MA39688B1 - Composés hétéroaryle pour le traitement de maladies ophtalmiques - Google Patents
Composés hétéroaryle pour le traitement de maladies ophtalmiquesInfo
- Publication number
- MA39688B1 MA39688B1 MA39688A MA39688A MA39688B1 MA 39688 B1 MA39688 B1 MA 39688B1 MA 39688 A MA39688 A MA 39688A MA 39688 A MA39688 A MA 39688A MA 39688 B1 MA39688 B1 MA 39688B1
- Authority
- MA
- Morocco
- Prior art keywords
- rbp4
- treatment
- img
- ophthalmic diseases
- heteroaryl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
L'invention porte sur un composé hétérocyclique ayant une action abaissant la rbp4 supérieure et utile comme médicament pour la prophylaxie ou le traitement d'une maladie ou d'un symptôme médié par une augmentation de rbp4 ou de rétinol fourni par rbp4. Composé représenté par la formule (i): <img file="imga0001.Tif" frnum="0001" he="46" id="ia01" img-content="chem" img-format="tif" inline="no" orientation="portrait" pgnum="0001" wi="113"/> dans laquelle chaque symbole est tel que défini dans la description, ou un sel de celui-ci a une action abaissant la rbp4 supérieure, et est utile comme médicament pour la prophylaxie ou le traitement d'une maladie ou d'un symptôme à médiation par une augmentation de rbp4 ou de rétinol fourni par rbp4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014217770 | 2014-10-24 | ||
PCT/JP2015/079782 WO2016063933A1 (fr) | 2014-10-24 | 2015-10-22 | Composé hétérocyclique |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39688A MA39688A (fr) | 2017-08-30 |
MA39688B1 true MA39688B1 (fr) | 2021-02-26 |
Family
ID=55760964
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA053568A MA53568A (fr) | 2014-10-24 | 2015-10-22 | Médicaments pour le traitement de maladies ophtalmiques |
MA39688A MA39688B1 (fr) | 2014-10-24 | 2015-10-22 | Composés hétéroaryle pour le traitement de maladies ophtalmiques |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA053568A MA53568A (fr) | 2014-10-24 | 2015-10-22 | Médicaments pour le traitement de maladies ophtalmiques |
Country Status (37)
Country | Link |
---|---|
US (4) | US10214498B2 (fr) |
EP (2) | EP3848353A1 (fr) |
JP (2) | JP6588027B2 (fr) |
KR (1) | KR102490156B1 (fr) |
CN (2) | CN107108506B (fr) |
AR (1) | AR104342A1 (fr) |
AU (2) | AU2015336480B2 (fr) |
BR (1) | BR112017007138A2 (fr) |
CA (1) | CA2965465C (fr) |
CL (1) | CL2017000944A1 (fr) |
CO (1) | CO2017003699A2 (fr) |
CR (1) | CR20170160A (fr) |
CY (1) | CY1123842T1 (fr) |
DK (1) | DK3210973T3 (fr) |
DO (1) | DOP2017000098A (fr) |
EA (1) | EA033446B1 (fr) |
EC (1) | ECSP17026687A (fr) |
ES (1) | ES2848999T3 (fr) |
HR (1) | HRP20210320T1 (fr) |
HU (1) | HUE053443T2 (fr) |
IL (2) | IL285105B2 (fr) |
LT (1) | LT3210973T (fr) |
MA (2) | MA53568A (fr) |
MX (2) | MX2017004629A (fr) |
MY (1) | MY183209A (fr) |
PE (1) | PE20170669A1 (fr) |
PH (1) | PH12017500747A1 (fr) |
PL (1) | PL3210973T3 (fr) |
PT (1) | PT3210973T (fr) |
RS (1) | RS61504B1 (fr) |
SG (1) | SG11201702312UA (fr) |
SI (1) | SI3210973T1 (fr) |
TN (1) | TN2017000097A1 (fr) |
TW (2) | TWI703131B (fr) |
UA (1) | UA121871C2 (fr) |
WO (1) | WO2016063933A1 (fr) |
ZA (1) | ZA201703344B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3210973T1 (sl) | 2014-10-24 | 2021-04-30 | Takeda Pharmaceutical Company Limited | Heteroarilne spojine za zdravljenje oftalmičnih bolezni |
SG11201908691PA (en) | 2017-03-20 | 2019-10-30 | Broad Inst Inc | Compounds and methods for the treatment of parasitic diseases |
EP3829575A4 (fr) * | 2018-08-01 | 2022-07-20 | The Trustees of Columbia University in the City of New York | Antagonistes de rbp4 pour le traitement et la prévention de la stéatose hépatique non alcoolique et de la goutte |
CN111690698A (zh) * | 2020-05-19 | 2020-09-22 | 浙江工业大学 | 两步串联流动合成3-(苯并[d][1,3]二氧-5-氨基)丙羟肟酸的方法 |
CN111690695A (zh) * | 2020-05-19 | 2020-09-22 | 浙江工业大学 | 3-苯氨基丙羟肟酸的酶促微流控在线合成方法 |
WO2022256301A1 (fr) * | 2021-06-01 | 2022-12-08 | Stargazer Pharmaceuticals, Inc. | Méthodes et composés pour traiter des sujets atteints d'une maladie de stargardt |
CN116286900B (zh) * | 2022-10-28 | 2024-04-26 | 昆明理工大学 | 一种乙酸渗透酶A基因RkAcpa及其应用 |
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AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
CA2386517A1 (fr) | 1999-10-07 | 2001-04-12 | Takeda Chemical Industries, Ltd. | Derives d'amines |
BR0015466A (pt) | 1999-11-10 | 2002-08-06 | Takeda Chemical Industries Ltd | Composto, prodroga, composição farmacêutica, agentes para evitar ou tratar diabetes mellitus, hiperlipidemia e toler ncia à glicose prejudicada, para regular a função do receptor relacionado a retinóide e para melhorar a resistência à insulina e uso de um composto |
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EP3552664A1 (fr) | 2011-05-12 | 2019-10-16 | Proteostasis Therapeutics, Inc. | Régulateurs de proteostasis |
GB201205679D0 (en) | 2012-03-30 | 2012-05-16 | Dyson Technology Ltd | A hand held appliance |
WO2013166041A1 (fr) | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Ligands de la transthyrétine pouvant inhiber l'interaction de rbp4-ttr dépendante du rétinol pour le traitement de la dégénérescence maculaire liée à l'âge, de la maladie de stargardt et d'autres maladies de la rétine caractérisées par une accumulation excessive de lipofuscine |
US9580400B2 (en) | 2013-02-26 | 2017-02-28 | Northeastern University | Cannabinergic nitrate esters and related analogs |
WO2014160409A1 (fr) | 2013-03-14 | 2014-10-02 | The Trustees Of Columbia University In The City Of New York | Antagonistes de rbp4 pour le traitement de la dégénérescence maculaire liée à l'âge et de la maladie de stargardt |
WO2014153643A1 (fr) | 2013-03-26 | 2014-10-02 | The University Of British Columbia | Compositions et procédés d'utilisation associés dans le traitement de l'aniridie |
CA2941716A1 (fr) | 2014-03-07 | 2015-09-11 | The Johns Hopkins University | Inhibiteurs de la demethylase (lsd1) specifique d'une lysine d'histone et d'histones desacetylases (hdac) |
SI3210973T1 (sl) * | 2014-10-24 | 2021-04-30 | Takeda Pharmaceutical Company Limited | Heteroarilne spojine za zdravljenje oftalmičnih bolezni |
CN107074804B (zh) | 2014-10-24 | 2020-02-18 | 百时美施贵宝公司 | 咔唑衍生物 |
SG11201703188QA (en) | 2014-10-24 | 2017-05-30 | Bristol Myers Squibb Co | Indole carboxamides compounds useful as kinase inhibitors |
WO2016172631A2 (fr) | 2015-04-24 | 2016-10-27 | President And Fellows Of Harvard College | Inhibiteurs sélectifs de substrats d'enzyme dégradant l'insuline (ide) et utilisations associées |
US10189797B2 (en) | 2015-12-30 | 2019-01-29 | Duke University | Chemical modulators of immune checkpoints and therapeutic use |
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