JP2005536503A5 - - Google Patents

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Publication number
JP2005536503A5
JP2005536503A5 JP2004520900A JP2004520900A JP2005536503A5 JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5 JP 2004520900 A JP2004520900 A JP 2004520900A JP 2004520900 A JP2004520900 A JP 2004520900A JP 2005536503 A5 JP2005536503 A5 JP 2005536503A5
Authority
JP
Japan
Prior art keywords
compound according
formula
compound
pharmaceutically acceptable
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004520900A
Other languages
English (en)
Japanese (ja)
Other versions
JP4575156B2 (ja
JP2005536503A (ja
Filing date
Publication date
Priority claimed from GB0216656A external-priority patent/GB0216656D0/en
Priority claimed from GB0301480A external-priority patent/GB0301480D0/en
Priority claimed from GB0313679A external-priority patent/GB0313679D0/en
Application filed filed Critical
Priority claimed from PCT/GB2003/003099 external-priority patent/WO2004007453A1/en
Publication of JP2005536503A publication Critical patent/JP2005536503A/ja
Publication of JP2005536503A5 publication Critical patent/JP2005536503A5/ja
Application granted granted Critical
Publication of JP4575156B2 publication Critical patent/JP4575156B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004520900A 2002-07-17 2003-07-17 グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 Expired - Fee Related JP4575156B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0216656A GB0216656D0 (en) 2002-07-17 2002-07-17 Novel compounds
GB0301480A GB0301480D0 (en) 2003-01-22 2003-01-22 Novel compounds
GB0313679A GB0313679D0 (en) 2003-06-13 2003-06-13 Novel compounds
PCT/GB2003/003099 WO2004007453A1 (en) 2002-07-17 2003-07-17 Piperidinetriol derivatives as inhibitors of glycosylceramide synthase

Publications (3)

Publication Number Publication Date
JP2005536503A JP2005536503A (ja) 2005-12-02
JP2005536503A5 true JP2005536503A5 (enExample) 2006-09-07
JP4575156B2 JP4575156B2 (ja) 2010-11-04

Family

ID=30118831

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004520900A Expired - Fee Related JP4575156B2 (ja) 2002-07-17 2003-07-17 グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体

Country Status (7)

Country Link
US (1) US7985760B2 (enExample)
EP (1) EP1534676B1 (enExample)
JP (1) JP4575156B2 (enExample)
AU (1) AU2003246942B2 (enExample)
CA (1) CA2492404C (enExample)
ES (1) ES2393331T3 (enExample)
WO (1) WO2004007453A1 (enExample)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
JP4585851B2 (ja) * 2002-07-17 2010-11-24 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
EP1534676B1 (en) 2002-07-17 2012-09-12 Actelion Pharmaceuticals Ltd. Piperidinetriol derivatives as inhibitors of glycosylceramide synthase
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
EP1528056A1 (en) * 2003-10-29 2005-05-04 Academisch Ziekenhuis bij de Universiteit van Amsterdam Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
US20060025449A1 (en) * 2004-03-25 2006-02-02 United Therapeutics Use of N-substituted imino sugars for appetite suppression
CA2586761A1 (en) 2004-11-10 2006-05-18 Genzyme Corporation Methods of treating diabetes mellitus
EP2032134B1 (en) 2006-05-09 2015-06-24 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
US8304447B2 (en) 2007-05-31 2012-11-06 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
KR20160085917A (ko) 2007-10-05 2016-07-18 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
WO2010014554A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
US8309593B2 (en) 2008-10-03 2012-11-13 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
WO2011085544A1 (zh) * 2010-01-13 2011-07-21 安徽辉克药业有限公司 有效清除肿瘤细胞的化合物
MY173998A (en) * 2011-03-18 2020-03-03 Genzyme Corp Glucosylceramide synthase inhibitors
JOP20130273B1 (ar) 2012-09-11 2021-08-17 Genzyme Corp مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
SG11201703330YA (en) * 2014-11-05 2017-05-30 Emergent Virology Llc Iminosugars useful for the treatment of viral diseases
WO2017087364A1 (en) * 2015-11-16 2017-05-26 Ptc Therapeutics, Inc. Hydrogen isotope-enriched analogues of 1,2,4-oxandiazole benzoic acid compounds, compositions and uses thereof
PT3920912T (pt) 2019-02-04 2025-09-09 Genzyme Corp Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs)
WO2020229968A1 (en) 2019-05-10 2020-11-19 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof
EP4100009A1 (en) 2020-02-03 2022-12-14 Genzyme Corporation Methods for treating neurological symptoms associated with lysosomal storage diseases
WO2021224865A1 (en) * 2020-05-07 2021-11-11 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof
EP4146623A4 (en) * 2020-05-07 2024-05-01 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof
CA3186766A1 (en) 2020-07-24 2022-01-27 Danielle Combessis Pharmaceutical compositions comprising venglustat

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DE3024901A1 (de) 1980-07-01 1982-01-28 Bayer Ag, 5090 Leverkusen Herbizide mittel auf basis von piperidin-derivaten
DE3247615A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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WO1998002161A1 (en) 1996-07-15 1998-01-22 Universiteit Van Amsterdam Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
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WO2000056334A1 (en) 1999-03-19 2000-09-28 The Trustees Of Boston College Use of imino sugars for anti-tumor therapy
GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
GB9909064D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
AU6050600A (en) * 1999-07-26 2001-02-13 G.D. Searle & Co. Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases
HK1046869A1 (zh) 1999-08-10 2003-01-30 The Chancellor, Masters And Scholars Of The University Of Oxford 使用长链n烷基化合物及其恶衍生物作为抗病毒成分
US7256005B2 (en) * 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
KR20050025144A (ko) * 2002-03-13 2005-03-11 데르 스포엘 아아르노우드 씨 반 수컷 피임에 대한 비호르몬적 접근법
EP1534676B1 (en) 2002-07-17 2012-09-12 Actelion Pharmaceuticals Ltd. Piperidinetriol derivatives as inhibitors of glycosylceramide synthase
JP4585851B2 (ja) * 2002-07-17 2010-11-24 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
GB0313677D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0400812D0 (en) * 2004-01-14 2004-02-18 Celltech R&D Ltd Novel compounds

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