JP2012509263A5 - - Google Patents
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- Publication number
- JP2012509263A5 JP2012509263A5 JP2011536395A JP2011536395A JP2012509263A5 JP 2012509263 A5 JP2012509263 A5 JP 2012509263A5 JP 2011536395 A JP2011536395 A JP 2011536395A JP 2011536395 A JP2011536395 A JP 2011536395A JP 2012509263 A5 JP2012509263 A5 JP 2012509263A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- trifluoromethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- -1 cyano, chloro, methyl Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11533208P | 2008-11-17 | 2008-11-17 | |
| US61/115,332 | 2008-11-17 | ||
| PCT/US2009/063370 WO2010056588A1 (en) | 2008-11-17 | 2009-11-05 | Tetrasubstituted pyridazine hedgehog pathway antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509263A JP2012509263A (ja) | 2012-04-19 |
| JP2012509263A5 true JP2012509263A5 (enExample) | 2012-12-13 |
| JP5518887B2 JP5518887B2 (ja) | 2014-06-11 |
Family
ID=41722877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536395A Expired - Fee Related JP5518887B2 (ja) | 2008-11-17 | 2009-11-05 | 四置換ピリダジンヘッジホッグ経路アンタゴニスト |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8507490B2 (enExample) |
| EP (1) | EP2358698B1 (enExample) |
| JP (1) | JP5518887B2 (enExample) |
| KR (1) | KR101342184B1 (enExample) |
| CN (1) | CN102216285B (enExample) |
| AU (1) | AU2009314349B2 (enExample) |
| BR (1) | BRPI0921782A2 (enExample) |
| CA (1) | CA2743483C (enExample) |
| CY (1) | CY1113377T1 (enExample) |
| DK (1) | DK2358698T3 (enExample) |
| EA (1) | EA017386B1 (enExample) |
| ES (1) | ES2392759T3 (enExample) |
| HR (1) | HRP20120762T1 (enExample) |
| MX (1) | MX2011005177A (enExample) |
| PL (1) | PL2358698T3 (enExample) |
| PT (1) | PT2358698E (enExample) |
| SI (1) | SI2358698T1 (enExample) |
| WO (1) | WO2010056588A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200817354A (en) * | 2006-07-17 | 2008-04-16 | Syngenta Participations Ag | Novel pyridazine derivatives |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| MX2011004683A (es) | 2008-11-03 | 2011-06-20 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida. |
| BRPI0921777A2 (pt) | 2008-11-17 | 2016-01-12 | Lilly Co Eli | antagonistas da via hedgehog de piridazina tetrassubstituída |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
| GB2528298A (en) * | 2014-07-16 | 2016-01-20 | Redx Pharma Plc | Compounds |
| CN105130980B (zh) * | 2015-09-09 | 2018-05-22 | 沈阳药科大学 | N-3-苯并咪唑噻唑胺类衍生物及其制备方法与应用 |
| CN107163028B (zh) * | 2017-05-24 | 2019-07-12 | 东南大学 | 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用 |
| CN110208424A (zh) * | 2019-06-28 | 2019-09-06 | 江苏恒生检测有限公司 | 一种农药氟啶虫酰胺中含有杂质的分析方法 |
| WO2021071981A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
| US12605377B2 (en) | 2020-10-13 | 2026-04-21 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| JP2023546536A (ja) | 2020-10-13 | 2023-11-02 | エンデバー バイオメディシンズ， インコーポレイテッド | 線維症を処置する方法 |
| WO2023034836A1 (en) * | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| MY117098A (en) | 1996-01-15 | 2004-05-31 | Janssen Pharmaceutica Nv | Angiogenesis inhibiting pyridazinamines |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP5067986B2 (ja) | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| ATE283700T1 (de) | 1999-06-08 | 2004-12-15 | Lorantis Ltd | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
| EP1496905B1 (en) | 2002-04-22 | 2008-08-13 | Johns Hopkins University School of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| TW200533356A (en) | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| WO2006004589A2 (en) | 2004-05-08 | 2006-01-12 | Neurogen Corporation | 3-aryl-5,6-disubstituted pyridazines |
| ES2377430T3 (es) | 2004-09-02 | 2012-03-27 | Genentech, Inc. | Inhibidores piridílicos de la señalización de hedgehog |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| CA2681162C (en) | 2007-03-15 | 2015-11-24 | Novartis Ag | Benzyl and pyridine derivatives as modulators of hedgehog pathway |
| US8153633B2 (en) | 2007-06-25 | 2012-04-10 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| US8222251B2 (en) | 2007-09-07 | 2012-07-17 | Amgen Inc. | Pyridopyridazine compounds, compositions and methods of use |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| MX2011004683A (es) | 2008-11-03 | 2011-06-20 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida. |
| BRPI0921777A2 (pt) | 2008-11-17 | 2016-01-12 | Lilly Co Eli | antagonistas da via hedgehog de piridazina tetrassubstituída |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-11-05 KR KR1020117011148A patent/KR101342184B1/ko not_active Expired - Fee Related
- 2009-11-05 CA CA2743483A patent/CA2743483C/en not_active Expired - Fee Related
- 2009-11-05 EA EA201170699A patent/EA017386B1/ru not_active IP Right Cessation
- 2009-11-05 HR HRP20120762AT patent/HRP20120762T1/hr unknown
- 2009-11-05 DK DK09752059.7T patent/DK2358698T3/da active
- 2009-11-05 PT PT09752059T patent/PT2358698E/pt unknown
- 2009-11-05 JP JP2011536395A patent/JP5518887B2/ja not_active Expired - Fee Related
- 2009-11-05 MX MX2011005177A patent/MX2011005177A/es active IP Right Grant
- 2009-11-05 SI SI200930351T patent/SI2358698T1/sl unknown
- 2009-11-05 ES ES09752059T patent/ES2392759T3/es active Active
- 2009-11-05 US US13/122,216 patent/US8507490B2/en not_active Expired - Fee Related
- 2009-11-05 PL PL09752059T patent/PL2358698T3/pl unknown
- 2009-11-05 CN CN200980145554.8A patent/CN102216285B/zh not_active Expired - Fee Related
- 2009-11-05 WO PCT/US2009/063370 patent/WO2010056588A1/en not_active Ceased
- 2009-11-05 BR BRPI0921782A patent/BRPI0921782A2/pt not_active IP Right Cessation
- 2009-11-05 EP EP09752059A patent/EP2358698B1/en not_active Not-in-force
- 2009-11-05 AU AU2009314349A patent/AU2009314349B2/en not_active Ceased
-
2012
- 2012-10-25 CY CY20121101019T patent/CY1113377T1/el unknown