CN103874690B - 含酰肼的核运输调节剂及其用途
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含酰肼的核运输调节剂及其用途
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Publication number
CN103874690B
CN103874690B
CN201280047939.2A
CN201280047939A
CN103874690B
CN 103874690 B
CN103874690 B
CN 103874690B
CN 201280047939 A
CN201280047939 A
CN 201280047939A
CN 103874690 B
CN103874690 B
CN 103874690B
Authority
CN
China
Prior art keywords
compound
formula
trifluoromethyl
phenyl
double
Prior art date
2011-07-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280047939.2A
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English (en )
Other versions
CN103874690A
(zh
Inventor
V·P·桑达纳亚卡
S·沙查姆
D·麦考利
S·谢克特尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karyopharm Therapeutics Inc
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Karyopharm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2011-07-29
Filing date
2012-07-26
Publication date
2016-07-06
Priority claimed from US201161513432P
external-priority
2012-07-26
Application filed by Karyopharm Therapeutics Inc
filed
Critical
Karyopharm Therapeutics Inc
2012-07-26
Priority to CN201610414957.XA
priority
Critical
patent/CN106083827B/zh
2012-07-26
Priority to CN201910730981.8A
priority
patent/CN110372672A/zh
2012-07-26
Priority to CN201910734865.3A
priority
patent/CN110372673A/zh
2014-06-18
Publication of CN103874690A
publication
Critical
patent/CN103874690A/zh
2016-07-06
Application granted
granted
Critical
2016-07-06
Publication of CN103874690B
publication
Critical
patent/CN103874690B/zh
Status
Active
legal-status
Critical
Current
2032-07-26
Anticipated expiration
legal-status
Critical
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(2S,3S)-2-[(2S,4R,5R,6R)-4-[(2S,4R,5R,6R)-4-[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-6-[(2S,4R,5S,6R)-4-[(2S,4R,5S,6R)-4,5-dih
Chemical compound
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(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Chemical compound
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(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
Chemical compound
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0.000
description
1
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(5-methylpyridin-2-yl)hydrazine
Chemical compound
CC1=CC=C(NN)N=C1
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0.000
description
1
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(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Chemical compound
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0.000
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1
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(6-chloropyrimidin-4-yl)hydrazine
Chemical compound
NNC1=CC(Cl)=NC=N1
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0.000
description
1
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(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
Chemical compound
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0.000
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(E)-2-hydroxybut-2-enedioic acid
Chemical compound
OC(=O)\C=C(\O)C(O)=O
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description
1
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(E)-3-(2-methoxyphenyl)-2-phenylprop-2-enoic acid
Chemical compound
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(Z)-3-iodoprop-2-enoic acid
Chemical compound
OC(=O)\C=C/I
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1,1'-Bis(diphenylphosphino)ferrocene
Chemical compound
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1,3-butylene glycol
Drugs
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1,4-Butanediol, dimethanesulfonate
Chemical compound
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1-Butyne
Chemical group
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1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
Chemical compound
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC
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1-methyl-1-(3-methylpyridin-2-yl)hydrazine
Chemical compound
CN(N)C1=NC=CC=C1C
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0.000
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1
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1-methyl-1-pyridin-3-ylhydrazine
Chemical compound
CN(N)C1=CC=CN=C1
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1-phosphatidylinositol-3-kinase activity proteins
Human genes
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1-phosphatidylinositol-3-kinase activity proteins
Proteins
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1-pyrroline
Chemical compound
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2,3-dihydroxypropyl formate
Chemical compound
OCC(O)COC=O
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2,6-Lutidine
Chemical class
CC1=CC=CC(C)=N1
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0.000
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2-Methylpentane
Chemical class
CCCC(C)C
AFABGHUZZDYHJO-UHFFFAOYSA-N
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2-Methylpyridine
Chemical compound
CC1=CC=CC=N1
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0.000
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2-amino-2-(hydroxymethyl)propane-1,3-diol
Chemical compound
OCC(N)(CO)CO
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2-bromopyridine
Chemical compound
BrC1=CC=CC=N1
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0.000
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2-chloropyrazine
Chemical compound
ClC1=CN=CC=N1
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0.000
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1
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2-chloroquinoxaline
Chemical compound
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2-hydroxybenzothiazole
Chemical compound
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229940080296
2-naphthalenesulfonate
Drugs
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2-phenoxybenzoic acid
Chemical compound
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2-propynyl group
Chemical group
[H]C#CC([H])([H])*
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2qpq
Chemical compound
[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O
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3-(dimethylamino)propanenitrile
Chemical compound
CN(C)CCC#N
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0.000
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1
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3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride
Chemical compound
Cl.CCN=C=NCCCN(C)C
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0.000
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3-[13-[1-[1-[8,12-bis(2-carboxyethyl)-17-(1-hydroxyethyl)-3,7,13,18-tetramethyl-21,24-dihydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-8-(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid
Chemical compound
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3-fluoro-5-(trifluoromethyl)benzonitrile
Chemical compound
FC1=CC(C#N)=CC(C(F)(F)F)=C1
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4-Hydroxybenzoic acid
Chemical compound
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4-[5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1,3-dihydrobenzimidazol-2-ylidene]cyclohexa-2,5-dien-1-one
Chemical compound
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4-aminofolic acid
Chemical compound
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5'-Guanidinonaltrindole
Chemical compound
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5-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazole
Chemical class
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5-flurouricil
Chemical compound
FC1=CNC(=O)NC1=O
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6-azauridine
Chemical compound
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Human genes
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AMRUBICIN
Chemical compound
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Human genes
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Actinomycin D
Chemical compound
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Altretamine
Chemical compound
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Alvocidib
Chemical compound
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Amsacrine
Chemical compound
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Chemical compound
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Atrasentan
Chemical compound
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Belotecan
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Belustine
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Bendamustine
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Betamethasone
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Bosutinib
Chemical compound
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Idarubicin hydrochloride
Chemical compound
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Ifosfamide
Chemical compound
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Imatinib
Chemical compound
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Intaxel
Chemical compound
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Chemical compound
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Irinotecan
Chemical compound
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Irofulven
Chemical compound
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Isoflurane
Chemical compound
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Isoxazole
Chemical compound
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L-methotrexate
Chemical compound
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Lactobionic acid
Chemical compound
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Lapatinib
Chemical compound
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Lenalidomide
Chemical compound
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Lonidamine
Chemical compound
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Malic acid
Chemical compound
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Mannomustine
Chemical compound
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Masoprocol
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Masoprocol
Chemical compound
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MeCN acetonitrile
Chemical compound
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MeOH methanol
Chemical compound
OC.OC
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Melphalan
Chemical compound
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Mercaptopurine
Chemical compound
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Meta-Chloroperoxybenzoic acid
Chemical compound
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Methyl iodide
Chemical compound
IC
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Methylmagnesium chloride
Chemical compound
C[Mg]Cl
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Mitobronitol
Chemical compound
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Mitoxantrone
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Mitoxantrone
Chemical compound
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Mytomycin
Chemical compound
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N-methyl-N-phenacylnitrous amide
Chemical compound
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Chemical compound
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Chemical compound
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Nicotinamide adenine dinucleotide
Chemical compound
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Nicotinamide adenine dinucleotide phosphate
Chemical compound
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Nilotinib
Chemical compound
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Nimustine
Chemical compound
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Ninhydrin
Chemical compound
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Omacetaxine mepesuccinate
Chemical compound
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P-Toluenesulfonic acid
Chemical compound
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Pemetrexed
Chemical compound
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Penicillin G
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Pentostatin
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239000002924
silencing RNA
Substances
0.000
description
1
238000010898
silica gel chromatography
Methods