DE60326468D1 - Neue aryl-4-halogen-4-(heteroarylmethylamino)methyl piperidin-1-yl-methanonderivate, herstellungsverfahren und deren verwendung als medikamente - Google Patents

Neue aryl-4-halogen-4-(heteroarylmethylamino)methyl piperidin-1-yl-methanonderivate, herstellungsverfahren und deren verwendung als medikamente

Info

Publication number
DE60326468D1
DE60326468D1 DE60326468T DE60326468T DE60326468D1 DE 60326468 D1 DE60326468 D1 DE 60326468D1 DE 60326468 T DE60326468 T DE 60326468T DE 60326468 T DE60326468 T DE 60326468T DE 60326468 D1 DE60326468 D1 DE 60326468D1
Authority
DE
Germany
Prior art keywords
heteroarylmethylamino
methylpiperidin
medicaments
halogen
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60326468T
Other languages
German (de)
English (en)
Inventor
Bernard Vacher
Bernard Bonnaud
Jean-Louis Maurel
Francis Colpaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Application granted granted Critical
Publication of DE60326468D1 publication Critical patent/DE60326468D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE60326468T 2002-06-18 2003-06-18 Neue aryl-4-halogen-4-(heteroarylmethylamino)methyl piperidin-1-yl-methanonderivate, herstellungsverfahren und deren verwendung als medikamente Expired - Lifetime DE60326468D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0207470A FR2840900B1 (fr) 2002-06-18 2002-06-18 Nouveaux derives d'aryl[4-halogeno-4- [(heteroaryl-methylamino)-methyl]-piperidin-1-yl]-methanone, leur procede de preparation et leur utilisation a titre de medicaments
PCT/FR2003/001873 WO2003106449A1 (fr) 2002-06-18 2003-06-18 Nouveaux derives d'aryl-{4-halogeno-4-[heteroaryl-methylamino)-methyl]-piperidin-1-yl}-methanone, leur procede de preparation et leur utilisation a titre de medicaments

Publications (1)

Publication Number Publication Date
DE60326468D1 true DE60326468D1 (de) 2009-04-16

Family

ID=29595331

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60326468T Expired - Lifetime DE60326468D1 (de) 2002-06-18 2003-06-18 Neue aryl-4-halogen-4-(heteroarylmethylamino)methyl piperidin-1-yl-methanonderivate, herstellungsverfahren und deren verwendung als medikamente

Country Status (14)

Country Link
US (1) US7547700B2 (enExample)
EP (1) EP1539738B1 (enExample)
JP (1) JP4699027B2 (enExample)
CN (1) CN1308325C (enExample)
AT (1) ATE424396T1 (enExample)
AU (1) AU2003258816B2 (enExample)
BR (1) BRPI0311976B8 (enExample)
CA (1) CA2489723C (enExample)
DE (1) DE60326468D1 (enExample)
ES (1) ES2321927T3 (enExample)
FR (1) FR2840900B1 (enExample)
MX (1) MXPA05000024A (enExample)
WO (1) WO2003106449A1 (enExample)
ZA (1) ZA200500467B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852244B1 (fr) 2003-03-13 2007-09-07 Pf Medicament Utilisation de derives de pyridin-2-yl-methylamine pour la preparation d'un medicament destine au traitement des symptomes de la douleur chronique d'origine neuropathique ou psychogene
FR2891274B1 (fr) * 2005-09-27 2007-11-23 Pierre Fabre Medicament Sa Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.
US8389534B2 (en) * 2008-05-19 2013-03-05 The University Of Tennessee Research Foundation Pyrimidine non-classical cannabinoid compounds and related methods of use
CA2724737A1 (en) * 2008-05-19 2009-11-26 The University Of Tennessee Research Foundation Pyrimidine non-classical cannabinoid compounds and related methods of use
FR2946344B1 (fr) 2009-06-05 2012-05-25 Pf Medicament Nouveaux derives d'aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl} methanone, leur procede de preparation et leur utilisation a titre de medicaments
EP2338873A1 (en) 2009-12-22 2011-06-29 Gmeiner, Peter New aminotetraline derivatives
WO2018057576A1 (en) * 2016-09-22 2018-03-29 Auspex Pharmaceuticals, Inc. Deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds
US11191758B2 (en) 2017-07-20 2021-12-07 Neurolixis Use of selective serotonin 5-HT1A receptor agonists for treating side-effects of VMAT inhibitors
WO2023144166A1 (en) 2022-01-26 2023-08-03 Neurolixis Use of serotonin 5-ht1a receptor agonists to treat diseases associated with sudden unexpected death in epilepsy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN169588B (enExample) * 1986-10-07 1991-11-16 Pfizer Hospital Prod
FR2755967B1 (fr) * 1996-11-21 1999-01-29 Pf Medicament Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments
FR2784378B1 (fr) * 1998-10-09 2000-12-29 Pf Medicament Nouveaux derives d'aryl-(4-fluoro-4-[(2-pyridin-2-yl- ethylamino)-methyl]-piperidin-1-yl)-methanone, leur procede de preparation et leur utilisation a titre de medicaments
FR2820743B1 (fr) * 2001-02-09 2005-02-25 Pf Medicament Procede et intermediaires de synthese pour la preparation de derives de pyridin-2-yl-methylamine

Also Published As

Publication number Publication date
CA2489723A1 (fr) 2003-12-24
HK1075452A1 (en) 2005-12-16
ZA200500467B (en) 2005-12-28
JP4699027B2 (ja) 2011-06-08
ES2321927T3 (es) 2009-06-15
BRPI0311976B1 (pt) 2015-08-18
EP1539738B1 (fr) 2009-03-04
AU2003258816A1 (en) 2003-12-31
BR0311976A (pt) 2005-03-29
AU2003258816B2 (en) 2008-08-21
US7547700B2 (en) 2009-06-16
WO2003106449A1 (fr) 2003-12-24
CA2489723C (fr) 2011-08-02
CN1308325C (zh) 2007-04-04
EP1539738A1 (fr) 2005-06-15
US20060100244A1 (en) 2006-05-11
BRPI0311976B8 (pt) 2021-05-25
ATE424396T1 (de) 2009-03-15
CN1675194A (zh) 2005-09-28
WO2003106449A8 (fr) 2005-02-17
FR2840900A1 (fr) 2003-12-19
JP2005534668A (ja) 2005-11-17
FR2840900B1 (fr) 2005-02-25
MXPA05000024A (es) 2005-04-08

Similar Documents

Publication Publication Date Title
ATE430150T1 (de) 8-ä3-amino-piperidin-1-ylü-xanthine, deren herstellung und deren verwendung als dpp-iv hemmer
WO2004037811A8 (de) Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
NO20082388L (no) Heteroaryl substituerte piperidinderivater som L-CPT1 inhibitorer
DE60326468D1 (de) Neue aryl-4-halogen-4-(heteroarylmethylamino)methyl piperidin-1-yl-methanonderivate, herstellungsverfahren und deren verwendung als medikamente
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
ATE496893T1 (de) Isochinolinonderivate und deren verwendung als medikamente
DE60332023D1 (de) Chinolinderivate und deren verwendung als mycobakterielle inhibitoren
ATE359286T1 (de) Heterozyklische verbindungen, verfahren zu deren herstellung sowie deren verwendung als antibiotika
NO20064077L (no) Kemokinreseptorantagonister
DE60334651D1 (de) Nicotinamide und deren Verwendung als P38 Inhibitoren
ATE422198T1 (de) Arylsulfonylnaphthalinderivate als 5ht2a- antagonisten
NO20054852L (no) GFAT inhibitorer
ATE498618T1 (de) Neue zyklische harnstoffderivate, deren herstellung und pharmazeutische verwendung damit als kinase-inhibitoren
DE50202504D1 (de) Neue 4-aminofuropyrimidine und ihre verwendung
ATE373009T1 (de) Verfahren zur vorbereitung von telithromycin
TR200103490T2 (tr) Antihistaminik ve antialerjik maddeler olarak indolilpiperidin türevleri
ATE444747T1 (de) Verfahren zur herstellung von expoxybutanol- zwischenprodukten
DE60203481D1 (de) Piperidinderivate als neurokinin 1 antagonisten
ATE332304T1 (de) Cefdinir salze als zwischenprodukte
ATE553095T1 (de) Neue imidazolderivate, deren herstellung und deren verwendung als intermediate zur herstellung von arzneimitteln und pestiziden
ATE403649T1 (de) Neue imidazolderivative, deren herstellung und deren verwendung als medikament
ATE525364T1 (de) Verfahren zur herstellung von 3,6-dihydro-1,3,5- triazin-derivaten
SG165416A1 (en) Chemical process
DE60323748D1 (de) 1,3-diaza-dibenzoazulene als inhibitoren der produfür deren herstellung
DE602005005024D1 (de) Substituierte thieno- und thiazoloä2,3-düpyrimidine und ä2,3-cüpyridine als inhibitoren von tie2

Legal Events

Date Code Title Description
8364 No opposition during term of opposition