JP2002513793A5 - - Google Patents
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- Publication number
- JP2002513793A5 JP2002513793A5 JP2000547088A JP2000547088A JP2002513793A5 JP 2002513793 A5 JP2002513793 A5 JP 2002513793A5 JP 2000547088 A JP2000547088 A JP 2000547088A JP 2000547088 A JP2000547088 A JP 2000547088A JP 2002513793 A5 JP2002513793 A5 JP 2002513793A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- hydrogen
- alkyl
- cycloalkyl
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- -1 - cycloalkoxy Chemical compound 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108124.3 | 1998-05-05 | ||
| EP98108124 | 1998-05-05 | ||
| PCT/EP1999/002827 WO1999057118A1 (de) | 1998-05-05 | 1999-04-27 | Neue n-oxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002513793A JP2002513793A (ja) | 2002-05-14 |
| JP2002513793A5 true JP2002513793A5 (enExample) | 2006-06-22 |
Family
ID=8231880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547088A Withdrawn JP2002513793A (ja) | 1998-05-05 | 1999-04-27 | 新規ｎ−オキシド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6306869B1 (enExample) |
| EP (1) | EP1075477B1 (enExample) |
| JP (1) | JP2002513793A (enExample) |
| AT (1) | ATE234301T1 (enExample) |
| AU (1) | AU3928999A (enExample) |
| CA (1) | CA2330738A1 (enExample) |
| DE (1) | DE59904535D1 (enExample) |
| DK (1) | DK1075477T3 (enExample) |
| ES (1) | ES2195571T3 (enExample) |
| PT (1) | PT1075477E (enExample) |
| SI (1) | SI1075477T1 (enExample) |
| WO (1) | WO1999057118A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
| CZ302882B6 (cs) * | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| JP2003519686A (ja) | 2000-01-11 | 2003-06-24 | アルタナ ファルマ アクチエンゲゼルシャフト | フェナントリジン−ｎ−オキシド |
| SI1377574T1 (enExample) * | 2001-02-21 | 2005-08-31 | Altana Pharma Ag | |
| US20060113968A1 (en) * | 2002-08-17 | 2006-06-01 | Altana Pharma Ag | Novel benzonaphthyridines |
| ATE353217T1 (de) * | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
| JP4587294B2 (ja) * | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン |
| US7470704B2 (en) * | 2002-09-04 | 2008-12-30 | Nycomed Gmbh | Benzonaphthyridines |
| JP4638736B2 (ja) * | 2002-09-04 | 2011-02-23 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のベンゾナフチリジン |
| IS7839A (is) * | 2002-11-22 | 2004-05-23 | Merck Frosst Canada Ltd. | 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar |
| JP4728259B2 (ja) | 2004-02-18 | 2011-07-20 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン |
| CN104803973A (zh) | 2004-03-03 | 2015-07-29 | 塔科达有限责任公司 | 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| CA2558375A1 (en) * | 2004-03-09 | 2005-09-15 | Altana Pharma Ag | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| US20070259909A1 (en) * | 2004-03-10 | 2007-11-08 | Altana Pharma Ag | Novel Difluoroethoxy-Substituted Hydroxy-6-Phenylphenanthridines and Their Use as Pde4 Inhibitors |
| KR20060130697A (ko) * | 2004-03-10 | 2006-12-19 | 알타나 파마 아게 | 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도 |
| KR20060124783A (ko) * | 2004-03-10 | 2006-12-05 | 알타나 파마 아게 | 신규 티오-함유 히드록시-6-페닐페난트리딘 및 ｐｄｅ４억제제로서의 이의 용도 |
| JP2007529471A (ja) * | 2004-03-17 | 2007-10-25 | アルタナ ファルマ アクチエンゲゼルシャフト | 新規のｎ−（アルコキシアルキル）カルバモイル置換された６−フェニル−ベンゾナフチリジン誘導体及びｐｄｅ３／４インヒビターとしてのそれらの使用 |
| EP1791847A2 (en) * | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
| JP5009799B2 (ja) * | 2004-09-08 | 2012-08-22 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の３−オキサ−１０−アザ−フェナントレン |
| ES2440590T3 (es) | 2005-03-02 | 2014-01-29 | Takeda Gmbh | Nuevas sales de derivados de hexahidrofenantridina 6-heterociclil-sustituidos |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247971A3 (en) * | 1986-05-29 | 1990-01-17 | Sandoz Ag | Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin |
| EP0937074B1 (en) | 1996-11-11 | 2003-03-12 | ALTANA Pharma AG | Benzonaphthyridines as bronchial therapeutics |
-
1999
- 1999-04-27 AT AT99922133T patent/ATE234301T1/de not_active IP Right Cessation
- 1999-04-27 EP EP99922133A patent/EP1075477B1/de not_active Expired - Lifetime
- 1999-04-27 JP JP2000547088A patent/JP2002513793A/ja not_active Withdrawn
- 1999-04-27 DK DK99922133T patent/DK1075477T3/da active
- 1999-04-27 ES ES99922133T patent/ES2195571T3/es not_active Expired - Lifetime
- 1999-04-27 SI SI9930279T patent/SI1075477T1/xx unknown
- 1999-04-27 US US09/673,649 patent/US6306869B1/en not_active Expired - Fee Related
- 1999-04-27 AU AU39289/99A patent/AU3928999A/en not_active Abandoned
- 1999-04-27 PT PT99922133T patent/PT1075477E/pt unknown
- 1999-04-27 CA CA002330738A patent/CA2330738A1/en not_active Abandoned
- 1999-04-27 DE DE59904535T patent/DE59904535D1/de not_active Expired - Fee Related
- 1999-04-27 WO PCT/EP1999/002827 patent/WO1999057118A1/de not_active Ceased
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