JP2005536503A5 - - Google Patents

Download PDF

Info

Publication number
JP2005536503A5
JP2005536503A5 JP2004520900A JP2004520900A JP2005536503A5 JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5 JP 2004520900 A JP2004520900 A JP 2004520900A JP 2004520900 A JP2004520900 A JP 2004520900A JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5
Authority
JP
Japan
Prior art keywords
compound according
formula
compound
pharmaceutically acceptable
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004520900A
Other languages
English (en)
Japanese (ja)
Other versions
JP4575156B2 (ja
JP2005536503A (ja
Filing date
Publication date
Priority claimed from GB0216656A external-priority patent/GB0216656D0/en
Priority claimed from GB0301480A external-priority patent/GB0301480D0/en
Priority claimed from GB0313679A external-priority patent/GB0313679D0/en
Application filed filed Critical
Priority claimed from PCT/GB2003/003099 external-priority patent/WO2004007453A1/en
Publication of JP2005536503A publication Critical patent/JP2005536503A/ja
Publication of JP2005536503A5 publication Critical patent/JP2005536503A5/ja
Application granted granted Critical
Publication of JP4575156B2 publication Critical patent/JP4575156B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004520900A 2002-07-17 2003-07-17 グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 Expired - Fee Related JP4575156B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0216656A GB0216656D0 (en) 2002-07-17 2002-07-17 Novel compounds
GB0301480A GB0301480D0 (en) 2003-01-22 2003-01-22 Novel compounds
GB0313679A GB0313679D0 (en) 2003-06-13 2003-06-13 Novel compounds
PCT/GB2003/003099 WO2004007453A1 (en) 2002-07-17 2003-07-17 Piperidinetriol derivatives as inhibitors of glycosylceramide synthase

Publications (3)

Publication Number Publication Date
JP2005536503A JP2005536503A (ja) 2005-12-02
JP2005536503A5 true JP2005536503A5 (enExample) 2006-09-07
JP4575156B2 JP4575156B2 (ja) 2010-11-04

Family

ID=30118831

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004520900A Expired - Fee Related JP4575156B2 (ja) 2002-07-17 2003-07-17 グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体

Country Status (7)

Country Link
US (1) US7985760B2 (enExample)
EP (1) EP1534676B1 (enExample)
JP (1) JP4575156B2 (enExample)
AU (1) AU2003246942B2 (enExample)
CA (1) CA2492404C (enExample)
ES (1) ES2393331T3 (enExample)
WO (1) WO2004007453A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0100889D0 (en) 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
WO2004007453A1 (en) 2002-07-17 2004-01-22 Oxford Glycosciences (Uk) Ltd Piperidinetriol derivatives as inhibitors of glycosylceramide synthase
JP4585851B2 (ja) * 2002-07-17 2010-11-24 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0313677D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
EP1528056A1 (en) * 2003-10-29 2005-05-04 Academisch Ziekenhuis bij de Universiteit van Amsterdam Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
EP1746992A2 (en) * 2004-03-25 2007-01-31 United Therapeutics Use of n-substituted imino sugars for appetite suppression
EP1811991B1 (en) * 2004-11-10 2018-11-07 Genzyme Corporation Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis
PT2032134E (pt) * 2006-05-09 2015-10-07 Genzyme Corp Métodos de tratamento da doença do fígado gorduroso
EP2594563B1 (en) 2007-05-31 2018-07-18 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
SG10201707161PA (en) * 2007-10-05 2017-10-30 Genzyme Corp Method of treating polycystic kidney diseases with ceramide derivatives
US8389517B2 (en) 2008-07-28 2013-03-05 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
CA2738768C (en) 2008-10-03 2017-10-31 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
WO2011085544A1 (zh) * 2010-01-13 2011-07-21 安徽辉克药业有限公司 有效清除肿瘤细胞的化合物
UA118248C2 (uk) * 2011-03-18 2018-12-26 Джензім Корпорейшн Інгібітори глюкозилцерамідсинтази
MA37975B2 (fr) 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
US10428022B2 (en) 2014-11-05 2019-10-01 Emergent Virology Llc Iminosugars useful for the treatment of viral diseases
EP3377476B1 (en) * 2015-11-16 2022-10-26 PTC Therapeutics, Inc. Hydrogen isotope-enriched analogues of 1,2,4-oxadiazole benzoic acid compounds, compositions and uses thereof
WO2020229968A1 (en) 2019-05-10 2020-11-19 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof
US12083115B2 (en) 2020-02-03 2024-09-10 Genzyme Corporation Methods for treating neurological symptoms associated with lysosomal storage diseases
CR20220600A (es) * 2020-05-07 2023-04-11 Alectos Therapeutics Inc Inhibidores de glucosilceramidasa no lisosomal y los usos de los mismos
US20230174486A1 (en) * 2020-05-07 2023-06-08 ALECTOS THERAPEUTICS lNC. Non-lysosomal glucosylceramidase inhibitors and uses thereof
BR112023000798A2 (pt) 2020-07-24 2023-02-07 Genzyme Corp Composições farmacêuticas compreendendo venglustat

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3495570A (en) * 1967-07-03 1970-02-17 Amchem Prod Applicator for liquid chemical conversion coating material
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3024901A1 (de) 1980-07-01 1982-01-28 Bayer Ag, 5090 Leverkusen Herbizide mittel auf basis von piperidin-derivaten
DE3247615A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3737523A1 (de) * 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel
US5003072A (en) * 1988-11-03 1991-03-26 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
JPH02306962A (ja) 1989-05-19 1990-12-20 Meiji Seika Kaisha Ltd 新規ｎ―置換―１―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤
JPH0324057A (ja) 1989-06-22 1991-02-01 Tosoh Corp ポリヒドロキシピペリジン類及びその製造法
EP0491041A4 (en) 1989-09-07 1993-03-03 Nippon Shinyaku Company, Limited Antiviral drug
WO1992000277A1 (en) * 1990-06-29 1992-01-09 Nippon Shinyaku Co., Ltd. Piperidine derivative
US5276120A (en) * 1991-05-30 1994-01-04 The Scripps Research Institute Process for forming omega-deuxy-azasugars
US5916759A (en) 1993-05-05 1999-06-29 Boehringer Mannheim Gmbh Cholesterol oxidase from Brevibacterium sterolicum
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
WO1998002161A1 (en) 1996-07-15 1998-01-22 Universiteit Van Amsterdam Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
IL132170A0 (en) * 1997-05-06 2001-03-19 Novo Nordisk As Novel heterocyclic compounds
WO1999001555A1 (en) * 1997-07-03 1999-01-14 The United States Of America Represented By The Secretary, Department Of Health And Human Services Genes for niemann-pick type c disease
ES2216327T3 (es) 1997-11-10 2004-10-16 G.D. SEARLE & CO. Uso de iminoazucares alquilados para tratar la resistencia a multiples a farmacos.
US6610703B1 (en) 1998-12-10 2003-08-26 G.D. Searle & Co. Method for treatment of glycolipid storage diseases
WO2000056334A1 (en) 1999-03-19 2000-09-28 The Trustees Of Boston College Use of imino sugars for anti-tumor therapy
GB9909064D0 (en) 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
CA2378776A1 (en) * 1999-07-26 2001-02-01 G.D. Searle & Co. Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases
US7256005B2 (en) * 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
JP2003506406A (ja) 1999-08-10 2003-02-18 ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード 長鎖ｎ−アルキル化合物およびそのオキサ誘導体
CA2479027A1 (en) * 2002-03-13 2003-09-18 Aarnoud C. Van Der Spoel A non-hormonal approach to male contraception
JP4585851B2 (ja) * 2002-07-17 2010-11-24 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
WO2004007453A1 (en) 2002-07-17 2004-01-22 Oxford Glycosciences (Uk) Ltd Piperidinetriol derivatives as inhibitors of glycosylceramide synthase
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0400812D0 (en) 2004-01-14 2004-02-18 Celltech R&D Ltd Novel compounds

Similar Documents

Publication Publication Date Title
JP2005536503A5 (enExample)
JP2006509749A5 (enExample)
JP2014500861A5 (enExample)
JP2006514012A5 (enExample)
JP2006526031A5 (enExample)
JP2004516314A5 (enExample)
JP2005053931A5 (enExample)
JP2006524660A5 (enExample)
JP2009502743A5 (enExample)
JP2012502037A5 (enExample)
MA32633B1 (fr) Formes cristallines d'un derive 2-thiazolyl-4-quinolinyl-oxy, un inhibiteur puissant du vhc
JP2008501000A5 (enExample)
JP2005518413A5 (enExample)
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
JP2010527913A5 (enExample)
JP2002513793A5 (enExample)
RU2011133128A (ru) Противоопухолевые соединения дигидропиран-2-она
ATE512961T1 (de) Amorphes nebivolol hydrochlorid und seine herstellung
JP2003306481A5 (enExample)
JP2012513416A5 (enExample)
EP2308828A3 (en) CaSR antagonist
JP2011527299A5 (enExample)
CN114829365A (zh) 作为erk抑制剂的噻唑并内酰胺类化合物及其应用
JP2014505017A5 (enExample)
JP2010505865A5 (enExample)