MX2009004112A - Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3. - Google Patents

Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3.

Info

Publication number
MX2009004112A
MX2009004112A MX2009004112A MX2009004112A MX2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A
Authority
MX
Mexico
Prior art keywords
bombesin receptor
receptor subtype
modulators
substituted imidazoles
brs
Prior art date
Application number
MX2009004112A
Other languages
English (en)
Inventor
Linus S Lin
Ravi P Nargund
Iyassu K Sebhat
David Chen
Christopher L Franklin
Peter R Guzzo
Michael M-C Lo
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX2009004112A publication Critical patent/MX2009004112A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ciertos imidazoles novedosos sustituidos son ligandos del receptor de bombesina humano y, en particular, son ligandos selectivos del receptor de bombesina subtipo-3 (BRS-3); por lo tanto son útiles para el tratamiento, control, o prevención de enfermedades y trastornos sensibles a la modulación de BRS-3, tal como obesidad, y diabetes.
MX2009004112A 2006-10-20 2007-10-16 Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3. MX2009004112A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85319306P 2006-10-20 2006-10-20
PCT/US2007/022087 WO2008051406A2 (en) 2006-10-20 2007-10-16 Substituted imidazoles as bombesin receptor subtype-3 modulators

Publications (1)

Publication Number Publication Date
MX2009004112A true MX2009004112A (es) 2009-05-11

Family

ID=39325111

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004112A MX2009004112A (es) 2006-10-20 2007-10-16 Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3.

Country Status (13)

Country Link
US (1) US8193228B2 (es)
EP (1) EP2091937A2 (es)
JP (1) JP5047299B2 (es)
KR (1) KR20090064458A (es)
CN (1) CN101528730A (es)
AU (1) AU2007309570B2 (es)
BR (1) BRPI0717976A2 (es)
CA (1) CA2666310C (es)
IL (1) IL198004A0 (es)
MX (1) MX2009004112A (es)
NO (1) NO20091957L (es)
RU (1) RU2009118935A (es)
WO (1) WO2008051406A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2667003A1 (en) 2006-10-20 2008-05-02 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
AU2007309568A1 (en) 2006-10-20 2008-05-02 Merck Sharp & Dohme Corp. Substituted imidazoles as bombesin receptor subtype-3 modulators
WO2009123164A1 (ja) * 2008-04-02 2009-10-08 塩野義製薬株式会社 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013135674A1 (en) * 2012-03-12 2013-09-19 Syngenta Participations Ag Insecticidal 2-aryl-acetamide compounds
CN103497159B (zh) * 2013-09-18 2015-08-12 苏州岚云医药科技有限公司 1,2-二取代-5-磺酰基咪唑类化合物的制备方法

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US5326776A (en) 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
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PT1424330E (pt) 2001-08-10 2011-12-22 Nippon Chemiphar Co Activador do receptor ä responsivo a proliferadores peroxissomais
US20040248956A1 (en) * 2002-01-29 2004-12-09 Hagmann William K Substituted imidazoles as cannabinoid receptor modulators
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Also Published As

Publication number Publication date
JP2010506919A (ja) 2010-03-04
CA2666310A1 (en) 2008-05-02
RU2009118935A (ru) 2010-11-27
BRPI0717976A2 (pt) 2013-11-12
AU2007309570B2 (en) 2012-07-12
IL198004A0 (en) 2009-12-24
NO20091957L (no) 2009-07-17
CN101528730A (zh) 2009-09-09
WO2008051406A3 (en) 2008-07-24
CA2666310C (en) 2012-07-31
JP5047299B2 (ja) 2012-10-10
US8193228B2 (en) 2012-06-05
AU2007309570A1 (en) 2008-05-02
WO2008051406A2 (en) 2008-05-02
US20100022598A1 (en) 2010-01-28
EP2091937A2 (en) 2009-08-26
KR20090064458A (ko) 2009-06-18

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