JP2011529054A5 - - Google Patents
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- Publication number
- JP2011529054A5 JP2011529054A5 JP2011520095A JP2011520095A JP2011529054A5 JP 2011529054 A5 JP2011529054 A5 JP 2011529054A5 JP 2011520095 A JP2011520095 A JP 2011520095A JP 2011520095 A JP2011520095 A JP 2011520095A JP 2011529054 A5 JP2011529054 A5 JP 2011529054A5
- Authority
- JP
- Japan
- Prior art keywords
- acceptable salt
- methyl
- compound according
- pharmaceutically acceptable
- morpholin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 amino, dimethylamino, fluoro, cyclopropyl Chemical group 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- PQCVYHSKABCYON-UHFFFAOYSA-N 2-oxo-1h-pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1O PQCVYHSKABCYON-UHFFFAOYSA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 0 C*1=CCN=C1 Chemical compound C*1=CCN=C1 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8329408P | 2008-07-24 | 2008-07-24 | |
| US61/083,294 | 2008-07-24 | ||
| US8508208P | 2008-07-31 | 2008-07-31 | |
| US61/085,082 | 2008-07-31 | ||
| US10865908P | 2008-10-27 | 2008-10-27 | |
| US61/108,659 | 2008-10-27 | ||
| PCT/US2009/050640 WO2010011538A1 (en) | 2008-07-24 | 2009-07-15 | Amidophenoxyindazoles useful as inhibitors of c-met |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529054A JP2011529054A (ja) | 2011-12-01 |
| JP2011529054A5 true JP2011529054A5 (enExample) | 2012-03-15 |
| JP5414794B2 JP5414794B2 (ja) | 2014-02-12 |
Family
ID=41010247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520095A Expired - Fee Related JP5414794B2 (ja) | 2008-07-24 | 2009-07-15 | Ｃ−ｍｅｔの阻害剤として有用なアミドフェノキシインダゾール |
Country Status (35)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293897B2 (en) | 2008-10-14 | 2012-10-23 | Ning Xi | Compounds comprising a spiro-ring and methods of use |
| CA2752421C (en) | 2009-03-21 | 2013-08-06 | Ning Xi | Amino ester derivatives, salts thereof and methods of use |
| JP5707518B2 (ja) | 2011-02-28 | 2015-04-30 | カリトル サイエンシズ， エルエルシー | 置換型キノリン化合物及び使用方法 |
| JP5970003B2 (ja) * | 2011-03-04 | 2016-08-17 | ローカス ファーマシューティカルズ インコーポレイテッド | アミノピラジン化合物 |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| CN104334581B (zh) * | 2012-05-09 | 2018-02-02 | 伊莱利利公司 | 抗‑c‑Met抗体 |
| EP2961744B1 (en) * | 2013-02-27 | 2017-06-28 | Array Biopharma, Inc. | Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof |
| CN104140393B (zh) * | 2013-12-10 | 2016-09-21 | 郑州泰基鸿诺医药股份有限公司 | 一种芳环/芳杂环叔丁醇酯类化合物的制备方法 |
| US20150299219A1 (en) | 2014-04-22 | 2015-10-22 | Calitor Sciences, Llc | Bicyclic pyrazolone compounds and methods of use |
| TW201716085A (zh) * | 2015-08-12 | 2017-05-16 | 應克隆公司 | 癌症之組合療法 |
| JP2019511541A (ja) | 2016-04-15 | 2019-04-25 | イーライ リリー アンド カンパニー | 結腸直腸癌の処置における使用のためのラムシルマブとメレスチニブとの組み合わせ |
| HRP20250113T1 (hr) | 2016-06-02 | 2025-03-28 | Immunocore Limited | Režim doziranja za gp100-specifični tcr - anti-cd3 scfv fuzijski protein |
| EP3490676A1 (en) * | 2016-07-29 | 2019-06-05 | Eli Lilly and Company | Combination therapy with merestinib and anti-pd-l1 or anti-pd-1 inhibitors for use in the treatment of cancer |
| CN108069938A (zh) * | 2016-11-15 | 2018-05-25 | 中国药科大学 | 2,4-二取代吡啶类化合物及其制备方法和应用 |
| ES2866348T3 (es) | 2016-11-16 | 2021-10-19 | Lilly Co Eli | Terapia de combinación para el cáncer con mutación o mutaciones de omisión del exón 14 o fenotipo de omisión del exón 14 |
| WO2018093654A1 (en) | 2016-11-16 | 2018-05-24 | Eli Lilly And Company | Treatment of cancer with exon 14 skipping mutation(s) or exon 14 skipping phenotype |
| CN107311983A (zh) * | 2017-07-06 | 2017-11-03 | 北京万全德众医药生物技术有限公司 | 吲哚类小分子c‑met抑制剂 |
| CN107382968A (zh) * | 2017-07-06 | 2017-11-24 | 北京万全德众医药生物技术有限公司 | 一种吲哚类c‑Met抑制剂的制备方法 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| EP3480201A1 (en) | 2017-11-06 | 2019-05-08 | Oncostellae, S.L. | New analogs as androgen receptor and glucocorticoid receptor modulators |
| US11623923B2 (en) | 2017-11-24 | 2023-04-11 | Medshine Discovery, Inc. | Uracil compound as c-MET/AXL inhibitor |
| EP3741752A4 (en) * | 2018-01-17 | 2021-05-26 | Nanjing Transthera Biosciences Co., Ltd. | Tam family kinase /and csf1r kinase inhibitor and use thereof |
| EP3762392B1 (en) | 2018-03-08 | 2024-05-15 | Wellmarker Bio Co., Ltd. | Thienopyridine derivatives and pharmaceutical composition comprising same |
| JP2021536436A (ja) * | 2018-08-24 | 2021-12-27 | 南京薬捷安康生物科技有限公司Nanjing Transthera Biosciences Co., Ltd. | キノリン誘導体から調製される新規な阻害剤 |
| CN112739691B (zh) * | 2018-09-03 | 2023-05-23 | 泰励生物科技（上海）有限公司 | 用作抗癌药的trk抑制剂 |
| CN112771053A (zh) | 2019-09-06 | 2021-05-07 | 伟迈可生物有限公司 | 基于生物标志物的治疗组合物 |
| WO2022270881A1 (ko) * | 2021-06-22 | 2022-12-29 | 주식회사 엘지화학 | 단백질 키나아제 억제제로서의 신규한 화합물 |
| WO2023110936A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Reversible macrocyclic kinase inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
| US5484681A (en) * | 1994-10-31 | 1996-01-16 | Xerox Corporation | Conductive composite particles and processes for the preparation thereof |
| IL114149A0 (en) * | 1995-06-14 | 1995-10-31 | Yeda Res & Dev | Modified avidin and streptavidin molecules and use thereof |
| US5747577A (en) * | 1995-12-27 | 1998-05-05 | Xerox Corporation | Conductive particles containing carbon black and processes for the preparation thereof |
| DE10046029A1 (de) | 2000-09-18 | 2002-03-28 | Bayer Ag | Indazole |
| EP1400808B1 (en) * | 2001-05-18 | 2006-06-28 | Srl, Inc. | Immunoassay method |
| US6956084B2 (en) * | 2001-10-04 | 2005-10-18 | Bridgestone Corporation | Nano-particle preparation and applications |
| JP2004067703A (ja) * | 2002-04-24 | 2004-03-04 | Japan Science & Technology Corp | 架橋ポリマー、微粒子および製造方法 |
| US7192780B2 (en) * | 2002-10-23 | 2007-03-20 | Evident Technologies | Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals |
| WO2004039796A1 (de) | 2002-10-28 | 2004-05-13 | Bayer Healthcare Ag | Heteroaryloxy-substituierte phenylaminopyrimidine als rho-kinaseinhibitoren |
| CN102746529B (zh) * | 2003-07-17 | 2015-11-18 | 生命科技公司 | 包覆的磁性颗粒的制备方法 |
| US7163998B2 (en) * | 2003-09-09 | 2007-01-16 | Eastman Kodak Company | Stabilized polymer beads and method of preparation |
| US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| ME02736B (me) | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| JP2009529047A (ja) * | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| EP2038320B1 (en) * | 2006-06-29 | 2014-03-12 | Life Technologies AS | Particles containing multi- block polymers |
| PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| NZ575336A (en) | 2006-10-23 | 2012-04-27 | Sgx Pharmaceuticals Inc | Bicyclic triazoles as protein kinase modulators |
| WO2009003084A1 (en) | 2007-06-27 | 2008-12-31 | Arkema Inc. | Process for the manufacture of hydrofluoroolefins |
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2009
- 2009-07-10 TW TW098123519A patent/TWI365185B/zh not_active IP Right Cessation
- 2009-07-12 JO JO2009256A patent/JO2788B1/en active
- 2009-07-13 AR ARP090102636A patent/AR074632A1/es active IP Right Grant
- 2009-07-15 CA CA2731773A patent/CA2731773C/en not_active Expired - Fee Related
- 2009-07-15 NZ NZ590013A patent/NZ590013A/en not_active IP Right Cessation
- 2009-07-15 EP EP09790440A patent/EP2310382B1/en active Active
- 2009-07-15 DK DK09790440.3T patent/DK2310382T3/da active
- 2009-07-15 AT AT09790440T patent/ATE546444T1/de active
- 2009-07-15 KR KR1020117001628A patent/KR101334456B1/ko not_active Expired - Fee Related
- 2009-07-15 AU AU2009274256A patent/AU2009274256B2/en not_active Ceased
- 2009-07-15 HR HR20120202T patent/HRP20120202T1/hr unknown
- 2009-07-15 PL PL09790440T patent/PL2310382T3/pl unknown
- 2009-07-15 PE PE2011000061A patent/PE20110150A1/es active IP Right Grant
- 2009-07-15 US US12/503,223 patent/US8030302B2/en not_active Ceased
- 2009-07-15 PT PT09790440T patent/PT2310382E/pt unknown
- 2009-07-15 RS RS20120176A patent/RS52261B/sr unknown
- 2009-07-15 EA EA201170252A patent/EA018385B1/ru not_active IP Right Cessation
- 2009-07-15 BR BRPI0916286A patent/BRPI0916286B8/pt not_active IP Right Cessation
- 2009-07-15 JP JP2011520095A patent/JP5414794B2/ja not_active Expired - Fee Related
- 2009-07-15 SI SI200930193T patent/SI2310382T1/sl unknown
- 2009-07-15 MX MX2011000925A patent/MX2011000925A/es active IP Right Grant
- 2009-07-15 ES ES09790440T patent/ES2379587T3/es active Active
- 2009-07-15 MY MYPI2011000343A patent/MY163852A/en unknown
- 2009-07-15 WO PCT/US2009/050640 patent/WO2010011538A1/en not_active Ceased
- 2009-07-15 CN CN200980128694.4A patent/CN102105462B/zh not_active Expired - Fee Related
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2011
- 2011-01-06 IL IL210490A patent/IL210490A/en active IP Right Grant
- 2011-01-07 DO DO2011000009A patent/DOP2011000009A/es unknown
- 2011-01-07 ZA ZA2011/00219A patent/ZA201100219B/en unknown
- 2011-01-19 CO CO11005437A patent/CO6351737A2/es not_active Application Discontinuation
- 2011-01-21 CL CL2011000134A patent/CL2011000134A1/es unknown
- 2011-01-21 EC EC2011010778A patent/ECSP11010778A/es unknown
- 2011-01-21 SV SV2011003816A patent/SV2011003816A/es active IP Right Grant
- 2011-01-24 CR CR20110046A patent/CR20110046A/es unknown
- 2011-01-24 MA MA33555A patent/MA32594B1/fr unknown
- 2011-12-08 US US13/374,053 patent/USRE43878E1/en not_active Expired - Fee Related
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2012
- 2012-04-04 CY CY20121100337T patent/CY1112595T1/el unknown