JP2009143956A5 - - Google Patents
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- Publication number
- JP2009143956A5 JP2009143956A5 JP2009036918A JP2009036918A JP2009143956A5 JP 2009143956 A5 JP2009143956 A5 JP 2009143956A5 JP 2009036918 A JP2009036918 A JP 2009036918A JP 2009036918 A JP2009036918 A JP 2009036918A JP 2009143956 A5 JP2009143956 A5 JP 2009143956A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- substituted
- unsubstituted
- azabicycloalkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical group 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 9
- 239000012458 free base Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- -1 cyano, formyl Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220581.3 | 2002-09-04 | ||
| GB0220581A GB0220581D0 (en) | 2002-09-04 | 2002-09-04 | Organic Compound |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533455A Division JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009143956A JP2009143956A (ja) | 2009-07-02 |
| JP2009143956A5 true JP2009143956A5 (enExample) | 2009-08-13 |
| JP5124714B2 JP5124714B2 (ja) | 2013-01-23 |
Family
ID=9943515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533455A Expired - Lifetime JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
| JP2009036918A Expired - Fee Related JP5124714B2 (ja) | 2002-09-04 | 2009-02-19 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533455A Expired - Lifetime JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US20060167002A1 (enExample) |
| EP (3) | EP2308876A1 (enExample) |
| JP (2) | JP4348422B2 (enExample) |
| KR (2) | KR100808324B1 (enExample) |
| CN (1) | CN1325493C (enExample) |
| AT (1) | ATE448225T1 (enExample) |
| AU (1) | AU2003260486C1 (enExample) |
| BR (2) | BRPI0314325B8 (enExample) |
| CA (1) | CA2495685C (enExample) |
| CY (1) | CY1109765T1 (enExample) |
| DE (1) | DE60330015D1 (enExample) |
| DK (1) | DK1537104T3 (enExample) |
| EC (1) | ECSP055621A (enExample) |
| ES (1) | ES2336099T3 (enExample) |
| GB (1) | GB0220581D0 (enExample) |
| IL (2) | IL166918A (enExample) |
| MX (1) | MXPA05002546A (enExample) |
| NO (1) | NO331556B1 (enExample) |
| NZ (1) | NZ538534A (enExample) |
| PL (1) | PL209425B1 (enExample) |
| PT (1) | PT1537104E (enExample) |
| RU (1) | RU2352569C2 (enExample) |
| SI (1) | SI1537104T1 (enExample) |
| WO (1) | WO2004022556A1 (enExample) |
| ZA (1) | ZA200500816B (enExample) |
Families Citing this family (55)
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| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| US7750022B2 (en) | 2003-08-13 | 2010-07-06 | Neurosearch A/S | Quinuclidine derivatives and their pharmaceutical use |
| US7309699B2 (en) | 2003-12-22 | 2007-12-18 | Abbott Laboratories | 3-Quinuclidinyl amino-substituted biaryl derivatives |
| US7241773B2 (en) | 2003-12-22 | 2007-07-10 | Abbott Laboratories | 3-quinuclidinyl heteroatom bridged biaryl derivatives |
| US7655657B2 (en) | 2003-12-22 | 2010-02-02 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US7160876B2 (en) | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20050137398A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-Quinuclidinyl heteroatom bridged biaryl derivatives |
| CA2551486A1 (en) * | 2003-12-22 | 2006-06-22 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20050137217A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | Spirocyclic quinuclidinic ether derivatives |
| US20050137203A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-quinuclidinyl amino-substituted biaryl derivatives |
| US20050245531A1 (en) * | 2003-12-22 | 2005-11-03 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| WO2006034341A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| GB0424564D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
| GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| JP2009526777A (ja) | 2006-02-14 | 2009-07-23 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体作用薬としての３，９−ジアザビシクロ（３．３．１）ノナ−３−イル−アリールメタノン誘導体 |
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| MX2009001875A (es) | 2006-08-21 | 2009-03-02 | Genentech Inc | Compuestos de aza-benzotiofenilo y metodos de uso de los mismos. |
| RU2010107462A (ru) * | 2007-08-02 | 2011-09-10 | Таргасепт, Инк. (Us) | ЛЕЧЕНИЕ α7-СЕЛЕКТИВНЫМИ ЛИГАНДАМИ |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| EP2307364B1 (en) | 2008-07-01 | 2013-06-19 | Genentech, Inc. | Isoindolone derivatives as mek kinase inhibitors and methods of use |
| EP2310373A1 (en) | 2008-07-01 | 2011-04-20 | Genentech, Inc. | Bicyclic heterocycles as mek kinase inhibitors |
| CN105687190A (zh) * | 2008-11-19 | 2016-06-22 | 福拉姆医药股份有限公司 | 用(R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺及其可药用盐治疗认知障碍 |
| PE20120324A1 (es) * | 2009-05-11 | 2012-04-17 | Envivo Pharmaceuticals Inc | Combinacion que comprende (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y donezepilo como moduladora de trastornos cognitivos |
| US20120157464A1 (en) | 2009-07-23 | 2012-06-21 | Novartis Ag | Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| AU2010305825A1 (en) | 2009-10-13 | 2012-04-19 | Merck Sharp & Dohme B.V. | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
| KR20180101641A (ko) | 2010-05-17 | 2018-09-12 | 포럼 파마슈티칼즈 인크. | (R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태 |
| MX2013008704A (es) * | 2011-01-27 | 2013-08-21 | Novartis Ag | Uso de activadores del receptor de acetil-colina nicotinico alfa-7. |
| MX2013010698A (es) * | 2011-03-18 | 2014-02-17 | Novartis Ag | Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson. |
| TWI589576B (zh) * | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
| CA2852268C (en) * | 2011-10-20 | 2020-08-25 | Novartis Ag | Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
| EP3461481A1 (en) | 2012-05-08 | 2019-04-03 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
| CA2894384C (en) * | 2012-12-11 | 2018-03-06 | Novartis Ag | Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
| EP2742940B1 (en) * | 2012-12-13 | 2017-07-26 | IP Gesellschaft für Management mbH | Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily |
| KR101879921B1 (ko) * | 2013-01-15 | 2018-07-18 | 노파르티스 아게 | 기면증의 치료를 위한 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도 |
| ES2865736T3 (es) * | 2013-01-15 | 2021-10-15 | Novartis Ag | Uso de agonistas del receptor de acetilcolina nicotínico alfa 7 |
| JP6338223B2 (ja) * | 2013-01-15 | 2018-06-06 | ノバルティス アーゲー | アルファ７ニコチン性アセチルコリン受容体アゴニストの使用 |
| US20150313884A1 (en) * | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| UY38687A (es) | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| JP2023553354A (ja) * | 2020-11-25 | 2023-12-21 | バンダ・ファーマシューティカルズ・インコーポレイテッド | アルファ－７ニコチン性アセチルコリン受容体アゴニストを用いた、スピーチ不安の治療 |
| CN116761604A (zh) * | 2020-11-25 | 2023-09-15 | 万达制药公司 | 用α-7烟碱型乙酰胆碱受体激动剂治疗当众讲话焦虑 |
| CN119212992A (zh) * | 2022-05-05 | 2024-12-27 | 菲利普莫里斯生产公司 | 烟碱乙酰胆碱受体配体 |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| WO2025188847A1 (en) * | 2024-03-07 | 2025-09-12 | The Texas A&M University System | Method for treating epilepsy |
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2002
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2003
- 2003-09-03 KR KR20057003665A patent/KR100808324B1/ko not_active Expired - Lifetime
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- 2003-09-03 EP EP20100184187 patent/EP2308876A1/en not_active Withdrawn
- 2003-09-03 WO PCT/EP2003/009772 patent/WO2004022556A1/en not_active Ceased
- 2003-09-03 DE DE60330015T patent/DE60330015D1/de not_active Expired - Lifetime
- 2003-09-03 US US10/526,759 patent/US20060167002A1/en not_active Abandoned
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- 2003-09-03 SI SI200331746T patent/SI1537104T1/sl unknown
- 2003-09-03 EP EP20090164576 patent/EP2100893A1/en not_active Withdrawn
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