HK1212673A1 - 氯胺酮衍生物 - Google Patents
氯胺酮衍生物 Download PDFInfo
- Publication number
- HK1212673A1 HK1212673A1 HK16100661.0A HK16100661A HK1212673A1 HK 1212673 A1 HK1212673 A1 HK 1212673A1 HK 16100661 A HK16100661 A HK 16100661A HK 1212673 A1 HK1212673 A1 HK 1212673A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyl
- compound
- chlorophenyl
- oxocyclohexyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ60288512 | 2012-10-08 | ||
| NZ602885 | 2012-10-08 | ||
| NZ61120213 | 2013-05-28 | ||
| NZ611202 | 2013-05-28 | ||
| PCT/IB2013/059191 WO2014057414A1 (en) | 2012-10-08 | 2013-10-08 | Ketamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1212673A1 true HK1212673A1 (zh) | 2016-06-17 |
Family
ID=50476991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16100661.0A HK1212673A1 (zh) | 2012-10-08 | 2013-10-08 | 氯胺酮衍生物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20150259277A1 (enExample) |
| EP (1) | EP2903963A4 (enExample) |
| JP (2) | JP6309957B2 (enExample) |
| KR (1) | KR20150065873A (enExample) |
| CN (1) | CN104837810B (enExample) |
| AU (1) | AU2013328280B2 (enExample) |
| BR (1) | BR112015007647A2 (enExample) |
| CA (1) | CA2922340A1 (enExample) |
| EA (1) | EA201590697A1 (enExample) |
| HK (1) | HK1212673A1 (enExample) |
| IN (1) | IN2015DN03854A (enExample) |
| MX (1) | MX2015004362A (enExample) |
| WO (1) | WO2014057414A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6309957B2 (ja) * | 2012-10-08 | 2018-04-11 | オークランド ユニサービシーズ リミティド | ケタミン誘導体 |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| CN107847469A (zh) | 2015-06-27 | 2018-03-27 | 美国神农制药责任有限公司 | 氯胺酮透皮递送系统 |
| US11827606B2 (en) | 2015-11-18 | 2023-11-28 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| US11111210B2 (en) | 2015-11-18 | 2021-09-07 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| CN109311801B (zh) | 2016-03-25 | 2022-07-26 | 美国政府健康及人类服务部 | (2r,6r)-羟基去甲氯胺酮和(2s,6s)-羟基去甲氯胺酮的晶型和合成方法 |
| JP7167168B2 (ja) | 2018-01-10 | 2022-11-08 | エックスダブリューファルマ リミテッド | ケタミンのプロドラッグ、組成物及びそれらの使用 |
| WO2019186357A1 (en) * | 2018-03-26 | 2019-10-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| CN112424157B (zh) * | 2018-06-04 | 2024-02-20 | 美国政府健康及人类服务部 | 用于合成和纯化(2r,6r)-羟基去甲氯胺酮的方法 |
| CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种氯胺酮、其衍生物或其盐的消旋化方法 |
| DE102021105268A1 (de) * | 2021-03-04 | 2022-09-08 | Lts Lohmann Therapie-Systeme Ag. | Oraler Dünnfilm |
| AU2022326513B9 (en) | 2021-08-13 | 2025-10-23 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
| CN115677444A (zh) * | 2022-10-26 | 2023-02-03 | 公安部第三研究所 | 同位素毒品代谢物标记化合物及其制备方法、用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254124A (en) * | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
| GB1134146A (en) * | 1967-09-15 | 1968-11-20 | Parke Davis & Co | New organic amines and methods for their production |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5466700A (en) | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5866591A (en) | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| CN1441790A (zh) * | 2000-01-28 | 2003-09-10 | 罗姆和哈斯公司 | 增强性质的药物 |
| US20040248963A1 (en) | 2001-11-23 | 2004-12-09 | Bueno Melendo Ana Belen | Prodrugs of excitatory amino acids |
| ATE492565T1 (de) | 2002-01-31 | 2011-01-15 | Randox Lab Ltd | Immunogene, antikörper und konjugate für ketamin und dessen metaboliten |
| JP2006510618A (ja) * | 2002-11-18 | 2006-03-30 | ヤウポン セラピューティクス，インコーポレーテッド | ノルケタミンおよびケタミン／ノルケタミンプロドラッグの鎮痛的使用 |
| CN101309667A (zh) * | 2005-09-28 | 2008-11-19 | 奥里斯医学股份有限公司 | 治疗内耳疾病的药用合成物 |
| BRPI0809843A2 (pt) | 2007-04-26 | 2014-09-23 | Auspex Pharmaceuticals Inc | "composto, composição farmacêutica e uso de um composto" |
| EP2766339B1 (en) | 2011-10-14 | 2021-06-09 | The United States Of America, as represented by the Secretary, Department of Health & Human Services | The use of (2r, 6r)-hydroxynorketamine and other stereoisomeric hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain |
| JP6309957B2 (ja) * | 2012-10-08 | 2018-04-11 | オークランド ユニサービシーズ リミティド | ケタミン誘導体 |
-
2013
- 2013-10-08 JP JP2015535162A patent/JP6309957B2/ja not_active Expired - Fee Related
- 2013-10-08 WO PCT/IB2013/059191 patent/WO2014057414A1/en not_active Ceased
- 2013-10-08 IN IN3854DEN2015 patent/IN2015DN03854A/en unknown
- 2013-10-08 US US14/433,957 patent/US20150259277A1/en not_active Abandoned
- 2013-10-08 BR BR112015007647A patent/BR112015007647A2/pt not_active Application Discontinuation
- 2013-10-08 CN CN201380061537.2A patent/CN104837810B/zh not_active Expired - Fee Related
- 2013-10-08 EP EP13846133.0A patent/EP2903963A4/en not_active Withdrawn
- 2013-10-08 EA EA201590697A patent/EA201590697A1/ru unknown
- 2013-10-08 KR KR1020157012009A patent/KR20150065873A/ko not_active Ceased
- 2013-10-08 AU AU2013328280A patent/AU2013328280B2/en not_active Ceased
- 2013-10-08 CA CA2922340A patent/CA2922340A1/en not_active Abandoned
- 2013-10-08 MX MX2015004362A patent/MX2015004362A/es unknown
- 2013-10-08 HK HK16100661.0A patent/HK1212673A1/zh unknown
-
2017
- 2017-03-20 US US15/463,532 patent/US10239825B2/en not_active Expired - Fee Related
-
2018
- 2018-03-14 JP JP2018046540A patent/JP2018127466A/ja active Pending
-
2019
- 2019-02-06 US US16/269,015 patent/US20190169113A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2922340A1 (en) | 2014-04-17 |
| US20190169113A1 (en) | 2019-06-06 |
| WO2014057414A9 (en) | 2014-12-18 |
| JP2015535847A (ja) | 2015-12-17 |
| US20150259277A1 (en) | 2015-09-17 |
| AU2013328280B2 (en) | 2017-12-21 |
| IN2015DN03854A (enExample) | 2015-10-02 |
| US20170190653A1 (en) | 2017-07-06 |
| JP2018127466A (ja) | 2018-08-16 |
| US10239825B2 (en) | 2019-03-26 |
| CN104837810B (zh) | 2019-08-06 |
| KR20150065873A (ko) | 2015-06-15 |
| EA201590697A1 (ru) | 2015-09-30 |
| BR112015007647A2 (pt) | 2017-07-04 |
| EP2903963A4 (en) | 2016-05-25 |
| MX2015004362A (es) | 2015-12-08 |
| JP6309957B2 (ja) | 2018-04-11 |
| WO2014057414A1 (en) | 2014-04-17 |
| AU2013328280A1 (en) | 2015-05-14 |
| EP2903963A1 (en) | 2015-08-12 |
| CN104837810A (zh) | 2015-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1212673A1 (zh) | 氯胺酮衍生物 | |
| CN115190815B (zh) | 芳基环己基胺衍生物及其在精神障碍的治疗中的用途 | |
| CN116472274B (zh) | 氮杂环丁烷基色胺和治疗精神障碍的方法 | |
| JP2013523599A (ja) | 新規なオピオイドのジカルボン酸結合アミノ酸及びペプチドプロドラッグ並びにその用途 | |
| WO2011083304A1 (en) | Prodrugs of opioids and uses thereof | |
| WO2022006186A1 (en) | Phenalkylamines and methods of treating mood disorders | |
| ES2770978T3 (es) | Análogos de morfanos y morfinanos y métodos de uso | |
| BR102012024778A2 (pt) | Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica | |
| CN109071392B (zh) | 苯环衍生物及其制备方法和在医药上的应用 | |
| MXPA03002740A (es) | Uso de aminoacidos para el tratamiento del dolor. | |
| ITFI20100001A1 (it) | Composti ad efficacia sia analgesica che antiperalgesica. | |
| CN114344313A (zh) | 用于预防或治疗神经系统退行性疾病的白桦脂酸衍生物 | |
| CN118496144A (zh) | 蟾蜍色胺衍生物及其在镇痛、抗抑郁药物中的应用 | |
| WO2017066787A1 (en) | Compounds, compositions, and methods of making and using the same | |
| WO2014159501A2 (en) | Processes for preparing tetrahydroisoquinolines | |
| CN119384406A (zh) | 化合物 | |
| NZ619257B2 (en) | Ketamine derivatives | |
| WO2023277116A1 (ja) | アミノシクロヘキサン誘導体及びその医薬用途 | |
| EP2588476A1 (en) | Synthesis and use of kinase inhibitors | |
| US6172078B1 (en) | Quinolinomorphinane derivatives and medicinal use thereof | |
| ES2282440T3 (es) | Compuestos de 1-arilbut-3-enilamina y 1-arilbut-2-enilamina sustituidos. | |
| CN116023322B (zh) | 一种n-乙酰苯胺类阳离子化合物及其制备方法和应用 | |
| CN104262292A (zh) | 苯乙酸酯化合物及其应用 | |
| KR20110101488A (ko) | 올란자핀 지나포에이트염 및 이의 용도 | |
| WO2018030382A1 (ja) | モルヒナン誘導体 |