JP2005536503A5 - - Google Patents
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- Publication number
- JP2005536503A5 JP2005536503A5 JP2004520900A JP2004520900A JP2005536503A5 JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5 JP 2004520900 A JP2004520900 A JP 2004520900A JP 2004520900 A JP2004520900 A JP 2004520900A JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- formula
- compound
- pharmaceutically acceptable
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000044956 Ceramide glucosyltransferases Human genes 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 108091000114 ceramide glucosyltransferase Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- RZLAXWZVPCMNHD-NMTNWJIDSA-N C[C@@H](C(Nc1ccc(CN(C[C@@H](C2O)O)[C@@H](CO)[C@H]2O)cc1)=O)c1ccccc1 Chemical compound C[C@@H](C(Nc1ccc(CN(C[C@@H](C2O)O)[C@@H](CO)[C@H]2O)cc1)=O)c1ccccc1 RZLAXWZVPCMNHD-NMTNWJIDSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0216656A GB0216656D0 (en) | 2002-07-17 | 2002-07-17 | Novel compounds |
| GB0301480A GB0301480D0 (en) | 2003-01-22 | 2003-01-22 | Novel compounds |
| GB0313679A GB0313679D0 (en) | 2003-06-13 | 2003-06-13 | Novel compounds |
| PCT/GB2003/003099 WO2004007453A1 (en) | 2002-07-17 | 2003-07-17 | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005536503A JP2005536503A (ja) | 2005-12-02 |
| JP2005536503A5 true JP2005536503A5 (enExample) | 2006-09-07 |
| JP4575156B2 JP4575156B2 (ja) | 2010-11-04 |
Family
ID=30118831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520900A Expired - Fee Related JP4575156B2 (ja) | 2002-07-17 | 2003-07-17 | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7985760B2 (enExample) |
| EP (1) | EP1534676B1 (enExample) |
| JP (1) | JP4575156B2 (enExample) |
| AU (1) | AU2003246942B2 (enExample) |
| CA (1) | CA2492404C (enExample) |
| ES (1) | ES2393331T3 (enExample) |
| WO (1) | WO2004007453A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| US7994198B2 (en) * | 2002-07-17 | 2011-08-09 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
| WO2004007453A1 (en) | 2002-07-17 | 2004-01-22 | Oxford Glycosciences (Uk) Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| WO2005092334A2 (en) * | 2004-03-25 | 2005-10-06 | David Priestman | Use of n-substituted imino sugars for appetite suppression |
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| US8716327B2 (en) | 2006-05-09 | 2014-05-06 | Genzyme Corporation | Methods of treating fatty liver disease |
| EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| CN102940627A (zh) | 2007-10-05 | 2013-02-27 | 简詹姆公司 | 使用脑酰胺衍生物治疗多囊性肾疾病的方法 |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| MX2011003517A (es) | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
| WO2011085544A1 (zh) * | 2010-01-13 | 2011-07-21 | 安徽辉克药业有限公司 | 有效清除肿瘤细胞的化合物 |
| PT2685986T (pt) * | 2011-03-18 | 2020-03-05 | Genzyme Corp | Inibidor de glicosilceramida-sintase |
| JOP20130273B1 (ar) | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
| JP6826986B2 (ja) * | 2014-11-05 | 2021-02-10 | エマージェント バイロロジー エルエルシー | ウィルス性疾患の治療に有用なイミノ糖類 |
| US20200262800A1 (en) * | 2015-11-16 | 2020-08-20 | Ptc Therapeutics, Inc. | Hydrogen isotope-enriched analogues of 1,2,4-oxadiazole benzoic acid compounds, compositions and uses thereof |
| JP7594548B2 (ja) | 2019-05-10 | 2024-12-04 | アレクトス セラピューティックス インコーポレイテッド | 非リソソームグルコシルセラミダーゼ阻害剤及びその使用 |
| US12083115B2 (en) | 2020-02-03 | 2024-09-10 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| CN115803025B (zh) | 2020-05-07 | 2025-09-02 | 阿勒克图治疗公司 | 非溶酶体葡糖神经酰胺酶抑制剂及其用途 |
| IL297972A (en) * | 2020-05-07 | 2023-01-01 | Alectos Therapeutics Inc | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| BR112023000798A2 (pt) | 2020-07-24 | 2023-02-07 | Genzyme Corp | Composições farmacêuticas compreendendo venglustat |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3495570A (en) * | 1967-07-03 | 1970-02-17 | Amchem Prod | Applicator for liquid chemical conversion coating material |
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE3007078A1 (de) | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3024901A1 (de) | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| JPH02306962A (ja) * | 1989-05-19 | 1990-12-20 | Meiji Seika Kaisha Ltd | 新規ｎ―置換―１―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤 |
| JPH0324057A (ja) | 1989-06-22 | 1991-02-01 | Tosoh Corp | ポリヒドロキシピペリジン類及びその製造法 |
| EP0491041A4 (en) | 1989-09-07 | 1993-03-03 | Nippon Shinyaku Company, Limited | Antiviral drug |
| EP0536402A4 (en) | 1990-06-29 | 1993-05-12 | Nippon Shinyaku Company, Limited | Piperidine derivative |
| US5276120A (en) * | 1991-05-30 | 1994-01-04 | The Scripps Research Institute | Process for forming omega-deuxy-azasugars |
| US5916759A (en) | 1993-05-05 | 1999-06-29 | Boehringer Mannheim Gmbh | Cholesterol oxidase from Brevibacterium sterolicum |
| US5798366A (en) | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
| US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
| EP0912179B1 (en) | 1996-07-15 | 2006-04-12 | MacroZyme DNM B.V. | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| WO1998050359A1 (en) | 1997-05-06 | 1998-11-12 | Novo Nordisk A/S | Novel heterocyclic compounds |
| US6426198B1 (en) | 1997-07-03 | 2002-07-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Genes for Niemann-Pick type C disease |
| AU753336B2 (en) * | 1997-11-10 | 2002-10-17 | G.D. Searle & Co. | Use of alkylated iminosugars to treat multidrug resistance |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| WO2000056334A1 (en) | 1999-03-19 | 2000-09-28 | The Trustees Of Boston College | Use of imino sugars for anti-tumor therapy |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| GB9909064D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| JP2003505430A (ja) | 1999-07-26 | 2003-02-12 | ジー・ディー・サール・アンド・カンパニー | デオキシノジリマイシンの長鎖ｎ−アルキル誘導体およびグルコセレブロシダーゼ酵素の糖脂質異常蓄積疾患の治療用の薬剤の製造のための使用 |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| JP2003506406A (ja) | 1999-08-10 | 2003-02-18 | ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード | 長鎖ｎ−アルキル化合物およびそのオキサ誘導体 |
| WO2003075916A1 (en) * | 2002-03-13 | 2003-09-18 | Van Der Spoel Aarnoud C | A non-hormonal approach to male contraception |
| WO2004007453A1 (en) | 2002-07-17 | 2004-01-22 | Oxford Glycosciences (Uk) Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| US7994198B2 (en) | 2002-07-17 | 2011-08-09 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
-
2003
- 2003-07-17 WO PCT/GB2003/003099 patent/WO2004007453A1/en not_active Ceased
- 2003-07-17 ES ES03764025T patent/ES2393331T3/es not_active Expired - Lifetime
- 2003-07-17 CA CA2492404A patent/CA2492404C/en not_active Expired - Fee Related
- 2003-07-17 US US10/522,208 patent/US7985760B2/en not_active Expired - Fee Related
- 2003-07-17 AU AU2003246942A patent/AU2003246942B2/en not_active Ceased
- 2003-07-17 EP EP03764025A patent/EP1534676B1/en not_active Expired - Lifetime
- 2003-07-17 JP JP2004520900A patent/JP4575156B2/ja not_active Expired - Fee Related
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