JP2010539110A5 - - Google Patents

Download PDF

Info

Publication number
JP2010539110A5
JP2010539110A5 JP2010524375A JP2010524375A JP2010539110A5 JP 2010539110 A5 JP2010539110 A5 JP 2010539110A5 JP 2010524375 A JP2010524375 A JP 2010524375A JP 2010524375 A JP2010524375 A JP 2010524375A JP 2010539110 A5 JP2010539110 A5 JP 2010539110A5
Authority
JP
Japan
Prior art keywords
alkyl
fluoro
chloro
group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010524375A
Other languages
English (en)
Japanese (ja)
Other versions
JP5461402B2 (ja
JP2010539110A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/007137 external-priority patent/WO2009033581A1/en
Publication of JP2010539110A publication Critical patent/JP2010539110A/ja
Publication of JP2010539110A5 publication Critical patent/JP2010539110A5/ja
Application granted granted Critical
Publication of JP5461402B2 publication Critical patent/JP5461402B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010524375A 2007-09-14 2008-09-02 置換三環式化合物およびその使用方法 Expired - Fee Related JP5461402B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07018082.3 2007-09-14
EP07018082 2007-09-14
PCT/EP2008/007137 WO2009033581A1 (en) 2007-09-14 2008-09-02 Substituted tricyclic compounds and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2010539110A JP2010539110A (ja) 2010-12-16
JP2010539110A5 true JP2010539110A5 (enExample) 2011-10-20
JP5461402B2 JP5461402B2 (ja) 2014-04-02

Family

ID=40130858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010524375A Expired - Fee Related JP5461402B2 (ja) 2007-09-14 2008-09-02 置換三環式化合物およびその使用方法

Country Status (6)

Country Link
US (1) US8524722B2 (enExample)
EP (1) EP2212332B1 (enExample)
JP (1) JP5461402B2 (enExample)
CA (1) CA2699349C (enExample)
ES (1) ES2396602T3 (enExample)
WO (1) WO2009033581A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010054285A2 (en) 2008-11-10 2010-05-14 National Health Research Institutes Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
WO2010131921A2 (ko) * 2009-05-14 2010-11-18 코오롱생명과학 주식회사 알킬아민 유도체의 제조방법
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
EP2722055A1 (en) * 2009-08-17 2014-04-23 Tracon Pharmaceuticals, Inc. Combination therapy with antibodies and anti-VEGF agents for the treatment of cancer
GB0915515D0 (en) * 2009-09-04 2009-10-07 Ucl Business Plc Treatment of vasculoproliferative conditions
CN103119047B (zh) 2010-07-23 2016-06-15 哈佛大学校长及研究员协会 三环类蛋白酶体活性增强化合物
WO2012148889A1 (en) * 2011-04-28 2012-11-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of human apurinic/apyrimidinic endonuclease 1
CN102875535B (zh) * 2011-07-12 2016-06-08 上海药明康德新药开发有限公司 1,5-[(取代)-甲桥]-四氢-1H-吡咯[1,2-c]-咪唑-3(2H)-酮衍生物及制备方法
EP2806876A4 (en) * 2012-01-25 2016-03-02 Proteostasis Therapeutics Inc Proteasome activity enhancing compounds
WO2013112706A1 (en) 2012-01-25 2013-08-01 Proteostasis Therapeutics, Inc. Proteasome activity modulating compounds
WO2013144191A1 (de) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Substituierte 2 -amino - 3 - cyanopyridine als inhibitoren des natrium calcium austausches und ihre verwendung bei kardiovaskulären erkrankungen
CA2873971A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyrimidines
UA115789C2 (uk) 2012-09-05 2017-12-26 Трейкон Фармасутікалз, Інк. Композиція антитіла до cd105 та її застосування
EP2961409A1 (en) * 2013-02-26 2016-01-06 Senex Biotechnology, Inc. Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer
JP6087192B2 (ja) * 2013-04-03 2017-03-01 京セラ株式会社 発電システムおよび発電システムの制御方法ならびに燃料電池
CN104016983B (zh) * 2013-10-08 2018-11-02 上海创诺制药有限公司 吡咯并三嗪类衍生物及其制法和用途
AU2015346444A1 (en) 2014-11-12 2017-05-04 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
ES2718175T3 (es) 2014-12-02 2019-06-28 Lilly Co Eli Compuestos de 1-oxo-1,2-dihidroisoquinolin-7-il-(tiofen-2-il-5-sustituido)-sulfonamida, formulaciones que contienen esos compuestos, y su uso como inhibidores de AICARFT en el tratamiento de cánceres
CN104529800B (zh) * 2014-12-08 2017-01-25 重庆威鹏药业有限公司 反式‑4‑二甲基氨基巴豆酸及盐的制备方法
WO2016133888A1 (en) * 2015-02-16 2016-08-25 Biota Pharmaceuticals, Inc. Compounds for treating respiratory syncytial virus infections
US10561749B2 (en) 2015-07-03 2020-02-18 Kyoto University Nuclear medicine diagnostic imaging agent
JP6709552B2 (ja) * 2015-07-03 2020-06-17 国立大学法人京都大学 核医学画像診断薬
CN108285421A (zh) * 2018-01-26 2018-07-17 黑龙江鑫创生物科技开发有限公司 一种微通道反应器合成拉帕替尼中间体的方法
WO2020191151A1 (en) * 2019-03-19 2020-09-24 Oncovalent Therapeutics Inc. Sumo inhibitor compounds and uses thereof
WO2021041539A2 (en) * 2019-08-28 2021-03-04 Ferro Therapeutics, Inc. Compounds and methods of use
KR20240044458A (ko) * 2021-08-05 2024-04-04 브리스톨-마이어스 스큅 컴퍼니 Her2 억제제로서 사용하기 위한 트리시클릭 융합된 피리미딘 화합물
IL310338A (en) * 2021-08-31 2024-03-01 Eisai R&D Man Co Ltd Production method for synthetic intermediate of monocyclic pyridine derivative
CN115724790A (zh) * 2022-11-21 2023-03-03 安庆朗坤药业有限公司 一种n-(3-氯-4-(2-吡啶甲氧基)苯胺的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127188D0 (en) 1991-12-21 1992-02-19 Smithkline Beecham Plc Novel compounds
CA2365578A1 (en) 1999-03-30 2000-10-12 Seiichi Uchida Thienopyrimidine compounds and salts thereof and process for the preparation of the same
AR028261A1 (es) * 2000-03-28 2003-04-30 Wyeth Corp Inhibidores triciclicos de la proteina quinasa
CN101100472A (zh) 2001-04-30 2008-01-09 美国拜尔公司 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
JPWO2003035653A1 (ja) 2001-10-26 2005-02-10 日本曹達株式会社 ピリドチエノピリミジン化合物およびその塩
JP4712702B2 (ja) * 2003-07-24 2011-06-29 バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト 高増殖性疾患を処置するために有用な置換されたテトラヒドロベンゾチエノピリミジンアミン化合物
US7427625B2 (en) 2006-02-08 2008-09-23 Janssen Pharmaceutica, N.V. Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors
US20100234351A1 (en) 2006-02-23 2010-09-16 Takeda Pharmaceutical Company Limited Fused nitrogen-comprising heterocyclic compound
AR059901A1 (es) * 2006-03-20 2008-05-07 Bayer Pharmaceuticals Corp Compuestos de tetrahidropiridotienopirimidina utiles para tratar o prevenir trastornos proliferativos celulares.

Similar Documents

Publication Publication Date Title
JP2017525757A5 (enExample)
JP6534675B2 (ja) ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン
JP2017533968A5 (enExample)
JP2019518766A5 (enExample)
JP2014507455A5 (enExample)
RU2016137181A (ru) Противофиброзные пиридиноны
JP2016500661A5 (enExample)
AU2014234909B2 (en) Acyclic cyanoethylpyrazolo pyridones as Janus kinase inhibitors
JP2016532673A5 (enExample)
JP2005509622A5 (enExample)
RU2016115868A (ru) Замещенные гетероциклические сульфонамидные соединения, полезные в качестве модуляторов trpa 1
JP2013542996A5 (enExample)
KR20260042557A (ko) 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체
JP2014513110A5 (enExample)
JP2013510120A5 (enExample)
JP2014508811A5 (enExample)
JP2021502387A5 (enExample)
JP2011509309A5 (enExample)
JP2015529224A5 (enExample)
RU2013154412A (ru) Аминопиримидины в качестве ингибиторов syc
EP3227270A2 (en) Heterocyclic derivatives and use thereof
JP2005505618A5 (enExample)
TW201838991A (zh) 芳基烴受體(AhR)調節劑化合物
JP2011509301A5 (enExample)
JP2018529690A5 (enExample)