FR2891274B1 - Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires. - Google Patents

Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.

Info

Publication number
FR2891274B1
FR2891274B1 FR0509852A FR0509852A FR2891274B1 FR 2891274 B1 FR2891274 B1 FR 2891274B1 FR 0509852 A FR0509852 A FR 0509852A FR 0509852 A FR0509852 A FR 0509852A FR 2891274 B1 FR2891274 B1 FR 2891274B1
Authority
FR
France
Prior art keywords
fluoro
methyl
methanone
pyrimidin
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0509852A
Other languages
English (en)
Other versions
FR2891274A1 (fr
Inventor
Bernard Vacher
Jean Louis Maurel
Serge Brunel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0509852A priority Critical patent/FR2891274B1/fr
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to JP2008532746A priority patent/JP2009510017A/ja
Priority to EP06793769A priority patent/EP1928857B1/fr
Priority to DE602006015070T priority patent/DE602006015070D1/de
Priority to US11/992,596 priority patent/US20090118507A1/en
Priority to AT06793769T priority patent/ATE471935T1/de
Priority to CA002624020A priority patent/CA2624020A1/fr
Priority to PCT/EP2006/066658 priority patent/WO2007039499A1/fr
Priority to TW095135518A priority patent/TW200745082A/zh
Priority to ARP060104233A priority patent/AR056543A1/es
Publication of FR2891274A1 publication Critical patent/FR2891274A1/fr
Application granted granted Critical
Publication of FR2891274B1 publication Critical patent/FR2891274B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
FR0509852A 2005-09-27 2005-09-27 Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires. Expired - Fee Related FR2891274B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR0509852A FR2891274B1 (fr) 2005-09-27 2005-09-27 Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.
PCT/EP2006/066658 WO2007039499A1 (fr) 2005-09-27 2006-09-22 Procédé de préparation de la (3-chloro-4-fluorophényl)-(4-fluoro-4-{[(5-méthyl-pyrimidin-2-ylméthyl)-amino]-méthyl}-pipéridin-1-yl)-méthanone et nouveaux dérivés pyrimidine intermédiaires
DE602006015070T DE602006015070D1 (de) 2005-09-27 2006-09-22 VERFAHREN ZUR HERSTELLUNG VON (3-CHLOR-4-FLUORPHENYL)-(4-FLUOR-4-äÄ(5METHYLPYRIMIDIN-2-YLMETHYL)AMINOÜMETHYLüPIPERIDIN-1-YL)METHANON UND NEUE PYRIMIDINDERIVATZWISCHENPRODUKTE
US11/992,596 US20090118507A1 (en) 2005-09-27 2006-09-22 Method for Preparing (3-Chloro-4-Fluorophenyl)-(4-Fluoro-4--Piperidin-1-Yl)-Methanone and Novel Intermediate Pyrimidine Derivatives
AT06793769T ATE471935T1 (de) 2005-09-27 2006-09-22 Verfahren zur herstellung von (3-chlor-4- fluorphenyl)-(4-fluor-4-ää(5methylpyrimidin-2- ylmethyl)aminoümethylüpiperidin-1-yl)methanon und neue pyrimidinderivatzwischenprodukte
CA002624020A CA2624020A1 (fr) 2005-09-27 2006-09-22 Procede de preparation de la (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone et nouveaux derives pyrimidine intermediaires
JP2008532746A JP2009510017A (ja) 2005-09-27 2006-09-22 （３−クロロ−４−フルオロフェニル）−（４−フルオロ−４−｛［（５−メチル−ピリミジン−２−イルメチル）−アミノ］−メチル｝−ピペリジン−１−イル）−メタノンの製造方法および新規な中間体ピリミジン誘導体
EP06793769A EP1928857B1 (fr) 2005-09-27 2006-09-22 Procédé de préparation de la (3-chloro-4-fluorophényl)-(4-fluoro-4-{[(5-méthyl-pyrimidin-2-ylméthyl)-amino]-méthyl}-pipéridin-1-yl)-méthanone et nouveaux dérivés pyrimidine intermédiaires
TW095135518A TW200745082A (en) 2005-09-27 2006-09-26 Method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone and novel intermediate pyrimidine derivatives
ARP060104233A AR056543A1 (es) 2005-09-27 2006-09-27 Metodo de preparacion de (3-cloro-4-fluorofenil)-(4-fluoro-4[[(5-metil-pirimidin-2-ilmetil)-amino]-metil]-piperidin-1-il)-metanona y compuestos intermediarios derivados de pirimidina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0509852A FR2891274B1 (fr) 2005-09-27 2005-09-27 Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.

Publications (2)

Publication Number Publication Date
FR2891274A1 FR2891274A1 (fr) 2007-03-30
FR2891274B1 true FR2891274B1 (fr) 2007-11-23

Family

ID=36593226

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0509852A Expired - Fee Related FR2891274B1 (fr) 2005-09-27 2005-09-27 Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.

Country Status (10)

Country Link
US (1) US20090118507A1 (fr)
EP (1) EP1928857B1 (fr)
JP (1) JP2009510017A (fr)
AR (1) AR056543A1 (fr)
AT (1) ATE471935T1 (fr)
CA (1) CA2624020A1 (fr)
DE (1) DE602006015070D1 (fr)
FR (1) FR2891274B1 (fr)
TW (1) TW200745082A (fr)
WO (1) WO2007039499A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104086539A (zh) * 2014-07-17 2014-10-08 天津炜捷制药有限公司 一种利伐沙班的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
FR2755967B1 (fr) * 1996-11-21 1999-01-29 Pf Medicament Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments
FR2820743B1 (fr) * 2001-02-09 2005-02-25 Pf Medicament Procede et intermediaires de synthese pour la preparation de derives de pyridin-2-yl-methylamine
FR2827172B1 (fr) * 2001-07-13 2004-07-02 Pf Medicament Derives de pyridin-2-yl-methylamine pour le traitement de la dependance aux opioides
FR2840900B1 (fr) * 2002-06-18 2005-02-25 Pf Medicament Nouveaux derives d'aryl[4-halogeno-4- [(heteroaryl-methylamino)-methyl]-piperidin-1-yl]-methanone, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
US20090118507A1 (en) 2009-05-07
EP1928857A1 (fr) 2008-06-11
FR2891274A1 (fr) 2007-03-30
ATE471935T1 (de) 2010-07-15
TW200745082A (en) 2007-12-16
DE602006015070D1 (de) 2010-08-05
CA2624020A1 (fr) 2007-04-12
EP1928857B1 (fr) 2010-06-23
AR056543A1 (es) 2007-10-10
WO2007039499A1 (fr) 2007-04-12
JP2009510017A (ja) 2009-03-12

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Effective date: 20110531