FR2829765A1 - Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique - Google Patents

Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique

Info

Publication number
FR2829765A1
FR2829765A1 FR0111952A FR0111952A FR2829765A1 FR 2829765 A1 FR2829765 A1 FR 2829765A1 FR 0111952 A FR0111952 A FR 0111952A FR 0111952 A FR0111952 A FR 0111952A FR 2829765 A1 FR2829765 A1 FR 2829765A1
Authority
FR
France
Prior art keywords
optionally substituted
alkyl
halo
alkoxy
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR0111952A
Other languages
English (en)
Inventor
Gerard Moinet
Jean Claude Correc
Eric Metais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to FR0111952A priority Critical patent/FR2829765A1/fr
Priority to PCT/EP2002/009832 priority patent/WO2003024937A1/fr
Publication of FR2829765A1 publication Critical patent/FR2829765A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Abstract

L'invention concerne des composés de formule générale (I) :dans laquelle R1, R2, R3, R4, R5, A et B sont tels que définis dans la revendication 1.Ces composés sont utilisables dans le traitement des pathologies associées à une hyperglycémie.
FR0111952A 2001-09-14 2001-09-14 Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique Withdrawn FR2829765A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR0111952A FR2829765A1 (fr) 2001-09-14 2001-09-14 Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
PCT/EP2002/009832 WO2003024937A1 (fr) 2001-09-14 2002-09-03 Derives d'acide benzimidazolylalcoxyarylalcanoique et leur utilisation en tant qu'agents antihyperglycemiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0111952A FR2829765A1 (fr) 2001-09-14 2001-09-14 Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique

Publications (1)

Publication Number Publication Date
FR2829765A1 true FR2829765A1 (fr) 2003-03-21

Family

ID=8867319

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0111952A Withdrawn FR2829765A1 (fr) 2001-09-14 2001-09-14 Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique

Country Status (2)

Country Link
FR (1) FR2829765A1 (fr)
WO (1) WO2003024937A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2538784A1 (fr) * 2010-02-25 2013-01-02 Merck Sharp & Dohme Corp. Nouveaux dérivés benzimidazole cycliques utiles comme agents antidiabétiques

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE375350T1 (de) * 2002-02-21 2007-10-15 Lilly Co Eli Modulatoren von peroxisome proliferator- aktivierten rezeptoren
CA2476594C (fr) 2002-03-05 2012-10-09 Transtech Pharma, Inc. Derives de l'azole et derives bicycliques fusionnes de l'azole, agents therapeutiques
WO2004013109A1 (fr) * 2002-08-02 2004-02-12 Sankyo Company, Limited Derive de resorcinol
AU2004253543B2 (en) * 2003-07-01 2009-02-19 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
JPWO2006057448A1 (ja) * 2004-11-26 2008-06-05 武田薬品工業株式会社 アリールアルカン酸誘導体
AU2008291148B2 (en) * 2007-08-27 2011-03-17 F. Hoffmann-La Roche Ag Benzimidazole derivatives used as FXR agonists
EP3924343A1 (fr) 2008-09-26 2021-12-22 Merck Sharp & Dohme Corp. Nouveaux dérivés de benzimidazole cycliques utiles en tant qu agents anti-diabétiques
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
AU2009309007A1 (en) 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
US8580833B2 (en) 2009-09-30 2013-11-12 Transtech Pharma, Inc. Substituted imidazole derivatives and methods of use thereof
HUE033209T2 (hu) 2010-10-06 2017-11-28 Glaxosmithkline Llc PI3 kináz inhibitor hatású benzimidazol-származékok
KR20150075120A (ko) * 2011-02-25 2015-07-02 머크 샤프 앤드 돔 코포레이션 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체
EP2809656A2 (fr) * 2011-12-28 2014-12-10 Allergan, Inc. Dérivés de benzimidazole comme bloqueurs sélectifs de courant sodique persistant
EP2858983B1 (fr) 2012-06-11 2018-04-18 UCB Biopharma SPRL Benzimidazoles modulant le tnf-alpha

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147274A (en) * 1962-05-24 1964-09-01 Dow Chemical Co Anisic acid derivatives of benzimidazoles
DE2641060A1 (de) * 1976-09-11 1978-03-16 Hoechst Ag Beta-lactamverbindungen und verfahren zu ihrer herstellung
WO1996000730A1 (fr) * 1994-06-29 1996-01-11 Smithkline Beecham Corporation Antagonistes du recepteur de la vitronectine
EP0745600A1 (fr) * 1995-06-01 1996-12-04 Sankyo Company Limited Dérivés de Benzimidazole, leur préparation et leur utilisation thérapeutique
WO2000006558A1 (fr) * 1998-07-28 2000-02-10 Merck Patent Gmbh Derives antidiabetiques de piperazine, leurs procedes de preparation et compositions les contenant
WO2000059889A1 (fr) * 1999-04-06 2000-10-12 Sankyo Company, Limited DERIVES D'ACIDE CARBOXYLIQUE α-SUBSTITUES

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147274A (en) * 1962-05-24 1964-09-01 Dow Chemical Co Anisic acid derivatives of benzimidazoles
DE2641060A1 (de) * 1976-09-11 1978-03-16 Hoechst Ag Beta-lactamverbindungen und verfahren zu ihrer herstellung
WO1996000730A1 (fr) * 1994-06-29 1996-01-11 Smithkline Beecham Corporation Antagonistes du recepteur de la vitronectine
EP0745600A1 (fr) * 1995-06-01 1996-12-04 Sankyo Company Limited Dérivés de Benzimidazole, leur préparation et leur utilisation thérapeutique
WO2000006558A1 (fr) * 1998-07-28 2000-02-10 Merck Patent Gmbh Derives antidiabetiques de piperazine, leurs procedes de preparation et compositions les contenant
WO2000059889A1 (fr) * 1999-04-06 2000-10-12 Sankyo Company, Limited DERIVES D'ACIDE CARBOXYLIQUE α-SUBSTITUES
EP1167357A1 (fr) * 1999-04-06 2002-01-02 Sankyo Company, Limited Derives d'acide carboxylique alpha-substitues

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MUSSER J H ET AL: "N-[(Arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotrienes D4 antagonists of novel structure", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 1, 1990, pages 240 - 245, XP000567005 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2538784A1 (fr) * 2010-02-25 2013-01-02 Merck Sharp & Dohme Corp. Nouveaux dérivés benzimidazole cycliques utiles comme agents antidiabétiques
EP2538784A4 (fr) * 2010-02-25 2013-07-10 Merck Sharp & Dohme Nouveaux dérivés benzimidazole cycliques utiles comme agents antidiabétiques
AU2011218830B2 (en) * 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents

Also Published As

Publication number Publication date
WO2003024937A1 (fr) 2003-03-27

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