JP2010506919A5 - - Google Patents
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- Publication number
- JP2010506919A5 JP2010506919A5 JP2009533350A JP2009533350A JP2010506919A5 JP 2010506919 A5 JP2010506919 A5 JP 2010506919A5 JP 2009533350 A JP2009533350 A JP 2009533350A JP 2009533350 A JP2009533350 A JP 2009533350A JP 2010506919 A5 JP2010506919 A5 JP 2010506919A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- group
- unsubstituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 65
- 229910052736 halogen Inorganic materials 0.000 claims 29
- 150000002367 halogens Chemical class 0.000 claims 26
- 125000001424 substituent group Chemical group 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- -1 alkoxy carbon Chemical compound 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 102100028628 Bombesin receptor subtype-3 Human genes 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 108010063504 bombesin receptor subtype 3 Proteins 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical group C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical group C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical group C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 150000003852 triazoles Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85319306P | 2006-10-20 | 2006-10-20 | |
| US60/853,193 | 2006-10-20 | ||
| PCT/US2007/022087 WO2008051406A2 (en) | 2006-10-20 | 2007-10-16 | Substituted imidazoles as bombesin receptor subtype-3 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506919A JP2010506919A (ja) | 2010-03-04 |
| JP2010506919A5 true JP2010506919A5 (enExample) | 2012-07-12 |
| JP5047299B2 JP5047299B2 (ja) | 2012-10-10 |
Family
ID=39325111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533350A Expired - Fee Related JP5047299B2 (ja) | 2006-10-20 | 2007-10-16 | ボンベシン受容体サブタイプ−３モジュレータとしての置換イミダゾール |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8193228B2 (enExample) |
| EP (1) | EP2091937A2 (enExample) |
| JP (1) | JP5047299B2 (enExample) |
| KR (1) | KR20090064458A (enExample) |
| CN (1) | CN101528730A (enExample) |
| AU (1) | AU2007309570B2 (enExample) |
| BR (1) | BRPI0717976A2 (enExample) |
| CA (1) | CA2666310C (enExample) |
| IL (1) | IL198004A0 (enExample) |
| MX (1) | MX2009004112A (enExample) |
| NO (1) | NO20091957L (enExample) |
| RU (1) | RU2009118935A (enExample) |
| WO (1) | WO2008051406A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010506916A (ja) | 2006-10-20 | 2010-03-04 | メルク エンド カムパニー インコーポレーテッド | ボンベシンレセプターサブタイプ３モジュレーターとしての置換イミダゾール |
| EP2083623A1 (en) | 2006-10-20 | 2009-08-05 | Merck & Co., Inc. | Substituted imidazoles as bombesin receptor subtype-3 modulators |
| WO2009123164A1 (ja) * | 2008-04-02 | 2009-10-08 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013135674A1 (en) * | 2012-03-12 | 2013-09-19 | Syngenta Participations Ag | Insecticidal 2-aryl-acetamide compounds |
| CN103497159B (zh) * | 2013-09-18 | 2015-08-12 | 苏州岚云医药科技有限公司 | 1,2-二取代-5-磺酰基咪唑类化合物的制备方法 |
| SI3364958T1 (sl) | 2015-10-23 | 2023-05-31 | Navitor Pharmaceuticals, Inc. | Modulatorji interakcije sestrina in gator2 ter njihova uporaba |
| ES3040534T3 (en) | 2017-04-26 | 2025-11-03 | Navitor Pharm Inc | Modulator of sestrin-gator2 interaction for use in the treatment of treatment-resistant depression |
| CA3117336A1 (en) | 2018-10-24 | 2020-04-30 | Navitor Pharmaceuticals, Inc. | Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1 |
| IL292612A (en) | 2019-11-01 | 2022-07-01 | Navitor Pharm Inc | Treatment methods using mtorc1 modulator |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962117A (en) | 1987-11-25 | 1990-10-09 | Merck Frosst Canada, Inc. | Heterazole dialkanoic acids |
| WO1993017681A1 (en) | 1992-03-02 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| JPH07243068A (ja) | 1994-03-08 | 1995-09-19 | Murata:Kk | 金属表面の電解処理方法 |
| AU2381397A (en) | 1996-04-19 | 1997-11-12 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| AU730224B2 (en) | 1996-12-23 | 2001-03-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| JPH11217348A (ja) | 1997-10-15 | 1999-08-10 | Otsuka Pharmaceut Co Ltd | フルオレノン誘導体の製造法 |
| WO1999032454A1 (en) | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
| AR024077A1 (es) | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| JP3842976B2 (ja) | 2000-03-17 | 2006-11-08 | 富士通株式会社 | 分布帰還型半導体レーザとその製造方法 |
| EP1310494B1 (en) | 2000-08-11 | 2012-01-25 | Nippon Chemiphar Co., Ltd. | PPAR (delta) ACTIVATORS |
| EP1394147A4 (en) | 2001-06-04 | 2007-10-24 | Eisai R&D Man Co Ltd | CARBOXYLENE DERIVATIVE AND A SALT OR AN ESTER CONTAINING MEDICINE |
| IL160304A0 (en) | 2001-08-10 | 2004-07-25 | Nippon Chemiphar Co | ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR delta |
| WO2003063781A2 (en) | 2002-01-29 | 2003-08-07 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| JP2003321455A (ja) | 2002-02-28 | 2003-11-11 | Nissan Chem Ind Ltd | ｏ−置換ベンゾイル化合物及びこれを有効成分とする除草剤 |
| DE10224844A1 (de) | 2002-06-05 | 2004-01-08 | Solvay Pharmaceuticals Gmbh | Nicht-peptidische BRS-3-Agonisten |
| WO2004007464A1 (ja) | 2002-07-10 | 2004-01-22 | Sumitomo Pharmaceuticals Co., Ltd. | イミダゾール誘導体 |
| MXPA05004115A (es) * | 2002-10-18 | 2005-06-22 | Pfizer Prod Inc | Ligandos del receptor cannabionoide y usos de los mismos. |
| PL378238A1 (pl) | 2002-11-19 | 2006-03-20 | Galderma Research & Development, S.N.C. | Związki biaromatyczne, które aktywują receptory typu PPAR<$Egamma>, oraz ich zastosowanie w kompozycjach kosmetycznych albo farmaceutycznych |
| JP2006516550A (ja) | 2002-11-25 | 2006-07-06 | ガルデルマ・リサーチ・アンド・デヴェロップメント・エス・エヌ・セ | ＰＰＡＲγ＋タイプ受容体を活性化する新規な二芳香族化合物および化粧品組成物または医薬組成物でのその使用 |
| WO2004058176A2 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Acyclic pyrazole compounds |
| WO2004071509A1 (ja) | 2003-02-12 | 2004-08-26 | Nippon Chemiphar Co., Ltd. | オリゴデンドロサイト分化促進剤 |
| CN1747936A (zh) * | 2003-02-12 | 2006-03-15 | 特兰斯泰克制药公司 | 作为治疗试剂的取代吡咯衍生物 |
| US20040167188A1 (en) | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| EP1628666B1 (en) | 2003-05-14 | 2015-09-23 | NeuroGenetic Pharmaceuticals, Inc. | Compouds and uses thereof in modulating amyloid beta |
| US7141596B2 (en) | 2003-10-08 | 2006-11-28 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
| CA2548513A1 (en) | 2003-12-04 | 2005-07-07 | Wyeth | Biaryl sulfonamides and methods for using same |
| GB0328796D0 (en) | 2003-12-12 | 2004-01-14 | Biofocus Plc | Compounds which interact with the G-protein coupled receptor family |
| CN1894225A (zh) | 2003-12-17 | 2007-01-10 | 默克公司 | 作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯 |
| NZ548208A (en) * | 2004-02-12 | 2010-09-30 | Transtech Pharma Inc | Substituted azole derivatives, compositions, and methods of use |
| GB0403578D0 (en) | 2004-02-18 | 2004-03-24 | Biofocus Discovery Ltd | Compounds which interact with the G-protein coupled receptor family |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| JP2010506916A (ja) * | 2006-10-20 | 2010-03-04 | メルク エンド カムパニー インコーポレーテッド | ボンベシンレセプターサブタイプ３モジュレーターとしての置換イミダゾール |
| EP2083623A1 (en) | 2006-10-20 | 2009-08-05 | Merck & Co., Inc. | Substituted imidazoles as bombesin receptor subtype-3 modulators |
-
2007
- 2007-10-16 WO PCT/US2007/022087 patent/WO2008051406A2/en not_active Ceased
- 2007-10-16 KR KR1020097008073A patent/KR20090064458A/ko not_active Withdrawn
- 2007-10-16 JP JP2009533350A patent/JP5047299B2/ja not_active Expired - Fee Related
- 2007-10-16 EP EP07839615A patent/EP2091937A2/en not_active Withdrawn
- 2007-10-16 AU AU2007309570A patent/AU2007309570B2/en not_active Ceased
- 2007-10-16 MX MX2009004112A patent/MX2009004112A/es unknown
- 2007-10-16 BR BRPI0717976-6A patent/BRPI0717976A2/pt not_active Application Discontinuation
- 2007-10-16 CN CNA2007800387313A patent/CN101528730A/zh active Pending
- 2007-10-16 CA CA2666310A patent/CA2666310C/en not_active Expired - Fee Related
- 2007-10-16 US US12/311,487 patent/US8193228B2/en active Active
- 2007-10-16 RU RU2009118935/04A patent/RU2009118935A/ru not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL198004A patent/IL198004A0/en unknown
- 2009-05-19 NO NO20091957A patent/NO20091957L/no not_active Application Discontinuation