JP2014504646A5 - - Google Patents
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- Publication number
- JP2014504646A5 JP2014504646A5 JP2013552637A JP2013552637A JP2014504646A5 JP 2014504646 A5 JP2014504646 A5 JP 2014504646A5 JP 2013552637 A JP2013552637 A JP 2013552637A JP 2013552637 A JP2013552637 A JP 2013552637A JP 2014504646 A5 JP2014504646 A5 JP 2014504646A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- isopropoxy
- chloro
- medicament
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- -1 propane-2-sulfonyl Chemical group 0.000 claims 3
- 239000002146 L01XE16 - Crizotinib Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 claims 2
- 229960005061 crizotinib Drugs 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- BPMAKGFLDNAAQC-UHFFFAOYSA-N 6-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-(1-methylpiperidin-4-yl)-5-propan-2-yloxy-3h-isoindol-1-one Chemical compound O=C1C=2C=C(NC=3N=C(NC=4C(=CC=CC=4)S(=O)(=O)C(C)C)C(Cl)=CN=3)C(OC(C)C)=CC=2CN1C1CCN(C)CC1 BPMAKGFLDNAAQC-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- VERWOWGGCGHDQE-UHFFFAOYSA-N ceritinib Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCNCC1 VERWOWGGCGHDQE-UHFFFAOYSA-N 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 0 *c1ccccc1Nc1c(*)c(*)nc(Nc2c(*)cc(*)c(*)c2)n1 Chemical compound *c1ccccc1Nc1c(*)c(*)nc(Nc2c(*)cc(*)c(*)c2)n1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438878P | 2011-02-02 | 2011-02-02 | |
| US61/438,878 | 2011-02-02 | ||
| PCT/US2012/023669 WO2012106540A1 (en) | 2011-02-02 | 2012-02-02 | Methods of using alk inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504646A JP2014504646A (ja) | 2014-02-24 |
| JP2014504646A5 true JP2014504646A5 (enExample) | 2014-07-24 |
| JP5837095B2 JP5837095B2 (ja) | 2015-12-24 |
Family
ID=45582065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552637A Active JP5837095B2 (ja) | 2011-02-02 | 2012-02-02 | Ａｌｋ阻害剤の使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8703787B2 (enExample) |
| EP (1) | EP2670401B1 (enExample) |
| JP (1) | JP5837095B2 (enExample) |
| KR (1) | KR101521861B1 (enExample) |
| CN (1) | CN103458881B (enExample) |
| AU (1) | AU2012212142B2 (enExample) |
| BR (1) | BR112013019643B1 (enExample) |
| CA (1) | CA2824092C (enExample) |
| CY (1) | CY1116662T1 (enExample) |
| DK (1) | DK2670401T3 (enExample) |
| EA (1) | EA023404B1 (enExample) |
| ES (1) | ES2543567T3 (enExample) |
| HR (1) | HRP20150946T1 (enExample) |
| HU (1) | HUE025395T2 (enExample) |
| ME (1) | ME02200B (enExample) |
| MX (1) | MX2013008791A (enExample) |
| PL (1) | PL2670401T3 (enExample) |
| PT (1) | PT2670401E (enExample) |
| RS (1) | RS54189B1 (enExample) |
| SI (1) | SI2670401T1 (enExample) |
| SM (1) | SMT201500300B (enExample) |
| WO (1) | WO2012106540A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102156398B1 (ko) | 2012-11-06 | 2020-09-15 | 상하이 포천 파마슈티컬 씨오 엘티디 | Ａｌｋ 키나아제 억제제 |
| CA2890699A1 (en) * | 2012-11-07 | 2014-05-15 | Novartis Ag | Combination therapy |
| CN104109149B (zh) | 2013-04-22 | 2018-09-28 | 苏州泽璟生物制药有限公司 | 氘代的二氨基嘧啶化合物以及包含该化合物的药物组合物 |
| ITMI20131124A1 (it) * | 2013-07-04 | 2015-01-05 | Univ Milano Bicocca | 2-acilamminotiazoli per il trattamento del cancro |
| EP3019489A4 (en) | 2013-07-11 | 2016-12-28 | Betta Pharmaceuticals Co Ltd | MODULATORS OF TYROSINE KINASE PROTEIN AND METHODS OF USE |
| MX2016002580A (es) * | 2013-08-28 | 2016-10-26 | Novartis Ag | Combinacion de un inhibidor de alk y un inhibidor de cdk para el tratamiento de enfermedades celulares proliferativas. |
| CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| CA2934866A1 (en) * | 2013-12-23 | 2015-07-02 | Novartis Ag | Pharmaceutical combinations |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
| CN104876914B (zh) * | 2014-02-28 | 2017-04-19 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类间变性淋巴瘤激酶抑制剂 |
| JP6622726B2 (ja) * | 2014-06-17 | 2019-12-18 | コリア リサーチ インスティチュート オブ ケミカル テクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃｈｅｍｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ | ピリミジン‐２，４‐ジアミン誘導体及びそれを有効成分として含有する抗癌用医薬組成物 |
| CN105524045B (zh) * | 2014-10-22 | 2020-04-10 | 山东轩竹医药科技有限公司 | 四环类间变性淋巴瘤激酶抑制剂 |
| CN106146525B (zh) * | 2015-04-10 | 2018-11-02 | 山东轩竹医药科技有限公司 | 三并环类间变性淋巴瘤激酶抑制剂 |
| EP3287463A4 (en) | 2015-04-24 | 2018-07-11 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof |
| CN106699743B (zh) | 2015-11-05 | 2020-06-12 | 湖北生物医药产业技术研究院有限公司 | 嘧啶类衍生物及其用途 |
| CN106220608B (zh) * | 2016-07-25 | 2018-11-27 | 安润医药科技（苏州）有限公司 | 二苯氨基嘧啶及三嗪化合物、其药用组合物及用途 |
| CN107698603B (zh) * | 2016-08-09 | 2022-04-08 | 南京红云生物科技有限公司 | 噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用 |
| MX389265B (es) | 2016-08-29 | 2025-03-20 | Univ Michigan Regents | Aminopirimidinas como inhibidores de alk. |
| CN111484484B (zh) * | 2020-04-13 | 2021-11-23 | 沈阳药科大学 | 含芳杂环的2,4-二芳氨基嘧啶衍生物及其制备与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| BRPI0413616B8 (pt) * | 2003-08-15 | 2021-05-25 | Irm Llc | 2,4-pirimidinadiaminas, seus usos, e composição farmacêutica |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| ES2444222T3 (es) | 2006-07-10 | 2014-02-24 | Goji Limited | Preparación de alimentos |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| CN103641816A (zh) * | 2006-12-08 | 2014-03-19 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| CN101616895A (zh) * | 2006-12-08 | 2009-12-30 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| US8592432B2 (en) * | 2008-04-07 | 2013-11-26 | Bei Chen | Compounds and compositions as protein kinase inhibitors |
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2012
- 2012-02-02 US US13/981,046 patent/US8703787B2/en active Active
- 2012-02-02 BR BR112013019643-2A patent/BR112013019643B1/pt active IP Right Grant
- 2012-02-02 EP EP12703670.5A patent/EP2670401B1/en active Active
- 2012-02-02 SI SI201230285T patent/SI2670401T1/sl unknown
- 2012-02-02 PT PT127036705T patent/PT2670401E/pt unknown
- 2012-02-02 DK DK12703670.5T patent/DK2670401T3/en active
- 2012-02-02 HR HRP20150946TT patent/HRP20150946T1/hr unknown
- 2012-02-02 ME MEP-2015-127A patent/ME02200B/me unknown
- 2012-02-02 RS RS20150563A patent/RS54189B1/sr unknown
- 2012-02-02 KR KR1020137023001A patent/KR101521861B1/ko active Active
- 2012-02-02 JP JP2013552637A patent/JP5837095B2/ja active Active
- 2012-02-02 PL PL12703670T patent/PL2670401T3/pl unknown
- 2012-02-02 AU AU2012212142A patent/AU2012212142B2/en active Active
- 2012-02-02 EA EA201391114A patent/EA023404B1/ru not_active IP Right Cessation
- 2012-02-02 CN CN201280007465.9A patent/CN103458881B/zh active Active
- 2012-02-02 MX MX2013008791A patent/MX2013008791A/es unknown
- 2012-02-02 ES ES12703670.5T patent/ES2543567T3/es active Active
- 2012-02-02 HU HUE12703670A patent/HUE025395T2/en unknown
- 2012-02-02 WO PCT/US2012/023669 patent/WO2012106540A1/en not_active Ceased
- 2012-02-02 CA CA2824092A patent/CA2824092C/en active Active
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2015
- 2015-08-28 CY CY20151100758T patent/CY1116662T1/el unknown
- 2015-11-30 SM SM201500300T patent/SMT201500300B/it unknown