JPH1095778A5 - - Google Patents

Info

Publication number
JPH1095778A5
JPH1095778A5 JP1997232472A JP23247297A JPH1095778A5 JP H1095778 A5 JPH1095778 A5 JP H1095778A5 JP 1997232472 A JP1997232472 A JP 1997232472A JP 23247297 A JP23247297 A JP 23247297A JP H1095778 A5 JPH1095778 A5 JP H1095778A5
Authority
JP
Japan
Prior art keywords
alkyl
phenyl
substituted phenyl
ocoar
oso2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997232472A
Other languages
English (en)
Japanese (ja)
Other versions
JPH1095778A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JPH1095778A publication Critical patent/JPH1095778A/ja
Publication of JPH1095778A5 publication Critical patent/JPH1095778A5/ja
Ceased legal-status Critical Current

Links

JP9232472A 1996-08-29 1997-08-28 ベンゾ［ｂ］チオフェン化合物、中間体、製造法、組成物及び使用方法 Ceased JPH1095778A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2512496P 1996-08-29 1996-08-29
US60/025124 1996-08-29

Publications (2)

Publication Number Publication Date
JPH1095778A JPH1095778A (ja) 1998-04-14
JPH1095778A5 true JPH1095778A5 (enExample) 2005-05-26

Family

ID=21824170

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9232472A Ceased JPH1095778A (ja) 1996-08-29 1997-08-28 ベンゾ［ｂ］チオフェン化合物、中間体、製造法、組成物及び使用方法

Country Status (7)

Country Link
US (4) US5843965A (enExample)
EP (1) EP0827959B1 (enExample)
JP (1) JPH1095778A (enExample)
AT (1) ATE255574T1 (enExample)
CA (1) CA2214072C (enExample)
DE (1) DE69726513T2 (enExample)
ES (1) ES2212048T3 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2214072C (en) * 1996-08-29 2006-11-14 Eli Lilly And Company Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods
AU735703B2 (en) * 1997-06-10 2001-07-12 Karo Bio Ab Estrogen receptor ligands
AU3053199A (en) * 1998-04-01 1999-10-25 Ono Pharmaceutical Co. Ltd. Fused thiophene derivatives and drugs containing the same as the active ingredient
BR9909492A (pt) * 1998-04-08 2000-12-12 Lilly Co Eli Liberação pulmonar e nasal de raloxifeno
US6258826B1 (en) 1998-10-13 2001-07-10 Eli Lilly And Company Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome
US6962928B2 (en) * 2001-05-22 2005-11-08 Eli Lilly And Company Tetrahydroquinoline derivatives for the inhibition of osteoporosis, estrogen dependent breast cancer, endometriosis and uterine fibrosis
JP2004531562A (ja) * 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー ２−置換１，２，３，４−テトラヒドロキノリンおよびその誘導体、組成物ならびに方法
US20150284357A1 (en) 2012-10-24 2015-10-08 Gregory R. Thatcher Compositions and methods for treating estrogen-related medical disorders
EP2911660B1 (en) 2012-10-24 2019-12-04 The Board of Trustees of the University of Illionis Compositions and methods for treating estrogen-related medical disorders
CN114516853A (zh) * 2022-02-24 2022-05-20 青岛科技大学 一种含药物分子的苯并噻吩衍生物的电催化制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300575B (de) * 1965-05-21 1969-08-07 Bristol Myers Co Benzo[b]thiophene
US3394125A (en) * 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
PH18628A (en) * 1981-04-03 1985-08-23 Lilly Co Eli "6-hydroxy-2-(4-hydroxyphenyl)-3 4-(2- piperidine or 3-methylpyrollidine -benzo b thiophene compounds
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
AU621811B2 (en) * 1987-09-25 1992-03-26 Ciba-Geigy Ag Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5461065A (en) * 1993-10-15 1995-10-24 Eli Lilly And Company Methods for inhibiting endometriosis
US5484798A (en) * 1994-09-20 1996-01-16 Eli Lilly And Company Benzothiopene compounds, compositions, and method of inhibiting restenosis
JP3989569B2 (ja) * 1995-02-28 2007-10-10 イーライ リリー アンド カンパニー ベンゾチオフェン化合物、中間体、組成物および方法
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
CA2214072C (en) * 1996-08-29 2006-11-14 Eli Lilly And Company Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods

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