AU2013328280B2 - Ketamine derivatives - Google Patents

Ketamine derivatives Download PDF

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Publication number
AU2013328280B2
AU2013328280B2 AU2013328280A AU2013328280A AU2013328280B2 AU 2013328280 B2 AU2013328280 B2 AU 2013328280B2 AU 2013328280 A AU2013328280 A AU 2013328280A AU 2013328280 A AU2013328280 A AU 2013328280A AU 2013328280 B2 AU2013328280 B2 AU 2013328280B2
Authority
AU
Australia
Prior art keywords
compound
amino
chlorophenyl
oxocyclohexyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013328280A
Other languages
English (en)
Other versions
AU2013328280A1 (en
Inventor
William Alexander Denny
Swarnalatha Akuratiya Gamage
Martyn Gregory HARVEY
Jiney JOSE
James Wallace SLEIGH
Logan James VOSS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auckland Uniservices Ltd
Original Assignee
Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd
Publication of AU2013328280A1 publication Critical patent/AU2013328280A1/en
Application granted granted Critical
Publication of AU2013328280B2 publication Critical patent/AU2013328280B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
AU2013328280A 2012-10-08 2013-10-08 Ketamine derivatives Ceased AU2013328280B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ60288512 2012-10-08
NZ602885 2012-10-08
NZ61120213 2013-05-28
NZ611202 2013-05-28
PCT/IB2013/059191 WO2014057414A1 (en) 2012-10-08 2013-10-08 Ketamine derivatives

Publications (2)

Publication Number Publication Date
AU2013328280A1 AU2013328280A1 (en) 2015-05-14
AU2013328280B2 true AU2013328280B2 (en) 2017-12-21

Family

ID=50476991

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013328280A Ceased AU2013328280B2 (en) 2012-10-08 2013-10-08 Ketamine derivatives

Country Status (13)

Country Link
US (3) US20150259277A1 (enExample)
EP (1) EP2903963A4 (enExample)
JP (2) JP6309957B2 (enExample)
KR (1) KR20150065873A (enExample)
CN (1) CN104837810B (enExample)
AU (1) AU2013328280B2 (enExample)
BR (1) BR112015007647A2 (enExample)
CA (1) CA2922340A1 (enExample)
EA (1) EA201590697A1 (enExample)
HK (1) HK1212673A1 (enExample)
IN (1) IN2015DN03854A (enExample)
MX (1) MX2015004362A (enExample)
WO (1) WO2014057414A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013328280B2 (en) * 2012-10-08 2017-12-21 Auckland Uniservices Limited Ketamine derivatives
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CN107847469A (zh) 2015-06-27 2018-03-27 美国神农制药责任有限公司 氯胺酮透皮递送系统
US11827606B2 (en) 2015-11-18 2023-11-28 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
WO2017087388A1 (en) * 2015-11-18 2017-05-26 Mitchell Woods Pharmaceuticals, Inc. Phenyl cyclohexanone derivatives and methods of making and using them
AU2017238859B2 (en) * 2016-03-25 2021-02-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
CN114805139B (zh) * 2018-01-10 2023-10-20 凯瑞康宁生物工程（武汉）有限公司 氯胺酮的前药、其组合物和用途
WO2019186357A1 (en) * 2018-03-26 2019-10-03 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
US11186539B2 (en) 2018-06-04 2021-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Process for synthesis and purification of (2R,6R)-hydroxynorketamine
CN112125816A (zh) * 2020-03-17 2020-12-25 国药集团工业有限公司 一种氯胺酮、其衍生物或其盐的消旋化方法
EP4168385A4 (en) 2020-06-17 2024-07-17 Spirify Pharma Inc. HYDROXYNORKETAMINE ANALOGS, COMPOSITIONS COMPRISING THEM AND METHODS OF USE THEREOF
DE102021105268A1 (de) * 2021-03-04 2022-09-08 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
TWI844074B (zh) 2021-08-13 2024-06-01 凱瑞康寧生技股份有限公司 氯胺酮衍生物之醫藥組成物及口服劑型
CN115677444A (zh) * 2022-10-26 2023-02-03 公安部第三研究所 同位素毒品代谢物标记化合物及其制备方法、用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045601A1 (en) * 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254124A (en) * 1962-06-29 1966-05-31 Parke Davis & Co Aminoketones and methods for their production
GB1134146A (en) * 1967-09-15 1968-11-20 Parke Davis & Co New organic amines and methods for their production
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
JP2004501067A (ja) * 2000-01-28 2004-01-15 ローム　アンド　ハース　カンパニー 高められた特性をもつ医薬
US20040248963A1 (en) 2001-11-23 2004-12-09 Bueno Melendo Ana Belen Prodrugs of excitatory amino acids
DE60335428D1 (de) 2002-01-31 2011-02-03 Randox Lab Ltd Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten
CA2620374C (en) * 2005-09-28 2012-12-11 Thomas Meyer Pharmaceutical compositions for the treatment of inner ear disorders
EP2139848A1 (en) 2007-04-26 2010-01-06 Auspex Pharmaceuticals, Inc. Deuterium labelled ketamine
JP6296985B2 (ja) 2011-10-14 2018-03-20 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ うつ病及び神経障害性疼痛の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミン、（ｓ）−デヒドロノルケタミン及び他の（ｒ，ｓ）−ケタミンの立体異性デヒドロ及びヒドロキシル化代謝生成物の使用
AU2013328280B2 (en) * 2012-10-08 2017-12-21 Auckland Uniservices Limited Ketamine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045601A1 (en) * 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs

Also Published As

Publication number Publication date
KR20150065873A (ko) 2015-06-15
CN104837810A (zh) 2015-08-12
HK1212673A1 (zh) 2016-06-17
CA2922340A1 (en) 2014-04-17
AU2013328280A1 (en) 2015-05-14
IN2015DN03854A (enExample) 2015-10-02
WO2014057414A1 (en) 2014-04-17
BR112015007647A2 (pt) 2017-07-04
US20170190653A1 (en) 2017-07-06
EP2903963A4 (en) 2016-05-25
MX2015004362A (es) 2015-12-08
CN104837810B (zh) 2019-08-06
US10239825B2 (en) 2019-03-26
JP2015535847A (ja) 2015-12-17
EA201590697A1 (ru) 2015-09-30
JP6309957B2 (ja) 2018-04-11
JP2018127466A (ja) 2018-08-16
US20190169113A1 (en) 2019-06-06
WO2014057414A9 (en) 2014-12-18
US20150259277A1 (en) 2015-09-17
EP2903963A1 (en) 2015-08-12

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired