KR20150065873A - 케타민 유도체 - Google Patents

케타민 유도체 Download PDF

Info

Publication number
KR20150065873A
KR20150065873A KR1020157012009A KR20157012009A KR20150065873A KR 20150065873 A KR20150065873 A KR 20150065873A KR 1020157012009 A KR1020157012009 A KR 1020157012009A KR 20157012009 A KR20157012009 A KR 20157012009A KR 20150065873 A KR20150065873 A KR 20150065873A
Authority
KR
South Korea
Prior art keywords
alkyl
chlorophenyl
compound
amino
oxocyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020157012009A
Other languages
English (en)
Korean (ko)
Inventor
제임스 월래스 슬레이
윌리엄 알렉산더 데니
지니 조스
스와날라타 아쿠라티야 가마지
마틴 그레고리 하비
로건 제임스 보스
Original Assignee
오클랜드 유니서비시즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오클랜드 유니서비시즈 리미티드 filed Critical 오클랜드 유니서비시즈 리미티드
Publication of KR20150065873A publication Critical patent/KR20150065873A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
KR1020157012009A 2012-10-08 2013-10-08 케타민 유도체 Ceased KR20150065873A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ602885 2012-10-08
NZ60288512 2012-10-08
NZ61120213 2013-05-28
NZ611202 2013-05-28
PCT/IB2013/059191 WO2014057414A1 (en) 2012-10-08 2013-10-08 Ketamine derivatives

Publications (1)

Publication Number Publication Date
KR20150065873A true KR20150065873A (ko) 2015-06-15

Family

ID=50476991

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157012009A Ceased KR20150065873A (ko) 2012-10-08 2013-10-08 케타민 유도체

Country Status (13)

Country Link
US (3) US20150259277A1 (enExample)
EP (1) EP2903963A4 (enExample)
JP (2) JP6309957B2 (enExample)
KR (1) KR20150065873A (enExample)
CN (1) CN104837810B (enExample)
AU (1) AU2013328280B2 (enExample)
BR (1) BR112015007647A2 (enExample)
CA (1) CA2922340A1 (enExample)
EA (1) EA201590697A1 (enExample)
HK (1) HK1212673A1 (enExample)
IN (1) IN2015DN03854A (enExample)
MX (1) MX2015004362A (enExample)
WO (1) WO2014057414A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201590697A1 (ru) * 2012-10-08 2015-09-30 Окленд Юнисервисиз Лимитед Производные кетамина
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
AU2016288188B2 (en) 2015-06-27 2021-08-05 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
US11827606B2 (en) 2015-11-18 2023-11-28 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
US11111210B2 (en) 2015-11-18 2021-09-07 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
AU2017238859B2 (en) 2016-03-25 2021-02-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
KR20260028033A (ko) 2018-01-10 2026-03-03 엑스더블유파마 리미티드 케타민의 전구약물, 및 이의 조성물 및 용도
WO2019186357A1 (en) * 2018-03-26 2019-10-03 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
CA3102387A1 (en) * 2018-06-04 2019-12-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Process for synthesis and purification of (2r,6r)-hydroxynorketamine
CN112125816A (zh) * 2020-03-17 2020-12-25 国药集团工业有限公司 一种氯胺酮、其衍生物或其盐的消旋化方法
DE102021105268A1 (de) * 2021-03-04 2022-09-08 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
US11690811B2 (en) 2021-08-13 2023-07-04 XWPharma Ltd. Pharmaceutical compositions and oral dosage forms of ketamine derivatives
CN115677444A (zh) * 2022-10-26 2023-02-03 公安部第三研究所 同位素毒品代谢物标记化合物及其制备方法、用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254124A (en) * 1962-06-29 1966-05-31 Parke Davis & Co Aminoketones and methods for their production
GB1134146A (en) * 1967-09-15 1968-11-20 Parke Davis & Co New organic amines and methods for their production
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
JP2004501067A (ja) * 2000-01-28 2004-01-15 ローム　アンド　ハース　カンパニー 高められた特性をもつ医薬
US20040248963A1 (en) 2001-11-23 2004-12-09 Bueno Melendo Ana Belen Prodrugs of excitatory amino acids
ATE492565T1 (de) * 2002-01-31 2011-01-15 Randox Lab Ltd Immunogene, antikörper und konjugate für ketamin und dessen metaboliten
CA2506615A1 (en) * 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs
PT1928405E (pt) * 2005-09-28 2014-10-20 Auris Medical Ag Composições farmacêuticas para o tratamento de distúrbios do ouvido interno
CN101765582A (zh) * 2007-04-26 2010-06-30 奥斯拜客斯制药有限公司 氘标记的氯胺酮
CN104395283A (zh) 2011-10-14 2015-03-04 美国政府健康及人类服务部 (2r,6r)-羟基去甲氯胺酮、(s)-脱氢去甲氯胺酮以及(r,s)-氯胺酮的其他立体异构脱氢和羟基化代谢物在治疗忧郁症和神经性疼痛中的应用
EA201590697A1 (ru) * 2012-10-08 2015-09-30 Окленд Юнисервисиз Лимитед Производные кетамина

Also Published As

Publication number Publication date
WO2014057414A1 (en) 2014-04-17
EP2903963A1 (en) 2015-08-12
CN104837810A (zh) 2015-08-12
US10239825B2 (en) 2019-03-26
AU2013328280A1 (en) 2015-05-14
IN2015DN03854A (enExample) 2015-10-02
CA2922340A1 (en) 2014-04-17
US20190169113A1 (en) 2019-06-06
CN104837810B (zh) 2019-08-06
AU2013328280B2 (en) 2017-12-21
EA201590697A1 (ru) 2015-09-30
WO2014057414A9 (en) 2014-12-18
BR112015007647A2 (pt) 2017-07-04
EP2903963A4 (en) 2016-05-25
HK1212673A1 (zh) 2016-06-17
JP6309957B2 (ja) 2018-04-11
US20170190653A1 (en) 2017-07-06
US20150259277A1 (en) 2015-09-17
JP2018127466A (ja) 2018-08-16
MX2015004362A (es) 2015-12-08
JP2015535847A (ja) 2015-12-17

Similar Documents

Publication Publication Date Title
JP6309957B2 (ja) ケタミン誘導体
DE69425662T2 (de) Als heilmittel nutzbare piperazin verbindungen
JP6041886B2 (ja) オピオイド受容体の調節物質およびそれを含む薬学的組成物
JPH06509561A (ja) 新規中枢神経作用性置換フェニルアザシクロアルカン類
JP5860895B2 (ja) ５−メチル−１−（ナフタレン−２−イル）−１ｈ−ピラゾール誘導体
WO2013147160A1 (ja) 環状アミン誘導体及びその医薬用途
US20110086910A1 (en) Method of treating or preventing pain
JP6949057B2 (ja) 動物及びヒトの抗トリパノソーマならびに抗リーシュマニア薬
CN114344313A (zh) 用于预防或治疗神经系统退行性疾病的白桦脂酸衍生物
ES2421171T3 (es) Inhibidores de reabsorción triples y su uso en métodos
WO2017066787A1 (en) Compounds, compositions, and methods of making and using the same
HUE024560T2 (hu) Pantenil-dokozahexanoát, valamint ennek alkalmazása szív-érrendszeri betegségek kezelésére és megelõzésére
NZ619257B2 (en) Ketamine derivatives
DE60312511T2 (de) Oxophenylcyclohexylpropanolaminderivate, deren herstellung und verwendung in therapeutika
CN116023322B (zh) 一种n-乙酰苯胺类阳离子化合物及其制备方法和应用
US8455550B2 (en) Derivatives of aminocyclobutane or aminocyclobutene, their method of preparation and their use as medical products
JP6531330B2 (ja) 疼痛に関する化合物及び医薬組成物
WO2015046405A1 (ja) 鎮痛剤
JPS6350327B2 (enExample)
JP3681770B2 (ja) 老年性痴呆症又はアルツハイマー病治療剤
US10604476B2 (en) Fluorinated amide derivatives and their uses as therapeutic agents
EP4353713A1 (en) T-type calcium channel blocker
JPS59231057A (ja) カルボン酸アミド化合物およびその誘導体
US20140275060A1 (en) Compounds for the treatment of neurologic disorders
JP4888751B2 (ja) トリフルオロプロピルアミノペンタン誘導体及びその製造方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20150507

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20181005

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20200420

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20200803

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20200420

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I