CN104837810B - 氯胺酮衍生物 - Google Patents

氯胺酮衍生物 Download PDF

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Publication number
CN104837810B
CN104837810B CN201380061537.2A CN201380061537A CN104837810B CN 104837810 B CN104837810 B CN 104837810B CN 201380061537 A CN201380061537 A CN 201380061537A CN 104837810 B CN104837810 B CN 104837810B
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CN
China
Prior art keywords
alkyl
amino
oxocyclohexyl
halogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380061537.2A
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English (en)
Chinese (zh)
Other versions
CN104837810A (zh
Inventor
J·W·斯莱
W·A·丹尼
J·乔斯
S·A·加米奇
M·G·哈维
L·J·福斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auckland Uniservices Ltd
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Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN104837810A publication Critical patent/CN104837810A/zh
Application granted granted Critical
Publication of CN104837810B publication Critical patent/CN104837810B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
CN201380061537.2A 2012-10-08 2013-10-08 氯胺酮衍生物 Expired - Fee Related CN104837810B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ602885 2012-10-08
NZ60288512 2012-10-08
NZ611202 2013-05-28
NZ61120213 2013-05-28
PCT/IB2013/059191 WO2014057414A1 (en) 2012-10-08 2013-10-08 Ketamine derivatives

Publications (2)

Publication Number Publication Date
CN104837810A CN104837810A (zh) 2015-08-12
CN104837810B true CN104837810B (zh) 2019-08-06

Family

ID=50476991

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380061537.2A Expired - Fee Related CN104837810B (zh) 2012-10-08 2013-10-08 氯胺酮衍生物

Country Status (13)

Country Link
US (3) US20150259277A1 (enExample)
EP (1) EP2903963A4 (enExample)
JP (2) JP6309957B2 (enExample)
KR (1) KR20150065873A (enExample)
CN (1) CN104837810B (enExample)
AU (1) AU2013328280B2 (enExample)
BR (1) BR112015007647A2 (enExample)
CA (1) CA2922340A1 (enExample)
EA (1) EA201590697A1 (enExample)
HK (1) HK1212673A1 (enExample)
IN (1) IN2015DN03854A (enExample)
MX (1) MX2015004362A (enExample)
WO (1) WO2014057414A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1212673A1 (zh) * 2012-10-08 2016-06-17 奥克兰服务有限公司 氯胺酮衍生物
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
US11191734B2 (en) 2015-06-27 2021-12-07 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
US11111210B2 (en) 2015-11-18 2021-09-07 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
US11827606B2 (en) 2015-11-18 2023-11-28 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
CN109311801B (zh) * 2016-03-25 2022-07-26 美国政府健康及人类服务部 (2r,6r)-羟基去甲氯胺酮和(2s,6s)-羟基去甲氯胺酮的晶型和合成方法
RU2756512C1 (ru) * 2018-01-10 2021-10-01 ЭксДабл-ЮФАРМА ЛТД. Пролекарства кетамина, его композиции и применения
EP3761970A4 (en) * 2018-03-26 2022-06-08 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISEASES
EP3802480B1 (en) * 2018-06-04 2023-08-02 The United States of America, as represented by the Secretary, Department of Health and Human Services Process for synthesis and purification of (2r,6r)-hydroxynorketamine
CN112125816A (zh) * 2020-03-17 2020-12-25 国药集团工业有限公司 一种氯胺酮、其衍生物或其盐的消旋化方法
DE102021105268A1 (de) * 2021-03-04 2022-09-08 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
JP7737544B2 (ja) 2021-08-13 2025-09-10 エックスダブリューファーマ リミテッド ケタミン誘導体の医薬組成物及び経口剤形
CN115677444A (zh) * 2022-10-26 2023-02-03 公安部第三研究所 同位素毒品代谢物标记化合物及其制备方法、用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045601A1 (en) * 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254124A (en) * 1962-06-29 1966-05-31 Parke Davis & Co Aminoketones and methods for their production
GB1134146A (en) * 1967-09-15 1968-11-20 Parke Davis & Co New organic amines and methods for their production
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
WO2001054481A2 (en) * 2000-01-28 2001-08-02 Rohm And Haas Company Enhanced propertied pharmaceuticals
US20040248963A1 (en) 2001-11-23 2004-12-09 Bueno Melendo Ana Belen Prodrugs of excitatory amino acids
DE60335428D1 (de) 2002-01-31 2011-02-03 Randox Lab Ltd Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten
EA017264B1 (ru) * 2005-09-28 2012-11-30 Аурис Медикаль Аг Применение композиции арилциклоалкиламида для получения лекарственного препарата для лечения нарушения внутреннего уха
AU2008245662A1 (en) 2007-04-26 2008-11-06 Auspex Pharmaceuticals, Inc. Deuterium labelled ketamine
EP3904332B1 (en) 2011-10-14 2024-12-04 The United States of America, as represented by The Secretary, Department of Health and Human Services The use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain
HK1212673A1 (zh) * 2012-10-08 2016-06-17 奥克兰服务有限公司 氯胺酮衍生物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045601A1 (en) * 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Structure–activity relationships for ketamine esters as short-acting anaesthetics;Jiney Jose et al.;《Bioorganic & Medicinal Chemistry》;20130627;第21卷;第5098-5106页 *

Also Published As

Publication number Publication date
JP2018127466A (ja) 2018-08-16
AU2013328280A1 (en) 2015-05-14
IN2015DN03854A (enExample) 2015-10-02
US10239825B2 (en) 2019-03-26
BR112015007647A2 (pt) 2017-07-04
CN104837810A (zh) 2015-08-12
EP2903963A4 (en) 2016-05-25
JP2015535847A (ja) 2015-12-17
JP6309957B2 (ja) 2018-04-11
MX2015004362A (es) 2015-12-08
US20190169113A1 (en) 2019-06-06
CA2922340A1 (en) 2014-04-17
EP2903963A1 (en) 2015-08-12
KR20150065873A (ko) 2015-06-15
WO2014057414A1 (en) 2014-04-17
EA201590697A1 (ru) 2015-09-30
WO2014057414A9 (en) 2014-12-18
US20170190653A1 (en) 2017-07-06
US20150259277A1 (en) 2015-09-17
HK1212673A1 (zh) 2016-06-17
AU2013328280B2 (en) 2017-12-21

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