JP2013506674A5 - - Google Patents

Info

Publication number

JP2013506674A5

JP2013506674A5 JP2012532199A JP2012532199A JP2013506674A5 JP 2013506674 A5 JP2013506674 A5 JP 2013506674A5 JP 2012532199 A JP2012532199 A JP 2012532199A JP 2012532199 A JP2012532199 A JP 2012532199A JP 2013506674 A5 JP2013506674 A5 JP 2013506674A5

Authority

JP

Japan

Prior art keywords

phenoxy

compound

pharmaceutically acceptable

acceptable salt

imidazol

Prior art date

2010-09-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 17
• 150000003839 salts Chemical class 0.000 claims 12
• -1 4- {2-Butyl-1- [4- (4-chloro-phenoxy) -phenyl] -1H-imidazol-4-yl} -phenoxy Chemical group 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 230000001404 mediated effect Effects 0.000 claims 3
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
• 150000001412 amines Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• PDPNOZPJWZRUJY-AREMUKBSSA-N (2r)-1-[4-[1-[4-(4-chlorophenoxy)phenyl]-2-(ethoxymethyl)imidazol-4-yl]phenoxy]-3-(diethylamino)propan-2-ol Chemical compound CCOCC1=NC(C=2C=CC(OC[C@H](O)CN(CC)CC)=CC=2)=CN1C(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 PDPNOZPJWZRUJY-AREMUKBSSA-N 0.000 claims 1
• FKXWPTYNTDSMRR-XMMPIXPASA-N (2r)-1-[4-[1-[4-(4-chlorophenoxy)phenyl]-2-(ethoxymethyl)imidazol-4-yl]phenoxy]-3-(dimethylamino)propan-2-ol Chemical compound CCOCC1=NC(C=2C=CC(OC[C@H](O)CN(C)C)=CC=2)=CN1C(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 FKXWPTYNTDSMRR-XMMPIXPASA-N 0.000 claims 1
• FKXWPTYNTDSMRR-DEOSSOPVSA-N (2s)-1-[4-[1-[4-(4-chlorophenoxy)phenyl]-2-(ethoxymethyl)imidazol-4-yl]phenoxy]-3-(dimethylamino)propan-2-ol Chemical compound CCOCC1=NC(C=2C=CC(OC[C@@H](O)CN(C)C)=CC=2)=CN1C(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 FKXWPTYNTDSMRR-DEOSSOPVSA-N 0.000 claims 1
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1