WO2010131921A2 - 알킬아민 유도체의 제조방법 - Google Patents

알킬아민 유도체의 제조방법 Download PDF

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Publication number
WO2010131921A2
WO2010131921A2 PCT/KR2010/003057 KR2010003057W WO2010131921A2 WO 2010131921 A2 WO2010131921 A2 WO 2010131921A2 KR 2010003057 W KR2010003057 W KR 2010003057W WO 2010131921 A2 WO2010131921 A2 WO 2010131921A2
Authority
WO
WIPO (PCT)
Prior art keywords
producing
amine derivative
alkyl amine
impurities
provides
Prior art date
Application number
PCT/KR2010/003057
Other languages
English (en)
French (fr)
Other versions
WO2010131921A3 (ko
Inventor
최윤환
장원태
Original Assignee
코오롱생명과학 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코오롱생명과학 주식회사 filed Critical 코오롱생명과학 주식회사
Priority to US13/318,268 priority Critical patent/US8779192B2/en
Priority to JP2012510755A priority patent/JP5622842B2/ja
Publication of WO2010131921A2 publication Critical patent/WO2010131921A2/ko
Publication of WO2010131921A3 publication Critical patent/WO2010131921A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Abstract

본 발명은 불순물이 거의 생성되지 않아 고순도를 나타내며 대량 생산이 가능한 알킬아민 유도체의 제조방법을 제공한다.
PCT/KR2010/003057 2009-05-14 2010-05-14 알킬아민 유도체의 제조방법 WO2010131921A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/318,268 US8779192B2 (en) 2009-05-14 2010-05-14 Process of preparing an alkylamine derivative
JP2012510755A JP5622842B2 (ja) 2009-05-14 2010-05-14 アルキルアミン誘導体の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17811709P 2009-05-14 2009-05-14
US61/178,117 2009-05-14

Publications (2)

Publication Number Publication Date
WO2010131921A2 true WO2010131921A2 (ko) 2010-11-18
WO2010131921A3 WO2010131921A3 (ko) 2011-03-24

Family

ID=43085471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/003057 WO2010131921A2 (ko) 2009-05-14 2010-05-14 알킬아민 유도체의 제조방법

Country Status (4)

Country Link
US (1) US8779192B2 (ko)
JP (1) JP5622842B2 (ko)
KR (1) KR20120016053A (ko)
WO (1) WO2010131921A2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073941B2 (en) 2010-06-28 2015-07-07 Academia Sinica Compounds and methods for treating tuberculosis infection

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1948179A1 (en) 2005-11-11 2008-07-30 Boehringer Ingelheim International GmbH Quinazoline derivatives for the treatment of cancer diseases
JP5963672B2 (ja) 2009-07-06 2016-08-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｉｂｗ２９９２、その塩及びこの活性成分を含む固体医薬製剤の乾燥方法
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
EP3148977A4 (en) 2014-06-02 2018-01-31 Sun Pharmaceutical Industries Ltd Process for the preparation of 4-dimethylaminocrotonic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004066919A2 (en) * 2003-01-21 2004-08-12 Wyeth Synthesis of 4amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
WO2006127203A2 (en) * 2005-05-25 2006-11-30 Wyeth Methods of synthesizing 6-alkylaminoquinoline derivatives
WO2009033581A1 (en) * 2007-09-14 2009-03-19 Bayer Schering Pharma Aktiengesellschaft Substituted tricyclic compounds and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
AR031129A1 (es) * 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004066919A2 (en) * 2003-01-21 2004-08-12 Wyeth Synthesis of 4amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
WO2006127203A2 (en) * 2005-05-25 2006-11-30 Wyeth Methods of synthesizing 6-alkylaminoquinoline derivatives
WO2009033581A1 (en) * 2007-09-14 2009-03-19 Bayer Schering Pharma Aktiengesellschaft Substituted tricyclic compounds and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073941B2 (en) 2010-06-28 2015-07-07 Academia Sinica Compounds and methods for treating tuberculosis infection

Also Published As

Publication number Publication date
JP2012526802A (ja) 2012-11-01
WO2010131921A3 (ko) 2011-03-24
US8779192B2 (en) 2014-07-15
JP5622842B2 (ja) 2014-11-12
KR20120016053A (ko) 2012-02-22
US20120046494A1 (en) 2012-02-23

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