KR101334456B1 - Ｃ-ｍｅｔ의 억제제로서 유용한 아미도페녹시인다졸 - Google Patents

Ｃ-ｍｅｔ의 억제제로서 유용한 아미도페녹시인다졸 Download PDF

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Publication number
KR101334456B1
KR101334456B1 KR1020117001628A KR20117001628A KR101334456B1 KR 101334456 B1 KR101334456 B1 KR 101334456B1 KR 1020117001628 A KR1020117001628 A KR 1020117001628A KR 20117001628 A KR20117001628 A KR 20117001628A KR 101334456 B1 KR101334456 B1 KR 101334456B1
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South Korea
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mmol
methyl
added
fluoro
etoac
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Korean (ko)
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KR20110022691A (ko
Inventor
티차오 리
마크 앤드류 포반즈
추안 시
지페이 우
웨이 제니퍼 양
보유 종
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020117001628A 2008-07-24 2009-07-15 Ｃ-ｍｅｔ의 억제제로서 유용한 아미도페녹시인다졸 Expired - Fee Related KR101334456B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8329408P 2008-07-24 2008-07-24
US61/083,294 2008-07-24
US8508208P 2008-07-31 2008-07-31
US61/085,082 2008-07-31
US10865908P 2008-10-27 2008-10-27
US61/108,659 2008-10-27
PCT/US2009/050640 WO2010011538A1 (en) 2008-07-24 2009-07-15 Amidophenoxyindazoles useful as inhibitors of c-met

Publications (2)

Publication Number Publication Date
KR20110022691A KR20110022691A (ko) 2011-03-07
KR101334456B1 true KR101334456B1 (ko) 2013-11-29

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KR1020117001628A Expired - Fee Related KR101334456B1 (ko) 2008-07-24 2009-07-15 Ｃ-ｍｅｔ의 억제제로서 유용한 아미도페녹시인다졸

Country Status (35)

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US (2) US8030302B2 (enExample)
EP (1) EP2310382B1 (enExample)
JP (1) JP5414794B2 (enExample)
KR (1) KR101334456B1 (enExample)
CN (1) CN102105462B (enExample)
AR (1) AR074632A1 (enExample)
AT (1) ATE546444T1 (enExample)
AU (1) AU2009274256B2 (enExample)
BR (1) BRPI0916286B8 (enExample)
CA (1) CA2731773C (enExample)
CL (1) CL2011000134A1 (enExample)
CO (1) CO6351737A2 (enExample)
CR (1) CR20110046A (enExample)
CY (1) CY1112595T1 (enExample)
DK (1) DK2310382T3 (enExample)
DO (1) DOP2011000009A (enExample)
EA (1) EA018385B1 (enExample)
EC (1) ECSP11010778A (enExample)
ES (1) ES2379587T3 (enExample)
HR (1) HRP20120202T1 (enExample)
IL (1) IL210490A (enExample)
JO (1) JO2788B1 (enExample)
MA (1) MA32594B1 (enExample)
MX (1) MX2011000925A (enExample)
MY (1) MY163852A (enExample)
NZ (1) NZ590013A (enExample)
PE (1) PE20110150A1 (enExample)
PL (1) PL2310382T3 (enExample)
PT (1) PT2310382E (enExample)
RS (1) RS52261B (enExample)
SI (1) SI2310382T1 (enExample)
SV (1) SV2011003816A (enExample)
TW (1) TWI365185B (enExample)
WO (1) WO2010011538A1 (enExample)
ZA (1) ZA201100219B (enExample)

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WO2010045095A1 (en) 2008-10-14 2010-04-22 Ning Xi Compounds and methods of use
WO2010111063A1 (en) 2009-03-21 2010-09-30 Ning Xi Amino ester derivatives, salts thereof and methods of use
EP2680886B1 (en) 2011-02-28 2016-08-10 Calitor Sciences, LLC Substituted quinoline compounds
JP5970003B2 (ja) * 2011-03-04 2016-08-17 ローカス ファーマシューティカルズ インコーポレイテッド アミノピラジン化合物
KR20130118612A (ko) * 2012-04-20 2013-10-30 (주)네오믹스 신규한 아미노피리딘 유도체 및 이의 용도
JP6129956B2 (ja) * 2012-05-09 2017-05-17 イーライ リリー アンド カンパニー 抗ｃ−Ｍｅｔ抗体
JP6433922B2 (ja) * 2013-02-27 2018-12-05 アレイ バイオファーマ、インコーポレイテッド インダゾール誘導体の調製に使用するための中間体およびその調製方法
CN104140393B (zh) * 2013-12-10 2016-09-21 郑州泰基鸿诺医药股份有限公司 一种芳环/芳杂环叔丁醇酯类化合物的制备方法
US9718841B2 (en) 2014-04-22 2017-08-01 Calitor Sciences, Llc Bicyclic pyrazolone compounds and methods of use
TW201716085A (zh) * 2015-08-12 2017-05-16 應克隆公司 癌症之組合療法
US20190336599A1 (en) * 2016-04-15 2019-11-07 Eli Lilly And Company Combination of ramucirumab and merestinib for use in treatment of colorectal cancer
ES3008636T3 (en) 2016-06-02 2025-03-24 Immunocore Ltd Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein
US20190269666A1 (en) * 2016-07-29 2019-09-05 Eli Lilly And Company Combination therapy with merestinib and anti-pd-l1 or anti-pd-1 inhibitors for use in the treatment of cancer
CN108069938A (zh) * 2016-11-15 2018-05-25 中国药科大学 2,4-二取代吡啶类化合物及其制备方法和应用
JP2019536771A (ja) 2016-11-16 2019-12-19 イーライ リリー アンド カンパニー エクソン１４スキッピング変異またはエクソン１４スキッピング表現型を有する癌の治療
WO2018093669A1 (en) 2016-11-16 2018-05-24 Eli Lilly And Company Combination therapy for cancer with exon 14 skipping mutation(s) or exon 14 skipping phenotype
CN107382968A (zh) * 2017-07-06 2017-11-24 北京万全德众医药生物技术有限公司 一种吲哚类c‑Met抑制剂的制备方法
CN107311983A (zh) * 2017-07-06 2017-11-03 北京万全德众医药生物技术有限公司 吲哚类小分子c‑met抑制剂
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
EP3480201A1 (en) 2017-11-06 2019-05-08 Oncostellae, S.L. New analogs as androgen receptor and glucocorticoid receptor modulators
WO2019101178A1 (zh) 2017-11-24 2019-05-31 南京明德新药研发股份有限公司 作为c-MET/AXL抑制剂的尿嘧啶类化合物
US20210177828A1 (en) * 2018-01-17 2021-06-17 Nanjing Transthera Biosciences Co., Ltd. Tam family kinase /and csf1r kinase inhibitor and use thereof
WO2019182274A1 (en) 2018-03-08 2019-09-26 Wellmarker Bio Co., Ltd. Thienopyridine derivatives and pharmaceutical composition comprising same
WO2020038460A1 (zh) * 2018-08-24 2020-02-27 南京药捷安康生物科技有限公司 一种新型的喹啉衍生物抑制剂
CA3111105A1 (en) * 2018-09-03 2020-03-12 Tyligand Bioscience (Shanghai) Limited Trk inhibitors useful as anticancer drugs
KR20220059386A (ko) 2019-09-06 2022-05-10 웰마커바이오 주식회사 바이오마커 기반 치료용 조성물
CN117355533A (zh) * 2021-06-22 2024-01-05 株式会社Lg化学 作为蛋白激酶抑制剂的新型化合物
WO2023110936A1 (en) 2021-12-14 2023-06-22 Netherlands Translational Research Center Holding B.V Reversible macrocyclic kinase inhibitors

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CO6351737A2 (es) 2011-12-20
ECSP11010778A (es) 2011-02-28
USRE43878E1 (en) 2012-12-25
MA32594B1 (fr) 2011-09-01
AR074632A1 (es) 2011-02-02
KR20110022691A (ko) 2011-03-07
EP2310382B1 (en) 2012-02-22
PE20110150A1 (es) 2011-03-07
TWI365185B (en) 2012-06-01
AU2009274256A1 (en) 2010-01-28
DOP2011000009A (es) 2011-03-31
MX2011000925A (es) 2011-03-21
IL210490A0 (en) 2011-03-31
ATE546444T1 (de) 2012-03-15
DK2310382T3 (da) 2012-03-26
SV2011003816A (es) 2011-03-17
MY163852A (en) 2017-10-31
CL2011000134A1 (es) 2011-07-08
HRP20120202T1 (hr) 2012-03-31
NZ590013A (en) 2012-06-29
CA2731773C (en) 2013-03-12
CA2731773A1 (en) 2010-01-28
EA018385B1 (ru) 2013-07-30
WO2010011538A1 (en) 2010-01-28
EA201170252A1 (ru) 2011-06-30
AU2009274256B2 (en) 2013-07-11
CN102105462B (zh) 2014-07-23
ES2379587T3 (es) 2012-04-27
BRPI0916286B8 (pt) 2021-05-25
PT2310382E (pt) 2012-04-11
IL210490A (en) 2013-06-27
JP5414794B2 (ja) 2014-02-12
SI2310382T1 (sl) 2012-04-30
CY1112595T1 (el) 2016-02-10
CR20110046A (es) 2011-04-27
EP2310382A1 (en) 2011-04-20
US8030302B2 (en) 2011-10-04
CN102105462A (zh) 2011-06-22
TW201006817A (en) 2010-02-16
ZA201100219B (en) 2012-06-27
PL2310382T3 (pl) 2012-07-31
US20100022529A1 (en) 2010-01-28
BRPI0916286B1 (pt) 2019-10-08
RS52261B (sr) 2012-10-31
JO2788B1 (en) 2014-03-15
JP2011529054A (ja) 2011-12-01
HK1155172A1 (en) 2012-05-11

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