JP2005536503A5 - - Google Patents

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Publication number
JP2005536503A5
JP2005536503A5 JP2004520900A JP2004520900A JP2005536503A5 JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5 JP 2004520900 A JP2004520900 A JP 2004520900A JP 2004520900 A JP2004520900 A JP 2004520900A JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5
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JP
Japan
Prior art keywords
compound according
formula
compound
pharmaceutically acceptable
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004520900A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005536503A (ja
JP4575156B2 (ja
Filing date
Publication date
Priority claimed from GB0216656A external-priority patent/GB0216656D0/en
Priority claimed from GB0301480A external-priority patent/GB0301480D0/en
Priority claimed from GB0313679A external-priority patent/GB0313679D0/en
Application filed filed Critical
Priority claimed from PCT/GB2003/003099 external-priority patent/WO2004007453A1/en
Publication of JP2005536503A publication Critical patent/JP2005536503A/ja
Publication of JP2005536503A5 publication Critical patent/JP2005536503A5/ja
Application granted granted Critical
Publication of JP4575156B2 publication Critical patent/JP4575156B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004520900A 2002-07-17 2003-07-17 グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 Expired - Fee Related JP4575156B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0216656A GB0216656D0 (en) 2002-07-17 2002-07-17 Novel compounds
GB0301480A GB0301480D0 (en) 2003-01-22 2003-01-22 Novel compounds
GB0313679A GB0313679D0 (en) 2003-06-13 2003-06-13 Novel compounds
PCT/GB2003/003099 WO2004007453A1 (en) 2002-07-17 2003-07-17 Piperidinetriol derivatives as inhibitors of glycosylceramide synthase

Publications (3)

Publication Number Publication Date
JP2005536503A JP2005536503A (ja) 2005-12-02
JP2005536503A5 true JP2005536503A5 (enExample) 2006-09-07
JP4575156B2 JP4575156B2 (ja) 2010-11-04

Family

ID=30118831

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004520900A Expired - Fee Related JP4575156B2 (ja) 2002-07-17 2003-07-17 グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体

Country Status (7)

Country Link
US (1) US7985760B2 (enExample)
EP (1) EP1534676B1 (enExample)
JP (1) JP4575156B2 (enExample)
AU (1) AU2003246942B2 (enExample)
CA (1) CA2492404C (enExample)
ES (1) ES2393331T3 (enExample)
WO (1) WO2004007453A1 (enExample)

Families Citing this family (24)

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GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
US7985760B2 (en) 2002-07-17 2011-07-26 Actelion Pharmaceuticals Ltd. Piperidinetriol derivatives as inhibitors of glycosyceramid synthase
AU2003248960B2 (en) * 2002-07-17 2009-06-25 Idorsia Pharmaceuticals Ltd Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
EP1528056A1 (en) 2003-10-29 2005-05-04 Academisch Ziekenhuis bij de Universiteit van Amsterdam Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
US20060025449A1 (en) * 2004-03-25 2006-02-02 United Therapeutics Use of N-substituted imino sugars for appetite suppression
JP2008519840A (ja) 2004-11-10 2008-06-12 ジェンザイム・コーポレイション 糖尿病の処置方法
WO2007134086A2 (en) * 2006-05-09 2007-11-22 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
EP2594562B1 (en) 2007-05-31 2016-07-20 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
KR101640263B1 (ko) 2007-10-05 2016-07-15 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
JP2011529500A (ja) * 2008-07-28 2011-12-08 ジェンザイム コーポレーション 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害
US8309593B2 (en) 2008-10-03 2012-11-13 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
WO2011085544A1 (zh) * 2010-01-13 2011-07-21 安徽辉克药业有限公司 有效清除肿瘤细胞的化合物
CN103917094B (zh) * 2011-03-18 2016-11-09 建新公司 葡萄糖基神经酰胺合酶抑制剂
MA37975B2 (fr) 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
CA2966893C (en) 2014-11-05 2023-10-24 Emergent Virology Llc Iminosugars
EP3377476B1 (en) * 2015-11-16 2022-10-26 PTC Therapeutics, Inc. Hydrogen isotope-enriched analogues of 1,2,4-oxadiazole benzoic acid compounds, compositions and uses thereof
US12527776B2 (en) 2019-02-04 2026-01-20 Genzyme Corporation Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS)
US12612380B2 (en) 2019-05-10 2026-04-28 Alectos Therapeutics 1Nc Non-lysosomal glucosylceramidase inhibitors and uses thereof
EP4100009A1 (en) 2020-02-03 2022-12-14 Genzyme Corporation Methods for treating neurological symptoms associated with lysosomal storage diseases
KR20230008826A (ko) * 2020-05-07 2023-01-16 알렉토스 테라퓨틱스 인크. 비-리소좀 글로코실세라미다아제 억제제 및 이의 용도
US12528773B2 (en) * 2020-05-07 2026-01-20 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof
KR20230043024A (ko) 2020-07-24 2023-03-30 젠자임 코포레이션 벤글루스타트를 포함하는 제약 조성물

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GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
JP2003505430A (ja) 1999-07-26 2003-02-12 ジー・ディー・サール・アンド・カンパニー デオキシノジリマイシンの長鎖ｎ−アルキル誘導体およびグルコセレブロシダーゼ酵素の糖脂質異常蓄積疾患の治療用の薬剤の製造のための使用
US7256005B2 (en) * 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
ES2302697T3 (es) 1999-08-10 2008-08-01 The Chancellor, Masters And Scholars Of The University Of Oxford Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
ES2271548T3 (es) 2002-03-13 2007-04-16 Unither Pharmaceuticals, Inc. Enfoque no hormonal de anticoncepcion masculina.
US7985760B2 (en) 2002-07-17 2011-07-26 Actelion Pharmaceuticals Ltd. Piperidinetriol derivatives as inhibitors of glycosyceramid synthase
AU2003248960B2 (en) * 2002-07-17 2009-06-25 Idorsia Pharmaceuticals Ltd Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
GB0313677D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0400812D0 (en) 2004-01-14 2004-02-18 Celltech R&D Ltd Novel compounds

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