JP2015535847A5 - - Google Patents
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- Publication number
- JP2015535847A5 JP2015535847A5 JP2015535162A JP2015535162A JP2015535847A5 JP 2015535847 A5 JP2015535847 A5 JP 2015535847A5 JP 2015535162 A JP2015535162 A JP 2015535162A JP 2015535162 A JP2015535162 A JP 2015535162A JP 2015535847 A5 JP2015535847 A5 JP 2015535847A5
- Authority
- JP
- Japan
- Prior art keywords
- oxocyclohexyl
- chlorophenyl
- amino
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 28
- 125000001931 aliphatic group Chemical group 0.000 claims description 24
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 16
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 16
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000012453 solvate Substances 0.000 claims description 11
- 125000005843 halogen group Chemical group 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 8
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 8
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
- QFFBIIVCZDWTKZ-UHFFFAOYSA-N methyl 5-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]pentanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCCC(=O)OC)CCCCC1=O QFFBIIVCZDWTKZ-UHFFFAOYSA-N 0.000 claims description 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 5
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 5
- OSYLIDUZSLQOIW-UHFFFAOYSA-N ethyl 3-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]propanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCC(=O)OCC)CCCCC1=O OSYLIDUZSLQOIW-UHFFFAOYSA-N 0.000 claims description 5
- FZIHUEMGZWQMJF-UHFFFAOYSA-N ethyl 4-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]butanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCC(=O)OCC)CCCCC1=O FZIHUEMGZWQMJF-UHFFFAOYSA-N 0.000 claims description 5
- KFZMXHQTFSGYLL-UHFFFAOYSA-N ethyl 5-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]pentanoate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCCC(=O)OCC)CCCCC1=O KFZMXHQTFSGYLL-UHFFFAOYSA-N 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- BEMFAESGNZMDAI-UHFFFAOYSA-N 3-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]propyl acetate Chemical compound C=1C=CC=C(Cl)C=1C1(NCCCOC(=O)C)CCCCC1=O BEMFAESGNZMDAI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001624 sedative effect Effects 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- GODHIFXMNKQHEI-UHFFFAOYSA-N pentanoic acid;hydrochloride Chemical compound Cl.CCCCC(O)=O GODHIFXMNKQHEI-UHFFFAOYSA-N 0.000 description 2
- AFRWBGJRWRHQOV-UHFFFAOYSA-N ethyl 5-bromopentanoate Chemical compound CCOC(=O)CCCCBr AFRWBGJRWRHQOV-UHFFFAOYSA-N 0.000 description 1
- RUZLIIJDZBWWSA-INIZCTEOSA-N methyl 2-[[(1s)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoate Chemical group COC(=O)C1=CC=CC=C1N[C@@H](C)C1=CC(C)=CN2C(=O)C=C(N3CCOCC3)N=C12 RUZLIIJDZBWWSA-INIZCTEOSA-N 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- -1 rac-Methyl Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ60288512 | 2012-10-08 | ||
| NZ602885 | 2012-10-08 | ||
| NZ61120213 | 2013-05-28 | ||
| NZ611202 | 2013-05-28 | ||
| PCT/IB2013/059191 WO2014057414A1 (en) | 2012-10-08 | 2013-10-08 | Ketamine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018046540A Division JP2018127466A (ja) | 2012-10-08 | 2018-03-14 | ケタミン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535847A JP2015535847A (ja) | 2015-12-17 |
| JP2015535847A5 true JP2015535847A5 (enExample) | 2018-02-15 |
| JP6309957B2 JP6309957B2 (ja) | 2018-04-11 |
Family
ID=50476991
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535162A Expired - Fee Related JP6309957B2 (ja) | 2012-10-08 | 2013-10-08 | ケタミン誘導体 |
| JP2018046540A Pending JP2018127466A (ja) | 2012-10-08 | 2018-03-14 | ケタミン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018046540A Pending JP2018127466A (ja) | 2012-10-08 | 2018-03-14 | ケタミン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20150259277A1 (enExample) |
| EP (1) | EP2903963A4 (enExample) |
| JP (2) | JP6309957B2 (enExample) |
| KR (1) | KR20150065873A (enExample) |
| CN (1) | CN104837810B (enExample) |
| AU (1) | AU2013328280B2 (enExample) |
| BR (1) | BR112015007647A2 (enExample) |
| CA (1) | CA2922340A1 (enExample) |
| EA (1) | EA201590697A1 (enExample) |
| HK (1) | HK1212673A1 (enExample) |
| IN (1) | IN2015DN03854A (enExample) |
| MX (1) | MX2015004362A (enExample) |
| WO (1) | WO2014057414A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6309957B2 (ja) * | 2012-10-08 | 2018-04-11 | オークランド ユニサービシーズ リミティド | ケタミン誘導体 |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| CN107847469A (zh) | 2015-06-27 | 2018-03-27 | 美国神农制药责任有限公司 | 氯胺酮透皮递送系统 |
| US11827606B2 (en) | 2015-11-18 | 2023-11-28 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| US11111210B2 (en) | 2015-11-18 | 2021-09-07 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| CN109311801B (zh) | 2016-03-25 | 2022-07-26 | 美国政府健康及人类服务部 | (2r,6r)-羟基去甲氯胺酮和(2s,6s)-羟基去甲氯胺酮的晶型和合成方法 |
| JP7167168B2 (ja) | 2018-01-10 | 2022-11-08 | エックスダブリューファルマ リミテッド | ケタミンのプロドラッグ、組成物及びそれらの使用 |
| WO2019186357A1 (en) * | 2018-03-26 | 2019-10-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| CN112424157B (zh) * | 2018-06-04 | 2024-02-20 | 美国政府健康及人类服务部 | 用于合成和纯化(2r,6r)-羟基去甲氯胺酮的方法 |
| CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种氯胺酮、其衍生物或其盐的消旋化方法 |
| DE102021105268A1 (de) * | 2021-03-04 | 2022-09-08 | Lts Lohmann Therapie-Systeme Ag. | Oraler Dünnfilm |
| AU2022326513B9 (en) | 2021-08-13 | 2025-10-23 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
| CN115677444A (zh) * | 2022-10-26 | 2023-02-03 | 公安部第三研究所 | 同位素毒品代谢物标记化合物及其制备方法、用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254124A (en) * | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
| GB1134146A (en) * | 1967-09-15 | 1968-11-20 | Parke Davis & Co | New organic amines and methods for their production |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5466700A (en) | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5866591A (en) | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| CN1441790A (zh) * | 2000-01-28 | 2003-09-10 | 罗姆和哈斯公司 | 增强性质的药物 |
| US20040248963A1 (en) | 2001-11-23 | 2004-12-09 | Bueno Melendo Ana Belen | Prodrugs of excitatory amino acids |
| ATE492565T1 (de) | 2002-01-31 | 2011-01-15 | Randox Lab Ltd | Immunogene, antikörper und konjugate für ketamin und dessen metaboliten |
| JP2006510618A (ja) * | 2002-11-18 | 2006-03-30 | ヤウポン セラピューティクス，インコーポレーテッド | ノルケタミンおよびケタミン／ノルケタミンプロドラッグの鎮痛的使用 |
| CN101309667A (zh) * | 2005-09-28 | 2008-11-19 | 奥里斯医学股份有限公司 | 治疗内耳疾病的药用合成物 |
| BRPI0809843A2 (pt) | 2007-04-26 | 2014-09-23 | Auspex Pharmaceuticals Inc | "composto, composição farmacêutica e uso de um composto" |
| EP2766339B1 (en) | 2011-10-14 | 2021-06-09 | The United States Of America, as represented by the Secretary, Department of Health & Human Services | The use of (2r, 6r)-hydroxynorketamine and other stereoisomeric hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain |
| JP6309957B2 (ja) * | 2012-10-08 | 2018-04-11 | オークランド ユニサービシーズ リミティド | ケタミン誘導体 |
-
2013
- 2013-10-08 JP JP2015535162A patent/JP6309957B2/ja not_active Expired - Fee Related
- 2013-10-08 WO PCT/IB2013/059191 patent/WO2014057414A1/en not_active Ceased
- 2013-10-08 IN IN3854DEN2015 patent/IN2015DN03854A/en unknown
- 2013-10-08 US US14/433,957 patent/US20150259277A1/en not_active Abandoned
- 2013-10-08 BR BR112015007647A patent/BR112015007647A2/pt not_active Application Discontinuation
- 2013-10-08 CN CN201380061537.2A patent/CN104837810B/zh not_active Expired - Fee Related
- 2013-10-08 EP EP13846133.0A patent/EP2903963A4/en not_active Withdrawn
- 2013-10-08 EA EA201590697A patent/EA201590697A1/ru unknown
- 2013-10-08 KR KR1020157012009A patent/KR20150065873A/ko not_active Ceased
- 2013-10-08 AU AU2013328280A patent/AU2013328280B2/en not_active Ceased
- 2013-10-08 CA CA2922340A patent/CA2922340A1/en not_active Abandoned
- 2013-10-08 MX MX2015004362A patent/MX2015004362A/es unknown
- 2013-10-08 HK HK16100661.0A patent/HK1212673A1/zh unknown
-
2017
- 2017-03-20 US US15/463,532 patent/US10239825B2/en not_active Expired - Fee Related
-
2018
- 2018-03-14 JP JP2018046540A patent/JP2018127466A/ja active Pending
-
2019
- 2019-02-06 US US16/269,015 patent/US20190169113A1/en not_active Abandoned