MX2013008791A - Metodos para usar inhibidores de alk. - Google Patents
Metodos para usar inhibidores de alk.Info
- Publication number
- MX2013008791A MX2013008791A MX2013008791A MX2013008791A MX2013008791A MX 2013008791 A MX2013008791 A MX 2013008791A MX 2013008791 A MX2013008791 A MX 2013008791A MX 2013008791 A MX2013008791 A MX 2013008791A MX 2013008791 A MX2013008791 A MX 2013008791A
- Authority
- MX
- Mexico
- Prior art keywords
- phenyl
- carbon atoms
- isopropoxy
- chloro
- sulfonyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000003112 inhibitor Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- 239000002146 L01XE16 - Crizotinib Substances 0.000 claims abstract description 22
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 claims abstract description 22
- 229960005061 crizotinib Drugs 0.000 claims abstract description 22
- 230000001404 mediated effect Effects 0.000 claims abstract description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 42
- 206010028980 Neoplasm Diseases 0.000 claims description 41
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 19
- 201000005202 lung cancer Diseases 0.000 claims description 19
- 208000020816 lung neoplasm Diseases 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 15
- 125000005842 heteroatom Chemical group 0.000 claims description 12
- 229910052717 sulfur Inorganic materials 0.000 claims description 11
- -1 5-Chloro-2- (2-isopropoxy-5-methyl-4- (piperidin-4-yl) -phenyl) -N 4 - [2- (propan-2-sulfonyl) -phenyl] -pyrimidine-2,4- diamine Chemical compound 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 125000003386 piperidinyl group Chemical group 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical group 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- VERWOWGGCGHDQE-UHFFFAOYSA-N ceritinib Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCNCC1 VERWOWGGCGHDQE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- YZVRDSIPTUIXBL-UHFFFAOYSA-N 4-(2-propan-2-ylsulfonylphenyl)-1h-pyrimidine-2,4-diamine Chemical compound CC(C)S(=O)(=O)C1=CC=CC=C1C1(N)C=CN=C(N)N1 YZVRDSIPTUIXBL-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- VOASCOSDVNWJEV-UHFFFAOYSA-N 5-chloro-2-n-(5-methyl-4-piperidin-2-yl-2-propan-2-yloxyphenyl)-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCCCN1 VOASCOSDVNWJEV-UHFFFAOYSA-N 0.000 claims 3
- VOASCOSDVNWJEV-QFIPXVFZSA-N 5-chloro-2-n-[5-methyl-4-[(2s)-piperidin-2-yl]-2-propan-2-yloxyphenyl]-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1[C@@H]1CCCCN1 VOASCOSDVNWJEV-QFIPXVFZSA-N 0.000 claims 3
- IGUPHIBNKHHSSE-UHFFFAOYSA-N 5-chloro-2-n-(5-methyl-4-piperidin-3-yl-2-propan-2-yloxyphenyl)-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCCNC1 IGUPHIBNKHHSSE-UHFFFAOYSA-N 0.000 claims 2
- VOASCOSDVNWJEV-JOCHJYFZSA-N 5-chloro-2-n-[5-methyl-4-[(2r)-piperidin-2-yl]-2-propan-2-yloxyphenyl]-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1[C@H]1CCCCN1 VOASCOSDVNWJEV-JOCHJYFZSA-N 0.000 claims 2
- BPMAKGFLDNAAQC-UHFFFAOYSA-N 6-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-(1-methylpiperidin-4-yl)-5-propan-2-yloxy-3h-isoindol-1-one Chemical compound O=C1C=2C=C(NC=3N=C(NC=4C(=CC=CC=4)S(=O)(=O)C(C)C)C(Cl)=CN=3)C(OC(C)C)=CC=2CN1C1CCN(C)CC1 BPMAKGFLDNAAQC-UHFFFAOYSA-N 0.000 claims 2
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 claims 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 238000011579 SCID mouse model Methods 0.000 description 5
- 230000000259 anti-tumor effect Effects 0.000 description 5
- 229940125904 compound 1 Drugs 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 101150023956 ALK gene Proteins 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 108010082117 matrigel Proteins 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 108060001084 Luciferase Proteins 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 206010029260 Neuroblastoma Diseases 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 229940126069 ALK kinase inhibitor Drugs 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000258955 Echinodermata Species 0.000 description 1
- 231100001273 GLP toxicology study Toxicity 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 229940125895 MET kinase inhibitor Drugs 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 238000002701 cell growth assay Methods 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000012447 xenograft mouse model Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438878P | 2011-02-02 | 2011-02-02 | |
| PCT/US2012/023669 WO2012106540A1 (en) | 2011-02-02 | 2012-02-02 | Methods of using alk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013008791A true MX2013008791A (es) | 2013-10-07 |
Family
ID=45582065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013008791A MX2013008791A (es) | 2011-02-02 | 2012-02-02 | Metodos para usar inhibidores de alk. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8703787B2 (enExample) |
| EP (1) | EP2670401B1 (enExample) |
| JP (1) | JP5837095B2 (enExample) |
| KR (1) | KR101521861B1 (enExample) |
| CN (1) | CN103458881B (enExample) |
| AU (1) | AU2012212142B2 (enExample) |
| BR (1) | BR112013019643B1 (enExample) |
| CA (1) | CA2824092C (enExample) |
| CY (1) | CY1116662T1 (enExample) |
| DK (1) | DK2670401T3 (enExample) |
| EA (1) | EA023404B1 (enExample) |
| ES (1) | ES2543567T3 (enExample) |
| HR (1) | HRP20150946T1 (enExample) |
| HU (1) | HUE025395T2 (enExample) |
| ME (1) | ME02200B (enExample) |
| MX (1) | MX2013008791A (enExample) |
| PL (1) | PL2670401T3 (enExample) |
| PT (1) | PT2670401E (enExample) |
| RS (1) | RS54189B1 (enExample) |
| SI (1) | SI2670401T1 (enExample) |
| SM (1) | SMT201500300B (enExample) |
| WO (1) | WO2012106540A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015010221B1 (pt) | 2012-11-06 | 2022-09-13 | Shanghai Fochon Pharmaceutical Co., Ltd. | Inibidores de quinase alk, seus usos, composição farmacêutica, e método para fabricação de medicamento |
| MX2015005798A (es) * | 2012-11-07 | 2015-09-23 | Novartis Ag | Terapia de combinacion. |
| CN104109149B (zh) | 2013-04-22 | 2018-09-28 | 苏州泽璟生物制药有限公司 | 氘代的二氨基嘧啶化合物以及包含该化合物的药物组合物 |
| ITMI20131124A1 (it) * | 2013-07-04 | 2015-01-05 | Univ Milano Bicocca | 2-acilamminotiazoli per il trattamento del cancro |
| RU2656591C2 (ru) * | 2013-07-11 | 2018-06-06 | Бетта Фармасьютикалз Ко., Лтд | Модуляторы протеин-тирозинкиназы и способы их применения |
| CA2922684A1 (en) * | 2013-08-28 | 2015-03-05 | Novartis Ag | Combination of an alk inhibitor and a cdk inhibitor for the treatment of cell proliferative diseases |
| CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| RU2016129953A (ru) * | 2013-12-23 | 2018-01-30 | Новартис Аг | Фармацевтические комбинации |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
| CN104876914B (zh) * | 2014-02-28 | 2017-04-19 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类间变性淋巴瘤激酶抑制剂 |
| EP3159338A4 (en) * | 2014-06-17 | 2018-01-24 | Korea Research Institute of Chemical Technology | Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient |
| CN105524045B (zh) * | 2014-10-22 | 2020-04-10 | 山东轩竹医药科技有限公司 | 四环类间变性淋巴瘤激酶抑制剂 |
| CN106146525B (zh) * | 2015-04-10 | 2018-11-02 | 山东轩竹医药科技有限公司 | 三并环类间变性淋巴瘤激酶抑制剂 |
| US10259816B2 (en) | 2015-04-24 | 2019-04-16 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof |
| CN106699743B (zh) | 2015-11-05 | 2020-06-12 | 湖北生物医药产业技术研究院有限公司 | 嘧啶类衍生物及其用途 |
| CN106220608B (zh) * | 2016-07-25 | 2018-11-27 | 安润医药科技（苏州）有限公司 | 二苯氨基嘧啶及三嗪化合物、其药用组合物及用途 |
| CN107698603B (zh) * | 2016-08-09 | 2022-04-08 | 南京红云生物科技有限公司 | 噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用 |
| CN109715620B (zh) * | 2016-08-29 | 2022-05-06 | 密歇根大学董事会 | 作为alk抑制剂的氨基嘧啶 |
| CN111484484B (zh) * | 2020-04-13 | 2021-11-23 | 沈阳药科大学 | 含芳杂环的2,4-二芳氨基嘧啶衍生物及其制备与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| BR122019017579B8 (pt) * | 2003-08-15 | 2021-07-27 | Novartis Ag | 2,4-pirimidinadiaminas, seus usos, combinação e composição farmacêutica |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| EP2055146B1 (en) | 2006-07-10 | 2013-11-20 | Goji Limited | Food preparation |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| NZ590601A (en) * | 2006-12-08 | 2011-09-30 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
| PT2091918E (pt) * | 2006-12-08 | 2014-11-24 | Irm Llc | Compostos e composições como inibidores de proteína cinase |
| EA018282B1 (ru) * | 2008-04-07 | 2013-06-28 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
-
2012
- 2012-02-02 CA CA2824092A patent/CA2824092C/en active Active
- 2012-02-02 RS RS20150563A patent/RS54189B1/sr unknown
- 2012-02-02 HU HUE12703670A patent/HUE025395T2/en unknown
- 2012-02-02 US US13/981,046 patent/US8703787B2/en active Active
- 2012-02-02 EP EP12703670.5A patent/EP2670401B1/en active Active
- 2012-02-02 WO PCT/US2012/023669 patent/WO2012106540A1/en not_active Ceased
- 2012-02-02 KR KR1020137023001A patent/KR101521861B1/ko active Active
- 2012-02-02 PT PT127036705T patent/PT2670401E/pt unknown
- 2012-02-02 CN CN201280007465.9A patent/CN103458881B/zh active Active
- 2012-02-02 BR BR112013019643-2A patent/BR112013019643B1/pt active IP Right Grant
- 2012-02-02 ME MEP-2015-127A patent/ME02200B/me unknown
- 2012-02-02 PL PL12703670T patent/PL2670401T3/pl unknown
- 2012-02-02 HR HRP20150946TT patent/HRP20150946T1/hr unknown
- 2012-02-02 ES ES12703670.5T patent/ES2543567T3/es active Active
- 2012-02-02 DK DK12703670.5T patent/DK2670401T3/en active
- 2012-02-02 JP JP2013552637A patent/JP5837095B2/ja active Active
- 2012-02-02 EA EA201391114A patent/EA023404B1/ru not_active IP Right Cessation
- 2012-02-02 MX MX2013008791A patent/MX2013008791A/es unknown
- 2012-02-02 SI SI201230285T patent/SI2670401T1/sl unknown
- 2012-02-02 AU AU2012212142A patent/AU2012212142B2/en active Active
-
2015
- 2015-08-28 CY CY20151100758T patent/CY1116662T1/el unknown
- 2015-11-30 SM SM201500300T patent/SMT201500300B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012106540A1 (en) | 2012-08-09 |
| RS54189B1 (sr) | 2015-12-31 |
| SMT201500300B (it) | 2016-01-08 |
| EP2670401A1 (en) | 2013-12-11 |
| PT2670401E (pt) | 2015-10-12 |
| ES2543567T3 (es) | 2015-08-20 |
| EA201391114A1 (ru) | 2013-12-30 |
| US20130296357A1 (en) | 2013-11-07 |
| CN103458881B (zh) | 2015-08-12 |
| HUE025395T2 (en) | 2016-02-29 |
| BR112013019643B1 (pt) | 2022-04-19 |
| CY1116662T1 (el) | 2017-03-15 |
| PL2670401T3 (pl) | 2015-11-30 |
| CA2824092A1 (en) | 2012-08-09 |
| HRP20150946T1 (hr) | 2015-10-09 |
| EA023404B1 (ru) | 2016-05-31 |
| US8703787B2 (en) | 2014-04-22 |
| AU2012212142B2 (en) | 2015-09-24 |
| JP2014504646A (ja) | 2014-02-24 |
| CA2824092C (en) | 2020-06-30 |
| EP2670401B1 (en) | 2015-06-10 |
| JP5837095B2 (ja) | 2015-12-24 |
| SI2670401T1 (sl) | 2015-10-30 |
| BR112013019643A2 (pt) | 2016-10-04 |
| ME02200B (me) | 2016-02-20 |
| AU2012212142A1 (en) | 2013-08-15 |
| KR101521861B1 (ko) | 2015-05-21 |
| CN103458881A (zh) | 2013-12-18 |
| KR20130121174A (ko) | 2013-11-05 |
| DK2670401T3 (en) | 2015-09-07 |
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