HK1212673A1 - 氯胺酮衍生物 - Google Patents
氯胺酮衍生物 Download PDFInfo
- Publication number
- HK1212673A1 HK1212673A1 HK16100661.0A HK16100661A HK1212673A1 HK 1212673 A1 HK1212673 A1 HK 1212673A1 HK 16100661 A HK16100661 A HK 16100661A HK 1212673 A1 HK1212673 A1 HK 1212673A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyl
- compound
- chlorophenyl
- oxocyclohexyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ60288512 | 2012-10-08 | ||
| NZ602885 | 2012-10-08 | ||
| NZ61120213 | 2013-05-28 | ||
| NZ611202 | 2013-05-28 | ||
| PCT/IB2013/059191 WO2014057414A1 (en) | 2012-10-08 | 2013-10-08 | Ketamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1212673A1 true HK1212673A1 (zh) | 2016-06-17 |
Family
ID=50476991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16100661.0A HK1212673A1 (zh) | 2012-10-08 | 2013-10-08 | 氯胺酮衍生物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20150259277A1 (enExample) |
| EP (1) | EP2903963A4 (enExample) |
| JP (2) | JP6309957B2 (enExample) |
| KR (1) | KR20150065873A (enExample) |
| CN (1) | CN104837810B (enExample) |
| AU (1) | AU2013328280B2 (enExample) |
| BR (1) | BR112015007647A2 (enExample) |
| CA (1) | CA2922340A1 (enExample) |
| EA (1) | EA201590697A1 (enExample) |
| HK (1) | HK1212673A1 (enExample) |
| IN (1) | IN2015DN03854A (enExample) |
| MX (1) | MX2015004362A (enExample) |
| WO (1) | WO2014057414A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013328280B2 (en) * | 2012-10-08 | 2017-12-21 | Auckland Uniservices Limited | Ketamine derivatives |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| CN107847469A (zh) | 2015-06-27 | 2018-03-27 | 美国神农制药责任有限公司 | 氯胺酮透皮递送系统 |
| US11827606B2 (en) | 2015-11-18 | 2023-11-28 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| WO2017087388A1 (en) * | 2015-11-18 | 2017-05-26 | Mitchell Woods Pharmaceuticals, Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| AU2017238859B2 (en) * | 2016-03-25 | 2021-02-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine |
| CN114805139B (zh) * | 2018-01-10 | 2023-10-20 | 凯瑞康宁生物工程（武汉）有限公司 | 氯胺酮的前药、其组合物和用途 |
| WO2019186357A1 (en) * | 2018-03-26 | 2019-10-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| US11186539B2 (en) | 2018-06-04 | 2021-11-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Process for synthesis and purification of (2R,6R)-hydroxynorketamine |
| CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种氯胺酮、其衍生物或其盐的消旋化方法 |
| EP4168385A4 (en) | 2020-06-17 | 2024-07-17 | Spirify Pharma Inc. | HYDROXYNORKETAMINE ANALOGS, COMPOSITIONS COMPRISING THEM AND METHODS OF USE THEREOF |
| DE102021105268A1 (de) * | 2021-03-04 | 2022-09-08 | Lts Lohmann Therapie-Systeme Ag. | Oraler Dünnfilm |
| TWI844074B (zh) | 2021-08-13 | 2024-06-01 | 凱瑞康寧生技股份有限公司 | 氯胺酮衍生物之醫藥組成物及口服劑型 |
| CN115677444A (zh) * | 2022-10-26 | 2023-02-03 | 公安部第三研究所 | 同位素毒品代谢物标记化合物及其制备方法、用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254124A (en) * | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
| GB1134146A (en) * | 1967-09-15 | 1968-11-20 | Parke Davis & Co | New organic amines and methods for their production |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5466700A (en) | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5866591A (en) | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| JP2004501067A (ja) * | 2000-01-28 | 2004-01-15 | ローム アンド ハース カンパニー | 高められた特性をもつ医薬 |
| US20040248963A1 (en) | 2001-11-23 | 2004-12-09 | Bueno Melendo Ana Belen | Prodrugs of excitatory amino acids |
| DE60335428D1 (de) | 2002-01-31 | 2011-02-03 | Randox Lab Ltd | Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten |
| JP2006510618A (ja) * | 2002-11-18 | 2006-03-30 | ヤウポン セラピューティクス，インコーポレーテッド | ノルケタミンおよびケタミン／ノルケタミンプロドラッグの鎮痛的使用 |
| CA2620374C (en) * | 2005-09-28 | 2012-12-11 | Thomas Meyer | Pharmaceutical compositions for the treatment of inner ear disorders |
| EP2139848A1 (en) | 2007-04-26 | 2010-01-06 | Auspex Pharmaceuticals, Inc. | Deuterium labelled ketamine |
| JP6296985B2 (ja) | 2011-10-14 | 2018-03-20 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | うつ病及び神経障害性疼痛の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミン、（ｓ）−デヒドロノルケタミン及び他の（ｒ，ｓ）−ケタミンの立体異性デヒドロ及びヒドロキシル化代謝生成物の使用 |
| AU2013328280B2 (en) * | 2012-10-08 | 2017-12-21 | Auckland Uniservices Limited | Ketamine derivatives |
-
2013
- 2013-10-08 AU AU2013328280A patent/AU2013328280B2/en not_active Ceased
- 2013-10-08 WO PCT/IB2013/059191 patent/WO2014057414A1/en not_active Ceased
- 2013-10-08 JP JP2015535162A patent/JP6309957B2/ja not_active Expired - Fee Related
- 2013-10-08 EP EP13846133.0A patent/EP2903963A4/en not_active Withdrawn
- 2013-10-08 US US14/433,957 patent/US20150259277A1/en not_active Abandoned
- 2013-10-08 EA EA201590697A patent/EA201590697A1/ru unknown
- 2013-10-08 MX MX2015004362A patent/MX2015004362A/es unknown
- 2013-10-08 CN CN201380061537.2A patent/CN104837810B/zh not_active Expired - Fee Related
- 2013-10-08 IN IN3854DEN2015 patent/IN2015DN03854A/en unknown
- 2013-10-08 CA CA2922340A patent/CA2922340A1/en not_active Abandoned
- 2013-10-08 HK HK16100661.0A patent/HK1212673A1/zh unknown
- 2013-10-08 KR KR1020157012009A patent/KR20150065873A/ko not_active Ceased
- 2013-10-08 BR BR112015007647A patent/BR112015007647A2/pt not_active Application Discontinuation
-
2017
- 2017-03-20 US US15/463,532 patent/US10239825B2/en not_active Expired - Fee Related
-
2018
- 2018-03-14 JP JP2018046540A patent/JP2018127466A/ja active Pending
-
2019
- 2019-02-06 US US16/269,015 patent/US20190169113A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150065873A (ko) | 2015-06-15 |
| CN104837810A (zh) | 2015-08-12 |
| CA2922340A1 (en) | 2014-04-17 |
| AU2013328280B2 (en) | 2017-12-21 |
| AU2013328280A1 (en) | 2015-05-14 |
| IN2015DN03854A (enExample) | 2015-10-02 |
| WO2014057414A1 (en) | 2014-04-17 |
| BR112015007647A2 (pt) | 2017-07-04 |
| US20170190653A1 (en) | 2017-07-06 |
| EP2903963A4 (en) | 2016-05-25 |
| MX2015004362A (es) | 2015-12-08 |
| CN104837810B (zh) | 2019-08-06 |
| US10239825B2 (en) | 2019-03-26 |
| JP2015535847A (ja) | 2015-12-17 |
| EA201590697A1 (ru) | 2015-09-30 |
| JP6309957B2 (ja) | 2018-04-11 |
| JP2018127466A (ja) | 2018-08-16 |
| US20190169113A1 (en) | 2019-06-06 |
| WO2014057414A9 (en) | 2014-12-18 |
| US20150259277A1 (en) | 2015-09-17 |
| EP2903963A1 (en) | 2015-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6309957B2 (ja) | ケタミン誘導体 | |
| CN115190815B (zh) | 芳基环己基胺衍生物及其在精神障碍的治疗中的用途 | |
| CN116472274B (zh) | 氮杂环丁烷基色胺和治疗精神障碍的方法 | |
| JP2013523599A (ja) | 新規なオピオイドのジカルボン酸結合アミノ酸及びペプチドプロドラッグ並びにその用途 | |
| WO2011083304A1 (en) | Prodrugs of opioids and uses thereof | |
| WO2022006186A1 (en) | Phenalkylamines and methods of treating mood disorders | |
| ES2770978T3 (es) | Análogos de morfanos y morfinanos y métodos de uso | |
| BR102012024778A2 (pt) | Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica | |
| TW202409013A (zh) | 用於抑制ｎｌｒｐ３之側氧基吲哚啉基醯胺衍生物及其用途 | |
| CN109071392B (zh) | 苯环衍生物及其制备方法和在医药上的应用 | |
| MXPA03002740A (es) | Uso de aminoacidos para el tratamiento del dolor. | |
| ITFI20100001A1 (it) | Composti ad efficacia sia analgesica che antiperalgesica. | |
| CN114344313A (zh) | 用于预防或治疗神经系统退行性疾病的白桦脂酸衍生物 | |
| CN118496144A (zh) | 蟾蜍色胺衍生物及其在镇痛、抗抑郁药物中的应用 | |
| WO2017066787A1 (en) | Compounds, compositions, and methods of making and using the same | |
| WO2012012139A1 (en) | Synthesis and use of kinase inhibitors | |
| WO2014159501A2 (en) | Processes for preparing tetrahydroisoquinolines | |
| CN119384406A (zh) | 化合物 | |
| NZ619257B2 (en) | Ketamine derivatives | |
| WO2023277116A1 (ja) | アミノシクロヘキサン誘導体及びその医薬用途 | |
| US6172078B1 (en) | Quinolinomorphinane derivatives and medicinal use thereof | |
| ES2282440T3 (es) | Compuestos de 1-arilbut-3-enilamina y 1-arilbut-2-enilamina sustituidos. | |
| CN116023322B (zh) | 一种n-乙酰苯胺类阳离子化合物及其制备方法和应用 | |
| CN104262292A (zh) | 苯乙酸酯化合物及其应用 | |
| WO2018030382A1 (ja) | モルヒナン誘導体 |