160A (ru) |
AR (1) | AR104342A1 (ru) |
AU (2) | AU2015336480B2 (ru) |
BR (1) | BR112017007138A2 (ru) |
CA (1) | CA2965465C (ru) |
CL (1) | CL2017000944A1 (ru) |
CO (1) | CO2017003699A2 (ru) |
CR (1) | CR20170160A (ru) |
CY (1) | CY1123842T1 (ru) |
DK (1) | DK3210973T3 (ru) |
DO (1) | DOP2017000098A (ru) |
EA (1) | EA033446B1 (ru) |
EC (1) | ECSP17026687A (ru) |
ES (1) | ES2848999T3 (ru) |
HR (1) | HRP20210320T1 (ru) |
HU (1) | HUE053443T2 (ru) |
IL (2) | IL285105B2 (ru) |
LT (1) | LT3210973T (ru) |
MA (2) | MA39688B1 (ru) |
MX (2) | MX2017004629A (ru) |
MY (1) | MY183209A (ru) |
PE (1) | PE20170669A1 (ru) |
PH (1) | PH12017500747A1 (ru) |
PL (1) | PL3210973T3 (ru) |
PT (1) | PT3210973T (ru) |
RS (1) | RS61504B1 (ru) |
SG (1) | SG11201702312UA (ru) |
SI (1) | SI3210973T1 (ru) |
TN (1) | TN2017000097A1 (ru) |
TW (2) | TWI703131B (ru) |
UA (1) | UA121871C2 (ru) |
WO (1) | WO2016063933A1 (ru) |
ZA (1) | ZA201703344B (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY183209A (en) | 2014-10-24 | 2021-02-18 | Takeda Pharmaceuticals Co | Heterocyclic compound |
AU2018240031B2 (en) | 2017-03-20 | 2022-07-14 | President And Fellows Of Harvard College | Compounds and methods for the treatment of parasitic diseases |
CN112512521A (zh) * | 2018-08-01 | 2021-03-16 | 纽约市哥伦比亚大学理事会 | 用于治疗和预防非酒精性脂肪肝疾病和痛风的rbp4拮抗剂 |
CN111690698A (zh) * | 2020-05-19 | 2020-09-22 | 浙江工业大学 | 两步串联流动合成3-(苯并[d][1,3]二氧-5-氨基)丙羟肟酸的方法 |
CN111690695A (zh) * | 2020-05-19 | 2020-09-22 | 浙江工业大学 | 3-苯氨基丙羟肟酸的酶促微流控在线合成方法 |
WO2022256301A1 (en) * | 2021-06-01 | 2022-12-08 | Stargazer Pharmaceuticals, Inc. | Methods and compounds for treating subjects with stargardt disease |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009051244A1 (ja) * | 2007-10-18 | 2009-04-23 | Takeda Pharmaceutical Company Limited | 複素環化合物 |
WO2009145286A1 (ja) * | 2008-05-30 | 2009-12-03 | 武田薬品工業株式会社 | 複素環化合物 |
JP2010540541A (ja) * | 2007-09-27 | 2010-12-24 | リヴィジョン セラピューティクス,インク. | レチノール関連疾患を治療するための方法及び化合物 |
JP2012523461A (ja) * | 2009-04-13 | 2012-10-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | レチノール結合タンパク質4(rbp4)へのレチノールの結合を調節するための組成物および方法 |
JP2012524024A (ja) * | 2009-04-16 | 2012-10-11 | 武田薬品工業株式会社 | (とりわけ)糖尿病の予防または治療に有用なn−アシル−n’−フェニルピペラジンの誘導体 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3625970A (en) | 1968-04-17 | 1971-12-07 | Cutter Lab | 1-(disubstituted phenyl or benzyl)-1h-indazol-3-yloxyacetic acid |
US5239080A (en) | 1989-02-08 | 1993-08-24 | Takeda Chemical Industries, Ltd. | Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents |
EP0440183A1 (en) * | 1990-02-01 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Oxazole compounds, their production and use |
US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
WO1999022735A1 (en) | 1997-10-30 | 1999-05-14 | Merck & Co., Inc. | Somatostatin agonists |
AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
WO2001025228A1 (fr) | 1999-10-07 | 2001-04-12 | Tadeka Chemical Industries, Ltd. | Derives d'amines |
MXPA02004647A (es) | 1999-11-10 | 2002-10-31 | Takeda Chemical Industries Ltd | Compuestos heterociclicos de 5 miembros que contienen nitrogeno. |
GB0020351D0 (en) | 2000-08-17 | 2000-10-04 | Catalyst Biomedica Ltd | Treatment of hyperproliferative diseases |
DE10149568A1 (de) * | 2001-10-08 | 2003-04-24 | Consequence Gmbh | Verfahren zur Sequenzanalyse von Polypeptiden |
WO2003042204A1 (fr) | 2001-10-19 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Derive d'amine |
US20040214788A1 (en) | 2003-03-11 | 2004-10-28 | Raj Madhwa H.G. | Treatment of prostate cancer |
TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
ES2278346T3 (es) | 2003-08-20 | 2007-08-01 | Eli Lilly And Company | Compuestos, procedimientos y formulaciones para suministro oral de un compuesto peptido (glp)-1 del tipo de glucagon o un peptido agonista (glp)-4 del receptor 4 de melacortina (mc4). |
JP4869942B2 (ja) | 2003-12-11 | 2012-02-08 | ベス・イスラエル・ディーコネス・メディカル・センター,インコーポレイテッド | インスリン感受性/抵抗性、糖尿病および肥満におけるrbp4 |
US7838561B2 (en) | 2004-06-14 | 2010-11-23 | Wisconsin Alumni Research Foundation | Method for preventing or treating cardiac hypertrophy |
AU2005262558B8 (en) | 2004-06-23 | 2008-04-10 | Revision Therapeutics, Inc. | Methods and compositions for treating ophthalmic conditions with retinyl derivatives |
JP2008507557A (ja) | 2004-07-22 | 2008-03-13 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 眼疾患の治療法 |
US7947267B2 (en) | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
KR20090029814A (ko) | 2006-06-22 | 2009-03-23 | 시리온 테라퓨틱스, 인크. | 메갈린 활성의 조절을 통한 안질환의 치료 방법 및 조성물 |
AU2008268409B2 (en) | 2007-06-26 | 2013-12-05 | Lexicon Pharmaceuticals, Inc. | Compositions comprising tryptophan hydroxylase inhibitors |
BRPI0813212A2 (pt) | 2007-06-26 | 2014-12-23 | Lexicon Pharmaceuticals Inc | Métodos de tratamento de doenças e distúrbios mediados por serotonina |
US7973079B2 (en) | 2007-09-27 | 2011-07-05 | Revision Therapeutics, Inc. | Methods and compounds for treating retinol-related diseases |
US8541388B2 (en) | 2008-05-22 | 2013-09-24 | Isis Pharmaceuticals, Inc. | Methods for modulating expression of RBP4 |
JP2013509430A (ja) | 2009-10-28 | 2013-03-14 | リヴィジョン セラピューティクス,インク. | レチンアミドによる皮膚癌の予防 |
WO2011072275A2 (en) | 2009-12-11 | 2011-06-16 | Nono, Inc. | Agents and methods for treating ischemic and other diseases |
EP2560966B1 (en) | 2010-03-30 | 2021-01-06 | Verseon International Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
US8980924B2 (en) | 2010-11-24 | 2015-03-17 | The Trustees Of Columbia University In The City Of New York | Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease |
US9556166B2 (en) | 2011-05-12 | 2017-01-31 | Proteostasis Therapeutics, Inc. | Proteostasis regulators |
GB201205679D0 (en) | 2012-03-30 | 2012-05-16 | Dyson Technology Ltd | A hand held appliance |
WO2013166041A1 (en) | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular |
WO2014134127A1 (en) | 2013-02-26 | 2014-09-04 | Northeastern University | Cannabinergic nitrate esters and related analogs |
WO2014160409A1 (en) | 2013-03-14 | 2014-10-02 | The Trustees Of Columbia University In The City Of New York | Rbp4 antagonists for the treatment of age-related macular degeneration and stargardt disease |
WO2014153643A1 (en) | 2013-03-26 | 2014-10-02 | The University Of British Columbia | Compositions and methods for use thereof in the treatment of aniridia |
AU2015226881A1 (en) | 2014-03-07 | 2016-09-29 | Intonation Research Laboratories | Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACs) |
EP3209656B1 (en) | 2014-10-24 | 2020-04-01 | Bristol-Myers Squibb Company | Indole carboxamides compounds useful as kinase inhibitors |
MY183209A (en) * | 2014-10-24 | 2021-02-18 | Takeda Pharmaceuticals Co | Heterocyclic compound |
SG10201903619YA (en) | 2014-10-24 | 2019-05-30 | Bristol Myers Squibb Co | Carbazole derivatives |
US11040976B2 (en) | 2015-04-24 | 2021-06-22 | President And Fellows Of Harvard College | Substrate selective inhibitors of insulin-degrading enzyme (IDE) and uses thereof |
US10189797B2 (en) | 2015-12-30 | 2019-01-29 | Duke University | Chemical modulators of immune checkpoints and therapeutic use |
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2015
- 2015-10-22 MY MYPI2017701205A patent/MY183209A/en unknown
- 2015-10-22 MA MA39688A patent/MA39688B1/fr unknown
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010540541A (ja) * | 2007-09-27 | 2010-12-24 | リヴィジョン セラピューティクス,インク. | レチノール関連疾患を治療するための方法及び化合物 |
WO2009051244A1 (ja) * | 2007-10-18 | 2009-04-23 | Takeda Pharmaceutical Company Limited | 複素環化合物 |
WO2009145286A1 (ja) * | 2008-05-30 | 2009-12-03 | 武田薬品工業株式会社 | 複素環化合物 |
JP2012523461A (ja) * | 2009-04-13 | 2012-10-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | レチノール結合タンパク質4(rbp4)へのレチノールの結合を調節するための組成物および方法 |
JP2012524024A (ja) * | 2009-04-16 | 2012-10-11 | 武田薬品工業株式会社 | (とりわけ)糖尿病の予防または治療に有用なn−アシル−n’−フェニルピペラジンの誘導体 |
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