JP2005534668A5 - - Google Patents
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- Publication number
- JP2005534668A5 JP2005534668A5 JP2004513281A JP2004513281A JP2005534668A5 JP 2005534668 A5 JP2005534668 A5 JP 2005534668A5 JP 2004513281 A JP2004513281 A JP 2004513281A JP 2004513281 A JP2004513281 A JP 2004513281A JP 2005534668 A5 JP2005534668 A5 JP 2005534668A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- methanone
- piperidin
- ylmethyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000007522 mineralic acids Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 235000005985 organic acids Nutrition 0.000 claims 2
- CLSFKOVAEVOMBN-UHFFFAOYSA-N (3,4-dichlorophenyl)-[4-fluoro-4-[[(5-methylpyrimidin-2-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(C)=CN=C1CNCC1(F)CCN(C(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 CLSFKOVAEVOMBN-UHFFFAOYSA-N 0.000 claims 1
- AJEWINCTRQUEBR-UHFFFAOYSA-N (3,4-dichlorophenyl)-[4-fluoro-4-[[(6-methylpyridazin-3-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=NC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 AJEWINCTRQUEBR-UHFFFAOYSA-N 0.000 claims 1
- RCNYUDQCXUKYBA-UHFFFAOYSA-N (3,4-difluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(F)C(F)=CC=2)CC1 RCNYUDQCXUKYBA-UHFFFAOYSA-N 0.000 claims 1
- SALDQMKGRXMXGW-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-[[(5-chloropyridin-2-yl)methylamino]methyl]-4-fluoropiperidin-1-yl]methanone Chemical compound C1=C(Cl)C(F)=CC=C1C(=O)N1CCC(F)(CNCC=2N=CC(Cl)=CC=2)CC1 SALDQMKGRXMXGW-UHFFFAOYSA-N 0.000 claims 1
- NVTWGZZOUHDHMJ-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-chloro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(C)=CC=C1CNCC1(Cl)CCN(C(=O)C=2C=C(Cl)C(F)=CC=2)CC1 NVTWGZZOUHDHMJ-UHFFFAOYSA-N 0.000 claims 1
- SVCRXGVDWDIMLL-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-hydroxypyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(O)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(Cl)C(F)=CC=2)CC1 SVCRXGVDWDIMLL-UHFFFAOYSA-N 0.000 claims 1
- WAAXKNFGOFTGLP-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyrimidin-2-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(C)=CN=C1CNCC1(F)CCN(C(=O)C=2C=C(Cl)C(F)=CC=2)CC1 WAAXKNFGOFTGLP-UHFFFAOYSA-N 0.000 claims 1
- UDSFREKDDUDKDN-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(6-methylpyridazin-3-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=NC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(Cl)C(F)=CC=2)CC1 UDSFREKDDUDKDN-UHFFFAOYSA-N 0.000 claims 1
- XPMHHHJWQFUFAU-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[5-(fluoromethyl)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(CF)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(Cl)C(F)=CC=2)CC1 XPMHHHJWQFUFAU-UHFFFAOYSA-N 0.000 claims 1
- ZYDDGLQBPMAFOI-UHFFFAOYSA-N (4-chloro-3-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone Chemical compound N1=CC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(F)C(Cl)=CC=2)CC1 ZYDDGLQBPMAFOI-UHFFFAOYSA-N 0.000 claims 1
- CKPPJYLPMTUPAS-UHFFFAOYSA-N 2-fluoro-5-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidine-1-carbonyl]benzonitrile Chemical compound N1=CC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(C(F)=CC=2)C#N)CC1 CKPPJYLPMTUPAS-UHFFFAOYSA-N 0.000 claims 1
- UEEOOYQIXPMRQP-UHFFFAOYSA-N 6-[[[1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidin-4-yl]methylamino]methyl]pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(F)=CC=C1C(=O)N1CCC(F)(CNCC=2N=CC(=CC=2)C#N)CC1 UEEOOYQIXPMRQP-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- QFNPKPKDVHIBAU-UHFFFAOYSA-N [4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]-(4-fluorophenyl)methanone Chemical compound N1=CC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=CC(F)=CC=2)CC1 QFNPKPKDVHIBAU-UHFFFAOYSA-N 0.000 claims 1
- PTJQZFWLRCSHOS-UHFFFAOYSA-N [4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]-[3-(trifluoromethyl)phenyl]methanone Chemical compound N1=CC(C)=CC=C1CNCC1(F)CCN(C(=O)C=2C=C(C=CC=2)C(F)(F)F)CC1 PTJQZFWLRCSHOS-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR02/07470 | 2002-06-18 | ||
| FR0207470A FR2840900B1 (fr) | 2002-06-18 | 2002-06-18 | Nouveaux derives d'aryl[4-halogeno-4- [(heteroaryl-methylamino)-methyl]-piperidin-1-yl]-methanone, leur procede de preparation et leur utilisation a titre de medicaments |
| PCT/FR2003/001873 WO2003106449A1 (fr) | 2002-06-18 | 2003-06-18 | Nouveaux derives d'aryl-{4-halogeno-4-[heteroaryl-methylamino)-methyl]-piperidin-1-yl}-methanone, leur procede de preparation et leur utilisation a titre de medicaments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534668A JP2005534668A (ja) | 2005-11-17 |
| JP2005534668A5 true JP2005534668A5 (enExample) | 2006-08-10 |
| JP4699027B2 JP4699027B2 (ja) | 2011-06-08 |
Family
ID=29595331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513281A Expired - Lifetime JP4699027B2 (ja) | 2002-06-18 | 2003-06-18 | 新規なアリール−｛４−ハロ−４−〔（ヘテロアリールメチルアミノ）メチル〕ピペリジン−１−イル｝メタノン誘導体、その製造方法および医薬としてのその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7547700B2 (enExample) |
| EP (1) | EP1539738B1 (enExample) |
| JP (1) | JP4699027B2 (enExample) |
| CN (1) | CN1308325C (enExample) |
| AT (1) | ATE424396T1 (enExample) |
| AU (1) | AU2003258816B2 (enExample) |
| BR (1) | BRPI0311976B8 (enExample) |
| CA (1) | CA2489723C (enExample) |
| DE (1) | DE60326468D1 (enExample) |
| ES (1) | ES2321927T3 (enExample) |
| FR (1) | FR2840900B1 (enExample) |
| MX (1) | MXPA05000024A (enExample) |
| WO (1) | WO2003106449A1 (enExample) |
| ZA (1) | ZA200500467B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852244B1 (fr) | 2003-03-13 | 2007-09-07 | Pf Medicament | Utilisation de derives de pyridin-2-yl-methylamine pour la preparation d'un medicament destine au traitement des symptomes de la douleur chronique d'origine neuropathique ou psychogene |
| FR2891274B1 (fr) * | 2005-09-27 | 2007-11-23 | Pierre Fabre Medicament Sa | Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires. |
| JP2011520975A (ja) * | 2008-05-19 | 2011-07-21 | ユニヴァーシティ オブ テネシー リサーチ ファウンデーション，ザ | ピリミジンの非古典的カンナビノイド化合物及び関連する使用方法 |
| US8389534B2 (en) * | 2008-05-19 | 2013-03-05 | The University Of Tennessee Research Foundation | Pyrimidine non-classical cannabinoid compounds and related methods of use |
| FR2946344B1 (fr) | 2009-06-05 | 2012-05-25 | Pf Medicament | Nouveaux derives d'aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl} methanone, leur procede de preparation et leur utilisation a titre de medicaments |
| EP2338873A1 (en) | 2009-12-22 | 2011-06-29 | Gmeiner, Peter | New aminotetraline derivatives |
| WO2018057576A1 (en) * | 2016-09-22 | 2018-03-29 | Auspex Pharmaceuticals, Inc. | Deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds |
| US11191758B2 (en) | 2017-07-20 | 2021-12-07 | Neurolixis | Use of selective serotonin 5-HT1A receptor agonists for treating side-effects of VMAT inhibitors |
| WO2023144166A1 (en) | 2022-01-26 | 2023-08-03 | Neurolixis | Use of serotonin 5-ht1a receptor agonists to treat diseases associated with sudden unexpected death in epilepsy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN169588B (enExample) * | 1986-10-07 | 1991-11-16 | Pfizer Hospital Prod | |
| FR2755967B1 (fr) * | 1996-11-21 | 1999-01-29 | Pf Medicament | Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments |
| FR2784378B1 (fr) * | 1998-10-09 | 2000-12-29 | Pf Medicament | Nouveaux derives d'aryl-(4-fluoro-4-[(2-pyridin-2-yl- ethylamino)-methyl]-piperidin-1-yl)-methanone, leur procede de preparation et leur utilisation a titre de medicaments |
| FR2820743B1 (fr) * | 2001-02-09 | 2005-02-25 | Pf Medicament | Procede et intermediaires de synthese pour la preparation de derives de pyridin-2-yl-methylamine |
-
2002
- 2002-06-18 FR FR0207470A patent/FR2840900B1/fr not_active Expired - Lifetime
-
2003
- 2003-06-18 US US10/518,394 patent/US7547700B2/en active Active
- 2003-06-18 JP JP2004513281A patent/JP4699027B2/ja not_active Expired - Lifetime
- 2003-06-18 CA CA2489723A patent/CA2489723C/fr not_active Expired - Lifetime
- 2003-06-18 EP EP03760060A patent/EP1539738B1/fr not_active Expired - Lifetime
- 2003-06-18 WO PCT/FR2003/001873 patent/WO2003106449A1/fr not_active Ceased
- 2003-06-18 MX MXPA05000024A patent/MXPA05000024A/es active IP Right Grant
- 2003-06-18 CN CNB038186047A patent/CN1308325C/zh not_active Expired - Lifetime
- 2003-06-18 BR BRPI0311976A patent/BRPI0311976B8/pt not_active IP Right Cessation
- 2003-06-18 AU AU2003258816A patent/AU2003258816B2/en not_active Expired
- 2003-06-18 AT AT03760060T patent/ATE424396T1/de not_active IP Right Cessation
- 2003-06-18 DE DE60326468T patent/DE60326468D1/de not_active Expired - Lifetime
- 2003-06-18 ES ES03760060T patent/ES2321927T3/es not_active Expired - Lifetime
-
2005
- 2005-01-18 ZA ZA2005/00467A patent/ZA200500467B/en unknown