JP2017525757A5 - - Google Patents
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- Publication number
- JP2017525757A5 JP2017525757A5 JP2017522462A JP2017522462A JP2017525757A5 JP 2017525757 A5 JP2017525757 A5 JP 2017525757A5 JP 2017522462 A JP2017522462 A JP 2017522462A JP 2017522462 A JP2017522462 A JP 2017522462A JP 2017525757 A5 JP2017525757 A5 JP 2017525757A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxoisoindoline
- dioxopiperidin
- difluoro
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 O=C(C(C1=CC=*=CC=C1)(F)F)NCc(cc1CN2C(C=CC(N3)=O)C3=O)ccc1C2=O Chemical compound O=C(C(C1=CC=*=CC=C1)(F)F)NCc(cc1CN2C(C=CC(N3)=O)C3=O)ccc1C2=O 0.000 description 3
- NYVGCNSACSJVJQ-UHFFFAOYSA-N N#Cc(cc1CN2C(CCC(N3)=O)C3=O)ccc1C2=O Chemical compound N#Cc(cc1CN2C(CCC(N3)=O)C3=O)ccc1C2=O NYVGCNSACSJVJQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462023775P | 2014-07-11 | 2014-07-11 | |
| US62/023,775 | 2014-07-11 | ||
| PCT/US2015/039926 WO2016007848A1 (en) | 2014-07-11 | 2015-07-10 | Antiproliferative compounds and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173475A Division JP2021011495A (ja) | 2014-07-11 | 2020-10-14 | 抗増殖性化合物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525757A JP2017525757A (ja) | 2017-09-07 |
| JP2017525757A5 true JP2017525757A5 (enExample) | 2018-08-23 |
| JP6779870B2 JP6779870B2 (ja) | 2020-11-04 |
Family
ID=53682892
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522462A Active JP6779870B2 (ja) | 2014-07-11 | 2015-07-10 | 抗増殖性化合物及びその使用方法 |
| JP2020173475A Pending JP2021011495A (ja) | 2014-07-11 | 2020-10-14 | 抗増殖性化合物及びその使用方法 |
| JP2022171356A Pending JP2023011732A (ja) | 2014-07-11 | 2022-10-26 | 抗増殖性化合物及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173475A Pending JP2021011495A (ja) | 2014-07-11 | 2020-10-14 | 抗増殖性化合物及びその使用方法 |
| JP2022171356A Pending JP2023011732A (ja) | 2014-07-11 | 2022-10-26 | 抗増殖性化合物及びその使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US9499514B2 (enExample) |
| EP (2) | EP3166937B1 (enExample) |
| JP (3) | JP6779870B2 (enExample) |
| KR (1) | KR102477960B1 (enExample) |
| CN (2) | CN111170991B (enExample) |
| AR (1) | AR101189A1 (enExample) |
| AU (1) | AU2015287688B2 (enExample) |
| BR (1) | BR112017000550B1 (enExample) |
| CA (1) | CA2954784C (enExample) |
| CL (1) | CL2017000075A1 (enExample) |
| CO (1) | CO2017000223A2 (enExample) |
| CY (1) | CY1122340T1 (enExample) |
| DK (1) | DK3166937T3 (enExample) |
| EA (1) | EA033633B1 (enExample) |
| EC (1) | ECSP17002135A (enExample) |
| ES (2) | ES2968308T3 (enExample) |
| HR (1) | HRP20191821T1 (enExample) |
| HU (1) | HUE046000T2 (enExample) |
| IL (2) | IL276946B (enExample) |
| LT (1) | LT3166937T (enExample) |
| MX (2) | MX395482B (enExample) |
| PL (1) | PL3166937T3 (enExample) |
| PT (1) | PT3166937T (enExample) |
| RS (1) | RS59619B1 (enExample) |
| SA (1) | SA517380693B1 (enExample) |
| SG (2) | SG11201700126RA (enExample) |
| SI (1) | SI3166937T1 (enExample) |
| SM (1) | SMT201900686T1 (enExample) |
| TW (1) | TWI660952B (enExample) |
| WO (1) | WO2016007848A1 (enExample) |
| ZA (1) | ZA201700217B (enExample) |
Families Citing this family (43)
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| US9499514B2 (en) * | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| MX386886B (es) | 2014-09-09 | 2025-03-12 | Janssen Biotech Inc | Combinación de anticuerpos anti-cd38 y ácido todo-trans retinoico para usarse en terapias. |
| US10793630B2 (en) | 2014-12-04 | 2020-10-06 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute myeloid leukemia |
| KR102602754B1 (ko) | 2015-05-20 | 2023-11-14 | 얀센 바이오테크 인코포레이티드 | 경쇄 아밀로이드증 및 다른 cd38-양성 혈액학적 악성종양을 치료하기 위한 항-cd38 항체 |
| PE20181323A1 (es) | 2015-06-22 | 2018-08-14 | Janssen Biotech Inc | Terapias de combinacion para enfermedades malignas hematologicas con anticuerpos anti-cd38 e inhibidores de survivina |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| BR112018008901A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | formulações subcutâneas de anticorpos anti-cd 38 e seus usos |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| EP3399979B9 (en) * | 2016-01-08 | 2023-10-04 | Celgene Corporation | Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| CA3010794A1 (en) * | 2016-01-08 | 2017-07-13 | Celgene Corporation | Solid forms of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses |
| EP3399980B1 (en) * | 2016-01-08 | 2025-07-16 | Celgene Corporation | Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies |
| CN113662941A (zh) * | 2016-01-08 | 2021-11-19 | 细胞基因公司 | 抗增殖化合物以及其药物组合物和用途 |
| IL262565B (en) * | 2016-06-06 | 2022-08-01 | Celgene Corp | Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| US11535603B1 (en) | 2016-09-30 | 2022-12-27 | Deuterx, Llc | Deuterium-enriched piperidinonyl-oxoisoindolinyl acetamides and methods of treating medical disorders using same |
| CN106928253A (zh) * | 2017-03-09 | 2017-07-07 | 武汉工程大学 | 一种唑啉草酯的制备方法 |
| BR112019028101A2 (pt) * | 2017-06-30 | 2020-07-28 | Celgene Corporation | composições e métodos para uso de (2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida) |
| WO2019089832A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Biotech, Inc. | Methods of treating high risk multiple myeloma |
| CN107827721B (zh) * | 2017-11-17 | 2021-03-16 | 上海恩氟佳科技有限公司 | 一种合成4-氟环己酮的方法 |
| US20210069356A1 (en) * | 2018-01-02 | 2021-03-11 | Celgene Corporation | Isotopologues of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| KR20250020690A (ko) * | 2018-06-29 | 2025-02-11 | 다나-파버 캔서 인스티튜트 인크. | 세레블론(crbn)에 대한 리간드 |
| CN113347974A (zh) * | 2018-12-31 | 2021-09-03 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 |
| CN113329792B (zh) | 2019-02-15 | 2024-06-28 | 诺华股份有限公司 | 取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| BR112021022758A2 (pt) * | 2019-05-31 | 2022-03-22 | Celgene Corp | Compostos de 1-oxo-isoindolina-5-carboxamida substituídos, suas composições e métodos de tratamento com os mesmos |
| CN115607552B (zh) | 2019-10-21 | 2024-06-18 | 新基公司 | 取代的4-氨基异二氢吲哚-1,3-二酮化合物和第二种活性剂的组合用途 |
| MX2022005371A (es) | 2019-11-05 | 2022-08-04 | Celgene Corp | Terapia de combinacion con 2-(4-clorofenil)-n-((2-(2,6-dioxopiperi din-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. |
| GB201916600D0 (en) * | 2019-11-14 | 2020-01-01 | Syngenta Crop Protection Ag | 81991-gb-reg-org-nat-1 |
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| MX2022006133A (es) | 2019-12-06 | 2022-06-17 | Celgene Corp | Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. |
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| MX2022015891A (es) | 2020-06-25 | 2023-01-24 | Celgene Corp | Metodos para tratar cancer con terapias combinadas. |
| CN116457344A (zh) * | 2020-08-03 | 2023-07-18 | 凯普托尔治疗学股份有限公司 | 低分子量蛋白质降解剂及其应用 |
| PE20230847A1 (es) | 2020-09-23 | 2023-05-23 | St Jude Childrens Res Hospital Inc | Analogos de n-(2-(2,6-dioxopiperidin-3-il)-1,3-dioxoisoindolin-5-il)arilsufonamida sustituidos como modulares de la proteina cereblon |
| EP4277901A1 (en) | 2021-01-13 | 2023-11-22 | Monte Rosa Therapeutics, Inc. | Isoindolinone compounds |
| KR20240004749A (ko) * | 2021-05-06 | 2024-01-11 | 셀진 코포레이션 | N-((r)-1-(3-클로로피리딘-2-일)-2,2,2-트리플루오로에틸)-2-((s)-2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-카르복스아미드를 이용한 치료 방법 |
| BR112023023939A2 (pt) * | 2021-05-19 | 2024-04-30 | Syngenta Crop Protection Ag | Método de controle de ervas daninhas |
| EP4091449A1 (en) * | 2021-05-19 | 2022-11-23 | Syngenta Crop Protection AG | Weed control method |
| KR20240067085A (ko) * | 2021-09-08 | 2024-05-16 | 오름테라퓨틱 주식회사 | 항체 약물 접합체에 사용하기 위한 링커 |
| CN119546605A (zh) * | 2022-08-01 | 2025-02-28 | 苏州开拓药业股份有限公司 | 一种蛋白降解剂 |
| KR20250069578A (ko) * | 2022-10-06 | 2025-05-19 | 오름테라퓨틱 주식회사 | 신규분해약물 접합체 |
| KR20250133786A (ko) * | 2023-02-15 | 2025-09-08 | 씨에스피씨 메가리스 바이오파마슈티칼 씨오., 엘티디. | 도마이드계 분자 접착제 유도체 및 이의 용도 |
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