BR112013019643B1 - Uso de inibidores de álcali - Google Patents
Uso de inibidores de álcali Download PDFInfo
- Publication number
- BR112013019643B1 BR112013019643B1 BR112013019643-2A BR112013019643A BR112013019643B1 BR 112013019643 B1 BR112013019643 B1 BR 112013019643B1 BR 112013019643 A BR112013019643 A BR 112013019643A BR 112013019643 B1 BR112013019643 B1 BR 112013019643B1
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- isopropoxy
- compound
- chloro
- piperidin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract description 3
- 239000003513 alkali Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 35
- 239000002146 L01XE16 - Crizotinib Substances 0.000 claims abstract description 18
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 claims abstract description 18
- 229960005061 crizotinib Drugs 0.000 claims abstract description 18
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims abstract description 17
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims abstract description 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 11
- 241001465754 Metazoa Species 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000003386 piperidinyl group Chemical group 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- VERWOWGGCGHDQE-UHFFFAOYSA-N ceritinib Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCNCC1 VERWOWGGCGHDQE-UHFFFAOYSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 3
- BPMAKGFLDNAAQC-UHFFFAOYSA-N 6-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-(1-methylpiperidin-4-yl)-5-propan-2-yloxy-3h-isoindol-1-one Chemical compound O=C1C=2C=C(NC=3N=C(NC=4C(=CC=CC=4)S(=O)(=O)C(C)C)C(Cl)=CN=3)C(OC(C)C)=CC=2CN1C1CCN(C)CC1 BPMAKGFLDNAAQC-UHFFFAOYSA-N 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 claims description 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- VOASCOSDVNWJEV-UHFFFAOYSA-N 5-chloro-2-n-(5-methyl-4-piperidin-2-yl-2-propan-2-yloxyphenyl)-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCCCN1 VOASCOSDVNWJEV-UHFFFAOYSA-N 0.000 claims 1
- IGUPHIBNKHHSSE-UHFFFAOYSA-N 5-chloro-2-n-(5-methyl-4-piperidin-3-yl-2-propan-2-yloxyphenyl)-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1C1CCCNC1 IGUPHIBNKHHSSE-UHFFFAOYSA-N 0.000 claims 1
- VOASCOSDVNWJEV-JOCHJYFZSA-N 5-chloro-2-n-[5-methyl-4-[(2r)-piperidin-2-yl]-2-propan-2-yloxyphenyl]-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1[C@H]1CCCCN1 VOASCOSDVNWJEV-JOCHJYFZSA-N 0.000 claims 1
- VOASCOSDVNWJEV-QFIPXVFZSA-N 5-chloro-2-n-[5-methyl-4-[(2s)-piperidin-2-yl]-2-propan-2-yloxyphenyl]-4-n-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound CC=1C=C(NC=2N=C(NC=3C(=CC=CC=3)S(=O)(=O)C(C)C)C(Cl)=CN=2)C(OC(C)C)=CC=1[C@@H]1CCCCN1 VOASCOSDVNWJEV-QFIPXVFZSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 6
- 206010028980 Neoplasm Diseases 0.000 description 38
- 210000004027 cell Anatomy 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 230000000259 anti-tumor effect Effects 0.000 description 6
- 230000012010 growth Effects 0.000 description 6
- 229940125904 compound 1 Drugs 0.000 description 5
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 238000011579 SCID mouse model Methods 0.000 description 4
- 201000005202 lung cancer Diseases 0.000 description 4
- 208000020816 lung neoplasm Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 101150023956 ALK gene Proteins 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 108010082117 matrigel Proteins 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 102100027100 Echinoderm microtubule-associated protein-like 4 Human genes 0.000 description 2
- 101001057929 Homo sapiens Echinoderm microtubule-associated protein-like 4 Proteins 0.000 description 2
- 108060001084 Luciferase Proteins 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010029260 Neuroblastoma Diseases 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000012679 serum free medium Substances 0.000 description 2
- 229940126069 ALK kinase inhibitor Drugs 0.000 description 1
- 230000003350 DNA copy number gain Effects 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000258955 Echinodermata Species 0.000 description 1
- 231100001273 GLP toxicology study Toxicity 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 229940125895 MET kinase inhibitor Drugs 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 230000008711 chromosomal rearrangement Effects 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000011254 conventional chemotherapy Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000012447 xenograft mouse model Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438878P | 2011-02-02 | 2011-02-02 | |
| US61/438,878 | 2011-02-02 | ||
| PCT/US2012/023669 WO2012106540A1 (en) | 2011-02-02 | 2012-02-02 | Methods of using alk inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013019643A2 BR112013019643A2 (pt) | 2016-10-04 |
| BR112013019643B1 true BR112013019643B1 (pt) | 2022-04-19 |
Family
ID=45582065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013019643-2A BR112013019643B1 (pt) | 2011-02-02 | 2012-02-02 | Uso de inibidores de álcali |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8703787B2 (enExample) |
| EP (1) | EP2670401B1 (enExample) |
| JP (1) | JP5837095B2 (enExample) |
| KR (1) | KR101521861B1 (enExample) |
| CN (1) | CN103458881B (enExample) |
| AU (1) | AU2012212142B2 (enExample) |
| BR (1) | BR112013019643B1 (enExample) |
| CA (1) | CA2824092C (enExample) |
| CY (1) | CY1116662T1 (enExample) |
| DK (1) | DK2670401T3 (enExample) |
| EA (1) | EA023404B1 (enExample) |
| ES (1) | ES2543567T3 (enExample) |
| HR (1) | HRP20150946T1 (enExample) |
| HU (1) | HUE025395T2 (enExample) |
| ME (1) | ME02200B (enExample) |
| MX (1) | MX2013008791A (enExample) |
| PL (1) | PL2670401T3 (enExample) |
| PT (1) | PT2670401E (enExample) |
| RS (1) | RS54189B1 (enExample) |
| SI (1) | SI2670401T1 (enExample) |
| SM (1) | SMT201500300B (enExample) |
| WO (1) | WO2012106540A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6359020B6 (ja) | 2012-11-06 | 2018-08-15 | シャンハイ フォチョン ファーマシューティカル カンパニー リミテッド | Ａｌｋキナーゼ阻害剤 |
| AU2013341271A1 (en) * | 2012-11-07 | 2015-05-14 | Novartis Ag | Combination therapy |
| CN104109149B (zh) * | 2013-04-22 | 2018-09-28 | 苏州泽璟生物制药有限公司 | 氘代的二氨基嘧啶化合物以及包含该化合物的药物组合物 |
| ITMI20131124A1 (it) * | 2013-07-04 | 2015-01-05 | Univ Milano Bicocca | 2-acilamminotiazoli per il trattamento del cancro |
| TWI610923B (zh) | 2013-07-11 | 2018-01-11 | Betta Pharmaceuticals Co Ltd | 酪氨酸蛋白激酶調節劑及其應用方法 |
| JP6479812B2 (ja) * | 2013-08-28 | 2019-03-06 | ノバルティス アーゲー | 細胞増殖性疾患を治療するためのａｌｋ阻害剤とｃｄｋ阻害剤との組合せ |
| CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| AU2014372166B2 (en) * | 2013-12-23 | 2017-10-26 | Novartis Ag | Pharmaceutical combinations |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
| CN104876914B (zh) * | 2014-02-28 | 2017-04-19 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类间变性淋巴瘤激酶抑制剂 |
| JP6622726B2 (ja) * | 2014-06-17 | 2019-12-18 | コリア リサーチ インスティチュート オブ ケミカル テクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃｈｅｍｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ | ピリミジン‐２，４‐ジアミン誘導体及びそれを有効成分として含有する抗癌用医薬組成物 |
| CN105524045B (zh) * | 2014-10-22 | 2020-04-10 | 山东轩竹医药科技有限公司 | 四环类间变性淋巴瘤激酶抑制剂 |
| CN106146525B (zh) * | 2015-04-10 | 2018-11-02 | 山东轩竹医药科技有限公司 | 三并环类间变性淋巴瘤激酶抑制剂 |
| EP3287463A4 (en) | 2015-04-24 | 2018-07-11 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof |
| CN106699743B (zh) | 2015-11-05 | 2020-06-12 | 湖北生物医药产业技术研究院有限公司 | 嘧啶类衍生物及其用途 |
| CN106220608B (zh) * | 2016-07-25 | 2018-11-27 | 安润医药科技（苏州）有限公司 | 二苯氨基嘧啶及三嗪化合物、其药用组合物及用途 |
| CN107698603B (zh) * | 2016-08-09 | 2022-04-08 | 南京红云生物科技有限公司 | 噻吩并嘧啶类化合物、其制备方法、药用组合物及其应用 |
| WO2018044767A2 (en) | 2016-08-29 | 2018-03-08 | The Regents Of The University Of Michigan | Aminopyrimidines as alk inhibitors |
| CN111484484B (zh) * | 2020-04-13 | 2021-11-23 | 沈阳药科大学 | 含芳杂环的2,4-二芳氨基嘧啶衍生物及其制备与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| DK2287156T3 (da) * | 2003-08-15 | 2013-08-26 | Novartis Ag | 2,4-Di(phenylamino)-pyrimidiner egnede i behandling af neoplastiske sygdomme, inflammatoriske lidelser og lidelser i immunsystemet |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| EP2055146B1 (en) | 2006-07-10 | 2013-11-20 | Goji Limited | Food preparation |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| KR101149295B1 (ko) * | 2006-12-08 | 2012-07-05 | 아이알엠 엘엘씨 | 단백질 키나제 억제제로서의 화합물 |
| RS53588B1 (sr) * | 2006-12-08 | 2015-02-27 | Irm Llc | Jedinjenja i kompozicije kao inhibitori protein kinaza |
| JP5298187B2 (ja) * | 2008-04-07 | 2013-09-25 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
-
2012
- 2012-02-02 KR KR1020137023001A patent/KR101521861B1/ko active Active
- 2012-02-02 PL PL12703670T patent/PL2670401T3/pl unknown
- 2012-02-02 JP JP2013552637A patent/JP5837095B2/ja active Active
- 2012-02-02 SI SI201230285T patent/SI2670401T1/sl unknown
- 2012-02-02 PT PT127036705T patent/PT2670401E/pt unknown
- 2012-02-02 ME MEP-2015-127A patent/ME02200B/me unknown
- 2012-02-02 WO PCT/US2012/023669 patent/WO2012106540A1/en not_active Ceased
- 2012-02-02 DK DK12703670.5T patent/DK2670401T3/en active
- 2012-02-02 EA EA201391114A patent/EA023404B1/ru not_active IP Right Cessation
- 2012-02-02 MX MX2013008791A patent/MX2013008791A/es unknown
- 2012-02-02 US US13/981,046 patent/US8703787B2/en active Active
- 2012-02-02 CN CN201280007465.9A patent/CN103458881B/zh active Active
- 2012-02-02 AU AU2012212142A patent/AU2012212142B2/en active Active
- 2012-02-02 ES ES12703670.5T patent/ES2543567T3/es active Active
- 2012-02-02 EP EP12703670.5A patent/EP2670401B1/en active Active
- 2012-02-02 RS RS20150563A patent/RS54189B1/sr unknown
- 2012-02-02 HU HUE12703670A patent/HUE025395T2/en unknown
- 2012-02-02 CA CA2824092A patent/CA2824092C/en active Active
- 2012-02-02 BR BR112013019643-2A patent/BR112013019643B1/pt active IP Right Grant
- 2012-02-02 HR HRP20150946TT patent/HRP20150946T1/hr unknown
-
2015
- 2015-08-28 CY CY20151100758T patent/CY1116662T1/el unknown
- 2015-11-30 SM SM201500300T patent/SMT201500300B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013019643A2 (pt) | 2016-10-04 |
| KR20130121174A (ko) | 2013-11-05 |
| ES2543567T3 (es) | 2015-08-20 |
| HUE025395T2 (en) | 2016-02-29 |
| DK2670401T3 (en) | 2015-09-07 |
| MX2013008791A (es) | 2013-10-07 |
| SI2670401T1 (sl) | 2015-10-30 |
| CA2824092C (en) | 2020-06-30 |
| US20130296357A1 (en) | 2013-11-07 |
| WO2012106540A1 (en) | 2012-08-09 |
| JP2014504646A (ja) | 2014-02-24 |
| CA2824092A1 (en) | 2012-08-09 |
| AU2012212142A1 (en) | 2013-08-15 |
| PT2670401E (pt) | 2015-10-12 |
| EA201391114A1 (ru) | 2013-12-30 |
| CN103458881A (zh) | 2013-12-18 |
| US8703787B2 (en) | 2014-04-22 |
| EP2670401A1 (en) | 2013-12-11 |
| ME02200B (me) | 2016-02-20 |
| JP5837095B2 (ja) | 2015-12-24 |
| RS54189B1 (sr) | 2015-12-31 |
| EA023404B1 (ru) | 2016-05-31 |
| AU2012212142B2 (en) | 2015-09-24 |
| CY1116662T1 (el) | 2017-03-15 |
| SMT201500300B (it) | 2016-01-08 |
| HRP20150946T1 (hr) | 2015-10-09 |
| KR101521861B1 (ko) | 2015-05-21 |
| EP2670401B1 (en) | 2015-06-10 |
| CN103458881B (zh) | 2015-08-12 |
| PL2670401T3 (pl) | 2015-11-30 |
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