JP2008533007A5 - - Google Patents
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- Publication number
- JP2008533007A5 JP2008533007A5 JP2008500729A JP2008500729A JP2008533007A5 JP 2008533007 A5 JP2008533007 A5 JP 2008533007A5 JP 2008500729 A JP2008500729 A JP 2008500729A JP 2008500729 A JP2008500729 A JP 2008500729A JP 2008533007 A5 JP2008533007 A5 JP 2008533007A5
- Authority
- JP
- Japan
- Prior art keywords
- sdz
- rad isomer
- rad
- isomer
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical class C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 19
- 239000003960 organic solvent Substances 0.000 claims 7
- 239000012062 aqueous buffer Substances 0.000 claims 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- HKVAMNSJSFKALM-CPXURSODSA-N everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)\C(C)=C\C=C\C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-CPXURSODSA-N 0.000 claims 2
- 239000003880 polar aprotic solvent Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65937805P | 2005-03-07 | 2005-03-07 | |
| PCT/US2006/006125 WO2006096325A1 (en) | 2005-03-07 | 2006-02-22 | Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008533007A JP2008533007A (ja) | 2008-08-21 |
| JP2008533007A5 true JP2008533007A5 (enExample) | 2009-04-09 |
Family
ID=36572419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500729A Withdrawn JP2008533007A (ja) | 2005-03-07 | 2006-02-22 | ４２−ｏ−（２−ヒドロキシ）エチル−ラパマイシンのオキセパン異性体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7241771B2 (enExample) |
| EP (1) | EP1856131A1 (enExample) |
| JP (1) | JP2008533007A (enExample) |
| CN (1) | CN101137659A (enExample) |
| AU (1) | AU2006221024A1 (enExample) |
| BR (1) | BRPI0608885A2 (enExample) |
| CA (1) | CA2602010A1 (enExample) |
| MX (1) | MX2007010892A (enExample) |
| WO (1) | WO2006096325A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009518648A (ja) * | 2005-12-07 | 2009-05-07 | ワイス | 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法 |
| PE20070748A1 (es) * | 2005-12-07 | 2007-08-08 | Wyeth Corp | Proceso ajustable a escala para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina |
| AR058282A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer. |
| US7622477B2 (en) * | 2006-02-28 | 2009-11-24 | Cordis Corporation | Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| CA2937492C (en) | 2008-11-11 | 2019-08-13 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US10391059B2 (en) | 2009-11-11 | 2019-08-27 | Rapamycin Holdings, Inc. | Oral rapamycin nanoparticle preparations and use |
| JP5985474B2 (ja) * | 2010-08-04 | 2016-09-06 | メリル ライフ サイエンシズ ピーブィティ．エルティディ | 抗増殖特性を有する新規４２−ｏ−（ヘテロアルコキシアルキル）ラパマイシン化合物の調製プロセス |
| CN102268015B (zh) * | 2011-08-30 | 2013-08-28 | 成都摩尔生物医药有限公司 | 一种依维莫司的合成方法 |
| US20160030401A1 (en) | 2013-03-13 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors for prevention of intestinal polyp growth and cancer |
| CN103360411B (zh) * | 2013-07-17 | 2015-09-30 | 成都雅途生物技术有限公司 | 依维莫司结晶提纯方法 |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CA3061907A1 (en) | 2017-05-02 | 2018-11-08 | Revolution Medicines, Inc. | Rapamycin analogs as mtor inhibitors |
| EP3848065B1 (en) | 2017-05-15 | 2023-07-26 | C. R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
| EP3788050B1 (en) | 2018-05-01 | 2024-08-28 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| PL3788049T3 (pl) | 2018-05-01 | 2023-06-19 | Revolution Medicines, Inc. | Połączone z C40, C28 i C32 analogi rapamycyny jako inhibitory mTOR |
| JP7262581B2 (ja) | 2018-11-14 | 2023-04-21 | ルトニックス，インコーポレーテッド | 改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス |
| CN113939324A (zh) | 2019-04-08 | 2022-01-14 | 巴德外周血管股份有限公司 | 在经改性装置表面上具有药物洗脱涂层的医疗装置 |
| EP4531859A4 (en) | 2022-05-25 | 2026-05-27 | Revolution Medicines Inc | CANCER TREATMENT METHODS USING AN MTOR INHIBITOR |
| CN116813642B (zh) * | 2023-06-29 | 2024-04-19 | 浙江康润制药有限公司 | 一种依维莫司纯化方法 |
| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| NO921449L (no) | 1991-04-17 | 1992-10-19 | American Home Prod | Karbamater av rapamycin |
| JPH06502659A (ja) | 1991-05-31 | 1994-03-24 | ファイザー インク | 免疫抑制剤としてのラパマイシンプロドラッグの使用 |
| US5221740A (en) * | 1992-01-16 | 1993-06-22 | American Home Products Corporation | Oxepane isomers of rapamycin useful as immunosuppressive agents |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5516770A (en) | 1993-09-30 | 1996-05-14 | American Home Products Corporation | Rapamycin formulation for IV injection |
| US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| CA2319131A1 (en) * | 1998-01-26 | 1999-07-29 | Walter H. Moos | Mitochondria protecting agents for treating mitochondria associated diseases |
| US6331547B1 (en) * | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| US6670355B2 (en) * | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
| ATE278421T1 (de) | 2000-08-11 | 2004-10-15 | Wyeth Corp | Verfahren zur behandlung eines östrogenrezeptor positives karzinoms |
| JP2004509898A (ja) * | 2000-09-19 | 2004-04-02 | ワイス | 水溶性ラパマイシンエステル |
| US6399625B1 (en) * | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
| US6440991B1 (en) * | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
| US6680330B2 (en) * | 2001-08-22 | 2004-01-20 | Wyeth | Rapamycin dialdehydes |
| EP1419154B1 (en) * | 2001-08-22 | 2005-10-05 | Wyeth | Rapamycin 29-enols |
| EP1646635A1 (en) | 2003-07-16 | 2006-04-19 | Wyeth | Cci-779 isomer c |
-
2006
- 2006-02-22 AU AU2006221024A patent/AU2006221024A1/en not_active Abandoned
- 2006-02-22 EP EP06735687A patent/EP1856131A1/en not_active Withdrawn
- 2006-02-22 BR BRPI0608885A patent/BRPI0608885A2/pt not_active IP Right Cessation
- 2006-02-22 MX MX2007010892A patent/MX2007010892A/es active IP Right Grant
- 2006-02-22 US US11/359,166 patent/US7241771B2/en not_active Expired - Fee Related
- 2006-02-22 WO PCT/US2006/006125 patent/WO2006096325A1/en not_active Ceased
- 2006-02-22 JP JP2008500729A patent/JP2008533007A/ja not_active Withdrawn
- 2006-02-22 CA CA002602010A patent/CA2602010A1/en not_active Abandoned
- 2006-02-22 CN CNA2006800074672A patent/CN101137659A/zh not_active Withdrawn